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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046641
UUCD1 version UUC-HoS-00459
Ensembl Protein ID ENSP00000209884.4
UniProt Accession Q9Y2M5; B3KMA0; B4DUR0; Q5TZF2; Q5ZF45; Q9H457; KLH20_HUMAN
Genbank Protein ID CAH59617.1; BAA77027.1; BAG50912.1; BAG62422.1; CAI20377.1; CAI20377.1; CAH73000.1; CAH73000.1; AAH63418.1
Protein Name Kelch-like protein 20; Kelch-like ECT2-interacting protein; Kelch-like protein X
Genbank Nucleotide ID AJ844466; AB026190; AK001430; AK300755; AL109921; BX248409; BX248409; AL109921; BC063418
Gene Name KLHL20; KLEIP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000076321.10 ENST00000209884.4 ENSP00000209884.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanmiRecordsRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDPINAHINTMentha
InWeb_IM
Disease-associated Information
ClinVarGWASdbGWAS Central
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDBioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box BTB_3-box 20389280; 21670212
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 1.10e-21 78.6 68 135
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 1.50e-11 43.4 167 198
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv+lvvg +++ ah+++L+a+S++F+a+f++el es+ + +v+i+d++  +++ l++F Yt++++ +e
   Q: 68   CDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR-QTEVVIRDIDERAMELLIDFAYTSQITVEE 135
           9*************************************.*************************98765 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclgi++fAd+++c++L   a++f++++F+
   Q: 167  PSNCLGIRAFADTHSCRELLRIADKFTQHNFQ 198
           89*****************************6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).
 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).
Protein Sequence
(Fasta)
MEGKPMRRCT NIRPGETGMD VTSRCTLGDP NKLPEGVPQP ARMPYISDKH PRQTLEVINL 60
LRKHRELCDV VLVVGAKKIY AHRVILSACS PYFRAMFTGE LAESRQTEVV IRDIDERAME 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046641|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGGCCGGT GAAGGGAAAG GAAATAGCTC TACGAGCGGC ATCCTGCCTG CGTTAGCGGC 60
GGTGGAGGAG GAGGCAGAGA GGAGTGGAGG GCGGAGTAGA CGGAGGAGGC TGCTGCAGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046641|E3,BTB_3-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0030424--C:axon
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0016605--C:PML body
GO:0005802--C:trans-Golgi network
GO:0019964--F:interferon-gamma binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007010--P:cytoskeleton organization
GO:0006895--P:Golgi to endosome transport
GO:0043066--P:negative regulation of apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1990390--P:protein K33-linked ubiquitination
GO:0015031--P:protein transport
GO:0016567--P:protein ubiquitination
GO:0035455--P:response to interferon-alpha
KEGG hsa:27252
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001974 Ailuropoda melanoleuca 99.01 0.00e+00 1254.00
IUUC-Apl-003481 Anas platyrhynchos 99.34 0.00e+00 1258.00
IUUC-Aca-004877 Anolis carolinensis 99.18 0.00e+00 1255.00
IUUC-Aly-005957 Arabidopsis lyrata 36.30 6.00e-40 159.00
IUUC-Aor-010180 Aspergillus oryzae 24.65 2.00e-09 57.00
IUUC-Ame-011440 Astyanax mexicanus 98.82 0.00e+00 1220.00
IUUC-Bta-012603 Bos taurus 100.00 0.00e+00 1264.00
IUUC-Bra-016881 Brassica rapa 27.27 5.00e-17 83.20
IUUC-Cel-018464 Caenorhabditis elegans 59.51 0.00e+00 716.00
IUUC-Cja-019119 Callithrix jacchus 100.00 0.00e+00 1264.00
IUUC-Cfa-020169 Canis familiaris 100.00 0.00e+00 1264.00
IUUC-Cpo-021519 Cavia porcellus 99.84 0.00e+00 1262.00
IUUC-Csa-024173 Chlorocebus sabaeus 100.00 0.00e+00 1264.00
IUUC-Cho-024820 Choloepus hoffmanni 91.42 0.00e+00 791.00
IUUC-Cin-025270 Ciona intestinalis 75.51 0.00e+00 890.00
IUUC-Csv-026308 Ciona savignyi 75.43 0.00e+00 898.00
IUUC-Dre-027423 Danio rerio 98.98 0.00e+00 1221.00
IUUC-Dno-029350 Dasypus novemcinctus 99.67 0.00e+00 1260.00
IUUC-Dor-031011 Dipodomys ordii 100.00 2.00e-168 585.00
IUUC-Dme-032170 Drosophila melanogaster 80.94 0.00e+00 959.00
IUUC-Ete-033187 Echinops telfairi 99.77 0.00e+00 887.00
IUUC-Eca-033751 Equus caballus 100.00 0.00e+00 1264.00
IUUC-Eeu-034901 Erinaceus europaeus 99.67 0.00e+00 1262.00
IUUC-Fca-035752 Felis catus 98.91 0.00e+00 1123.00
IUUC-Fal-037630 Ficedula albicollis 99.18 0.00e+00 1254.00
IUUC-Gmo-039481 Gadus morhua 97.04 0.00e+00 1237.00
IUUC-Gga-040971 Gallus gallus 99.34 0.00e+00 1258.00
IUUC-Gac-042602 Gasterosteus aculeatus 97.37 0.00e+00 1239.00
IUUC-Ggo-044588 Gorilla gorilla 100.00 0.00e+00 1264.00
IUUC-Itr-048394 Ictidomys tridecemlineatus 100.00 0.00e+00 1254.00
IUUC-Lch-049968 Latimeria chalumnae 98.85 0.00e+00 1254.00
IUUC-Loc-052720 Lepisosteus oculatus 97.87 0.00e+00 1247.00
IUUC-Lma-053201 Leptosphaeria maculans 27.21 3.00e-09 56.20
IUUC-Laf-054156 Loxodonta africana 100.00 0.00e+00 1264.00
IUUC-Mcc-054629 Macaca mulatta 100.00 0.00e+00 1264.00
IUUC-Meu-056605 Macropus eugenii 99.36 0.00e+00 644.00
IUUC-Mga-060014 Meleagris gallopavo 98.51 0.00e+00 1230.00
IUUC-Mmr-060814 Microcebus murinus 99.34 0.00e+00 1250.00
IUUC-Mdo-062242 Monodelphis domestica 99.34 0.00e+00 1257.00
IUUC-Mmu-064309 Mus musculus 100.00 0.00e+00 1254.00
IUUC-Mpu-066587 Mustela putorius furo 100.00 0.00e+00 1264.00
IUUC-Mlu-066958 Myotis lucifugus 96.55 0.00e+00 1206.00
IUUC-Nle-069059 Nomascus leucogenys 98.52 0.00e+00 1240.00
IUUC-Ont-072129 Oreochromis niloticus 97.37 0.00e+00 1240.00
IUUC-Oan-073073 Ornithorhynchus anatinus 99.01 0.00e+00 1246.00
IUUC-Ocu-073909 Oryctolagus cuniculus 99.01 0.00e+00 1252.00
IUUC-Ola-086392 Oryzias latipes 96.73 0.00e+00 1231.00
IUUC-Oga-088693 Otolemur garnettii 98.85 0.00e+00 1253.00
IUUC-Oar-089905 Ovis aries 99.84 0.00e+00 1263.00
IUUC-Ptr-091059 Pan troglodytes 100.00 0.00e+00 1264.00
IUUC-Pan-091833 Papio anubis 94.87 0.00e+00 790.00
IUUC-Psi-093499 Pelodiscus sinensis 99.34 0.00e+00 1252.00
IUUC-Pma-094404 Petromyzon marinus 80.33 0.00e+00 945.00
IUUC-Ppa-095249 Physcomitrella patens 31.13 1.00e-14 74.70
IUUC-Pfo-096891 Poecilia formosa 97.70 0.00e+00 1242.00
IUUC-Pab-097715 Pongo abelii 95.57 0.00e+00 1196.00
IUUC-Pva-102944 Pteropus vampyrus 83.74 0.00e+00 1029.00
IUUC-Rno-104878 Rattus norvegicus 100.00 0.00e+00 1264.00
IUUC-Sha-107444 Sarcophilus harrisii 99.34 0.00e+00 1258.00
IUUC-Ssc-115565 Sus scrofa 100.00 0.00e+00 1251.00
IUUC-Tgu-116902 Taeniopygia guttata 99.18 0.00e+00 1257.00
IUUC-Tru-118692 Takifugu rubripes 97.70 0.00e+00 1242.00
IUUC-Tsy-119031 Tarsius syrichta 92.45 0.00e+00 1145.00
IUUC-Tbe-127517 Tupaia belangeri 93.84 0.00e+00 1157.00
IUUC-Ttr-128366 Tursiops truncatus 100.00 0.00e+00 1264.00
IUUC-Vpa-130465 Vicugna pacos 99.67 0.00e+00 1261.00
IUUC-Vvi-131673 Vitis vinifera 34.33 3.00e-42 166.00
IUUC-Xtr-132243 Xenopus tropicalis 98.36 0.00e+00 1247.00
IUUC-Xma-133192 Xiphophorus maculatus 97.54 0.00e+00 1240.00
Created Date 25-Jun-2017

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