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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046066
UUCD1 version UUC-HoS-00126
Ensembl Protein ID ENSP00000385684.1
UniProt Accession Q15034; A8K1S5; Q8IXX3; HERC3_HUMAN
Genbank Protein ID BAA04945.2; BAF82679.1; EAX06024.1; AAH38960.1
Protein Name Probable E3 ubiquitin-protein ligase HERC3; HECT domain and RCC1-like domain-containing protein 3; HECT-type E3 ubiquitin transferase HERC3
Genbank Nucleotide ID D25215; AK289990; AC083829; BC038960
Gene Name HERC3; KIAA0032
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000138641.15 ENST00000402738.5 ENSP00000385684.1
ENSG00000138641.15 ENST00000407637.5 ENSP00000384005.1
ENSG00000138641.15 ENST00000512194.1 ENSP00000421021.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetTRANSFACmiRWalkTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 11163799
Classification
Family E-value Score Start End
E3 activity/HECT 2.30e-94 318.2 726 1049
Active Site
Position(s) Description Evidence
1018 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+ +g+a++++ ++dl+++
   Q: 726  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV-----EHNWFHLIGITCGLAIYNSTVVDLHFP 810
           899******************************************9999999776554.....579************************ PP
   S: 94   ksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlk 183
            ++yk+ll++k  ledl+e+ p+  +sl+e++++  +d+ee+ ++l+f++  e++g +++++L+pgG+n+ V ++N++e+v+++v+y ++
   Q: 811  LALYKKLLNVKPGLEDLKELSPTEGRSLQELLDYPGEDVEET-FCLNFTICRESYGVIEQKKLIPGGDNVTVCKDNRQEFVDAYVNYVFQ 899
           **********************************99999997.******99*************************************** PP
   S: 184  egikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssr 273
            +++e ++af++Gf +v+  ++l+lF+++el+ ++ G++++++e+l++++ ykg+y++++p+++ Fwe+++ef  e++k+fL F+Tgs+r
   Q: 900  ISVHEWYTAFSSGFLKVCGGKVLELFQPSELRAMMVGNSNYNWEELEETAIYKGDYSATHPTVKLFWETFHEFPLEKKKKFLLFLTGSDR 989
           ****************************************************************************************** PP
   S: 274  lPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +P+ G+a+l+   +vi+  ++ ++ lP ++TC+n+L+LP+Ysskeil  +L+ A ++ +gF+l
   Q: 990  IPIYGMASLQ---IVIQStASGEEYLPVAHTCYNLLDLPKYSSKEILSARLTQALDNYEGFSL 1049
           **********...8888867788**************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MLCWGYWSLG QPGISTNLQG IVAEPQVCGF ISDRSVKEVA CGGNHSVFLL EDGEVYTCGL 60
NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS DRGQLFSWGA GSDGQLGLMT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046066|E3,HECT|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TAATGTCAAA GAAATGAAGG TAATTTTACA AACTCAGTTT TTGTAAGTAC ATGAAGTTTC 60
TATTTGATTA TGTGGTTTTA TATCACATTC GTTCAAATGC ATTTCTCTCC CTTAGAGGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046066|E3,HECT|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
Pfam

PF00632--HECT
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM00119--HECTc
Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity
KEGG hsa:8916
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001673 Ailuropoda melanoleuca 98.95 0.00e+00 2099.00
IUUC-Apl-003535 Anas platyrhynchos 88.29 0.00e+00 1885.00
IUUC-Aca-005223 Anolis carolinensis 85.52 0.00e+00 1831.00
IUUC-Ame-010816 Astyanax mexicanus 65.92 0.00e+00 1162.00
IUUC-Bta-013373 Bos taurus 97.90 0.00e+00 2085.00
IUUC-Cel-018150 Caenorhabditis elegans 33.21 2.00e-154 540.00
IUUC-Cja-019609 Callithrix jacchus 99.33 0.00e+00 2102.00
IUUC-Cfa-021071 Canis familiaris 98.76 0.00e+00 2095.00
IUUC-Cpo-021548 Cavia porcellus 97.62 0.00e+00 2074.00
IUUC-Csa-023987 Chlorocebus sabaeus 99.81 0.00e+00 2110.00
IUUC-Cho-024325 Choloepus hoffmanni 98.41 0.00e+00 1206.00
IUUC-Dre-027472 Danio rerio 66.44 0.00e+00 1399.00
IUUC-Dno-029241 Dasypus novemcinctus 97.34 0.00e+00 2068.00
IUUC-Dor-030672 Dipodomys ordii 92.54 0.00e+00 1135.00
IUUC-Ete-032642 Echinops telfairi 92.29 0.00e+00 1902.00
IUUC-Eca-033646 Equus caballus 98.57 0.00e+00 2090.00
IUUC-Eeu-035098 Erinaceus europaeus 85.02 0.00e+00 1380.00
IUUC-Fal-036952 Ficedula albicollis 88.00 0.00e+00 1879.00
IUUC-Gmo-039297 Gadus morhua 64.10 0.00e+00 1316.00
IUUC-Gga-040591 Gallus gallus 87.25 0.00e+00 1860.00
IUUC-Gac-041741 Gasterosteus aculeatus 65.18 0.00e+00 1379.00
IUUC-Gma-043616 Glycine max 37.79 1.00e-51 197.00
IUUC-Ggo-044769 Gorilla gorilla 99.90 0.00e+00 2111.00
IUUC-Itr-048311 Ictidomys tridecemlineatus 98.76 0.00e+00 2087.00
IUUC-Lch-050301 Latimeria chalumnae 73.43 0.00e+00 1618.00
IUUC-Loc-052803 Lepisosteus oculatus 67.44 0.00e+00 1459.00
IUUC-Laf-053364 Loxodonta africana 98.76 0.00e+00 2094.00
IUUC-Mcc-054930 Macaca mulatta 99.71 0.00e+00 2110.00
IUUC-Meu-056274 Macropus eugenii 79.27 0.00e+00 871.00
IUUC-Mtr-058277 Medicago truncatula 37.25 3.00e-52 199.00
IUUC-Mga-059563 Meleagris gallopavo 87.71 0.00e+00 1875.00
IUUC-Mmr-060792 Microcebus murinus 96.57 0.00e+00 2036.00
IUUC-Mdo-062195 Monodelphis domestica 91.72 0.00e+00 1957.00
IUUC-Mmu-063855 Mus musculus 95.33 0.00e+00 2044.00
IUUC-Mpu-066308 Mustela putorius furo 99.05 0.00e+00 2101.00
IUUC-Mlu-066927 Myotis lucifugus 97.90 0.00e+00 2076.00
IUUC-Nle-070090 Nomascus leucogenys 99.81 0.00e+00 2110.00
IUUC-Opr-070891 Ochotona princeps 86.00 0.00e+00 1769.00
IUUC-Ont-072201 Oreochromis niloticus 63.99 0.00e+00 1337.00
IUUC-Ocu-074770 Oryctolagus cuniculus 98.10 0.00e+00 2086.00
IUUC-Ola-086550 Oryzias latipes 65.15 0.00e+00 1387.00
IUUC-Olu-087836 Ostreococcus lucimarinus 34.44 9.00e-42 164.00
IUUC-Oga-088831 Otolemur garnettii 98.76 0.00e+00 2090.00
IUUC-Oar-090449 Ovis aries 97.81 0.00e+00 2080.00
IUUC-Pan-092135 Papio anubis 99.71 0.00e+00 2106.00
IUUC-Psi-093832 Pelodiscus sinensis 85.63 0.00e+00 1876.00
IUUC-Pfo-097268 Poecilia formosa 65.53 0.00e+00 1383.00
IUUC-Pab-098249 Pongo abelii 99.71 0.00e+00 2110.00
IUUC-Pca-100855 Procavia capensis 93.85 0.00e+00 1432.00
IUUC-Pva-102506 Pteropus vampyrus 89.82 0.00e+00 1841.00
IUUC-Rno-105242 Rattus norvegicus 95.62 0.00e+00 2085.00
IUUC-Sha-107186 Sarcophilus harrisii 89.39 0.00e+00 1199.00
IUUC-Sar-113612 Sorex araneus 95.40 0.00e+00 747.00
IUUC-Ssc-115473 Sus scrofa 97.71 0.00e+00 2077.00
IUUC-Tgu-116974 Taeniopygia guttata 88.20 0.00e+00 1857.00
IUUC-Tru-118077 Takifugu rubripes 63.55 0.00e+00 1316.00
IUUC-Tsy-119619 Tarsius syrichta 87.24 0.00e+00 1857.00
IUUC-Tni-120807 Tetraodon nigroviridis 63.74 0.00e+00 1340.00
IUUC-Tbe-127640 Tupaia belangeri 94.76 0.00e+00 1957.00
IUUC-Ttr-129172 Tursiops truncatus 97.43 0.00e+00 2066.00
IUUC-Vpa-130442 Vicugna pacos 82.96 0.00e+00 1701.00
IUUC-Xtr-132194 Xenopus tropicalis 71.46 0.00e+00 1439.00
Created Date 25-Jun-2017

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