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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Cel-018294
UUCD1 version UUC-CaE-00027
Ensembl Protein ID D2045.6
UniProt Accession Q17389; Q18985; CUL1_CAEEL
Genbank Protein ID AAC47120.1; CAA84695.2
Protein Name Cullin-1; Abnormal cell lineage protein 19
Genbank Nucleotide ID U58083; Z35639
Gene Name cul-1; lin-19; D2045.6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00000836 D2045.6 D2045.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/Cullin Cullin_N_terminal 19172179
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/Cullin 3.10e-220 733.3 20 678
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk...........................vgaklYkklkevleefikqvkkkveesedeqlLktynreWek 75
    l+++++ +r+e++ k+y++lyt+vy++c+s vg+++Y++++e++++++ +v++k +e ++e+lLk+y++eWe+
   Q: 20 LQDGLDVAYRRENMaPKDYMTLYTSVYDYCTSItlstsrrdgedgraesstpartagadfVGHEMYQRVEEYVKAYVIAVCEKGAELSGEDLLKYYTTEWEN 121
    7899999*********************************************************************************************** PP
   S: 76 freqlkvlrkifayldrtyvkk.....skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveLslnk............ 160
    fr+++kv++ ifayl+r+++++ ++++++v++Lal +w++++++d+k+++++++l+li++eR+g+++++r++sgvve+lveL++++
   Q: 122 FRISSKVMDGIFAYLNRHWIRReldegHENIYMVYTLALVVWKRNLFNDLKDKVIDAMLELIRSERTGSMINSRYISGVVECLVELGVDDsetdakkdaetk 223
    *****************************************************************************************9************ PP
   S: 161 .laiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllaelvallrdkktedlsrmyk 260
    la+yke FE+kfleat+ fy++e+a+fl++ +v++Y+ kve+rln+e++r++ yl++st+t+L++++e++li+++l++l++++ ll dk+++dlsrm+k
   Q: 224 kLAVYKEFFEVKFLEATRGFYTQEAANFLSNgGNVTDYMIKVETRLNQEDDRCQLYLNSSTKTPLATCCESVLISNQLDFLQRHFGGLLVDKRDDDLSRMFK 325
    ****************************************************************************************************** PP
   S: 261 Llsrvlngleellkeleshikeqgkaalt..aeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlka.......akspEllA 353
    L++rv+ngl+el+k+le+hi+++g++al+ a+e+++d+k yV++lle+++++q+lv+++F+n++ F+++ldka+++f+n+n+v+k+ +ks+EllA
   Q: 326 LCDRVPNGLDELRKSLENHIAKEGHQALErvAMEAATDAKLYVKTLLEVHERYQSLVNRSFKNEPGFMQSLDKAATSFINNNAVTKRappqaqlTKSAELLA 427
    ******************************9*********************************************************************** PP
   S: 354 ryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeek 455
    ry+DqlLrkssk+++e+ele+ ++k+++vfkyi++kdvF+k+Y+k+++kRL+s++sas+eaE+++i+kLk++cg+e+t++L++M++d++vS+dl+++Fke+k
   Q: 428 RYCDQLLRKSSKMPDEAELEELQTKIMVVFKYIDDKDVFSKFYTKMFSKRLISELSASDEAEANFITKLKSMCGYEYTARLSKMVNDTQVSKDLTADFKEKK 529
    ****************************************************************************************************** PP
   S: 456 enteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveel 557
    +++ ++sve++vlvLs+g+Wpt+++t+ ++LP++l+ktie+f +fY+ek++gR+L+W ++++r+e++ +++ +ky ++++t Qm+++L+fn++++++ve++
   Q: 530 ADMLGQKSVEFNVLVLSSGSWPTFPTTP-ITLPQQLSKTIEIFGQFYNEKFNGRRLTWVYSQSRGEITSTAFPKKYVFTATTAQMCTMLLFNEQDSYTVEQI 630
    **************************99.************************************************************************* PP
   S: 558 kkatelpeeeLrrtlqsLvsskkqvlkkepeske...ieeedlfsvNqef 604
    ++at+++e++ +++sL+++ vlk+++e ++ + +++++s+N+++
   Q: 631 AAATKMDEKSAPAIVGSLIKNL--VLKADTELQKedeVPMTATVSLNKAY 678
    ********************87..9999998865578**********987 PP
   

Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description



     Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.
Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway.
Protein Sequence
(Fasta)
MTNSEPRRMT CDSEVVWKKL QDGLDVAYRR ENMAPKDYMT LYTSVYDYCT SITLSTSRRD 60
GEDGRAESST PARTAGADFV GHEMYQRVEE YVKAYVIAVC EKGAELSGED LLKYYTTEWE 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Cel-018294|E3,Cullin|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TATGACAAAT AGCGAACCGA GAAGAATGAC GTGTGATTCC GAGGTGGTTT GGAAGAAATT 60
ACAAGATGGA CTTGATGTAG CGTATCGCAG AGAAAATATG GCGCCAAAAG ACTATATGAC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Cel-018294|E3,Cullin|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031461--C:cullin-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0031625--F:ubiquitin protein ligase binding
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0008340--P:determination of adult lifespan
GO:0009792--P:embryo development ending in birth or egg hatching
GO:0043066--P:negative regulation of apoptotic process
GO:0008285--P:negative regulation of cell proliferation
GO:0010826--P:negative regulation of centrosome duplication
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045930--P:negative regulation of mitotic cell cycle
GO:0002119--P:nematode larval development
GO:0043065--P:positive regulation of apoptotic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0008361--P:regulation of cell size
GO:0031647--P:regulation of protein stability
GO:0000003--P:reproduction
GO:0042594--P:response to starvation

KEGG cel:CELE_D2045.6
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002277 Ailuropoda melanoleuca 46.55 0.00e+00 679.00
IUUC-Atr-002822 Amborella trichopoda 29.03 9.00e-89 320.00
IUUC-Apl-003503 Anas platyrhynchos 46.66 1.00e-158 551.00
IUUC-Aca-005030 Anolis carolinensis 39.80 5.00e-146 510.00
IUUC-Aly-005410 Arabidopsis lyrata 29.51 1.00e-84 306.00
IUUC-Ath-006626 Arabidopsis thaliana 29.76 5.00e-86 310.00
IUUC-Ago-007977 Ashbya gossypii 30.05 1.00e-100 359.00
IUUC-Acl-008190 Aspergillus clavatus 40.49 2.00e-149 521.00
IUUC-Afl-008542 Aspergillus flavus 38.01 8.00e-119 420.00
IUUC-Afu-009007 Aspergillus fumigatus 41.59 1.00e-143 502.00
IUUC-Ani-009290 Aspergillus nidulans 39.48 5.00e-155 540.00
IUUC-Ang-009600 Aspergillus niger 40.92 3.00e-147 514.00
IUUC-Aor-009978 Aspergillus oryzae 39.33 2.00e-129 455.00
IUUC-Ate-010584 Aspergillus terreus 40.23 1.00e-149 521.00
IUUC-Ame-011861 Astyanax mexicanus 46.48 0.00e+00 676.00
IUUC-Bgr-012209 Blumeria graminis 38.01 7.00e-144 503.00
IUUC-Bta-012878 Bos taurus 46.41 0.00e+00 683.00
IUUC-Bci-013941 Botrytis cinerea 37.87 1.00e-152 532.00
IUUC-Bol-016015 Brassica oleracea 29.16 7.00e-84 303.00
IUUC-Bra-017658 Brassica rapa 28.80 1.00e-83 302.00
IUUC-Cja-018965 Callithrix jacchus 45.54 0.00e+00 654.00
IUUC-Cfa-020671 Canis familiaris 46.41 0.00e+00 683.00
IUUC-Cpo-021762 Cavia porcellus 46.54 0.00e+00 686.00
IUUC-Csa-023873 Chlorocebus sabaeus 46.54 0.00e+00 685.00
IUUC-Cin-025547 Ciona intestinalis 43.87 0.00e+00 626.00
IUUC-Csv-026083 Ciona savignyi 43.85 0.00e+00 663.00
IUUC-Cgl-026452 Colletotrichum gloeosporioides 38.14 4.00e-151 527.00
IUUC-Cne-026919 Cryptococcus neoformans 37.56 3.00e-147 514.00
IUUC-Dre-027875 Danio rerio 46.35 0.00e+00 672.00
IUUC-Dno-028931 Dasypus novemcinctus 46.41 0.00e+00 678.00
IUUC-Dor-030846 Dipodomys ordii 46.53 1.00e-129 456.00
IUUC-Dse-031472 Dothistroma septosporum 37.32 2.00e-145 508.00
IUUC-Dme-031793 Drosophila melanogaster 42.05 2.00e-172 598.00
IUUC-Ete-033112 Echinops telfairi 39.13 1.00e-64 240.00
IUUC-Eca-034309 Equus caballus 46.41 0.00e+00 683.00
IUUC-Eeu-034450 Erinaceus europaeus 35.94 8.00e-85 306.00
IUUC-Fca-036330 Felis catus 45.19 0.00e+00 654.00
IUUC-Fal-036899 Ficedula albicollis 46.96 1.00e-166 578.00
IUUC-Fox-037705 Fusarium oxysporum 39.30 6.00e-147 513.00
IUUC-Fso-038367 Fusarium solani 40.25 4.00e-152 530.00
IUUC-Gmo-038708 Gadus morhua 46.04 0.00e+00 665.00
IUUC-Ggr-039917 Gaeumannomyces graminis 38.54 4.00e-150 523.00
IUUC-Gga-041038 Gallus gallus 46.54 0.00e+00 685.00
IUUC-Gac-041820 Gasterosteus aculeatus 46.04 0.00e+00 682.00
IUUC-Gma-044070 Glycine max 30.12 4.00e-92 331.00
IUUC-Ggo-045154 Gorilla gorilla 40.27 2.00e-131 461.00
IUUC-Hsa-046034 Homo sapiens 46.54 0.00e+00 685.00
IUUC-Itr-048285 Ictidomys tridecemlineatus 46.54 0.00e+00 686.00
IUUC-Kpa-049231 Komagataella pastoris 34.13 2.00e-112 399.00
IUUC-Lch-049673 Latimeria chalumnae 46.54 0.00e+00 682.00
IUUC-Loc-052490 Lepisosteus oculatus 46.61 0.00e+00 670.00
IUUC-Lma-053191 Leptosphaeria maculans 39.39 5.00e-152 530.00
IUUC-Laf-054582 Loxodonta africana 46.41 0.00e+00 683.00
IUUC-Mcc-055162 Macaca mulatta 45.89 0.00e+00 669.00
IUUC-Meu-055904 Macropus eugenii 41.16 3.00e-68 252.00
IUUC-Mor-057035 Magnaporthe oryzae 38.73 3.00e-144 504.00
IUUC-Mpo-057555 Magnaporthe poae 38.54 6.00e-151 526.00
IUUC-Mtr-057953 Medicago truncatula 30.47 8.00e-92 330.00
IUUC-Mla-059021 Melampsora laricipopulina 41.34 2.00e-155 541.00
IUUC-Mga-060078 Meleagris gallopavo 46.54 0.00e+00 685.00
IUUC-Mvi-060519 Microbotryum violaceum 38.13 4.00e-152 531.00
IUUC-Mmr-061312 Microcebus murinus 46.54 0.00e+00 685.00
IUUC-Mdo-062867 Monodelphis domestica 46.15 0.00e+00 679.00
IUUC-Mmu-063336 Mus musculus 46.54 0.00e+00 685.00
IUUC-Mac-065440 Musa acuminata 29.84 2.00e-93 335.00
IUUC-Mpu-066400 Mustela putorius furo 46.79 4.00e-166 577.00
IUUC-Mlu-067800 Myotis lucifugus 46.55 0.00e+00 679.00
IUUC-Nfi-068384 Neosartorya fischeri 41.59 3.00e-144 504.00
IUUC-Ncr-068965 Neurospora crassa 39.53 5.00e-151 526.00
IUUC-Nle-069729 Nomascus leucogenys 46.54 0.00e+00 685.00
IUUC-Ont-071729 Oreochromis niloticus 46.41 0.00e+00 686.00
IUUC-Oan-073309 Ornithorhynchus anatinus 46.81 0.00e+00 684.00
IUUC-Ocu-074661 Oryctolagus cuniculus 46.54 0.00e+00 678.00
IUUC-Ola-087422 Oryzias latipes 46.37 0.00e+00 678.00
IUUC-Olu-087721 Ostreococcus lucimarinus 28.09 9.00e-77 280.00
IUUC-Oga-088130 Otolemur garnettii 46.54 0.00e+00 685.00
IUUC-Oar-089510 Ovis aries 44.99 0.00e+00 637.00
IUUC-Ptr-090665 Pan troglodytes 46.54 0.00e+00 685.00
IUUC-Pan-092218 Papio anubis 46.54 0.00e+00 685.00
IUUC-Psi-093175 Pelodiscus sinensis 46.54 0.00e+00 685.00
IUUC-Pma-094502 Petromyzon marinus 46.35 0.00e+00 685.00
IUUC-Pno-095067 Phaeosphaeria nodorum 40.74 1.00e-162 565.00
IUUC-Pfo-096705 Poecilia formosa 46.41 0.00e+00 694.00
IUUC-Pab-097578 Pongo abelii 46.54 0.00e+00 685.00
IUUC-Pop-099019 Populus trichocarpa 29.31 9.00e-91 326.00
IUUC-Pca-100242 Procavia capensis 43.49 9.00e-139 486.00
IUUC-Ppe-101405 Prunus persica 30.69 8.00e-92 330.00
IUUC-Pva-102155 Pteropus vampyrus 40.73 7.00e-162 563.00
IUUC-Pgr-103297 Puccinia graminis 40.90 2.00e-164 571.00
IUUC-Ptt-103706 Puccinia triticina 37.47 2.00e-74 273.00
IUUC-Pte-104257 Pyrenophora teres 40.25 1.00e-161 561.00
IUUC-Pyt-104795 Pyrenophora triticirepentis 40.38 5.00e-162 563.00
IUUC-Rno-105939 Rattus norvegicus 46.54 0.00e+00 685.00
IUUC-Sce-106293 Saccharomyces cerevisiae 29.37 1.00e-99 356.00
IUUC-Sha-106949 Sarcophilus harrisii 46.54 0.00e+00 685.00
IUUC-Sja-107737 Schizosaccharomyces japonicus 33.98 2.00e-113 402.00
IUUC-Spo-108280 Schizosaccharomyces pombe 33.51 1.00e-123 436.00
IUUC-Sly-111067 Solanum lycopersicum 29.96 6.00e-92 330.00
IUUC-Stu-112374 Solanum tuberosum 29.86 6.00e-87 313.00
IUUC-Sre-114984 Sporisorium reilianum 38.28 2.00e-145 508.00
IUUC-Ssc-115829 Sus scrofa 46.42 0.00e+00 675.00
IUUC-Tgu-116950 Taeniopygia guttata 46.54 0.00e+00 685.00
IUUC-Tru-118558 Takifugu rubripes 46.41 0.00e+00 685.00
IUUC-Tni-120460 Tetraodon nigroviridis 46.41 0.00e+00 691.00
IUUC-Tca-121586 Theobroma cacao 29.49 9.00e-89 320.00
IUUC-Tre-122223 Trichoderma reesei 39.10 4.00e-142 497.00
IUUC-Tvi-122539 Trichoderma virens 35.62 2.00e-136 478.00
IUUC-Tme-126926 Tuber melanosporum 38.52 9.00e-150 522.00
IUUC-Tbe-127369 Tupaia belangeri 44.64 3.00e-79 288.00
IUUC-Ttr-129022 Tursiops truncatus 44.18 7.00e-140 489.00
IUUC-Uma-129341 Ustilago maydis 38.01 2.00e-136 478.00
IUUC-Vda-129857 Verticillium dahliae 37.66 3.00e-141 494.00
IUUC-Vpa-130166 Vicugna pacos 44.12 1.00e-152 532.00
IUUC-Vvi-131423 Vitis vinifera 30.49 3.00e-91 328.00
IUUC-Xtr-131818 Xenopus tropicalis 46.41 0.00e+00 683.00
IUUC-Xma-134206 Xiphophorus maculatus 46.41 0.00e+00 687.00
IUUC-Yli-134486 Yarrowia lipolytica 33.54 5.00e-122 430.00
Created Date 25-Jun-2017

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