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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063199
UUCD1 version UUC-MuM-00788
Ensembl Protein ID ENSMUSP00000036915.4
UniProt Accession Q8R307; Q8BGV6; Q8BZX6; Q8C126; VPS18_MOUSE
Genbank Protein ID BAC26302.1; BAC28236.1; BAC29637.1; AAH26870.1; AAH36129.1; AAH39176.1
Protein Name Vacuolar protein sorting-associated protein 18 homolog
Genbank Nucleotide ID AK029109; AK033333; AK036915; BC026870; BC036129; BC039176
Gene Name Vps18
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000034216.12 ENSMUST00000037280.4 ENSMUSP00000036915.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
PHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 95.79 0.00e+00 1870.00 IUUC-Hsa-046635
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:14517315, PubMed:22854957). Involved in dendrite development of Pukinje cells (PubMed:22699122).
 Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (By similarity). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:14517315, PubMed:22854957). Involved in dendrite development of Pukinje cells (PubMed:22699122).
Protein Sequence
(Fasta)
MASILDEYED SLSRSAVLQT GCPSVGIPHS GYVSAHLEKE VPIFTKQRVD FTPSERITSL 60
VVSCNQLCMS LGKDTLLRID LGKASEPNRV ELGRKDDAKV HKMFLDHTGS HLLVALSSTE 120
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Protein Fasta Sequence


>IUUC-Mmu-063199|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
ACGCGTCACG GGGGCGGGAG TCAGCTGAGC TGCCTGGGCG AGGTTGTGAT TACCTGGGAT 60
CTGCTAAGGG GAGCCTATAA TCTCTTGGGA CTGGAGCTGG GGTGCAAAGC TGCGCCATGG 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063199|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000547--Clathrin_H-chain/VPS_repeat
IPR007810--Pep3_Vps18
IPR011990--TPR-like_helical_dom
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50236--CHCR
Pfam

PF00637--Clathrin
PF05131--Pep3_Vps18
Gene Ontology

GO:0005884--C:actin filament
GO:0005776--C:autophagosome
GO:0030136--C:clathrin-coated vesicle
GO:0033263--C:CORVET complex
GO:0005769--C:early endosome
GO:0030897--C:HOPS complex
GO:0005770--C:late endosome
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0003779--F:actin binding
GO:0046872--F:metal ion binding
GO:0030674--F:protein binding, bridging
GO:0019905--F:syntaxin binding
GO:0006914--P:autophagy
GO:0007032--P:endosome organization
GO:0008333--P:endosome to lysosome transport
GO:0006886--P:intracellular protein transport
GO:0007040--P:lysosome organization
GO:0035542--P:regulation of SNARE complex assembly
GO:0006904--P:vesicle docking involved in exocytosis
GO:0046718--P:viral entry into host cell
KEGG mmu:228545
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000419 Aegilops tauschii 31.90 1.00e-106 381.00
IUUC-Aml-001240 Ailuropoda melanoleuca 95.89 0.00e+00 1862.00
IUUC-Atr-003125 Amborella trichopoda 32.84 3.00e-122 432.00
IUUC-Apl-004181 Anas platyrhynchos 71.77 0.00e+00 1458.00
IUUC-Aca-004437 Anolis carolinensis 71.56 0.00e+00 1436.00
IUUC-Aly-006046 Arabidopsis lyrata 33.33 1.00e-133 471.00
IUUC-Ath-006932 Arabidopsis thaliana 33.58 6.00e-133 468.00
IUUC-Ago-007800 Ashbya gossypii 23.49 3.00e-55 210.00
IUUC-Acl-008035 Aspergillus clavatus 31.43 2.00e-111 397.00
IUUC-Afl-008714 Aspergillus flavus 30.86 1.00e-108 387.00
IUUC-Afu-009063 Aspergillus fumigatus 31.89 2.00e-111 396.00
IUUC-Ani-009384 Aspergillus nidulans 31.95 1.00e-113 404.00
IUUC-Ang-009507 Aspergillus niger 32.07 1.00e-109 391.00
IUUC-Aor-010094 Aspergillus oryzae 30.86 3.00e-108 386.00
IUUC-Ate-010421 Aspergillus terreus 31.35 3.00e-95 343.00
IUUC-Ame-011797 Astyanax mexicanus 64.93 0.00e+00 1282.00
IUUC-Bgr-012107 Blumeria graminis 31.05 1.00e-108 387.00
IUUC-Bta-012339 Bos taurus 95.68 0.00e+00 1870.00
IUUC-Bci-013895 Botrytis cinerea 33.11 5.00e-119 422.00
IUUC-Bdi-014554 Brachypodium distachyon 33.81 5.00e-124 439.00
IUUC-Bol-015270 Brassica oleracea 33.61 5.00e-134 472.00
IUUC-Bra-017424 Brassica rapa 33.16 9.00e-129 454.00
IUUC-Cel-018455 Caenorhabditis elegans 26.25 1.00e-85 311.00
IUUC-Cja-019629 Callithrix jacchus 94.55 0.00e+00 1858.00
IUUC-Cfa-020425 Canis familiaris 96.09 0.00e+00 1859.00
IUUC-Cpo-021349 Cavia porcellus 94.66 0.00e+00 1827.00
IUUC-Cre-022799 Chlamydomonas reinhardtii 29.82 5.00e-28 120.00
IUUC-Csa-023559 Chlorocebus sabaeus 95.58 0.00e+00 1868.00
IUUC-Cho-024862 Choloepus hoffmanni 87.72 0.00e+00 1373.00
IUUC-Cin-025599 Ciona intestinalis 41.86 3.00e-175 608.00
IUUC-Csv-026152 Ciona savignyi 42.98 0.00e+00 760.00
IUUC-Cgl-026551 Colletotrichum gloeosporioides 31.13 1.00e-109 390.00
IUUC-Cne-026907 Cryptococcus neoformans 31.43 1.00e-111 398.00
IUUC-Dre-027747 Danio rerio 65.30 0.00e+00 1324.00
IUUC-Dno-029668 Dasypus novemcinctus 95.17 0.00e+00 1848.00
IUUC-Dor-030404 Dipodomys ordii 89.62 0.00e+00 1728.00
IUUC-Dse-031345 Dothistroma septosporum 33.48 2.00e-121 430.00
IUUC-Dme-031711 Drosophila melanogaster 34.00 5.00e-148 518.00
IUUC-Ete-032308 Echinops telfairi 89.38 0.00e+00 906.00
IUUC-Eca-033637 Equus caballus 95.89 0.00e+00 1868.00
IUUC-Eeu-035151 Erinaceus europaeus 95.28 0.00e+00 1384.00
IUUC-Fca-035585 Felis catus 95.79 0.00e+00 1850.00
IUUC-Fal-037122 Ficedula albicollis 71.59 0.00e+00 1460.00
IUUC-Fox-038030 Fusarium oxysporum 33.67 4.00e-119 422.00
IUUC-Fso-038426 Fusarium solani 33.50 5.00e-125 442.00
IUUC-Gmo-038784 Gadus morhua 65.42 0.00e+00 1289.00
IUUC-Ggr-039973 Gaeumannomyces graminis 33.47 8.00e-121 428.00
IUUC-Gga-040692 Gallus gallus 73.20 0.00e+00 1484.00
IUUC-Gac-041868 Gasterosteus aculeatus 64.14 0.00e+00 1287.00
IUUC-Gma-044274 Glycine max 34.01 4.00e-134 472.00
IUUC-Ggo-045053 Gorilla gorilla 95.58 0.00e+00 1858.00
IUUC-Hsa-046635 Homo sapiens 95.79 0.00e+00 1861.00
IUUC-Hvu-047361 Hordeum vulgare 33.71 5.00e-124 439.00
IUUC-Itr-048868 Ictidomys tridecemlineatus 95.89 0.00e+00 1855.00
IUUC-Kpa-049270 Komagataella pastoris 24.00 1.00e-76 281.00
IUUC-Lch-050188 Latimeria chalumnae 67.73 0.00e+00 1203.00
IUUC-Lpe-051026 Leersia perrieri 34.34 4.00e-128 452.00
IUUC-Loc-051821 Lepisosteus oculatus 65.99 0.00e+00 1312.00
IUUC-Lma-053178 Leptosphaeria maculans 36.20 1.00e-99 357.00
IUUC-Laf-053552 Loxodonta africana 95.38 0.00e+00 1854.00
IUUC-Mcc-054667 Macaca mulatta 95.68 0.00e+00 1859.00
IUUC-Meu-056422 Macropus eugenii 92.59 0.00e+00 863.00
IUUC-Mor-056981 Magnaporthe oryzae 33.16 1.00e-119 424.00
IUUC-Mtr-058703 Medicago truncatula 34.21 4.00e-129 456.00
IUUC-Mla-059088 Melampsora laricipopulina 34.71 4.00e-92 332.00
IUUC-Mga-059798 Meleagris gallopavo 73.00 0.00e+00 1481.00
IUUC-Mvi-060404 Microbotryum violaceum 33.70 3.00e-119 423.00
IUUC-Mmr-061630 Microcebus murinus 95.99 0.00e+00 1863.00
IUUC-Mdo-062354 Monodelphis domestica 92.29 0.00e+00 1810.00
IUUC-Mac-065595 Musa acuminata 35.57 4.00e-112 399.00
IUUC-Mpu-066596 Mustela putorius furo 95.68 0.00e+00 1868.00
IUUC-Mlu-067455 Myotis lucifugus 95.89 0.00e+00 1853.00
IUUC-Nfi-068565 Neosartorya fischeri 32.15 2.00e-113 403.00
IUUC-Ncr-068748 Neurospora crassa 33.07 3.00e-124 439.00
IUUC-Nle-068979 Nomascus leucogenys 95.69 0.00e+00 1663.00
IUUC-Opr-070711 Ochotona princeps 94.35 0.00e+00 1841.00
IUUC-Ont-072603 Oreochromis niloticus 64.60 0.00e+00 1305.00
IUUC-Oan-073136 Ornithorhynchus anatinus 84.32 0.00e+00 813.00
IUUC-Ocu-074496 Oryctolagus cuniculus 95.89 0.00e+00 1863.00
IUUC-Oba-075933 Oryza barthii 33.00 6.00e-109 388.00
IUUC-Obr-076290 Oryza brachyantha 33.68 4.00e-129 456.00
IUUC-Ogu-078728 Oryza glumaepatula 33.00 5.00e-109 389.00
IUUC-Oin-079954 Oryza indica 33.23 2.00e-120 427.00
IUUC-Olo-081033 Oryza longistaminata 31.92 1.00e-103 371.00
IUUC-Ome-081797 Oryza meridionalis 32.97 1.00e-115 411.00
IUUC-Oni-082802 Oryza nivara 33.00 5.00e-109 389.00
IUUC-Opu-083595 Oryza punctata 35.13 4.00e-129 456.00
IUUC-Oru-084199 Oryza rufipogon 33.00 5.00e-109 389.00
IUUC-Osa-085349 Oryza sativa 33.68 4.00e-128 452.00
IUUC-Ola-087482 Oryzias latipes 64.14 0.00e+00 1292.00
IUUC-Olu-087797 Ostreococcus lucimarinus 24.78 1.00e-63 238.00
IUUC-Oga-088817 Otolemur garnettii 95.38 0.00e+00 1865.00
IUUC-Oar-090350 Ovis aries 93.45 0.00e+00 1433.00
IUUC-Ptr-090999 Pan troglodytes 95.48 0.00e+00 1855.00
IUUC-Pan-092704 Papio anubis 95.68 0.00e+00 1859.00
IUUC-Psi-093529 Pelodiscus sinensis 72.90 0.00e+00 1456.00
IUUC-Pma-094400 Petromyzon marinus 56.53 0.00e+00 1083.00
IUUC-Pno-094875 Phaeosphaeria nodorum 32.89 3.00e-118 419.00
IUUC-Ppa-095231 Physcomitrella patens 33.49 1.00e-128 454.00
IUUC-Pfo-096967 Poecilia formosa 64.09 0.00e+00 1294.00
IUUC-Pab-098300 Pongo abelii 95.48 0.00e+00 1857.00
IUUC-Pop-098966 Populus trichocarpa 34.48 2.00e-139 490.00
IUUC-Pca-100643 Procavia capensis 94.30 0.00e+00 1745.00
IUUC-Ppe-101589 Prunus persica 33.81 1.00e-134 474.00
IUUC-Pva-102766 Pteropus vampyrus 95.27 0.00e+00 1811.00
IUUC-Pgr-103330 Puccinia graminis 30.45 4.00e-108 386.00
IUUC-Ptt-103809 Puccinia triticina 31.56 7.00e-91 328.00
IUUC-Pte-104319 Pyrenophora teres 32.09 3.00e-117 416.00
IUUC-Pyt-104798 Pyrenophora triticirepentis 30.69 1.00e-104 374.00
IUUC-Rno-105817 Rattus norvegicus 98.25 0.00e+00 1910.00
IUUC-Sce-106255 Saccharomyces cerevisiae 22.98 9.00e-43 169.00
IUUC-Sha-107479 Sarcophilus harrisii 92.44 0.00e+00 1799.00
IUUC-Sja-107976 Schizosaccharomyces japonicus 24.80 2.00e-68 254.00
IUUC-Spo-108146 Schizosaccharomyces pombe 26.55 2.00e-70 261.00
IUUC-Ssl-108663 Sclerotinia sclerotiorum 33.16 1.00e-109 390.00
IUUC-Smo-109585 Selaginella moellendorffii 34.30 1.00e-119 424.00
IUUC-Sit-110275 Setaria italica 34.50 3.00e-128 453.00
IUUC-Sly-111073 Solanum lycopersicum 34.71 7.00e-133 468.00
IUUC-Stu-112392 Solanum tuberosum 28.16 8.00e-14 70.50
IUUC-Sar-113718 Sorex araneus 91.27 0.00e+00 1763.00
IUUC-Sbi-114080 Sorghum bicolor 34.60 1.00e-132 468.00
IUUC-Sre-115160 Sporisorium reilianum 32.44 2.00e-122 434.00
IUUC-Ssc-115997 Sus scrofa 95.38 0.00e+00 1856.00
IUUC-Tgu-116904 Taeniopygia guttata 72.63 0.00e+00 1319.00
IUUC-Tru-117946 Takifugu rubripes 63.99 0.00e+00 1298.00
IUUC-Tni-119692 Tetraodon nigroviridis 64.39 0.00e+00 1293.00
IUUC-Tca-121455 Theobroma cacao 33.51 4.00e-134 472.00
IUUC-Tre-122128 Trichoderma reesei 32.05 8.00e-121 428.00
IUUC-Tvi-122657 Trichoderma virens 33.10 6.00e-123 435.00
IUUC-Tae-125953 Triticum aestivum 33.88 2.00e-125 443.00
IUUC-Tur-126110 Triticum urartu 30.61 8.00e-93 335.00
IUUC-Tme-127173 Tuber melanosporum 30.24 3.00e-102 366.00
IUUC-Ttr-128420 Tursiops truncatus 95.38 0.00e+00 1854.00
IUUC-Uma-129580 Ustilago maydis 33.84 2.00e-122 434.00
IUUC-Vda-129790 Verticillium dahliae 30.78 2.00e-107 384.00
IUUC-Vvi-131095 Vitis vinifera 33.54 5.00e-131 462.00
IUUC-Xtr-131906 Xenopus tropicalis 68.01 0.00e+00 1348.00
IUUC-Xma-134197 Xiphophorus maculatus 64.29 0.00e+00 1296.00
IUUC-Yli-134617 Yarrowia lipolytica 27.18 5.00e-95 342.00
IUUC-Zma-134979 Zea mays 32.26 3.00e-101 363.00
Created Date 25-Jun-2017

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