iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000063245.14	ENST00000270460.10	ENSP00000270460.5
ENSG00000063245.14	ENST00000085079.11	ENSP00000085079.6
ENSG00000063245.14	ENST00000411543.6	ENSP00000406209.1
ENSG00000063245.14	ENST00000589704.1	ENSP00000466593.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	11406394

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	1.90e-08	35.0	183	201
UBD/Alpha-Helix/UIM	0.00017	13.7	208	226

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+++LqlAla+S++E+++
   Q: 183  EEELQLQLALAMSKEEADQ 201
           79**************987 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           ++d++LqlAl lS++E+++
   Q: 208  EDDAQLQLALSLSREEHDK 226
           69**************985 PP

Organism

Homo sapiens

Functional Description
(View)

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis.

Protein Sequence
(Fasta)

MSTSSLRRQM KNIVHNYSEA EIKVREATSN DPWGPSSSLM SEIADLTYNV VAFSEIMSMI 60
WKRLNDHGKN WRHVYKAMTL MEYLIKTGSE RVSQQCKENM YAVQTLKDFQ YVDRDGKDQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGTTGCTTC CCGTCTCCTC GGCGGCTCCC CTCCCCCGCC CGGCTCTCCG CGCCCCTTCT 60
GGGCGGCGGG GCGGCGGAGC CGTCGGCGTG CGGCCCTCCT TGCGTTCGTG CGTGCGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0168--Coated pit
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR013809--ENTH
IPR008942--ENTH_VHS
IPR003903--UIM_dom

PROSITE

PS50942--ENTH
PS50330--UIM

Pfam

PF01417--ENTH

SMART

SM00273--ENTH
SM00726--UIM

Gene Ontology

GO:0005905--C:clathrin-coated pit
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0008289--F:lipid binding
GO:0048568--P:embryonic organ development
GO:0006897--P:endocytosis
GO:0007565--P:female pregnancy
GO:0001701--P:in utero embryonic development
GO:0061024--P:membrane organization
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007219--P:Notch signaling pathway

KEGG

hsa:29924

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002304	Ailuropoda melanoleuca	92.88	0.00e+00	752.00
IUUC-Aca-005208	Anolis carolinensis	64.20	2.00e-164	573.00
IUUC-Ame-011460	Astyanax mexicanus	79.85	2.00e-101	363.00
IUUC-Bta-013352	Bos taurus	93.75	0.00e+00	726.00
IUUC-Cel-018350	Caenorhabditis elegans	41.18	9.00e-75	274.00
IUUC-Cfa-020367	Canis familiaris	93.40	0.00e+00	747.00
IUUC-Csa-023208	Chlorocebus sabaeus	99.13	0.00e+00	764.00
IUUC-Cme-027132	Cyanidioschyzon merolae	40.58	4.00e-24	106.00
IUUC-Dre-028015	Danio rerio	78.28	7.00e-104	371.00
IUUC-Dno-029947	Dasypus novemcinctus	92.29	2.00e-171	595.00
IUUC-Dor-030137	Dipodomys ordii	99.61	1.00e-119	423.00
IUUC-Dme-032149	Drosophila melanogaster	38.31	2.00e-80	294.00
IUUC-Eca-034189	Equus caballus	95.83	0.00e+00	773.00
IUUC-Fca-036270	Felis catus	94.10	0.00e+00	776.00
IUUC-Gac-042085	Gasterosteus aculeatus	76.49	9.00e-98	350.00
IUUC-Itr-048041	Ictidomys tridecemlineatus	95.66	0.00e+00	761.00
IUUC-Kpa-049233	Komagataella pastoris	37.55	1.00e-35	144.00
IUUC-Laf-054571	Loxodonta africana	95.49	0.00e+00	781.00
IUUC-Mcc-055036	Macaca mulatta	99.31	0.00e+00	747.00
IUUC-Meu-056308	Macropus eugenii	82.30	6.00e-100	358.00
IUUC-Mmr-060634	Microcebus murinus	94.44	0.00e+00	778.00
IUUC-Mdo-062555	Monodelphis domestica	98.67	2.00e-101	363.00
IUUC-Mmu-063799	Mus musculus	94.79	0.00e+00	748.00
IUUC-Mac-064643	Musa acuminata	50.00	3.00e-43	170.00
IUUC-Mpu-066803	Mustela putorius furo	92.53	0.00e+00	763.00
IUUC-Mlu-067895	Myotis lucifugus	80.92	4.00e-95	342.00
IUUC-Nle-069810	Nomascus leucogenys	99.81	0.00e+00	726.00
IUUC-Ont-071888	Oreochromis niloticus	53.26	2.00e-108	386.00
IUUC-Ola-087447	Oryzias latipes	51.86	4.00e-107	382.00
IUUC-Oga-088369	Otolemur garnettii	93.40	0.00e+00	782.00
IUUC-Oar-090071	Ovis aries	87.02	6.00e-156	543.00
IUUC-Ptr-091336	Pan troglodytes	95.31	0.00e+00	648.00
IUUC-Pan-091921	Papio anubis	99.13	0.00e+00	744.00
IUUC-Ppa-095284	Physcomitrella patens	48.99	5.00e-44	173.00
IUUC-Pfo-097111	Poecilia formosa	55.18	4.00e-104	372.00
IUUC-Pab-098722	Pongo abelii	99.48	0.00e+00	805.00
IUUC-Pca-100297	Procavia capensis	86.63	0.00e+00	727.00
IUUC-Pva-102305	Pteropus vampyrus	83.40	5.00e-172	597.00
IUUC-Rno-104941	Rattus norvegicus	94.62	0.00e+00	762.00
IUUC-Spo-108319	Schizosaccharomyces pombe	51.85	7.00e-41	162.00
IUUC-Tru-117791	Takifugu rubripes	50.72	1.00e-94	340.00
IUUC-Ttr-128384	Tursiops truncatus	93.00	0.00e+00	636.00
IUUC-Xtr-131804	Xenopus tropicalis	63.59	4.00e-159	555.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence