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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046996
UUCD1 version UUC-HoS-01029
Ensembl Protein ID ENSP00000308179.4
UniProt Accession Q9UNX4; WDR3_HUMAN
Genbank Protein ID AAD45865.1
Protein Name WD repeat-containing protein 3
Genbank Nucleotide ID AF083217
Gene Name WDR3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000065183.15 ENST00000349139.5 ENSP00000308179.4
ENSG00000065183.15 ENST00000369441.7 ENSP00000358449.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosSNPPhosphositePlus
dbPTMHPRDPhospho.ELMUniProt
PHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.20e-44 149.1 589 628
UBD/Beta-Prp 3.40e-95 320.3 35 220
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH+ +v c++  +d  l+++Gs D ++k+W l+ g++ ks
   Q: 589  GHKLPVICMDIsHDgALIATGSADRNVKIWGLDFGDCHKS 628
           7999999**99977799*******************9875 PP
   

   UBD/Beta-Prp
   S: 64   gkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsG 155
           +  +v +   +++ +wdl++g+ + +l+g +++v++l  sp+g +l++G +d  ir++ l +g+    t++gh+++++++++++ g  l+sG
   Q: 35   KGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNV-TFNGHKAAITTLKYDQLGGRLASG 125
           5555555555678899999999999999999999999999999999999999999999999999999.999999999999999999999999 PP
   S: 156  slDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsir 247
           s+D+ + +Wd+ +++ l++l+g h+d+++   f ++++ lv+ ++d+ vk wdl t++c +t+ gh++ v+ + ++++++rl++g+sD  +r
   Q: 126  SKDTDIIVWDVINESGLYRLKG-HKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELR 216
           9999999999999999999999.999999999999999999999999999999999999999999999999999999999999999999999 PP
   S: 248  iWdl 251
           +Wd+
   Q: 217  VWDI 220
           9997 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MGLTKQYLRY VASAVFGVIG SQKGNIVFVT LRGEKGRYVA VPACEHVFIW DLRKGEKILI 60
LQGLKQEVTC LCPSPDGLHL AVGYEDGSIR IFSLLSGEGN VTFNGHKAAI TTLKYDQLGG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046996|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGACCCGGAA GGGGCAGGTC TTGTGGGCGG GTCCAATCGG CTGGGAGCCT CGTGGAGGCT 60
GAGGTGAGTC CTGGAGGTGC GTGGTTGGGG CGGAGAGCAT TATCTGCGGC TCCGATTTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046996|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR007148--SSU_processome_Utp12
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF04003--Utp12
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0034388--C:Pwp2p-containing subcomplex of 90S preribosome
GO:0032040--C:small-subunit processome
GO:0003723--F:RNA binding
GO:0030515--F:snoRNA binding
GO:0000462--P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364--P:rRNA processing
KEGG hsa:10885
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000784 Aegilops tauschii 38.68 2.00e-151 530.00
IUUC-Aml-001245 Ailuropoda melanoleuca 94.59 0.00e+00 1677.00
IUUC-Atr-002700 Amborella trichopoda 39.51 1.00e-180 627.00
IUUC-Apl-004164 Anas platyrhynchos 78.69 0.00e+00 1075.00
IUUC-Aca-004765 Anolis carolinensis 75.05 0.00e+00 1387.00
IUUC-Aly-006503 Arabidopsis lyrata 38.97 8.00e-180 624.00
IUUC-Ath-006848 Arabidopsis thaliana 39.26 0.00e+00 637.00
IUUC-Ago-007909 Ashbya gossypii 36.00 3.00e-151 529.00
IUUC-Acl-008238 Aspergillus clavatus 39.23 0.00e+00 648.00
IUUC-Afl-008544 Aspergillus flavus 39.35 0.00e+00 634.00
IUUC-Afu-008868 Aspergillus fumigatus 38.76 0.00e+00 636.00
IUUC-Ani-009367 Aspergillus nidulans 38.57 9.00e-179 620.00
IUUC-Ang-009732 Aspergillus niger 39.69 0.00e+00 645.00
IUUC-Aor-010140 Aspergillus oryzae 39.42 0.00e+00 635.00
IUUC-Ate-010572 Aspergillus terreus 38.48 0.00e+00 630.00
IUUC-Ame-010956 Astyanax mexicanus 64.56 0.00e+00 1159.00
IUUC-Bgr-012296 Blumeria graminis 37.35 2.00e-176 612.00
IUUC-Bta-012716 Bos taurus 94.49 0.00e+00 1676.00
IUUC-Bci-013699 Botrytis cinerea 37.11 2.00e-167 583.00
IUUC-Bdi-014525 Brachypodium distachyon 38.59 4.00e-165 575.00
IUUC-Bol-015117 Brassica oleracea 38.91 6.00e-178 618.00
IUUC-Bra-016869 Brassica rapa 39.01 9.00e-179 620.00
IUUC-Cel-018570 Caenorhabditis elegans 33.41 3.00e-132 466.00
IUUC-Cja-019425 Callithrix jacchus 95.45 0.00e+00 1726.00
IUUC-Cfa-020787 Canis familiaris 93.43 0.00e+00 1687.00
IUUC-Cpo-021729 Cavia porcellus 94.26 0.00e+00 1219.00
IUUC-Cre-022678 Chlamydomonas reinhardtii 43.20 2.00e-104 374.00
IUUC-Csa-024098 Chlorocebus sabaeus 98.41 0.00e+00 1775.00
IUUC-Cho-024495 Choloepus hoffmanni 79.84 0.00e+00 943.00
IUUC-Cin-025245 Ciona intestinalis 48.74 2.00e-168 585.00
IUUC-Cgl-026708 Colletotrichum gloeosporioides 38.59 3.00e-172 599.00
IUUC-Cne-026835 Cryptococcus neoformans 46.23 4.00e-132 466.00
IUUC-Cme-027162 Cyanidioschyzon merolae 25.80 8.00e-38 152.00
IUUC-Dre-027874 Danio rerio 71.31 0.00e+00 1321.00
IUUC-Dno-028905 Dasypus novemcinctus 93.43 0.00e+00 1687.00
IUUC-Dor-030383 Dipodomys ordii 89.08 0.00e+00 833.00
IUUC-Dse-031297 Dothistroma septosporum 37.59 6.00e-169 588.00
IUUC-Dme-031956 Drosophila melanogaster 42.17 0.00e+00 695.00
IUUC-Ete-032608 Echinops telfairi 83.73 0.00e+00 936.00
IUUC-Eca-034181 Equus caballus 94.70 0.00e+00 1669.00
IUUC-Eeu-034495 Erinaceus europaeus 92.15 0.00e+00 1594.00
IUUC-Fca-035994 Felis catus 93.65 0.00e+00 1574.00
IUUC-Fal-036611 Ficedula albicollis 77.33 0.00e+00 1364.00
IUUC-Fox-037807 Fusarium oxysporum 37.95 1.00e-174 607.00
IUUC-Fso-038090 Fusarium solani 37.51 7.00e-171 594.00
IUUC-Gmo-039018 Gadus morhua 64.13 0.00e+00 704.00
IUUC-Ggr-039748 Gaeumannomyces graminis 36.66 3.00e-166 579.00
IUUC-Gga-040707 Gallus gallus 80.15 0.00e+00 1388.00
IUUC-Gac-042334 Gasterosteus aculeatus 63.72 0.00e+00 685.00
IUUC-Gma-043860 Glycine max 38.04 2.00e-176 613.00
IUUC-Ggo-045334 Gorilla gorilla 99.47 0.00e+00 1736.00
IUUC-Hvu-047381 Hordeum vulgare 34.78 3.00e-90 326.00
IUUC-Itr-047938 Ictidomys tridecemlineatus 93.96 0.00e+00 1664.00
IUUC-Kpa-049185 Komagataella pastoris 35.55 2.00e-148 520.00
IUUC-Lch-050098 Latimeria chalumnae 67.85 0.00e+00 1178.00
IUUC-Lpe-050710 Leersia perrieri 36.93 4.00e-159 555.00
IUUC-Loc-052745 Lepisosteus oculatus 69.29 0.00e+00 1234.00
IUUC-Lma-053104 Leptosphaeria maculans 38.83 0.00e+00 632.00
IUUC-Laf-054395 Loxodonta africana 93.00 0.00e+00 1650.00
IUUC-Mcc-055077 Macaca mulatta 98.41 0.00e+00 1767.00
IUUC-Meu-056418 Macropus eugenii 82.94 0.00e+00 734.00
IUUC-Mor-057031 Magnaporthe oryzae 37.98 2.00e-160 560.00
IUUC-Mpo-057420 Magnaporthe poae 37.32 1.00e-172 600.00
IUUC-Mtr-057838 Medicago truncatula 38.56 0.00e+00 640.00
IUUC-Mla-058854 Melampsora laricipopulina 36.56 2.00e-162 566.00
IUUC-Mga-060120 Meleagris gallopavo 74.84 0.00e+00 1291.00
IUUC-Mvi-060407 Microbotryum violaceum 44.44 9.00e-142 498.00
IUUC-Mmr-060635 Microcebus murinus 93.86 0.00e+00 1647.00
IUUC-Mdo-063023 Monodelphis domestica 87.17 0.00e+00 1606.00
IUUC-Mmu-064103 Mus musculus 90.89 0.00e+00 1636.00
IUUC-Mac-065569 Musa acuminata 38.31 4.00e-175 608.00
IUUC-Mpu-066462 Mustela putorius furo 94.27 0.00e+00 1699.00
IUUC-Mlu-067894 Myotis lucifugus 94.06 0.00e+00 1703.00
IUUC-Nfi-068321 Neosartorya fischeri 38.89 0.00e+00 633.00
IUUC-Ncr-068661 Neurospora crassa 37.95 4.00e-174 605.00
IUUC-Nle-069409 Nomascus leucogenys 98.83 0.00e+00 1747.00
IUUC-Opr-070445 Ochotona princeps 83.70 0.00e+00 1519.00
IUUC-Ont-072339 Oreochromis niloticus 70.35 0.00e+00 1281.00
IUUC-Oan-073688 Ornithorhynchus anatinus 77.33 0.00e+00 1366.00
IUUC-Ocu-074227 Oryctolagus cuniculus 95.23 0.00e+00 1726.00
IUUC-Oba-075635 Oryza barthii 36.91 6.00e-154 538.00
IUUC-Obr-076897 Oryza brachyantha 37.97 1.00e-166 580.00
IUUC-Ogl-077555 Oryza glaberrima 36.80 1.00e-153 537.00
IUUC-Ogu-078724 Oryza glumaepatula 36.91 6.00e-155 541.00
IUUC-Oin-080030 Oryza indica 36.91 6.00e-154 538.00
IUUC-Olo-080687 Oryza longistaminata 35.05 8.00e-143 501.00
IUUC-Ome-081867 Oryza meridionalis 37.12 2.00e-155 543.00
IUUC-Oni-082559 Oryza nivara 36.91 7.00e-154 538.00
IUUC-Opu-083332 Oryza punctata 37.76 3.00e-145 509.00
IUUC-Oru-084455 Oryza rufipogon 36.91 5.00e-154 538.00
IUUC-Osa-085793 Oryza sativa 36.91 5.00e-154 538.00
IUUC-Ola-087395 Oryzias latipes 68.90 0.00e+00 1186.00
IUUC-Olu-087768 Ostreococcus lucimarinus 37.57 9.00e-158 550.00
IUUC-Oga-088574 Otolemur garnettii 94.70 0.00e+00 1707.00
IUUC-Oar-089453 Ovis aries 92.38 0.00e+00 1659.00
IUUC-Ptr-090694 Pan troglodytes 99.47 0.00e+00 1734.00
IUUC-Pan-092420 Papio anubis 98.20 0.00e+00 1761.00
IUUC-Psi-093683 Pelodiscus sinensis 82.59 0.00e+00 1466.00
IUUC-Pma-094197 Petromyzon marinus 56.58 5.00e-71 260.00
IUUC-Pno-094783 Phaeosphaeria nodorum 38.28 0.00e+00 633.00
IUUC-Ppa-095208 Physcomitrella patens 39.53 2.00e-177 616.00
IUUC-Pfo-096299 Poecilia formosa 69.07 0.00e+00 1284.00
IUUC-Pab-098706 Pongo abelii 99.05 0.00e+00 1739.00
IUUC-Pop-099275 Populus trichocarpa 38.86 4.00e-178 619.00
IUUC-Pca-100796 Procavia capensis 78.55 0.00e+00 1249.00
IUUC-Ppe-101861 Prunus persica 39.83 0.00e+00 640.00
IUUC-Pva-103241 Pteropus vampyrus 88.60 0.00e+00 1515.00
IUUC-Pgr-103432 Puccinia graminis 35.61 1.00e-160 560.00
IUUC-Ptt-103742 Puccinia triticina 40.70 3.00e-111 396.00
IUUC-Pte-104069 Pyrenophora teres 37.77 4.00e-170 592.00
IUUC-Pyt-104650 Pyrenophora triticirepentis 37.18 3.00e-167 582.00
IUUC-Rno-105219 Rattus norvegicus 90.36 0.00e+00 1592.00
IUUC-Sce-106271 Saccharomyces cerevisiae 37.54 3.00e-161 562.00
IUUC-Sha-107550 Sarcophilus harrisii 87.03 0.00e+00 1598.00
IUUC-Sja-107664 Schizosaccharomyces japonicus 37.81 9.00e-170 590.00
IUUC-Spo-108239 Schizosaccharomyces pombe 37.83 2.00e-174 606.00
IUUC-Ssl-108626 Sclerotinia sclerotiorum 37.83 1.00e-173 603.00
IUUC-Smo-108974 Selaginella moellendorffii 38.74 1.00e-171 597.00
IUUC-Sit-110000 Setaria italica 38.20 3.00e-157 549.00
IUUC-Sly-111595 Solanum lycopersicum 38.51 1.00e-180 627.00
IUUC-Stu-112516 Solanum tuberosum 38.27 1.00e-179 624.00
IUUC-Sar-113195 Sorex araneus 83.86 0.00e+00 1333.00
IUUC-Sbi-114465 Sorghum bicolor 36.78 3.00e-166 579.00
IUUC-Sre-115006 Sporisorium reilianum 34.77 3.00e-154 539.00
IUUC-Ssc-115929 Sus scrofa 93.53 0.00e+00 1639.00
IUUC-Tgu-117282 Taeniopygia guttata 77.44 0.00e+00 1362.00
IUUC-Tru-118406 Takifugu rubripes 68.61 0.00e+00 1230.00
IUUC-Tsy-119170 Tarsius syrichta 93.02 0.00e+00 1681.00
IUUC-Tni-119721 Tetraodon nigroviridis 67.31 0.00e+00 1202.00
IUUC-Tca-121761 Theobroma cacao 39.11 0.00e+00 642.00
IUUC-Tre-121908 Trichoderma reesei 36.63 1.00e-170 593.00
IUUC-Tvi-122547 Trichoderma virens 37.58 2.00e-173 603.00
IUUC-Tae-125496 Triticum aestivum 39.07 2.00e-163 570.00
IUUC-Tur-126811 Triticum urartu 40.53 3.00e-163 569.00
IUUC-Tme-126987 Tuber melanosporum 39.20 0.00e+00 644.00
IUUC-Tbe-127315 Tupaia belangeri 96.00 0.00e+00 890.00
IUUC-Ttr-129165 Tursiops truncatus 85.15 0.00e+00 1442.00
IUUC-Uma-129651 Ustilago maydis 34.88 5.00e-154 538.00
IUUC-Vda-129973 Verticillium dahliae 38.41 6.00e-167 582.00
IUUC-Vpa-130163 Vicugna pacos 84.70 0.00e+00 735.00
IUUC-Vvi-131402 Vitis vinifera 37.62 3.00e-180 625.00
IUUC-Xtr-132296 Xenopus tropicalis 73.17 0.00e+00 1303.00
IUUC-Xma-133028 Xiphophorus maculatus 69.15 0.00e+00 1290.00
IUUC-Yli-134484 Yarrowia lipolytica 38.59 1.00e-164 574.00
IUUC-Zma-135938 Zea mays 36.63 5.00e-164 572.00
Created Date 25-Jun-2017

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