iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000154710.15	ENST00000607882.5	ENSP00000476796.1
ENSG00000154710.15	ENST00000380828.6	ENSP00000370208.3
ENSG00000154710.15	ENST00000510829.6	ENSP00000421124.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/ZnF_A20	1.50e-18	68.1	27	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkkgCgfYGnpetngyCSkCyreelrrrr 35
           d+s+llCkkgCg+YGnp+++g+CSkC+ree++++r
   Q: 27   DQSDLLCKKGCGYYGNPAWQGFCSKCWREEYHKAR 61
           79*******************************86 PP

Organism

Homo sapiens

Functional Description
(View)

Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase (By similarity).

Protein Sequence
(Fasta)

MMASSYHEVV SRKKMSLKSE RRGIHVDQSD LLCKKGCGYY GNPAWQGFCS KCWREEYHKA 60
RQKQIQEDWE LAERLQREEE EAFASSQSSQ GAQSLTFSKF EEKKTNEKTR KVTTVKKFFS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGACCTGC CGAGCGACGT GGGCGAGCGG TGACCTGGAC CACGGCGCAG ACGCGGGCGA 60
GCTGCGGCTC GGACGCCAGC GGACACGCGG GCGAGGTACG GAGTGGACGG ACTGGGGCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0967--Endosome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003123--VPS9
IPR002653--Znf_A20

PROSITE

PS51205--VPS9
PS51036--ZF_A20

Pfam

PF02204--VPS9
PF01754--zf-A20

SMART

SM00167--VPS9
SM00259--ZnF_A20

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0031901--C:early endosome membrane
GO:0005730--C:nucleolus
GO:0055037--C:recycling endosome
GO:0003677--F:DNA binding
GO:0017137--F:Rab GTPase binding
GO:0017112--F:Rab guanyl-nucleotide exchange factor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0006897--P:endocytosis
GO:0061024--P:membrane organization
GO:0050728--P:negative regulation of inflammatory response
GO:1900165--P:negative regulation of interleukin-6 secretion
GO:1900235--P:negative regulation of Kit signaling pathway
GO:0002686--P:negative regulation of leukocyte migration
GO:0043305--P:negative regulation of mast cell degranulation
GO:0001933--P:negative regulation of protein phosphorylation
GO:0046580--P:negative regulation of Ras protein signal transduction
GO:0048261--P:negative regulation of receptor-mediated endocytosis
GO:0006612--P:protein targeting to membrane
GO:0060368--P:regulation of Fc receptor mediated stimulatory signaling pathway

KEGG

hsa:27342

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000198	Aegilops tauschii	32.42	5.00e-21	95.90
IUUC-Aml-001771	Ailuropoda melanoleuca	87.26	0.00e+00	743.00
IUUC-Atr-003154	Amborella trichopoda	36.11	1.00e-22	101.00
IUUC-Apl-004018	Anas platyrhynchos	91.46	0.00e+00	843.00
IUUC-Aca-005227	Anolis carolinensis	23.47	8.00e-09	56.20
IUUC-Aly-006138	Arabidopsis lyrata	33.96	5.00e-25	109.00
IUUC-Ath-006747	Arabidopsis thaliana	34.92	1.00e-24	108.00
IUUC-Ago-007776	Ashbya gossypii	30.13	5.00e-25	108.00
IUUC-Acl-008235	Aspergillus clavatus	31.47	6.00e-29	122.00
IUUC-Afl-008570	Aspergillus flavus	32.45	1.00e-31	131.00
IUUC-Afu-008815	Aspergillus fumigatus	31.13	1.00e-29	125.00
IUUC-Ani-009381	Aspergillus nidulans	31.12	3.00e-29	123.00
IUUC-Ang-009615	Aspergillus niger	31.27	8.00e-32	131.00
IUUC-Aor-010195	Aspergillus oryzae	32.12	2.00e-32	133.00
IUUC-Ate-010514	Aspergillus terreus	32.17	2.00e-30	127.00
IUUC-Ame-011365	Astyanax mexicanus	65.94	0.00e+00	664.00
IUUC-Bgr-012102	Blumeria graminis	28.75	3.00e-29	124.00
IUUC-Bta-013124	Bos taurus	97.35	0.00e+00	885.00
IUUC-Bci-013943	Botrytis cinerea	30.77	6.00e-30	126.00
IUUC-Bdi-014539	Brachypodium distachyon	38.33	2.00e-26	114.00
IUUC-Bol-016580	Brassica oleracea	35.14	4.00e-30	126.00
IUUC-Bra-017843	Brassica rapa	34.68	6.00e-30	125.00
IUUC-Cel-018199	Caenorhabditis elegans	33.85	2.00e-58	220.00
IUUC-Cja-019941	Callithrix jacchus	99.21	0.00e+00	928.00
IUUC-Cfa-020845	Canis familiaris	96.74	0.00e+00	805.00
IUUC-Cpo-022037	Cavia porcellus	96.13	0.00e+00	872.00
IUUC-Cre-022696	Chlamydomonas reinhardtii	32.49	4.00e-21	96.30
IUUC-Csa-023495	Chlorocebus sabaeus	99.19	0.00e+00	905.00
IUUC-Cho-025076	Choloepus hoffmanni	84.52	0.00e+00	730.00
IUUC-Cin-025400	Ciona intestinalis	43.45	1.00e-112	400.00
IUUC-Csv-025941	Ciona savignyi	37.37	3.00e-84	305.00
IUUC-Cgl-026725	Colletotrichum gloeosporioides	29.02	1.00e-26	115.00
IUUC-Cne-027057	Cryptococcus neoformans	31.76	3.00e-34	140.00
IUUC-Dre-028484	Danio rerio	70.89	0.00e+00	670.00
IUUC-Dno-028906	Dasypus novemcinctus	96.54	0.00e+00	862.00
IUUC-Dor-030124	Dipodomys ordii	86.53	0.00e+00	754.00
IUUC-Dse-031437	Dothistroma septosporum	29.43	6.00e-26	113.00
IUUC-Dme-031696	Drosophila melanogaster	33.33	2.00e-68	254.00
IUUC-Ete-032573	Echinops telfairi	92.00	0.00e+00	717.00
IUUC-Eca-033711	Equus caballus	97.35	0.00e+00	887.00
IUUC-Eeu-034459	Erinaceus europaeus	71.84	9.00e-77	281.00
IUUC-Fca-035447	Felis catus	94.30	0.00e+00	891.00
IUUC-Fal-036605	Ficedula albicollis	88.09	0.00e+00	781.00
IUUC-Fox-037967	Fusarium oxysporum	27.08	2.00e-18	88.20
IUUC-Fso-038110	Fusarium solani	29.72	1.00e-28	122.00
IUUC-Gmo-038785	Gadus morhua	66.40	0.00e+00	674.00
IUUC-Ggr-039760	Gaeumannomyces graminis	30.69	7.00e-27	115.00
IUUC-Gga-040584	Gallus gallus	92.07	0.00e+00	845.00
IUUC-Gac-042469	Gasterosteus aculeatus	63.78	2.00e-165	575.00
IUUC-Gma-044237	Glycine max	37.43	3.00e-26	112.00
IUUC-Ggo-044498	Gorilla gorilla	85.77	0.00e+00	752.00
IUUC-Hvu-047155	Hordeum vulgare	38.33	8.00e-27	115.00
IUUC-Itr-048753	Ictidomys tridecemlineatus	96.54	0.00e+00	878.00
IUUC-Kpa-049160	Komagataella pastoris	29.05	3.00e-24	107.00
IUUC-Lch-050529	Latimeria chalumnae	78.69	0.00e+00	852.00
IUUC-Lpe-051024	Leersia perrieri	34.84	9.00e-29	121.00
IUUC-Loc-052644	Lepisosteus oculatus	70.20	0.00e+00	665.00
IUUC-Lma-053102	Leptosphaeria maculans	30.99	1.00e-27	118.00
IUUC-Laf-054337	Loxodonta africana	94.30	0.00e+00	865.00
IUUC-Mcc-055659	Macaca mulatta	98.90	0.00e+00	634.00
IUUC-Meu-056084	Macropus eugenii	76.47	5.00e-95	342.00
IUUC-Mor-057255	Magnaporthe oryzae	29.60	2.00e-26	114.00
IUUC-Mpo-057454	Magnaporthe poae	30.69	9.00e-29	122.00
IUUC-Mtr-058098	Medicago truncatula	35.45	3.00e-30	126.00
IUUC-Mla-059068	Melampsora laricipopulina	30.83	2.00e-30	127.00
IUUC-Mga-059624	Meleagris gallopavo	78.49	0.00e+00	841.00
IUUC-Mvi-060282	Microbotryum violaceum	28.83	9.00e-26	112.00
IUUC-Mmr-061142	Microcebus murinus	96.02	0.00e+00	898.00
IUUC-Mdo-062289	Monodelphis domestica	92.06	0.00e+00	895.00
IUUC-Mmu-063961	Mus musculus	95.72	0.00e+00	872.00
IUUC-Mac-065188	Musa acuminata	32.55	7.00e-23	101.00
IUUC-Mpu-066291	Mustela putorius furo	95.78	0.00e+00	882.00
IUUC-Mlu-067431	Myotis lucifugus	91.97	0.00e+00	844.00
IUUC-Nfi-068422	Neosartorya fischeri	31.13	2.00e-30	127.00
IUUC-Ncr-068843	Neurospora crassa	29.93	4.00e-28	119.00
IUUC-Nle-069079	Nomascus leucogenys	99.39	0.00e+00	904.00
IUUC-Opr-070790	Ochotona princeps	94.44	2.00e-57	217.00
IUUC-Ont-071789	Oreochromis niloticus	68.97	1.00e-178	619.00
IUUC-Oan-072946	Ornithorhynchus anatinus	90.26	0.00e+00	816.00
IUUC-Ocu-073816	Oryctolagus cuniculus	97.57	0.00e+00	885.00
IUUC-Oba-075738	Oryza barthii	33.33	1.00e-17	84.70
IUUC-Obr-076355	Oryza brachyantha	38.46	9.00e-28	118.00
IUUC-Ogl-077217	Oryza glaberrima	36.76	2.00e-24	107.00
IUUC-Ogu-078197	Oryza glumaepatula	34.03	2.00e-25	110.00
IUUC-Oin-080047	Oryza indica	37.78	5.00e-26	112.00
IUUC-Olo-080317	Oryza longistaminata	33.86	3.00e-25	108.00
IUUC-Ome-081589	Oryza meridionalis	37.78	2.00e-26	114.00
IUUC-Oni-082700	Oryza nivara	33.33	8.00e-18	85.10
IUUC-Opu-083923	Oryza punctata	32.07	2.00e-20	93.20
IUUC-Oru-084318	Oryza rufipogon	33.33	8.00e-18	85.10
IUUC-Osa-086246	Oryza sativa	38.98	1.00e-06	44.30
IUUC-Ola-086730	Oryzias latipes	57.06	7.00e-150	523.00
IUUC-Olu-087719	Ostreococcus lucimarinus	34.64	3.00e-24	106.00
IUUC-Oga-088992	Otolemur garnettii	84.32	0.00e+00	888.00
IUUC-Oar-089789	Ovis aries	96.59	0.00e+00	885.00
IUUC-Ptr-091636	Pan troglodytes	100.00	0.00e+00	907.00
IUUC-Pan-092911	Papio anubis	98.79	0.00e+00	909.00
IUUC-Psi-093194	Pelodiscus sinensis	78.03	0.00e+00	830.00
IUUC-Pma-094212	Petromyzon marinus	48.29	4.00e-114	404.00
IUUC-Pno-094831	Phaeosphaeria nodorum	30.53	1.00e-27	118.00
IUUC-Ppa-095705	Physcomitrella patens	33.86	3.00e-29	123.00
IUUC-Pfo-096694	Poecilia formosa	64.82	4.00e-178	617.00
IUUC-Pab-097706	Pongo abelii	99.60	0.00e+00	912.00
IUUC-Pop-099891	Populus trichocarpa	37.78	4.00e-26	112.00
IUUC-Pca-100879	Procavia capensis	92.96	1.00e-90	326.00
IUUC-Ppe-101334	Prunus persica	33.78	1.00e-26	114.00
IUUC-Pva-103225	Pteropus vampyrus	81.21	0.00e+00	708.00
IUUC-Pgr-103564	Puccinia graminis	30.77	2.00e-31	130.00
IUUC-Ptt-103802	Puccinia triticina	29.84	2.00e-25	110.00
IUUC-Pte-104345	Pyrenophora teres	29.43	2.00e-27	118.00
IUUC-Pyt-104716	Pyrenophora triticirepentis	30.50	3.00e-28	120.00
IUUC-Rno-106101	Rattus norvegicus	94.79	0.00e+00	880.00
IUUC-Sce-106460	Saccharomyces cerevisiae	30.77	4.00e-25	109.00
IUUC-Sha-106919	Sarcophilus harrisii	77.97	0.00e+00	846.00
IUUC-Sja-107880	Schizosaccharomyces japonicus	32.17	8.00e-30	125.00
IUUC-Spo-108087	Schizosaccharomyces pombe	29.84	5.00e-27	115.00
IUUC-Ssl-108614	Sclerotinia sclerotiorum	29.82	2.00e-07	51.60
IUUC-Smo-109411	Selaginella moellendorffii	36.57	3.00e-27	116.00
IUUC-Sit-110678	Setaria italica	37.78	8.00e-27	115.00
IUUC-Sly-111526	Solanum lycopersicum	37.85	1.00e-25	111.00
IUUC-Stu-112494	Solanum tuberosum	38.42	3.00e-26	112.00
IUUC-Sar-112929	Sorex araneus	97.45	5.00e-162	564.00
IUUC-Sbi-114242	Sorghum bicolor	33.33	3.00e-28	119.00
IUUC-Sre-115224	Sporisorium reilianum	32.14	1.00e-30	128.00
IUUC-Ssc-115239	Sus scrofa	97.15	0.00e+00	880.00
IUUC-Tgu-117499	Taeniopygia guttata	89.82	0.00e+00	823.00
IUUC-Tru-118027	Takifugu rubripes	63.61	3.00e-142	498.00
IUUC-Tsy-119462	Tarsius syrichta	97.48	0.00e+00	865.00
IUUC-Tni-120855	Tetraodon nigroviridis	64.74	2.00e-173	602.00
IUUC-Tca-121213	Theobroma cacao	33.03	1.00e-24	107.00
IUUC-Tre-122186	Trichoderma reesei	29.84	5.00e-29	122.00
IUUC-Tvi-122541	Trichoderma virens	27.89	4.00e-29	122.00
IUUC-Tae-123631	Triticum aestivum	34.63	2.00e-27	117.00
IUUC-Tur-126572	Triticum urartu	39.44	5.00e-27	115.00
IUUC-Tme-127023	Tuber melanosporum	32.93	2.00e-31	130.00
IUUC-Tbe-127453	Tupaia belangeri	97.14	0.00e+00	778.00
IUUC-Ttr-128526	Tursiops truncatus	97.15	0.00e+00	882.00
IUUC-Uma-129660	Ustilago maydis	32.95	5.00e-31	130.00
IUUC-Vda-129737	Verticillium dahliae	28.62	6.00e-24	106.00
IUUC-Vpa-130505	Vicugna pacos	91.17	0.00e+00	716.00
IUUC-Vvi-131088	Vitis vinifera	37.08	2.00e-23	103.00
IUUC-Xtr-132799	Xenopus tropicalis	78.69	0.00e+00	742.00
IUUC-Xma-133345	Xiphophorus maculatus	65.42	1.00e-174	605.00
IUUC-Yli-134416	Yarrowia lipolytica	32.12	2.00e-31	130.00
IUUC-Zma-134750	Zea mays	37.78	2.00e-26	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence