iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000031751.14	ENSMUST00000053766.13	ENSMUSP00000052258.6
ENSMUSG00000031751.14	ENSMUST00000143265.1	ENSMUSP00000134924.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16709668; 25526307

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.20e-08	36.4	337	375
UBD/Alpha-Helix/CUE	2.00e-11	44.7	452	493

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 337  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 375
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 452  QLNAMAHQIQEMFPQVPYHLVLQDL-QMTRSVEITTDNILEGR 493
           5889*********************.***************95 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis (By similarity).

Protein Sequence
(Fasta)

MPLLFLERFP WPSLRTYTGL SGLALLGTIV SAYRALSQPE DGSGEPEPLT APLQPEARLT 60
AGGPRARDVA QYLLSDSLFV WVLVNTACCV LMLVAKLIQC IVFGPLRVSE RQHLKDKFWN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCCCAGGGT CGCCAAGGAT GCTGCAGGGG GCCGGGACGC GGGGCCCCAG GCCGGGTCCT 60
GTGCTCTCGG GGTTGCAGAG CGCCGGCTGT GGGCGGGGGA CGAAGGCCGC GCCCCCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0675--Receptor
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0030425--C:dendrite
GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0005794--C:Golgi apparatus
GO:0030426--C:growth cone
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0005887--C:integral component of plasma membrane
GO:0016020--C:membrane
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:1904288--F:BAT3 complex binding
GO:0051087--F:chaperone binding
GO:0000166--F:nucleotide binding
GO:0030674--F:protein binding, bridging
GO:0004872--F:receptor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0007568--P:aging
GO:0009987--P:cellular process
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0007611--P:learning or memory
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:23802

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	93.49	0.00e+00	1015.00
IUUC-Apl-003404	Anas platyrhynchos	87.99	0.00e+00	942.00
IUUC-Aca-004559	Anolis carolinensis	85.28	0.00e+00	875.00
IUUC-Ame-011640	Astyanax mexicanus	70.81	0.00e+00	838.00
IUUC-Bta-012980	Bos taurus	87.46	0.00e+00	1077.00
IUUC-Cel-018598	Caenorhabditis elegans	25.06	2.00e-34	140.00
IUUC-Cja-019577	Callithrix jacchus	94.09	0.00e+00	1197.00
IUUC-Cfa-020793	Canis familiaris	93.93	0.00e+00	1024.00
IUUC-Cpo-022387	Cavia porcellus	94.40	0.00e+00	1170.00
IUUC-Csa-023168	Chlorocebus sabaeus	94.40	0.00e+00	1204.00
IUUC-Cho-024433	Choloepus hoffmanni	95.98	0.00e+00	852.00
IUUC-Cin-025215	Ciona intestinalis	45.43	2.00e-147	516.00
IUUC-Csv-026133	Ciona savignyi	46.45	1.00e-133	469.00
IUUC-Dre-027594	Danio rerio	70.06	0.00e+00	801.00
IUUC-Dno-029407	Dasypus novemcinctus	95.70	0.00e+00	1026.00
IUUC-Dor-030961	Dipodomys ordii	96.42	0.00e+00	1056.00
IUUC-Ete-032962	Echinops telfairi	86.92	0.00e+00	871.00
IUUC-Eca-033683	Equus caballus	88.82	0.00e+00	1077.00
IUUC-Eeu-034515	Erinaceus europaeus	97.78	1.00e-78	286.00
IUUC-Fca-035398	Felis catus	96.09	0.00e+00	994.00
IUUC-Fal-036758	Ficedula albicollis	81.44	0.00e+00	882.00
IUUC-Gmo-039014	Gadus morhua	69.69	0.00e+00	777.00
IUUC-Gga-040575	Gallus gallus	85.11	0.00e+00	1024.00
IUUC-Gac-041414	Gasterosteus aculeatus	69.37	0.00e+00	763.00
IUUC-Hsa-046272	Homo sapiens	92.85	0.00e+00	1174.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	95.20	0.00e+00	1026.00
IUUC-Lch-050491	Latimeria chalumnae	75.90	0.00e+00	872.00
IUUC-Loc-052758	Lepisosteus oculatus	76.64	0.00e+00	863.00
IUUC-Laf-053452	Loxodonta africana	95.54	0.00e+00	1021.00
IUUC-Mcc-055820	Macaca mulatta	95.44	0.00e+00	1039.00
IUUC-Meu-056726	Macropus eugenii	83.90	0.00e+00	854.00
IUUC-Mga-059937	Meleagris gallopavo	86.98	0.00e+00	944.00
IUUC-Mmr-060730	Microcebus murinus	92.18	0.00e+00	1127.00
IUUC-Mdo-062771	Monodelphis domestica	89.22	0.00e+00	1085.00
IUUC-Mpu-066796	Mustela putorius furo	94.71	0.00e+00	1026.00
IUUC-Mlu-068189	Myotis lucifugus	93.01	0.00e+00	1017.00
IUUC-Nle-069239	Nomascus leucogenys	93.70	0.00e+00	1147.00
IUUC-Opr-070702	Ochotona princeps	89.13	1.00e-143	503.00
IUUC-Ont-072033	Oreochromis niloticus	71.95	0.00e+00	832.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.14	0.00e+00	867.00
IUUC-Ocu-074145	Oryctolagus cuniculus	92.38	0.00e+00	1158.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	1.00e-11	62.40
IUUC-Ola-087152	Oryzias latipes	70.35	0.00e+00	802.00
IUUC-Oga-088486	Otolemur garnettii	96.09	0.00e+00	1034.00
IUUC-Oar-089310	Ovis aries	94.29	0.00e+00	1046.00
IUUC-Ptr-090649	Pan troglodytes	95.34	0.00e+00	1058.00
IUUC-Pan-091692	Papio anubis	88.96	0.00e+00	1108.00
IUUC-Psi-093064	Pelodiscus sinensis	94.47	0.00e+00	774.00
IUUC-Pma-094763	Petromyzon marinus	77.46	8.00e-97	346.00
IUUC-Ppa-095969	Physcomitrella patens	29.38	6.00e-36	145.00
IUUC-Pfo-096810	Poecilia formosa	71.22	0.00e+00	810.00
IUUC-Pab-097859	Pongo abelii	95.44	0.00e+00	1041.00
IUUC-Pop-099576	Populus trichocarpa	27.65	4.00e-29	122.00
IUUC-Pca-100344	Procavia capensis	91.43	0.00e+00	1087.00
IUUC-Pva-103114	Pteropus vampyrus	66.92	0.00e+00	736.00
IUUC-Rno-105880	Rattus norvegicus	96.72	0.00e+00	1186.00
IUUC-Sha-107015	Sarcophilus harrisii	93.55	0.00e+00	1001.00
IUUC-Sar-113397	Sorex araneus	97.30	0.00e+00	760.00
IUUC-Ssc-115988	Sus scrofa	89.93	5.00e-144	503.00
IUUC-Tgu-116717	Taeniopygia guttata	89.42	0.00e+00	952.00
IUUC-Tru-117805	Takifugu rubripes	68.99	0.00e+00	828.00
IUUC-Tsy-119442	Tarsius syrichta	89.43	0.00e+00	951.00
IUUC-Tni-119777	Tetraodon nigroviridis	72.69	1.00e-172	599.00
IUUC-Tbe-127322	Tupaia belangeri	68.07	5.00e-114	404.00
IUUC-Ttr-128181	Tursiops truncatus	93.73	0.00e+00	1041.00
IUUC-Vpa-130483	Vicugna pacos	85.48	0.00e+00	663.00
IUUC-Xtr-132614	Xenopus tropicalis	74.88	0.00e+00	802.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence