iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118300

UUCD1 version

UUC-TaR-00657

Ensembl Protein ID

ENSTRUP00000031223.1

UniProt Accession

H2U2R2; H2U2R2_TAKRU

Protein Name

Uncharacterized protein

Gene Name

cbl (1 of many); CBL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000012330.1	ENSTRUT00000031344.1	ENSTRUP00000031223.1
ENSTRUG00000012330.1	ENSTRUT00000031345.1	ENSTRUP00000031224.1
ENSTRUG00000012330.1	ENSTRUT00000031346.1	ENSTRUP00000031225.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.60e-06	28.3	405	444

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e  kd +++ pC H+++++Cl +w    + +s  + CP Cr
   Q: 405  CKICAENDKD-VKIEPCRHLMCTSCLTAW----Q-ESEGQGCPFCR 444
           99********.******************....5.555555****8 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

VKPTPLFHTG RVRVFEGYRV RSSPRLTPVS PRRVPSSSAE EMAGYPRRGA GLIGLMKDAF 60
QPHQQPPQPQ QPAVVDRKMV EKCWKLMDKV VRLCQNPKVA LKNSPPYILD LLPDTYQHLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAAACCGA CCCCGCTGTT CCACACAGGC AGGGTGCGGG TTTTTGAGGG ATATCGCGTC 60
CGTAGTAGCC CGCGATTGAC ACCCGTAAGC CCGCGGCGAG TCCCGTCATC GAGCGCTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR015940--UBA
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS50030--UBA
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0045121--C:membrane raft
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0005509--F:calcium ion binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0017124--F:SH3 domain binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0006508--P:proteolysis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cel-018674	Caenorhabditis elegans	55.41	3.00e-134	471.00
IUUC-Gmo-039279	Gadus morhua	92.87	0.00e+00	872.00
IUUC-Gac-041760	Gasterosteus aculeatus	71.36	0.00e+00	1021.00
IUUC-Ont-072133	Oreochromis niloticus	74.43	0.00e+00	1161.00
IUUC-Ola-086885	Oryzias latipes	72.93	0.00e+00	1116.00
IUUC-Pfo-096049	Poecilia formosa	71.92	0.00e+00	1153.00
IUUC-Tni-119861	Tetraodon nigroviridis	81.71	0.00e+00	1218.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence