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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-047028
Ensembl Protein ID ENSP00000436679.1
UniProt Accession Q9UBU9; B4E269; Q99799; Q9UQL2; NXF1_HUMAN
Genbank Protein ID CAA10753.1; AAD39102.1; AAD20016.1; BAG65031.1; EAW74105.1; AAH04904.1; AAH28041.1; AAB81111.1
Protein Name Nuclear RNA export factor 1; Tip-associated protein; Tip-associating protein; mRNA export factor TAP
Genbank Nucleotide ID AJ132712; AF112880; AF126246; AK304137; AK027192; BC004904; BC028041; U80073
Gene Name NXF1; TAP
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000162231.13 ENST00000531709.6 ENSP00000453885.1
ENSG00000162231.13 ENST00000532297.5 ENSP00000436679.1
ENSG00000162231.13 ENST00000527902.5 ENSP00000434301.1
ENSG00000162231.13 ENST00000530875.5 ENSP00000435742.1
ENSG00000162231.13 ENST00000525576.1 ENSP00000432530.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtBioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
UBD/Alpha-Helix/UBA 24.74 7.00e-10 60.50 IUUC-Sce-106429
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.
 Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.
Protein Sequence
(Fasta)
MADEGKSYSE HDDERVNFPQ RKKKGRGPFR WKYGEGNRRS GRGGSGIRSS RLEEDDGDVA 60
MSDAQDGPRV RYNPYTTRPN RRGDTWHDRD RIHVTVRRDR APPERGGAGT SQDGTSKNWF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-047028|UBD,UBA|Homo sapiens
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Nucleotide Sequence
(Fasta)
ATAGAGACAA CAGTCAGGGG CTGGTGGTGG TGCTTTTGGG GGTCTAGGAG AGCCCAAGGC 60
CCTGATATTT TAAAATGTCC TCCTCGGCAT CTCCAGCAAG TTGCCACTGC TGGTGAGCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-047028|UBD,UBA|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0945--Host-virus interaction
KW-0433--Leucine-rich repeat
KW-0488--Methylation
KW-0509--mRNA transport
KW-0944--Nitration
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0813--Transport
Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR002075--NTF2
IPR032710--NTF2-like_dom
IPR018222--Nuclear_transport_factor_2_euk
IPR012677--Nucleotide-bd_a/b_plait
IPR030217--NXF_fam
IPR000504--RRM_dom
IPR005637--TAP_C_dom
IPR015245--Tap_RNA-bd
IPR009060--UBA-like
PROSITE

PS51450--LRR
PS50177--NTF2_DOMAIN
PS51281--TAP_C
Pfam

PF02136--NTF2
PF09162--Tap-RNA_bind
PF03943--TAP_C
SMART

SM00804--TAP_C
Gene Ontology

GO:0005829--C:cytosol
GO:0042405--C:nuclear inclusion body
GO:0005643--C:nuclear pore
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003729--F:mRNA binding
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0000166--F:nucleotide binding
GO:0003723--F:RNA binding
GO:0003727--F:single-stranded RNA binding
GO:0006406--P:mRNA export from nucleus
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0006405--P:RNA export from nucleus
GO:0016032--P:viral process
KEGG hsa:10482
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001516 Ailuropoda melanoleuca 92.69 0.00e+00 1082.00
IUUC-Apl-003526 Anas platyrhynchos 35.35 5.00e-03 35.00
IUUC-Aca-005187 Anolis carolinensis 64.59 0.00e+00 756.00
IUUC-Ath-006825 Arabidopsis thaliana 31.25 3.00e+00 26.60
IUUC-Ago-007780 Ashbya gossypii 23.06 3.00e-18 86.70
IUUC-Acl-008191 Aspergillus clavatus 24.59 1.00e-22 101.00
IUUC-Afl-008512 Aspergillus flavus 26.12 2.00e-26 114.00
IUUC-Afu-009048 Aspergillus fumigatus 25.81 1.00e-25 111.00
IUUC-Ani-009320 Aspergillus nidulans 22.00 9.00e-18 85.50
IUUC-Ang-009834 Aspergillus niger 24.54 2.00e-21 97.10
IUUC-Aor-010039 Aspergillus oryzae 25.66 9.00e-23 102.00
IUUC-Ate-010321 Aspergillus terreus 25.00 2.00e-20 94.40
IUUC-Ame-011034 Astyanax mexicanus 58.68 0.00e+00 650.00
IUUC-Bgr-012142 Blumeria graminis 25.49 2.00e-17 84.70
IUUC-Bta-013268 Bos taurus 92.75 0.00e+00 1063.00
IUUC-Bci-013951 Botrytis cinerea 27.17 2.00e-21 97.80
IUUC-Cel-018213 Caenorhabditis elegans 33.33 2.90e-01 28.90
IUUC-Cja-019064 Callithrix jacchus 98.38 0.00e+00 1134.00
IUUC-Cfa-020712 Canis familiaris 93.11 0.00e+00 1044.00
IUUC-Cpo-021814 Cavia porcellus 95.48 0.00e+00 1105.00
IUUC-Csa-023652 Chlorocebus sabaeus 99.84 0.00e+00 1155.00
IUUC-Cho-024546 Choloepus hoffmanni 54.55 2.80e-02 32.30
IUUC-Cin-025669 Ciona intestinalis 34.59 1.00e-93 337.00
IUUC-Csv-025957 Ciona savignyi 35.19 1.00e-85 310.00
IUUC-Cgl-026395 Colletotrichum gloeosporioides 26.78 4.00e-27 116.00
IUUC-Cne-026967 Cryptococcus neoformans 23.14 1.00e-04 41.60
IUUC-Dre-028476 Danio rerio 54.45 9.00e-153 533.00
IUUC-Dno-029301 Dasypus novemcinctus 92.57 0.00e+00 1053.00
IUUC-Dor-030764 Dipodomys ordii 94.68 0.00e+00 1101.00
IUUC-Dse-031489 Dothistroma septosporum 24.77 3.00e-17 84.00
IUUC-Dme-031623 Drosophila melanogaster 32.32 1.00e-77 284.00
IUUC-Ete-032992 Echinops telfairi 79.73 0.00e+00 825.00
IUUC-Eca-033208 Equus caballus 94.81 0.00e+00 1035.00
IUUC-Eeu-034759 Erinaceus europaeus 92.41 0.00e+00 1076.00
IUUC-Fca-035671 Felis catus 94.99 0.00e+00 1096.00
IUUC-Fal-036625 Ficedula albicollis 35.35 6.00e-03 34.70
IUUC-Fox-037892 Fusarium oxysporum 28.50 2.00e-21 97.80
IUUC-Fso-038402 Fusarium solani 26.91 7.00e-21 95.90
IUUC-Gmo-039325 Gadus morhua 54.96 4.00e-150 525.00
IUUC-Ggr-039736 Gaeumannomyces graminis 24.07 2.00e-12 68.20
IUUC-Gga-040508 Gallus gallus 72.81 0.00e+00 802.00
IUUC-Gac-041798 Gasterosteus aculeatus 58.04 0.00e+00 699.00
IUUC-Ggo-044655 Gorilla gorilla 99.34 0.00e+00 1118.00
IUUC-Itr-048415 Ictidomys tridecemlineatus 91.61 0.00e+00 1074.00
IUUC-Kpa-049280 Komagataella pastoris 23.30 5.00e-21 96.30
IUUC-Lch-049501 Latimeria chalumnae 70.70 0.00e+00 848.00
IUUC-Loc-052299 Lepisosteus oculatus 64.34 2.00e-173 602.00
IUUC-Laf-053523 Loxodonta africana 93.05 0.00e+00 1080.00
IUUC-Mcc-055389 Macaca mulatta 100.00 0.00e+00 1066.00
IUUC-Meu-056620 Macropus eugenii 58.35 6.00e-143 500.00
IUUC-Mor-057232 Magnaporthe oryzae 27.33 9.00e-28 118.00
IUUC-Mpo-057539 Magnaporthe poae 24.23 2.00e-10 60.80
IUUC-Mla-059053 Melampsora laricipopulina 26.48 6.00e-27 115.00
IUUC-Mga-059220 Meleagris gallopavo 35.35 5.00e-03 34.70
IUUC-Mvi-060283 Microbotryum violaceum 25.86 2.00e-21 97.80
IUUC-Mmr-061583 Microcebus murinus 97.42 0.00e+00 1124.00
IUUC-Mdo-062158 Monodelphis domestica 82.47 0.00e+00 971.00
IUUC-Mmu-064202 Mus musculus 91.11 0.00e+00 1027.00
IUUC-Mpu-065730 Mustela putorius furo 93.86 0.00e+00 1080.00
IUUC-Mlu-066975 Myotis lucifugus 91.13 0.00e+00 1013.00
IUUC-Nfi-068368 Neosartorya fischeri 26.02 4.00e-25 109.00
IUUC-Ncr-068724 Neurospora crassa 25.16 1.00e-15 78.60
IUUC-Nle-069816 Nomascus leucogenys 99.68 0.00e+00 1147.00
IUUC-Opr-070244 Ochotona princeps 43.74 1.00e-128 453.00
IUUC-Ont-072608 Oreochromis niloticus 58.86 0.00e+00 721.00
IUUC-Oan-073580 Ornithorhynchus anatinus 33.33 2.00e-03 36.20
IUUC-Ocu-074226 Oryctolagus cuniculus 94.02 0.00e+00 1139.00
IUUC-Ola-087008 Oryzias latipes 64.81 0.00e+00 684.00
IUUC-Oga-088317 Otolemur garnettii 93.25 0.00e+00 1029.00
IUUC-Oar-089720 Ovis aries 92.43 0.00e+00 1034.00
IUUC-Ptr-091148 Pan troglodytes 100.00 0.00e+00 1155.00
IUUC-Pan-091764 Papio anubis 99.84 0.00e+00 1153.00
IUUC-Psi-094071 Pelodiscus sinensis 66.03 0.00e+00 803.00
IUUC-Pno-095045 Phaeosphaeria nodorum 28.57 1.00e-03 37.70
IUUC-Pfo-096500 Poecilia formosa 60.10 0.00e+00 731.00
IUUC-Pab-098014 Pongo abelii 98.06 0.00e+00 1145.00
IUUC-Pca-100121 Procavia capensis 91.11 0.00e+00 1021.00
IUUC-Pva-102865 Pteropus vampyrus 93.86 0.00e+00 1032.00
IUUC-Pgr-103333 Puccinia graminis 25.14 1.00e-17 84.70
IUUC-Ptt-103702 Puccinia triticina 25.16 2.00e-20 94.40
IUUC-Pte-104388 Pyrenophora teres 22.50 5.30e-02 32.00
IUUC-Rno-106100 Rattus norvegicus 92.57 0.00e+00 1052.00
IUUC-Sce-106429 Saccharomyces cerevisiae 22.22 6.00e-15 75.90
IUUC-Sha-106834 Sarcophilus harrisii 81.76 0.00e+00 979.00
IUUC-Sja-107818 Schizosaccharomyces japonicus 26.24 1.00e-19 91.70
IUUC-Spo-108301 Schizosaccharomyces pombe 27.19 1.00e-33 137.00
IUUC-Ssl-108512 Sclerotinia sclerotiorum 25.88 3.00e-21 97.10
IUUC-Sar-112963 Sorex araneus 46.04 1.00e-127 449.00
IUUC-Sre-114950 Sporisorium reilianum 23.58 3.00e-21 97.10
IUUC-Ssc-116010 Sus scrofa 93.08 0.00e+00 1024.00
IUUC-Tgu-116603 Taeniopygia guttata 36.36 5.00e-03 35.00
IUUC-Tru-118148 Takifugu rubripes 59.00 0.00e+00 699.00
IUUC-Tsy-119506 Tarsius syrichta 40.62 1.00e-05 43.50
IUUC-Tre-121894 Trichoderma reesei 26.43 7.00e-27 115.00
IUUC-Tvi-122501 Trichoderma virens 27.91 4.00e-31 129.00
IUUC-Tme-127084 Tuber melanosporum 25.74 2.00e-27 117.00
IUUC-Tbe-127980 Tupaia belangeri 64.20 2.00e-90 325.00
IUUC-Ttr-128656 Tursiops truncatus 56.96 0.00e+00 676.00
IUUC-Uma-129530 Ustilago maydis 24.33 9.00e-27 115.00
IUUC-Vda-129709 Verticillium dahliae 26.39 2.00e-21 97.80
IUUC-Vpa-130739 Vicugna pacos 46.36 1.00e-104 373.00
IUUC-Xtr-132404 Xenopus tropicalis 61.06 0.00e+00 747.00
IUUC-Xma-133051 Xiphophorus maculatus 58.90 0.00e+00 705.00
IUUC-Yli-134681 Yarrowia lipolytica 24.88 3.00e-30 126.00
Created Date 25-Jun-2017

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