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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064227
UUCD1 version UUC-MuM-00552
Ensembl Protein ID ENSMUSP00000103350.1
UniProt Accession Q6ZWS8; Q3TLC2; Q5ST07; Q76LV9; SPOP_MOUSE
Genbank Protein ID AAT08952.1; BAC25809.1; BAC27114.1; BAE35119.1; BAE38870.1; CAI25973.1; AAH43131.1; AAH45205.1; BAB68542.1
Protein Name Speckle-type POZ protein; HIB homolog 1; PDX-1 C-terminal-interacting factor 1
Genbank Nucleotide ID AY538613; AK028201; AK030746; AK159482; AK166581; AL662875; BC043131; BC045205; AB071989
Gene Name Spop; Pcif1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000057522.15 ENSMUST00000107722.7 ENSMUSP00000103350.1
ENSMUSG00000057522.15 ENSMUST00000127713.1 ENSMUSP00000118922.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.40e-32 113.0 200 266
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 5.70e-09 35.2 299 329
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +D++l+v+g+ef+ahk++Laa+S+vF+a+f++e+eesk k++vei+dv+pevf+++++F+Ytgk+++ 
   Q: 200  TDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESK-KNRVEINDVEPEVFKEMMCFIYTGKAPNL 266
           7*************************************.*************************9986 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           +eN+++il +Adl+++++Lk +a+dfi++h 
   Q: 299  VENAAEILILADLHSADQLKTQAVDFINYHA 329
           79***************************95 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL (By similarity). In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation.
 Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL (By similarity). In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation.
Protein Sequence
(Fasta)
MSRVPSPPPP AEMSSGPVAE SWCYTQIKVV KFSYMWTINN FSFCREEMGE VIKSSTFSSG 60
ANDKLKWCLR VNPKGLDEES KDYLSLYLLL VSCPKSEVRA KFKFSILNAK GEETKAMESQ 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064227|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGCGGGTACG CGCTCGCTGC GTCGACGTGC TGACGACAGG ACGCCCAGGC CGGTGTGTGT 60
CGGTGTGTAT GTGTGTGTGT GTGTGTGTGT ATGTGTGTGT GTGTGTGTGT GTGTGGTGTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064227|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR000210--BTB/POZ_dom
IPR002083--MATH/TRAF_dom
IPR011333--SKP1/BTB/POZ
IPR034089--SPOP_C
IPR008974--TRAF-like
PROSITE

PS50097--BTB
PS50144--MATH
Pfam

PF00651--BTB
PF00917--MATH
SMART

SM00225--BTB
SM00061--MATH
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0001085--F:RNA polymerase II transcription factor binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0042593--P:glucose homeostasis
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:1902237--P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2000676--P:positive regulation of type B pancreatic cell apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030162--P:regulation of proteolysis
KEGG mmu:20747
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000920 Aegilops tauschii 31.53 3.00e-40 159.00
IUUC-Aml-002307 Ailuropoda melanoleuca 95.17 0.00e+00 700.00
IUUC-Apl-003488 Anas platyrhynchos 99.73 0.00e+00 715.00
IUUC-Aca-005010 Anolis carolinensis 99.47 0.00e+00 714.00
IUUC-Aly-005426 Arabidopsis lyrata 29.86 4.00e-41 162.00
IUUC-Ath-007670 Arabidopsis thaliana 28.77 1.00e-37 150.00
IUUC-Afl-008594 Aspergillus flavus 38.46 2.00e-03 36.20
IUUC-Aor-009945 Aspergillus oryzae 38.46 3.00e-04 36.60
IUUC-Bgr-012157 Blumeria graminis 35.00 1.00e-04 40.40
IUUC-Bta-012931 Bos taurus 100.00 0.00e+00 716.00
IUUC-Bdi-014743 Brachypodium distachyon 32.55 2.00e-43 169.00
IUUC-Cel-018671 Caenorhabditis elegans 65.90 1.00e-135 476.00
IUUC-Cja-019981 Callithrix jacchus 99.73 0.00e+00 712.00
IUUC-Cfa-020115 Canis familiaris 100.00 0.00e+00 716.00
IUUC-Cpo-021366 Cavia porcellus 99.47 0.00e+00 710.00
IUUC-Cin-025636 Ciona intestinalis 76.55 3.00e-159 554.00
IUUC-Csv-026167 Ciona savignyi 71.68 3.00e-156 544.00
IUUC-Cgl-026729 Colletotrichum gloeosporioides 30.30 8.00e-06 45.10
IUUC-Dre-027603 Danio rerio 97.33 0.00e+00 697.00
IUUC-Dno-029006 Dasypus novemcinctus 93.93 0.00e+00 645.00
IUUC-Dor-030503 Dipodomys ordii 100.00 0.00e+00 707.00
IUUC-Dme-032218 Drosophila melanogaster 79.68 5.00e-160 558.00
IUUC-Ete-032328 Echinops telfairi 99.43 0.00e+00 654.00
IUUC-Eca-033238 Equus caballus 100.00 0.00e+00 716.00
IUUC-Eeu-034739 Erinaceus europaeus 83.96 5.00e-176 610.00
IUUC-Fca-035435 Felis catus 100.00 0.00e+00 716.00
IUUC-Gmo-038600 Gadus morhua 95.99 0.00e+00 692.00
IUUC-Gga-040441 Gallus gallus 99.73 0.00e+00 715.00
IUUC-Gac-041911 Gasterosteus aculeatus 96.79 0.00e+00 696.00
IUUC-Gma-043988 Glycine max 31.22 3.00e-42 166.00
IUUC-Hsa-045835 Homo sapiens 100.00 0.00e+00 716.00
IUUC-Hvu-047528 Hordeum vulgare 31.10 8.00e-40 157.00
IUUC-Itr-048058 Ictidomys tridecemlineatus 97.83 0.00e+00 681.00
IUUC-Lch-050241 Latimeria chalumnae 98.66 0.00e+00 709.00
IUUC-Loc-052374 Lepisosteus oculatus 98.93 0.00e+00 709.00
IUUC-Lma-053106 Leptosphaeria maculans 23.53 2.00e-08 52.00
IUUC-Laf-054192 Loxodonta africana 99.73 0.00e+00 712.00
IUUC-Mcc-055322 Macaca mulatta 100.00 0.00e+00 716.00
IUUC-Meu-056330 Macropus eugenii 92.78 0.00e+00 660.00
IUUC-Mpo-057466 Magnaporthe poae 28.36 7.00e-08 50.80
IUUC-Mtr-058679 Medicago truncatula 30.14 1.00e-40 160.00
IUUC-Mga-059579 Meleagris gallopavo 95.15 0.00e+00 701.00
IUUC-Mmr-061309 Microcebus murinus 100.00 0.00e+00 716.00
IUUC-Mac-065306 Musa acuminata 30.10 2.00e-43 169.00
IUUC-Mpu-065693 Mustela putorius furo 100.00 0.00e+00 716.00
IUUC-Mlu-067827 Myotis lucifugus 99.47 0.00e+00 709.00
IUUC-Nle-069393 Nomascus leucogenys 100.00 0.00e+00 716.00
IUUC-Opr-070490 Ochotona princeps 98.13 0.00e+00 699.00
IUUC-Ont-071726 Oreochromis niloticus 97.06 0.00e+00 698.00
IUUC-Ocu-074932 Oryctolagus cuniculus 100.00 0.00e+00 716.00
IUUC-Obr-076031 Oryza brachyantha 28.65 1.00e-32 134.00
IUUC-Ogu-078752 Oryza glumaepatula 34.62 2.00e-38 154.00
IUUC-Olo-080833 Oryza longistaminata 32.56 2.00e-37 149.00
IUUC-Ome-081184 Oryza meridionalis 33.33 1.00e-38 155.00
IUUC-Opu-083303 Oryza punctata 32.20 7.00e-29 122.00
IUUC-Oru-085193 Oryza rufipogon 30.68 3.00e-41 164.00
IUUC-Ola-086989 Oryzias latipes 96.80 0.00e+00 693.00
IUUC-Olu-087691 Ostreococcus lucimarinus 31.73 2.00e-35 142.00
IUUC-Oga-089107 Otolemur garnettii 100.00 0.00e+00 716.00
IUUC-Oar-089943 Ovis aries 99.73 0.00e+00 712.00
IUUC-Ptr-091201 Pan troglodytes 100.00 0.00e+00 716.00
IUUC-Pan-092504 Papio anubis 100.00 0.00e+00 716.00
IUUC-Psi-093063 Pelodiscus sinensis 99.73 0.00e+00 715.00
IUUC-Pma-094310 Petromyzon marinus 85.24 7.00e-169 586.00
IUUC-Ppa-095322 Physcomitrella patens 31.56 2.00e-41 163.00
IUUC-Pfo-096411 Poecilia formosa 97.06 0.00e+00 698.00
IUUC-Pab-098640 Pongo abelii 100.00 0.00e+00 716.00
IUUC-Pop-099525 Populus trichocarpa 31.27 5.00e-30 125.00
IUUC-Pca-100243 Procavia capensis 84.04 4.00e-131 460.00
IUUC-Pva-102296 Pteropus vampyrus 93.05 0.00e+00 649.00
IUUC-Pyt-104526 Pyrenophora triticirepentis 23.53 1.00e-06 47.40
IUUC-Rno-105399 Rattus norvegicus 100.00 0.00e+00 716.00
IUUC-Sha-106700 Sarcophilus harrisii 99.47 0.00e+00 713.00
IUUC-Spo-108262 Schizosaccharomyces pombe 36.84 1.20e-01 32.00
IUUC-Ssl-108548 Sclerotinia sclerotiorum 28.77 1.00e-06 47.00
IUUC-Smo-108684 Selaginella moellendorffii 31.52 7.00e-31 128.00
IUUC-Sit-109872 Setaria italica 33.43 1.00e-41 164.00
IUUC-Sly-110931 Solanum lycopersicum 30.53 6.00e-43 168.00
IUUC-Stu-112216 Solanum tuberosum 31.09 1.00e-42 167.00
IUUC-Sar-113489 Sorex araneus 100.00 0.00e+00 716.00
IUUC-Sbi-114217 Sorghum bicolor 32.80 3.00e-44 172.00
IUUC-Tru-117832 Takifugu rubripes 96.26 0.00e+00 692.00
IUUC-Tsy-118969 Tarsius syrichta 94.92 0.00e+00 671.00
IUUC-Tni-120221 Tetraodon nigroviridis 96.26 0.00e+00 692.00
IUUC-Tca-121715 Theobroma cacao 30.93 1.00e-44 173.00
IUUC-Tae-122976 Triticum aestivum 32.39 8.00e-41 161.00
IUUC-Tbe-127298 Tupaia belangeri 99.47 0.00e+00 702.00
IUUC-Ttr-128952 Tursiops truncatus 99.73 0.00e+00 715.00
IUUC-Vpa-130735 Vicugna pacos 94.12 0.00e+00 644.00
IUUC-Vvi-130854 Vitis vinifera 31.65 6.00e-32 131.00
IUUC-Xtr-132806 Xenopus tropicalis 98.14 0.00e+00 702.00
Created Date 25-Jun-2017

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