iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000003147.8	ENSRNOT00000059255.5	ENSRNOP00000056021.3
ENSRNOG00000003147.8	ENSRNOT00000004308.6	ENSRNOP00000004308.6

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	25496309; 25761618; 25825496; 27236019

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	0.00064	20.2	395	429
ULD/UDP/UFD/PB1	3.50e-17	62.8	22	100

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGF.dreealqaLraa.nnnleaAvey 37
           + l q+ +MGF d+  +l+ L+++ n+++ aA++ 
   Q: 395  ESLSQMLSMGFsDEGGWLTRLLQTkNYDIGAALDT 429
           6799*******6666*****************985 PP

ULD/UDP/UFD/PB1

   S: 3    rvkvsykgeirsfaldlekpgkfedLlkavrt.ltelknsevalkYeDedGDlvtlksDedldkavsllaskksllrlliqkk 84
           r+ +++++e++  a+++++pg +e+Ll++v+  +++l+   ++ +Y+DedGDlv+++sDe+l++a+s+   k++++r++i++k
   Q: 22   RFSFCFSPEPE--AEAAAGPGPCERLLSRVAVlFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSY--VKDDIFRIYIKEK 100
           899*******6..69*****************999********************************7..9*********975 PP

Organism

Rattus norvegicus

Functional Description
(View)

Autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures) and links ALIS to the autophagic machinery. Involved in midbody ring degradation. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Isoform 1 is more potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2.

Protein Sequence
(Fasta)

MASLTVKAYL LGKEEAAREI RRFSFCFSPE PEAEAAAGPG PCERLLSRVA VLFPALRPGG 60
FQAHYRDEDG DLVAFSSDEE LTMAMSYVKD DIFRIYIKEK KECRREHRPP CAQEARSMVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCAGCTGT TTCCTCCGTA CCTAGTCTGC GGTTATGGCT TCGCTCACGG TGAAGGCCTA 60
TCTACTGGGC AAGGAGGAGG CGGCCCGCGA GATCCGCCGC TTCAGCTTCT GCTTCAGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0221--Differentiation
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000270--PB1_dom
IPR033741--SQSTM_UBA
IPR015940--UBA
IPR009060--UBA-like
IPR000433--Znf_ZZ

PROSITE

PS51745--PB1
PS50030--UBA
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF00564--PB1
PF16577--UBA_5
PF00569--ZZ

SMART

SM00666--PB1
SM00165--UBA
SM00291--ZnF_ZZ

Gene Ontology

GO:0016235--C:aggresome
GO:0044753--C:amphisome
GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0000932--C:P-body
GO:0016605--C:PML body
GO:0000407--C:pre-autophagosomal structure
GO:0097225--C:sperm midpiece
GO:0042802--F:identical protein binding
GO:0042803--F:protein homodimerization activity
GO:0005080--F:protein kinase C binding
GO:0042169--F:SH2 domain binding
GO:0043130--F:ubiquitin binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0006914--P:autophagy
GO:0030154--P:cell differentiation
GO:0002376--P:immune system process
GO:0016236--P:macroautophagy
GO:0044130--P:negative regulation of growth of symbiont in host
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016239--P:positive regulation of macroautophagy
GO:0098779--P:positive regulation of macromitophagy in response to mitochondrial depolarization
GO:0001934--P:positive regulation of protein phosphorylation
GO:0051291--P:protein heterooligomerization
GO:0043122--P:regulation of I-kappaB kinase/NF-kappaB signaling
GO:0061635--P:regulation of protein complex stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:113894

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001367	Ailuropoda melanoleuca	88.24	2.00e-168	584.00
IUUC-Apl-003897	Anas platyrhynchos	57.49	8.00e-119	420.00
IUUC-Aca-004699	Anolis carolinensis	49.24	5.00e-97	348.00
IUUC-Ame-010982	Astyanax mexicanus	71.30	5.00e-41	162.00
IUUC-Bta-012634	Bos taurus	88.69	0.00e+00	743.00
IUUC-Cel-018540	Caenorhabditis elegans	50.00	9.00e-10	58.90
IUUC-Cja-019684	Callithrix jacchus	88.01	0.00e+00	734.00
IUUC-Cfa-020573	Canis familiaris	81.82	5.00e-134	471.00
IUUC-Cpo-021425	Cavia porcellus	79.15	3.00e-180	624.00
IUUC-Csa-023968	Chlorocebus sabaeus	88.69	0.00e+00	708.00
IUUC-Cho-024596	Choloepus hoffmanni	81.53	2.00e-52	199.00
IUUC-Cin-025557	Ciona intestinalis	27.50	7.00e-14	71.20
IUUC-Csv-025974	Ciona savignyi	26.98	3.00e-16	79.30
IUUC-Dre-028621	Danio rerio	44.12	3.00e-96	345.00
IUUC-Dno-029060	Dasypus novemcinctus	85.36	0.00e+00	715.00
IUUC-Dor-030547	Dipodomys ordii	86.45	1.00e-136	479.00
IUUC-Ete-033201	Echinops telfairi	77.81	8.00e-165	572.00
IUUC-Eca-033456	Equus caballus	88.05	0.00e+00	667.00
IUUC-Eeu-035157	Erinaceus europaeus	81.65	1.00e-172	598.00
IUUC-Fca-035403	Felis catus	87.22	0.00e+00	699.00
IUUC-Fal-036798	Ficedula albicollis	57.42	2.00e-137	482.00
IUUC-Gmo-039619	Gadus morhua	42.01	6.00e-49	187.00
IUUC-Gga-040137	Gallus gallus	56.03	2.00e-132	465.00
IUUC-Gac-042410	Gasterosteus aculeatus	47.11	2.00e-97	348.00
IUUC-Ggo-044690	Gorilla gorilla	88.91	0.00e+00	714.00
IUUC-Hsa-046390	Homo sapiens	88.69	0.00e+00	710.00
IUUC-Itr-048536	Ictidomys tridecemlineatus	91.63	0.00e+00	777.00
IUUC-Lch-049658	Latimeria chalumnae	47.67	1.00e-110	393.00
IUUC-Loc-052589	Lepisosteus oculatus	47.23	2.00e-110	392.00
IUUC-Laf-053746	Loxodonta africana	79.24	0.00e+00	637.00
IUUC-Mcc-055635	Macaca mulatta	88.01	0.00e+00	718.00
IUUC-Meu-056528	Macropus eugenii	52.61	7.00e-108	383.00
IUUC-Mga-059458	Meleagris gallopavo	57.78	2.00e-118	419.00
IUUC-Mvi-060347	Microbotryum violaceum	51.16	1.00e-07	52.40
IUUC-Mmr-061539	Microcebus murinus	83.70	7.00e-133	466.00
IUUC-Mdo-063083	Monodelphis domestica	64.10	5.00e-155	540.00
IUUC-Mmu-063589	Mus musculus	95.93	0.00e+00	812.00
IUUC-Mpu-065727	Mustela putorius furo	87.13	3.00e-178	617.00
IUUC-Mlu-067026	Myotis lucifugus	85.15	4.00e-179	620.00
IUUC-Nle-069356	Nomascus leucogenys	62.88	1.00e-119	423.00
IUUC-Opr-071091	Ochotona princeps	66.55	2.00e-92	332.00
IUUC-Ont-071864	Oreochromis niloticus	48.53	4.00e-102	364.00
IUUC-Oan-073308	Ornithorhynchus anatinus	63.25	2.00e-142	498.00
IUUC-Ocu-074110	Oryctolagus cuniculus	86.65	0.00e+00	720.00
IUUC-Ola-086944	Oryzias latipes	46.19	8.00e-40	156.00
IUUC-Oga-088869	Otolemur garnettii	85.94	0.00e+00	723.00
IUUC-Oar-089857	Ovis aries	88.59	0.00e+00	645.00
IUUC-Ptr-091640	Pan troglodytes	88.91	0.00e+00	714.00
IUUC-Pan-092831	Papio anubis	88.39	0.00e+00	708.00
IUUC-Psi-093925	Pelodiscus sinensis	56.54	7.00e-130	457.00
IUUC-Pma-094576	Petromyzon marinus	31.30	6.00e-45	174.00
IUUC-Pfo-097297	Poecilia formosa	45.41	9.00e-93	333.00
IUUC-Pab-098725	Pongo abelii	81.22	0.00e+00	635.00
IUUC-Pca-101106	Procavia capensis	87.27	0.00e+00	702.00
IUUC-Pva-102710	Pteropus vampyrus	84.44	0.00e+00	652.00
IUUC-Sha-107469	Sarcophilus harrisii	59.64	1.00e-124	439.00
IUUC-Ssc-115526	Sus scrofa	89.82	0.00e+00	720.00
IUUC-Tgu-117194	Taeniopygia guttata	58.78	9.00e-120	423.00
IUUC-Tru-117896	Takifugu rubripes	48.09	7.00e-103	367.00
IUUC-Tni-119943	Tetraodon nigroviridis	48.54	8.00e-93	333.00
IUUC-Ttr-128676	Tursiops truncatus	88.91	0.00e+00	744.00
IUUC-Vda-129812	Verticillium dahliae	48.94	1.00e-06	48.50
IUUC-Vpa-130319	Vicugna pacos	94.00	3.00e-54	205.00
IUUC-Xtr-132907	Xenopus tropicalis	53.73	8.00e-129	453.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence