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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Dme-031854
Ensembl Protein ID FBpp0083801
UniProt Accession Q9V3J4; Q7KLW8; SEC13_DROME
Genbank Protein ID AEO27697.1; AAF56128.1; AHN57479.1; AAD46849.2
Protein Name Protein SEC13 homolog; Secretory protein 13
Genbank Nucleotide ID JN600259; AE014297; AE014297; AF160909
Gene Name Sec13; CG6773
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0024509 FBtr0084409 FBpp0083801
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.70e-26 91.2 54 91
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sd..tllvsGsdDgtikvWDlrtgv 34
           gH+++v+ +a+  +   ++l+s+s+D ++ vW  +t +
   Q: 54   GHQGPVWQVAWahPKfgNILASCSYDRKVIVWKSTTPR 91
           8***********9555599*************988765 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II (PubMed:20144761). Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development (PubMed:20144761). Required for reactivation of transcription after heat shock (PubMed:20144761). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758).
 Functions as a component of the nuclear pore complex (NPC) and the COPII coat (By similarity). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (By similarity). Recruited to transcriptionally active chromatin at the time of transcription initiation by RNA polymerase II (PubMed:20144761). Required for proper expression of ecdysone-responsive genes such as Eip74EF and Eip75B during larval development (PubMed:20144761). Required for reactivation of transcription after heat shock (PubMed:20144761). Required for nuclear import of phosphorylated Mad via importin msk (PubMed:20547758). Has no role in classical nuclear localization signal (cNLS)-dependent nuclear import via importin-beta (PubMed:20547758).
Protein Sequence
(Fasta)
MVSLLQEIDT EHEDMVHHAA LDFYGLLLAT CSSDGSVRIF HSRKNNKALA ELKGHQGPVW 60
QVAWAHPKFG NILASCSYDR KVIVWKSTTP RDWTKLYEYS NHDSSVNSVD FAPSEYGLVL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-031854|E3,WD_repeat|Drosophila melanogaster
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Nucleotide Sequence
(Fasta)
ATTTATACAC TGTGTCTGTT TATGTATCTT ACTATACATG TCCAACTTAA ATCAAAACTG 60
CTCCATAAAC GTTCATACCA AAACACCACC TAAACTGTAT CTAAAATCCC ACACAAGCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-031854|E3,WD_repeat|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat
Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0000785--C:chromatin
GO:0030127--C:COPII vesicle coat
GO:0061700--C:GATOR2 complex
GO:0000139--C:Golgi membrane
GO:0031080--C:nuclear pore outer ring
GO:0005654--C:nucleoplasm
GO:0005703--C:polytene chromosome puff
GO:0035859--C:Seh1-associated complex
GO:0003682--F:chromatin binding
GO:0005198--F:structural molecule activity
GO:0034605--P:cellular response to heat
GO:0035293--P:chitin-based larval cuticle pattern formation
GO:0090114--P:COPII-coated vesicle budding
GO:0035077--P:ecdysone-mediated polytene chromosome puffing
GO:0008363--P:larval chitin-based cuticle development
GO:0010629--P:negative regulation of gene expression
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060261--P:positive regulation of transcription initiation from RNA polymerase II promoter
GO:0007184--P:SMAD protein import into nucleus
KEGG dme:Dmel_CG6773
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000671 Aegilops tauschii 48.15 1.00e-82 298.00
IUUC-Aml-001832 Ailuropoda melanoleuca 58.09 2.00e-101 361.00
IUUC-Atr-002914 Amborella trichopoda 51.35 1.00e-86 311.00
IUUC-Apl-003992 Anas platyrhynchos 59.79 5.00e-97 346.00
IUUC-Aca-005283 Anolis carolinensis 59.60 9.00e-105 372.00
IUUC-Aly-005654 Arabidopsis lyrata 48.66 1.00e-81 295.00
IUUC-Ath-006816 Arabidopsis thaliana 48.66 3.00e-81 293.00
IUUC-Ago-007827 Ashbya gossypii 50.00 4.00e-75 273.00
IUUC-Acl-008205 Aspergillus clavatus 51.01 5.00e-73 266.00
IUUC-Afl-008748 Aspergillus flavus 49.17 2.00e-73 268.00
IUUC-Afu-008791 Aspergillus fumigatus 50.00 2.00e-71 261.00
IUUC-Ani-009152 Aspergillus nidulans 50.16 8.00e-76 276.00
IUUC-Ang-009765 Aspergillus niger 49.83 9.00e-74 269.00
IUUC-Aor-009927 Aspergillus oryzae 49.32 8.00e-71 259.00
IUUC-Ate-010248 Aspergillus terreus 50.00 2.00e-74 271.00
IUUC-Ame-011478 Astyanax mexicanus 59.06 2.00e-103 368.00
IUUC-Bgr-012276 Blumeria graminis 47.55 7.00e-69 253.00
IUUC-Bta-012700 Bos taurus 59.41 5.00e-103 366.00
IUUC-Bci-013722 Botrytis cinerea 48.64 5.00e-75 273.00
IUUC-Bdi-014818 Brachypodium distachyon 49.49 7.00e-84 302.00
IUUC-Bol-015779 Brassica oleracea 49.66 1.00e-82 298.00
IUUC-Bra-016973 Brassica rapa 49.49 8.00e-82 297.00
IUUC-Cel-018479 Caenorhabditis elegans 42.76 2.00e-67 248.00
IUUC-Cja-019956 Callithrix jacchus 58.28 9.00e-96 342.00
IUUC-Cfa-020752 Canis familiaris 58.75 1.00e-102 365.00
IUUC-Cpo-021871 Cavia porcellus 58.28 5.00e-101 359.00
IUUC-Cre-022797 Chlamydomonas reinhardtii 49.83 1.00e-82 298.00
IUUC-Csa-023393 Chlorocebus sabaeus 59.08 9.00e-103 365.00
IUUC-Cho-024786 Choloepus hoffmanni 46.86 2.00e-70 258.00
IUUC-Cin-025332 Ciona intestinalis 56.86 2.00e-96 344.00
IUUC-Csv-025926 Ciona savignyi 56.44 5.00e-97 346.00
IUUC-Cgl-026413 Colletotrichum gloeosporioides 49.13 2.00e-69 254.00
IUUC-Cne-027054 Cryptococcus neoformans 46.37 6.00e-67 246.00
IUUC-Cme-027165 Cyanidioschyzon merolae 35.28 1.00e-51 197.00
IUUC-Dre-027782 Danio rerio 59.60 4.00e-106 377.00
IUUC-Dno-029628 Dasypus novemcinctus 58.61 4.00e-102 363.00
IUUC-Dor-030650 Dipodomys ordii 60.34 2.00e-80 291.00
IUUC-Dse-031206 Dothistroma septosporum 44.97 1.00e-64 239.00
IUUC-Ete-032618 Echinops telfairi 46.94 7.00e-46 176.00
IUUC-Eca-033268 Equus caballus 59.27 2.00e-102 364.00
IUUC-Fca-035918 Felis catus 59.21 9.00e-103 365.00
IUUC-Fal-037551 Ficedula albicollis 59.72 8.00e-89 319.00
IUUC-Fox-037763 Fusarium oxysporum 47.80 3.00e-71 260.00
IUUC-Fso-038341 Fusarium solani 46.38 1.00e-69 255.00
IUUC-Gmo-038638 Gadus morhua 59.47 3.00e-103 367.00
IUUC-Ggr-039865 Gaeumannomyces graminis 47.28 2.00e-68 251.00
IUUC-Gga-040193 Gallus gallus 59.93 7.00e-104 369.00
IUUC-Gma-044311 Glycine max 51.52 4.00e-85 307.00
IUUC-Ggo-045252 Gorilla gorilla 59.08 7.00e-103 366.00
IUUC-Hsa-046565 Homo sapiens 58.75 4.00e-102 363.00
IUUC-Hvu-047835 Hordeum vulgare 49.83 3.00e-84 303.00
IUUC-Itr-048587 Ictidomys tridecemlineatus 59.27 9.00e-103 365.00
IUUC-Kpa-049148 Komagataella pastoris 51.36 2.00e-78 284.00
IUUC-Lch-050421 Latimeria chalumnae 60.26 2.00e-105 374.00
IUUC-Lpe-051187 Leersia perrieri 49.33 3.00e-83 303.00
IUUC-Loc-052167 Lepisosteus oculatus 58.22 3.00e-103 367.00
IUUC-Lma-053250 Leptosphaeria maculans 48.11 3.00e-69 254.00
IUUC-Laf-054304 Loxodonta africana 59.27 2.00e-102 364.00
IUUC-Mcc-055519 Macaca mulatta 58.75 2.00e-102 364.00
IUUC-Meu-056439 Macropus eugenii 59.27 2.00e-102 364.00
IUUC-Mor-057241 Magnaporthe oryzae 48.29 5.00e-68 249.00
IUUC-Mpo-057373 Magnaporthe poae 41.69 1.00e-56 211.00
IUUC-Mtr-058412 Medicago truncatula 49.49 8.00e-83 299.00
IUUC-Mla-058966 Melampsora laricipopulina 44.98 2.00e-72 265.00
IUUC-Mga-060066 Meleagris gallopavo 59.79 5.00e-97 346.00
IUUC-Mvi-060290 Microbotryum violaceum 42.90 1.00e-68 255.00
IUUC-Mmr-060717 Microcebus murinus 58.75 3.00e-102 363.00
IUUC-Mdo-062496 Monodelphis domestica 59.41 2.00e-103 367.00
IUUC-Mmu-063490 Mus musculus 59.74 1.00e-103 368.00
IUUC-Mac-064519 Musa acuminata 49.67 7.00e-84 302.00
IUUC-Mpu-066601 Mustela putorius furo 58.75 1.00e-102 365.00
IUUC-Mlu-067501 Myotis lucifugus 59.27 1.00e-102 365.00
IUUC-Nfi-068360 Neosartorya fischeri 50.19 5.00e-61 226.00
IUUC-Ncr-068928 Neurospora crassa 48.12 6.00e-72 263.00
IUUC-Nle-069028 Nomascus leucogenys 58.75 9.00e-103 365.00
IUUC-Opr-070446 Ochotona princeps 59.58 4.00e-97 346.00
IUUC-Ont-071587 Oreochromis niloticus 59.60 4.00e-103 367.00
IUUC-Oan-073211 Ornithorhynchus anatinus 58.75 1.00e-102 365.00
IUUC-Ocu-074306 Oryctolagus cuniculus 60.73 2.00e-104 371.00
IUUC-Oba-075069 Oryza barthii 49.49 3.00e-84 304.00
IUUC-Obr-076667 Oryza brachyantha 50.17 6.00e-86 309.00
IUUC-Ogl-077208 Oryza glaberrima 49.49 3.00e-84 304.00
IUUC-Ogu-078513 Oryza glumaepatula 49.49 3.00e-84 304.00
IUUC-Oin-079094 Oryza indica 49.49 3.00e-84 304.00
IUUC-Olo-080473 Oryza longistaminata 49.49 3.00e-84 304.00
IUUC-Ome-081643 Oryza meridionalis 49.49 3.00e-84 304.00
IUUC-Oni-082589 Oryza nivara 49.49 3.00e-84 304.00
IUUC-Opu-083677 Oryza punctata 49.49 2.00e-84 304.00
IUUC-Oru-084537 Oryza rufipogon 49.49 3.00e-84 304.00
IUUC-Osa-085449 Oryza sativa 49.49 3.00e-84 304.00
IUUC-Ola-087226 Oryzias latipes 60.26 9.00e-106 375.00
IUUC-Olu-087893 Ostreococcus lucimarinus 47.95 2.00e-73 268.00
IUUC-Oga-088837 Otolemur garnettii 59.74 6.00e-104 369.00
IUUC-Oar-089594 Ovis aries 59.41 3.00e-103 367.00
IUUC-Ptr-091132 Pan troglodytes 59.08 4.00e-103 366.00
IUUC-Psi-093568 Pelodiscus sinensis 60.42 3.00e-99 353.00
IUUC-Pma-094172 Petromyzon marinus 56.67 4.00e-46 176.00
IUUC-Pno-094955 Phaeosphaeria nodorum 48.29 3.00e-68 251.00
IUUC-Ppa-095578 Physcomitrella patens 49.67 8.00e-84 302.00
IUUC-Pfo-096063 Poecilia formosa 59.60 1.00e-104 372.00
IUUC-Pab-098674 Pongo abelii 59.21 1.00e-102 365.00
IUUC-Pop-099402 Populus trichocarpa 51.52 5.00e-85 306.00
IUUC-Pca-100824 Procavia capensis 44.55 6.00e-69 253.00
IUUC-Ppe-101278 Prunus persica 48.82 1.00e-83 302.00
IUUC-Pva-103161 Pteropus vampyrus 55.78 4.00e-96 343.00
IUUC-Pgr-103573 Puccinia graminis 46.86 6.00e-74 270.00
IUUC-Ptt-103700 Puccinia triticina 47.06 6.00e-69 253.00
IUUC-Pte-104267 Pyrenophora teres 48.62 2.00e-66 245.00
IUUC-Pyt-104535 Pyrenophora triticirepentis 48.78 5.00e-63 233.00
IUUC-Rno-104833 Rattus norvegicus 59.74 1.00e-103 368.00
IUUC-Sce-106437 Saccharomyces cerevisiae 49.32 3.00e-69 254.00
IUUC-Sha-106611 Sarcophilus harrisii 59.27 2.00e-102 364.00
IUUC-Sja-107654 Schizosaccharomyces japonicus 49.17 9.00e-74 269.00
IUUC-Spo-108362 Schizosaccharomyces pombe 47.57 9.00e-74 269.00
IUUC-Smo-109674 Selaginella moellendorffii 49.66 8.00e-84 302.00
IUUC-Sit-110132 Setaria italica 49.66 8.00e-85 305.00
IUUC-Sly-111852 Solanum lycopersicum 49.49 2.00e-81 294.00
IUUC-Stu-112195 Solanum tuberosum 50.17 3.00e-82 297.00
IUUC-Sbi-114229 Sorghum bicolor 50.51 3.00e-86 310.00
IUUC-Sre-114898 Sporisorium reilianum 47.09 2.00e-80 291.00
IUUC-Ssc-115995 Sus scrofa 57.65 8.00e-52 194.00
IUUC-Tgu-116793 Taeniopygia guttata 59.47 1.00e-93 335.00
IUUC-Tru-117797 Takifugu rubripes 59.47 7.00e-104 369.00
IUUC-Tni-120366 Tetraodon nigroviridis 58.94 2.00e-102 364.00
IUUC-Tca-121068 Theobroma cacao 49.83 4.00e-83 300.00
IUUC-Tre-121899 Trichoderma reesei 47.30 8.00e-70 256.00
IUUC-Tvi-122380 Trichoderma virens 46.96 1.00e-69 255.00
IUUC-Tae-123998 Triticum aestivum 49.83 1.00e-84 305.00
IUUC-Tur-126202 Triticum urartu 49.83 6.00e-85 306.00
IUUC-Tme-127181 Tuber melanosporum 50.00 1.00e-78 285.00
IUUC-Ttr-128448 Tursiops truncatus 51.82 2.00e-85 308.00
IUUC-Uma-129661 Ustilago maydis 46.76 3.00e-80 291.00
IUUC-Vda-129666 Verticillium dahliae 49.31 4.00e-72 263.00
IUUC-Vpa-130318 Vicugna pacos 59.08 4.00e-103 367.00
IUUC-Vvi-130868 Vitis vinifera 50.84 5.00e-85 306.00
IUUC-Xtr-131859 Xenopus tropicalis 60.60 2.00e-104 370.00
IUUC-Xma-133898 Xiphophorus maculatus 59.60 1.00e-104 372.00
IUUC-Yli-134559 Yarrowia lipolytica 50.00 1.00e-73 269.00
Created Date 25-Jun-2017

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