PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MSX2 TLE2 20211142 biogrid exp P P P P P P G P P P GP P P P GP G TLE2 BARHL1 20211142 biogrid exp G P GP P GP P P P G P GP P G P P GP P P GP MSX1 TLE2 20211142 biogrid exp G GP G GP G GP GP G GP GP GP G GP GP G GP G GP GP GP GP G GP P G TLE2 TLE2 9874198 biogrid exp G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G PRDM1 TLE2 9887105 hprd,biogrid exp G GP G G G G GP GP G G G G G G GP G G GP G GP G G GP GP G GP G G TLX3 TLE2 20211142 biogrid exp P P P P P P P P P P P P P P P PAX9 TLE2 20211142 biogrid exp P P G P P P P P GP GP G P P P P G HMGB1 TLE2 11748221 hprd exp G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G H3F3A, H3F3B TLE2 9334241 hprd exp G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 EMX2 20211142 biogrid exp G G GP P G GP G GP G P G G P G TLE2 NUDC 25036637 intact exp G GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G FOXA3 TLE2 20211142 biogrid exp P G G P P GP P G P GP P GP P P P GP GP P VENTX TLE2 20211142 biogrid exp GP P P GP P P P P P G GP G P P P P P P G RUNX1 TLE2 10825294, 25402006, 21836163 hprd,bci exp, pred P P P P P P P P P P P P P P P TLE2 CUL4A 17041588, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE2 RUNX2 25402006, 21836163 bci exp, pred G G G G G G G G G G GP G G G G G G G G G G G G UTY TLE2 9854018, 25402006 hprd,biogrid,bci exp, pred G G G G G G G G G G G G G GP G G G G G G G G G G G G G G G TLE2 TLE4 25402006 bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE1 TLE2 9874198, 25402006, 23023127, 21836163 hprd,biogrid,bci exp, pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 TLE3 25402006 bci exp, pred G G G G G GP G G GP G GP G GP G G GP GP G G G GP GP G G GP G GP GP G TLE2 LEF1 15768032, 25402006 biogrid exp, pred G G G G G GP G GP G GP GP GP G G GP G G G G G G G G G G TLE2 DDB1 17041588, 25402006 intact exp, pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 CUL4B 17041588, 25402006 biogrid,intact,bci exp, pred G GP G G G GP G GP GP G GP G G GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 HES1 9874198, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE2 WDR82 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAFAH1B1 TLE2 23023127 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G UBXN7 TLE2 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G NKX6-1 TLE2 21836163 pred P TLE2 DCAF6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE2 DET1 25402006 pred G G G G G GP G G G G G G GP GP G GP GP G GP G GP G G GP GP G GP G G TLE2 VPRBP 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G TLE2 BTRC 23023127 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 TRPC4AP 25402006 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G G G GP G GP GP G TCF7 TLE2 25402006 pred G G G G G G G G G G G G G GP G G G G G G G GP G G G G GP G G TLE2 SIRT1 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 HES4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G TLE2 DCAF5 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G SIX6 TLE2 25402006 pred G G P G P P G P P P GP G GP G G GP P P P G TLE2 NEDD8 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 COPS7B 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 COPS7A 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 GRWD1 25402006 pred G GP G G G GP G G GP G GP G G GP G GP GP G G G G G G GP GP G G GP G TLE2 ERCC8 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE2 COPS5 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 HES2 25402006 pred P P P P P P P GP P P P P TLE2 FBXW11 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TLE2 RBBP5 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP TLE2 AMBRA1 25402006 pred G GP G G G GP G GP GP G GP G GP G G GP GP G P G GP GP G GP GP G GP GP G TLE2 PHIP 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 WDR26 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 RUNX3 25402006, 21836163 pred G G G G G G G G G GP G G G G G G G G G TLE2 WDTC1 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G RELB TLE2 25402006 pred G GP G G GP GP GP G GP G GP GP G GP GP G G G G G G G GP G GP GP G TLE2 CAND1 25402006 pred G GP G G G G G G GP G GP G G G G GP G G G G G G G GP GP G G GP G TLE2 HES6 25402006 pred G G P P G P P P GP P GP G P GP GP RBX1 TLE2 25402006 pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G TLE2 DCAF11 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 DDA1 25402006 pred G GP G G G GP G GP GP G GP G GP G GP GP G P G GP GP G GP GP G GP GP G LRP5 TLE2 23023127 pred G GP P G GP GP GP G GP GP G GP P G GP G GP GP G GP GP G GP P G TLE2 DCAF10 25402006 pred G G G G G GP G GP G G G G GP G G G GP G G G G G G GP G G GP G G TLE2 DCAF12 25402006 pred G G G G G GP G G GP G G G GP GP G GP GP G GP G G G G GP GP G GP G G RELA TLE2 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 HIPK2 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G STRN TLE2 23023127 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 DTL 25402006 pred P G G P G P P G P G P P P P G G G GP TLE2 DCAF4 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G TLE2 HES7 25402006 pred G G G G G G G G G TLE2 HDAC2 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 SNW1 21836163 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G IL6ST TLE2 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 FOXA2 25402006 pred GP G GP GP GP P GP GP G TLE2 DCAF8 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G TLE2 DDB2 25402006 pred G GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP G G GP G GP GP G TLE2 AES 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SNRPD3 TLE2 21836163 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G CDKN1A TLE2 25402006 pred G GP G G G G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G UBXN1 TLE2 25402006 pred G GP G G G GP G G GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G AR TLE2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G GP G TLE2 HDAC1 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G NKX2-2 TLE2 21836163 pred P G GP P G P P GP GP GP G P P P GP GP P TLE2 LRP1 23023127 pred G G G G G GP G G G G G G GP G G G GP G G G GP G G G G G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q04725 far western blotting 9334241 association C 7 Q04725 pull down 10559189 association C 7 Q04725 Q04725 pull down 9874198 association Y 1 Q04725 Q04724 two hybrid 9874198 association X 2 Q04725 Q04724 pull down 9874198 association X 2 Q04725 pull down 10559189 association C 11 Q04725 anti tag coimmunoprecipitation 10559189 association C 11 Q04725 anti bait coimmunoprecipitation 17041588 association C 10 Q04725 anti bait coimmunoprecipitation 17041588 association C 3 Q04725 anti bait coimmunoprecipitation 17041588 association C 3 Q04725 Q16531 anti bait coimmunoprecipitation 17041588 physical association X 2 Q04725 Q9Y266 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UTY TLE2 MI:0018(two hybrid)|MI:0492(in vitro) 9854018 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_96465|HPRD_6006 bait|- prey|- MSX2 TLE2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128550 bait prey UBC TLE2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21890473,22053931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_266745|BIOGRID_263506 bait|bait prey|prey PAX9 TLE2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128575 bait prey PRDM1 TLE2 MI:0096(pull down)|MI:0492(in vitro) 9887105 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_109032|HPRD_8330 bait|- prey|- TLE2 CUL4B MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation) 17041588 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0914(association) (intact)|(intact)|(biogrid)|(biogrid)|MI:0468(hprd)|(intact) UniProt_87671|UniProt_87660|BIOGRID_129045|BIOGRID_128996|HPRD_39921|UniProt_87647 bait|prey|prey|prey|-|prey prey|bait|bait|bait|-|bait TLE2 CUL4A MI:0493(in vivo)|MI:0004(affinity chromatography technology) 17041588 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_39921|BIOGRID_129044 -|prey -|bait TLX3 TLE2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128721 prey bait H3F3A TLE2 MI:0493(in vivo) 9334241 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_8329 - - RUNX1 TLE2 MI:0493(in vivo) 10825294 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36930 - - TLE2 HES1 MI:0096(pull down)|MI:0096(pull down) 9874198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_116738|BIOGRID_116737 prey|prey bait|bait HMGB1 TLE2 MI:0492(in vitro) 11748221 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_38123 - - TLE1 TLE2 MI:0018(two hybrid)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 9874198 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_6511|BIOGRID_116736|BIOGRID_116734|BIOGRID_116732 -|prey|prey|bait -|bait|bait|prey TLE2 DDB1 MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo) 17041588 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (intact)|MI:0468(hprd) UniProt_87658|HPRD_39921 bait|- prey|- FOXA3 TLE2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128447 bait prey TLE2 EMX2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128364 prey bait TLE2 LEF1 MI:0096(pull down) 15768032 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_217754 bait prey VENTX TLE2 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128720 prey bait TLE2 BARHL1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128722 bait prey

PPI - HINT Gene A Gene B PMID Method Quality UTY TLE2 9854018 0018 LC TLX3 TLE2 20211142 0018 HT VENTX TLE2 20211142 0018 HT MSX1 TLE2 20211142 0018 HT MSX2 TLE2 20211142 0018 HT FOXA3 TLE2 20211142 0018 HT PAX9 TLE2 20211142 0018 HT TLE1 TLE2 9874198,9874198 0096,0018 LC TLE2 EMX2 20211142 0018 HT TLE2 HES1 9874198,9874198 0096,0018 LC TLE2 Q59EF7 9874198,9874198 0096,0018 LC TLE2 BARHL1 20211142 0018 HT TLE2 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q04725 O14607 TLE2 UTY 0.309 9854018 Q04725 Q04724 TLE2 TLE1 0.671 9874198 Q9Y266 Q04725 NUDC TLE2 0.126 25036637 Q04725 F5HCV3 TLE2 ORF50 0.569 19939918 Q04725 O95231 TLE2 VENTX 0.183 20211142 Q9UJU2 Q04725 LEF1 TLE2 0.309 15768032 Q04725 O43711 TLE2 TLX3 0.183 20211142 Q9BZE3 Q04725 BARHL1 TLE2 0.183 20211142 Q04725 Q04725 TLE2 TLE2 0.332 9874198 Q13620 Q04725 CUL4B TLE2 0.332 17041588 Q04743 Q04725 EMX2 TLE2 0.183 20211142 Q04725 O75626 TLE2 PRDM1 0.309 9887105 Q14469 Q04725 HES1 TLE2 0.523 9874198 Q16531 Q04725 DDB1 TLE2 0.236 17041588 Q04725 P35548 TLE2 MSX2 0.183 20211142 Q04725 P28360 TLE2 MSX1 0.183 20211142 Q13619 Q04725 CUL4A TLE2 0.126 17041588 Q04725 P55318 TLE2 FOXA3 0.183 20211142 Q04725 P55771 TLE2 PAX9 0.183 20211142

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UTY TLE2 MI:0045 experimental interaction detection MI:0461 interaction database SNAI2 TLE2 MI:0362 inference MI:0461 interaction database TLX3 TLE2 MI:0045 experimental interaction detection MI:0461 interaction database PRDM1 TLE2 MI:0045 experimental interaction detection MI:0461 interaction database VENTX TLE2 MI:0045 experimental interaction detection MI:0461 interaction database TPM1 TLE2 MI:0362 inference MI:0461 interaction database UBB TLE2 MI:0362 inference MI:1106 pathways database UBC TLE2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ELK1 TLE2 MI:0362 inference MI:0461 interaction database MSX1 TLE2 MI:0045 experimental interaction detection MI:0461 interaction database CTNNB1 TLE2 MI:0362 inference MI:1106 pathways database MSX2 TLE2 MI:0045 experimental interaction detection MI:0461 interaction database FOXA3 TLE2 MI:0045 experimental interaction detection MI:0461 interaction database PAX9 TLE2 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A TLE2 MI:0362 inference MI:1106 pathways database UBA52 TLE2 MI:0362 inference MI:1106 pathways database SUMO1 TLE2 MI:0045 experimental interaction detection MI:0461 interaction database XIAP TLE2 MI:0362 inference MI:1106 pathways database MECOM TLE2 MI:0362 inference MI:0461 interaction database TLE1 TLE2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TLE2 TLE3 MI:0362 inference MI:1106 pathways database TLE2 TLE4 MI:0362 inference MI:1106 pathways database TLE2 EMX2 MI:0045 experimental interaction detection MI:0461 interaction database TLE2 AES MI:0362 inference MI:1106 pathways database TLE2 FOXD4 MI:0362 inference MI:0461 interaction database TLE2 HDAC1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database TLE2 CUL4A MI:0045 experimental interaction detection MI:0461 interaction database TLE2 CUL4B MI:0045 experimental interaction detection MI:0461 interaction database TLE2 HES1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TLE2 DDB1 MI:0045 experimental interaction detection MI:0461 interaction database TLE2 FOXD4L6 MI:0362 inference MI:0461 interaction database TLE2 FOXD4L5 MI:0362 inference MI:0461 interaction database TLE2 FOXD4L3 MI:0362 inference MI:0461 interaction database TLE2 FOXD4L4 MI:0362 inference MI:0461 interaction database TLE2 HDAC2 MI:0362 inference MI:0461 interaction database TLE2 EYA1 MI:0362 inference MI:0461 interaction database TLE2 EIF3C MI:0362 inference MI:0461 interaction database TLE2 BARHL1 MI:0045 experimental interaction detection MI:0461 interaction database TLE2 TCF7L1 MI:0362 inference MI:0461 interaction database TLE2 TCF7L2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database TLE2 FOXD4L1 MI:0362 inference MI:0461 interaction database TLE2 LEF1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TLE2 TBX20 MI:0362 inference MI:0461 interaction database TLE2 NUDC MI:0045 experimental interaction detection MI:0461 interaction database TLE2 NR2E1 MI:0362 inference MI:0461 interaction database