iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	9.30e-100	334.7	733	1056

Active Site

Position(s)	Description	Evidence
1025	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l+++el +p++g+f+y e+++  ++ +++      e  +lF+++G+++g+a+++  ++dl
   Q: 733  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTF-----EDSDLFHLIGVICGLAIYNFTIVDL 814
           78999***********************************************88877.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k sl+dl+e++p++ +s+++++++ e+diee+ ++l+f+++ e++g t+++eL+ +G+++ V+++N++e+v+++
   Q: 815  HFPLALYKKLLKRKPSLDDLKELMPDVGRSMQQLLDYPEDDIEET-FCLNFTITVENFGATEVKELVLNGADTAVNKQNRQEFVDAY 900
           ***************************************9**998.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l lF+++el+ ++ G++++d+++l+k+t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 901  VDYIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 987
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP s+TCfn+L+LP+Y++ke+l+ kL+ Ai++++gF+l
   Q: 988  LLFLTGSDRIPILGMKSLK---LVIQStGGGESYLPVSHTCFNLLDLPKYTEKETLRCKLIQAIDHNEGFSL 1056
           *******************...7777758888**************************************86 PP

Organism

Rattus norvegicus

Functional Description
(View)

Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates.

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDEE IVLEPRKSDF FVNKKVRDVG CGLRHTVFVL DDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQNIVAVS CGEAHTLALN DKGQVYAWGL DSDGQLGLQG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAAACCAC CGCCCCTCTC CCTTGTCGCC AGCCTCTCCC TCGGCTCTCT CCACCCCTCG 60
TGTTCTCCGC CCTGCTCGCC ACCAGCCCTT CCCCTCCCGC TCCATCCGGG TCGCTGACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-1185--Reference proteome
KW-0677--Repeat
KW-0744--Spermatogenesis
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0001650--C:fibrillar center
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030154--P:cell differentiation
GO:0007283--P:spermatogenesis

KEGG

rno:309758

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	96.88	0.00e+00	1990.00
IUUC-Apl-003295	Anas platyrhynchos	87.71	0.00e+00	1892.00
IUUC-Aca-004336	Anolis carolinensis	85.47	0.00e+00	1842.00
IUUC-Ame-010768	Astyanax mexicanus	73.44	0.00e+00	1603.00
IUUC-Bta-013279	Bos taurus	96.50	0.00e+00	1988.00
IUUC-Cel-018150	Caenorhabditis elegans	34.25	5.00e-155	541.00
IUUC-Cja-019023	Callithrix jacchus	96.59	0.00e+00	1983.00
IUUC-Cfa-021074	Canis familiaris	97.07	0.00e+00	1996.00
IUUC-Cpo-021461	Cavia porcellus	94.90	0.00e+00	1944.00
IUUC-Csa-024261	Chlorocebus sabaeus	97.07	0.00e+00	1997.00
IUUC-Cho-024513	Choloepus hoffmanni	77.20	0.00e+00	1479.00
IUUC-Cin-025232	Ciona intestinalis	42.68	0.00e+00	833.00
IUUC-Dre-028829	Danio rerio	74.62	0.00e+00	1561.00
IUUC-Dno-029445	Dasypus novemcinctus	93.81	0.00e+00	1610.00
IUUC-Dor-030158	Dipodomys ordii	96.48	0.00e+00	882.00
IUUC-Dme-032103	Drosophila melanogaster	44.70	0.00e+00	892.00
IUUC-Ete-033072	Echinops telfairi	86.09	0.00e+00	1741.00
IUUC-Eca-033317	Equus caballus	94.89	0.00e+00	1948.00
IUUC-Fca-035682	Felis catus	96.69	0.00e+00	1978.00
IUUC-Fal-036969	Ficedula albicollis	86.47	0.00e+00	1866.00
IUUC-Gmo-038671	Gadus morhua	74.22	0.00e+00	1602.00
IUUC-Gga-041174	Gallus gallus	87.42	0.00e+00	1889.00
IUUC-Gac-042600	Gasterosteus aculeatus	74.25	0.00e+00	1548.00
IUUC-Ggo-044589	Gorilla gorilla	97.07	0.00e+00	2024.00
IUUC-Hsa-046772	Homo sapiens	96.97	0.00e+00	2020.00
IUUC-Lch-050147	Latimeria chalumnae	79.91	0.00e+00	1429.00
IUUC-Loc-052684	Lepisosteus oculatus	79.85	0.00e+00	1691.00
IUUC-Laf-053844	Loxodonta africana	96.31	0.00e+00	1981.00
IUUC-Mcc-055531	Macaca mulatta	94.82	0.00e+00	1979.00
IUUC-Mga-060151	Meleagris gallopavo	86.77	0.00e+00	1576.00
IUUC-Mmr-060954	Microcebus murinus	97.07	0.00e+00	1994.00
IUUC-Mdo-062246	Monodelphis domestica	91.96	0.00e+00	1771.00
IUUC-Mmu-063369	Mus musculus	98.11	0.00e+00	2053.00
IUUC-Mpu-065936	Mustela putorius furo	96.23	0.00e+00	1828.00
IUUC-Mlu-067326	Myotis lucifugus	95.93	0.00e+00	1937.00
IUUC-Nle-069453	Nomascus leucogenys	96.69	0.00e+00	1975.00
IUUC-Ont-071720	Oreochromis niloticus	74.62	0.00e+00	1572.00
IUUC-Oan-073464	Ornithorhynchus anatinus	92.36	0.00e+00	1790.00
IUUC-Ocu-074207	Oryctolagus cuniculus	94.76	0.00e+00	1833.00
IUUC-Ola-086762	Oryzias latipes	74.34	0.00e+00	1535.00
IUUC-Oga-088435	Otolemur garnettii	96.97	0.00e+00	1995.00
IUUC-Oar-089233	Ovis aries	96.69	0.00e+00	1989.00
IUUC-Ptr-091368	Pan troglodytes	97.16	0.00e+00	2023.00
IUUC-Pan-092300	Papio anubis	97.07	0.00e+00	1997.00
IUUC-Psi-093406	Pelodiscus sinensis	88.84	0.00e+00	1912.00
IUUC-Pma-094113	Petromyzon marinus	71.53	0.00e+00	1160.00
IUUC-Ppa-095354	Physcomitrella patens	33.58	6.00e-153	535.00
IUUC-Pfo-097021	Poecilia formosa	73.42	0.00e+00	1611.00
IUUC-Pab-098327	Pongo abelii	97.35	0.00e+00	2025.00
IUUC-Pca-101075	Procavia capensis	94.87	0.00e+00	818.00
IUUC-Pva-102909	Pteropus vampyrus	85.34	0.00e+00	1678.00
IUUC-Sha-106632	Sarcophilus harrisii	92.72	0.00e+00	1934.00
IUUC-Sar-113679	Sorex araneus	87.34	0.00e+00	1130.00
IUUC-Tgu-116849	Taeniopygia guttata	82.50	0.00e+00	1757.00
IUUC-Tru-118206	Takifugu rubripes	73.15	0.00e+00	1484.00
IUUC-Tsy-119521	Tarsius syrichta	82.97	0.00e+00	1603.00
IUUC-Tni-120233	Tetraodon nigroviridis	71.93	0.00e+00	1466.00
IUUC-Tbe-127941	Tupaia belangeri	80.17	0.00e+00	1360.00
IUUC-Ttr-128926	Tursiops truncatus	96.49	0.00e+00	1169.00
IUUC-Vpa-130448	Vicugna pacos	95.84	0.00e+00	1972.00
IUUC-Xtr-132719	Xenopus tropicalis	70.23	0.00e+00	1389.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence