iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000021189.11	ENSMUST00000021606.11	ENSMUSP00000021606.5
ENSMUSG00000021189.11	ENSMUST00000160186.1	ENSMUSP00000124178.1
ENSMUSG00000021189.11	ENSMUST00000160251.7	ENSMUSP00000125082.1
ENSMUSG00000021189.11	ENSMUST00000159883.1	ENSMUSP00000124419.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/Josephin	Josephin	20668528
UBD/Alpha-Helix/UIM	UIM	20668528; 21855799

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	8.20e-08	32.5	244	260
UBD/Alpha-Helix/UIM	4.3e-05	15.2	224	242

Active Site

Position(s)	Description	Evidence
14	Nucleophile	{ECO:0000250\|UniProtKB:P54252}
119	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00331}
134	N/A	{ECO:0000255\|PROSITE-ProRule:PRU00331}

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEe 17
           dE+++L++A++lS+q  
   Q: 244  DEEADLRRAIQLSMQGS 260
           7*************986 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +++++Lq+Ala S+qE ++
   Q: 224  EDEDDLQRALAISRQEIDM 242
           69**************886 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates. Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins. Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. In response to misfolded substrate ubiquitination, mediates deubiquitination of monoubiquitinated STUB1/CHIP. Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription.

Protein Sequence
(Fasta)

MESIFHEKQE GSLCAQHCLN NLLQGEYFSP VELSSIAHQL DEEERLRMAE GGVTSEDYRT 60
FLQQPSGNMD DSGFFSIQVI SNALKVWGLE LILFNSPEYQ RLRIDPINER SFICNYKEHW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGACCGG GGCTGAGGGG TGGGGCCGGG GGCGGAGCTG CTGGAGGGGG CTGCTCCGCG 60
CCGGGGCCGT TGGCTCCAGA CAAATAAACA TGGAGTCCAT CTTCCACGAG AAAGTGAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR033865--Ataxin-3
IPR006155--Josephin
IPR009068--S15_NS1_RNA-bd
IPR003903--UIM_dom

PROSITE

PS50957--JOSEPHIN
PS50330--UIM

Pfam

PF02099--Josephin
PF02809--UIM

SMART

SM01246--Josephin
SM00726--UIM

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005759--C:mitochondrial matrix
GO:0031966--C:mitochondrial membrane
GO:0042405--C:nuclear inclusion body
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0051117--F:ATPase binding
GO:0004407--F:histone deacetylase activity
GO:0042802--F:identical protein binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0001012--F:RNA polymerase II regulatory region DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0030036--P:actin cytoskeleton organization
GO:0034605--P:cellular response to heat
GO:0071218--P:cellular response to misfolded protein
GO:0035640--P:exploration behavior
GO:0070932--P:histone H3 deacetylation
GO:0045104--P:intermediate filament cytoskeleton organization
GO:0000226--P:microtubule cytoskeleton organization
GO:0006515--P:misfolded or incompletely synthesized protein catabolic process
GO:0035520--P:monoubiquitinated protein deubiquitination
GO:1904294--P:positive regulation of ERAD pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:1904379--P:protein localization to cytosolic proteasome complex involved in ERAD pathway
GO:0010810--P:regulation of cell-substrate adhesion
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:110616

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002015	Ailuropoda melanoleuca	87.61	7.00e-174	602.00
IUUC-Atr-002735	Amborella trichopoda	50.00	1.00e-06	44.30
IUUC-Apl-003210	Anas platyrhynchos	73.26	5.00e-141	493.00
IUUC-Aca-005171	Anolis carolinensis	69.05	2.00e-121	428.00
IUUC-Aly-005625	Arabidopsis lyrata	44.64	2.00e-40	159.00
IUUC-Ath-007088	Arabidopsis thaliana	44.64	2.00e-40	159.00
IUUC-Ame-010715	Astyanax mexicanus	70.06	2.00e-121	428.00
IUUC-Bta-013538	Bos taurus	78.23	4.00e-165	573.00
IUUC-Bdi-015000	Brachypodium distachyon	42.01	7.00e-36	144.00
IUUC-Bol-015894	Brassica oleracea	44.05	1.00e-40	160.00
IUUC-Bra-018020	Brassica rapa	44.31	8.00e-41	161.00
IUUC-Cel-018121	Caenorhabditis elegans	35.53	6.00e-45	174.00
IUUC-Cja-018840	Callithrix jacchus	82.22	6.00e-163	566.00
IUUC-Cfa-021035	Canis familiaris	86.07	8.00e-175	606.00
IUUC-Cpo-021776	Cavia porcellus	80.27	1.00e-167	582.00
IUUC-Csa-023257	Chlorocebus sabaeus	66.30	7.00e-130	456.00
IUUC-Cho-024878	Choloepus hoffmanni	85.06	3.00e-168	583.00
IUUC-Cgl-026754	Colletotrichum gloeosporioides	35.48	4.90e-01	30.40
IUUC-Cme-027158	Cyanidioschyzon merolae	31.22	1.00e-12	66.60
IUUC-Dre-027506	Danio rerio	66.94	5.00e-89	320.00
IUUC-Dno-029172	Dasypus novemcinctus	84.02	2.00e-172	597.00
IUUC-Dor-030900	Dipodomys ordii	79.57	3.00e-145	507.00
IUUC-Ete-033000	Echinops telfairi	55.59	1.00e-83	303.00
IUUC-Eca-034338	Equus caballus	86.08	9.00e-171	592.00
IUUC-Eeu-034585	Erinaceus europaeus	97.14	7.00e-57	213.00
IUUC-Fca-035441	Felis catus	78.01	5.00e-61	226.00
IUUC-Fal-037525	Ficedula albicollis	73.42	1.00e-131	462.00
IUUC-Gmo-039718	Gadus morhua	71.58	3.00e-111	394.00
IUUC-Gga-040774	Gallus gallus	75.20	6.00e-150	523.00
IUUC-Gac-041671	Gasterosteus aculeatus	72.26	1.00e-107	382.00
IUUC-Gma-042801	Glycine max	41.32	5.00e-37	148.00
IUUC-Ggo-044759	Gorilla gorilla	79.52	8.00e-132	462.00
IUUC-Hsa-046591	Homo sapiens	86.40	1.00e-162	565.00
IUUC-Hvu-047492	Hordeum vulgare	43.20	2.00e-34	139.00
IUUC-Itr-048851	Ictidomys tridecemlineatus	69.28	7.00e-121	426.00
IUUC-Lch-049519	Latimeria chalumnae	72.66	8.00e-107	379.00
IUUC-Lpe-050819	Leersia perrieri	43.27	8.00e-36	144.00
IUUC-Loc-051816	Lepisosteus oculatus	72.61	1.00e-126	446.00
IUUC-Laf-053784	Loxodonta africana	84.23	5.00e-175	606.00
IUUC-Mcc-055283	Macaca mulatta	85.60	2.00e-175	608.00
IUUC-Meu-056589	Macropus eugenii	70.87	1.00e-138	486.00
IUUC-Mtr-058233	Medicago truncatula	34.29	1.00e-37	150.00
IUUC-Mla-059013	Melampsora laricipopulina	39.70	5.00e-31	128.00
IUUC-Mga-059301	Meleagris gallopavo	73.84	7.00e-152	530.00
IUUC-Mmr-061038	Microcebus murinus	85.25	4.00e-179	620.00
IUUC-Mdo-062927	Monodelphis domestica	80.68	5.00e-146	510.00
IUUC-Mpu-065897	Mustela putorius furo	90.81	7.00e-152	530.00
IUUC-Mlu-067543	Myotis lucifugus	89.55	3.00e-153	534.00
IUUC-Nle-069847	Nomascus leucogenys	79.50	2.00e-159	555.00
IUUC-Opr-070550	Ochotona princeps	77.43	2.00e-149	521.00
IUUC-Ont-071723	Oreochromis niloticus	63.79	1.00e-110	393.00
IUUC-Oan-073569	Ornithorhynchus anatinus	74.26	1.00e-154	539.00
IUUC-Ocu-074632	Oryctolagus cuniculus	84.77	3.00e-173	600.00
IUUC-Oba-075288	Oryza barthii	43.27	6.00e-38	151.00
IUUC-Obr-076050	Oryza brachyantha	42.69	6.00e-34	138.00
IUUC-Ogl-077174	Oryza glaberrima	43.27	6.00e-38	151.00
IUUC-Ogu-078006	Oryza glumaepatula	43.27	6.00e-38	151.00
IUUC-Oin-079278	Oryza indica	40.88	2.00e-35	143.00
IUUC-Olo-080941	Oryza longistaminata	43.27	5.00e-38	151.00
IUUC-Ome-081172	Oryza meridionalis	43.27	6.00e-38	151.00
IUUC-Oni-082239	Oryza nivara	43.27	5.00e-38	151.00
IUUC-Opu-083939	Oryza punctata	42.69	2.00e-37	149.00
IUUC-Oru-084393	Oryza rufipogon	43.27	6.00e-38	151.00
IUUC-Osa-086080	Oryza sativa	43.27	5.00e-38	151.00
IUUC-Ola-087566	Oryzias latipes	71.48	1.00e-111	395.00
IUUC-Oga-088617	Otolemur garnettii	68.82	1.00e-125	442.00
IUUC-Oar-090052	Ovis aries	78.53	2.00e-165	575.00
IUUC-Ptr-091435	Pan troglodytes	85.91	2.00e-176	611.00
IUUC-Pan-092742	Papio anubis	66.57	2.00e-129	455.00
IUUC-Psi-093313	Pelodiscus sinensis	85.34	2.00e-126	444.00
IUUC-Pma-094374	Petromyzon marinus	60.98	3.00e-85	308.00
IUUC-Pno-095003	Phaeosphaeria nodorum	32.86	2.70e-01	31.20
IUUC-Ppa-095601	Physcomitrella patens	44.64	1.00e-44	173.00
IUUC-Pfo-097327	Poecilia formosa	69.02	1.00e-112	399.00
IUUC-Pab-098611	Pongo abelii	82.58	6.00e-142	496.00
IUUC-Pca-101022	Procavia capensis	98.21	5.00e-65	241.00
IUUC-Ppe-101545	Prunus persica	42.86	3.00e-38	152.00
IUUC-Pva-102844	Pteropus vampyrus	84.81	1.00e-173	602.00
IUUC-Rno-104896	Rattus norvegicus	94.08	0.00e+00	664.00
IUUC-Sha-107106	Sarcophilus harrisii	79.06	2.00e-161	561.00
IUUC-Sit-110477	Setaria italica	44.44	1.00e-37	150.00
IUUC-Sly-111416	Solanum lycopersicum	39.13	5.00e-18	84.00
IUUC-Stu-112227	Solanum tuberosum	40.86	5.00e-20	90.50
IUUC-Sar-113534	Sorex araneus	75.00	2.00e-144	504.00
IUUC-Sbi-114751	Sorghum bicolor	43.35	3.00e-36	145.00
IUUC-Ssc-115274	Sus scrofa	86.48	6.00e-177	613.00
IUUC-Tgu-117426	Taeniopygia guttata	75.50	4.00e-140	490.00
IUUC-Tru-118059	Takifugu rubripes	73.14	5.00e-111	393.00
IUUC-Tsy-119448	Tarsius syrichta	82.18	2.00e-87	315.00
IUUC-Tni-120681	Tetraodon nigroviridis	88.37	5.00e-62	229.00
IUUC-Tca-121442	Theobroma cacao	33.45	2.00e-39	155.00
IUUC-Tae-123969	Triticum aestivum	42.11	2.00e-32	133.00
IUUC-Tbe-127638	Tupaia belangeri	80.29	2.00e-157	548.00
IUUC-Ttr-129288	Tursiops truncatus	76.67	8.00e-151	526.00
IUUC-Uma-129359	Ustilago maydis	38.74	9.00e-35	141.00
IUUC-Vpa-130788	Vicugna pacos	83.80	6.00e-170	590.00
IUUC-Vvi-131227	Vitis vinifera	42.51	4.00e-36	144.00
IUUC-Xtr-132147	Xenopus tropicalis	69.15	9.00e-131	459.00
IUUC-Xma-133144	Xiphophorus maculatus	68.69	1.00e-109	389.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence