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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Cel-018461
Ensembl Protein ID C34G6.7a
UniProt Accession O01498; Q8I7I2; STAM1_CAEEL
Genbank Protein ID CCD66687.1; CCD66688.1
Protein Name Signal transducing adapter molecule 1; Prion-like-(Q/N-rich) domain-bearing protein 19
Genbank Nucleotide ID FO080778; FO080778
Gene Name stam-1; pqn-19; C34G6.7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004109 C34G6.7a C34G6.7a
WBGene00004109 C34G6.7b C34G6.7b
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/Alpha-Helix/UIM UIM 21193406; 25564854
UBD/Alpha-Helix/VHS VHS 21193406; 25564854
Classification
Family E-value Score Start End
UBD/Alpha-Helix/VHS 1.40e-45 154.8 20 147
UBD/SH3 2.70e-14 53.1 222 274
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/VHS
   S: 2    tselvtsedwelileicdliqetkegakdalralrkrinnknphvalraLtlLdscvsnCgkkfhvevaskdlleelrellknenepkvieKlkalivsW. 101
           t+ ++t+e+we+il++cd+i+++ eg+k+++++lrkr+nn++phv+l+a+++Ldsc++nC+++f++ev+s+++++el++l+ ++++++v+eK++ ++++W 
   Q: 20   TAPTITVENWEGILAFCDMINNDFEGSKTGIKSLRKRLNNRDPHVVLLAISVLDSCWANCEERFRKEVSSAQFINELKALC-TSSQRQVAEKMRLTVQKWv 119
           8899*****************************************************************************.99****************9 PP
   S: 102  adelknepalslivaliktlkeeGlefp 129
           ++e+k+e++lsliv+l+k+l ++G++f+
   Q: 120  DTECKTEQSLSLIVTLHKNLVADGYSFV 147
           9*************************95 PP
   

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           + v++lyd+ea++++eL++ +Gd++++   +e +  W+ g     +++GlfP+ Fv+
   Q: 222  KNVRALYDFEAAESNELSFVAGDIITIT--DESNPHWWTG--RIGTQQGLFPSSFVT 274
           679************************7..9*********..8************97 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1.
 Binds, sorts and targets the polycystin complex (lov-1 and pkd-2) for lysosomal degradation, acting on early endosomes located at the ciliary base. Functions in the germline together with the ephrin receptor (vab-1) signaling pathway to negatively regulate MAPK activation. May have a role as a positive regulator of meiotic maturation in oocytes, acting independently of vab-1.
Protein Sequence
(Fasta)
MKKQKSFPMS AYEDLLGKIT APTITVENWE GILAFCDMIN NDFEGSKTGI KSLRKRLNNR 60
DPHVVLLAIS VLDSCWANCE ERFRKEVSSA QFINELKALC TSSQRQVAEK MRLTVQKWVD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018461|UBD,UIM;UBD,VHS;UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGAGACTCAT TCAATTGAAC CTGATCACGT GCTGAAAGTC TGCTGTAACA ATGAAGGTTT 60
GTTCGTTTTC CTATCTCTAC TTTAATTAAA AATAGTGTTA AGAGTAATTG TTCATTCAAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018461|UBD,UIM;UBD,VHS;UBD,SH3|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-0969--Cilium
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0967--Endosome
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0813--Transport
Interpro

IPR008942--ENTH_VHS
IPR001452--SH3_domain
IPR003903--UIM_dom
IPR002014--VHS_dom
PROSITE

PS50002--SH3
PS50330--UIM
PS50179--VHS
Pfam

PF00018--SH3_1
PF00790--VHS
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
SM00288--VHS
Gene Ontology

GO:0005929--C:cilium
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0033565--C:ESCRT-0 complex
GO:0008022--F:protein C-terminus binding
GO:0043130--F:ubiquitin binding
GO:0008333--P:endosome to lysosome transport
GO:0048013--P:ephrin receptor signaling pathway
GO:0006886--P:intracellular protein transport
GO:0007275--P:multicellular organism development
GO:0043409--P:negative regulation of MAPK cascade
GO:0097499--P:protein localization to non-motile cilium
GO:0034606--P:response to hermaphrodite contact
KEGG cel:CELE_C34G6.7
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002392 Ailuropoda melanoleuca 34.47 1.00e-51 196.00
IUUC-Apl-003463 Anas platyrhynchos 35.52 5.00e-51 194.00
IUUC-Aca-005116 Anolis carolinensis 36.44 3.00e-54 204.00
IUUC-Ago-007874 Ashbya gossypii 24.73 1.00e-18 86.30
IUUC-Ang-009580 Aspergillus niger 25.84 2.00e-21 95.90
IUUC-Ame-011220 Astyanax mexicanus 33.90 1.00e-53 202.00
IUUC-Bta-013368 Bos taurus 34.31 4.00e-51 194.00
IUUC-Cja-019133 Callithrix jacchus 34.47 7.00e-51 193.00
IUUC-Cfa-020800 Canis familiaris 34.21 2.00e-51 195.00
IUUC-Cpo-021685 Cavia porcellus 36.44 4.00e-54 204.00
IUUC-Csa-023325 Chlorocebus sabaeus 34.31 1.00e-50 192.00
IUUC-Cho-024556 Choloepus hoffmanni 34.17 5.00e-49 187.00
IUUC-Cin-025766 Ciona intestinalis 31.66 5.00e-23 99.80
IUUC-Csv-026035 Ciona savignyi 32.05 7.00e-24 102.00
IUUC-Dre-028379 Danio rerio 32.05 1.00e-48 186.00
IUUC-Dno-029288 Dasypus novemcinctus 34.33 3.00e-51 194.00
IUUC-Dor-030515 Dipodomys ordii 34.35 2.00e-45 175.00
IUUC-Dse-031527 Dothistroma septosporum 27.81 8.00e-22 97.40
IUUC-Dme-031987 Drosophila melanogaster 34.61 6.00e-52 197.00
IUUC-Ete-032804 Echinops telfairi 32.58 1.00e-42 166.00
IUUC-Eca-033520 Equus caballus 36.46 6.00e-54 203.00
IUUC-Eeu-034820 Erinaceus europaeus 33.51 5.00e-49 187.00
IUUC-Fca-035914 Felis catus 34.21 3.00e-51 194.00
IUUC-Fal-037355 Ficedula albicollis 35.65 6.00e-51 193.00
IUUC-Fso-038126 Fusarium solani 23.79 3.00e-21 95.50
IUUC-Gmo-039628 Gadus morhua 33.78 3.00e-48 184.00
IUUC-Gga-041110 Gallus gallus 35.01 7.00e-52 197.00
IUUC-Gac-042301 Gasterosteus aculeatus 33.58 4.00e-52 197.00
IUUC-Ggo-044963 Gorilla gorilla 34.47 6.00e-51 193.00
IUUC-Hsa-046159 Homo sapiens 34.47 6.00e-51 193.00
IUUC-Itr-048399 Ictidomys tridecemlineatus 33.96 3.00e-46 177.00
IUUC-Lch-050447 Latimeria chalumnae 34.95 1.00e-51 196.00
IUUC-Loc-052761 Lepisosteus oculatus 33.75 1.00e-48 186.00
IUUC-Lma-053287 Leptosphaeria maculans 25.76 9.00e-21 94.00
IUUC-Laf-053662 Loxodonta africana 35.62 7.00e-51 193.00
IUUC-Mcc-055110 Macaca mulatta 34.47 1.00e-50 192.00
IUUC-Meu-056371 Macropus eugenii 28.79 2.00e-32 132.00
IUUC-Mga-060117 Meleagris gallopavo 35.62 2.00e-53 202.00
IUUC-Mmr-061413 Microcebus murinus 34.47 5.00e-51 194.00
IUUC-Mdo-061951 Monodelphis domestica 33.74 8.00e-52 196.00
IUUC-Mmu-063771 Mus musculus 35.36 5.00e-54 204.00
IUUC-Mpu-066335 Mustela putorius furo 33.15 5.00e-44 170.00
IUUC-Mlu-067740 Myotis lucifugus 35.77 5.00e-52 197.00
IUUC-Nle-069083 Nomascus leucogenys 34.47 6.00e-51 193.00
IUUC-Opr-070584 Ochotona princeps 29.10 6.00e-33 134.00
IUUC-Ont-072360 Oreochromis niloticus 33.41 1.00e-52 199.00
IUUC-Oan-073093 Ornithorhynchus anatinus 35.14 9.00e-54 203.00
IUUC-Ocu-074641 Oryctolagus cuniculus 34.47 4.00e-51 194.00
IUUC-Ola-087487 Oryzias latipes 34.04 4.00e-51 194.00
IUUC-Oga-088551 Otolemur garnettii 34.47 2.00e-51 195.00
IUUC-Oar-089972 Ovis aries 34.57 3.00e-51 195.00
IUUC-Ptr-090672 Pan troglodytes 34.47 6.00e-51 193.00
IUUC-Pan-092407 Papio anubis 34.47 1.00e-50 192.00
IUUC-Psi-092953 Pelodiscus sinensis 33.66 3.00e-49 188.00
IUUC-Pma-094312 Petromyzon marinus 33.00 2.00e-43 168.00
IUUC-Pfo-096030 Poecilia formosa 33.65 2.00e-49 188.00
IUUC-Pab-097691 Pongo abelii 34.47 6.00e-51 193.00
IUUC-Pca-100396 Procavia capensis 40.25 3.00e-28 118.00
IUUC-Pva-103120 Pteropus vampyrus 34.21 3.00e-51 194.00
IUUC-Pte-104251 Pyrenophora teres 24.00 5.00e-20 91.30
IUUC-Pyt-104694 Pyrenophora triticirepentis 24.00 5.00e-21 94.70
IUUC-Rno-105982 Rattus norvegicus 33.33 7.00e-51 193.00
IUUC-Sce-106209 Saccharomyces cerevisiae 28.36 2.00e-21 95.10
IUUC-Sha-106927 Sarcophilus harrisii 34.84 9.00e-55 206.00
IUUC-Sja-107859 Schizosaccharomyces japonicus 25.94 2.00e-19 88.60
IUUC-Spo-108333 Schizosaccharomyces pombe 26.95 1.00e-17 82.80
IUUC-Sar-113551 Sorex araneus 35.03 5.00e-55 207.00
IUUC-Ssc-115322 Sus scrofa 34.79 5.00e-50 190.00
IUUC-Tgu-116550 Taeniopygia guttata 35.52 2.00e-51 195.00
IUUC-Tru-118646 Takifugu rubripes 32.93 5.00e-49 187.00
IUUC-Tsy-118874 Tarsius syrichta 34.47 5.00e-51 194.00
IUUC-Tni-120235 Tetraodon nigroviridis 34.39 3.00e-47 181.00
IUUC-Tvi-122365 Trichoderma virens 24.16 5.00e-21 95.10
IUUC-Tbe-127233 Tupaia belangeri 35.03 2.00e-35 142.00
IUUC-Ttr-129298 Tursiops truncatus 33.51 5.00e-51 194.00
IUUC-Vda-129759 Verticillium dahliae 24.49 3.00e-21 95.50
IUUC-Vpa-130071 Vicugna pacos 31.51 7.00e-41 160.00
IUUC-Xtr-131863 Xenopus tropicalis 36.26 9.00e-52 196.00
IUUC-Xma-132992 Xiphophorus maculatus 33.00 2.00e-49 189.00
Created Date 25-Jun-2017

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