PTM - CPLM Gene Name UniProt ID Type Position Code AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 Ubiquitination 258 K AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 Ubiquitination 143 K AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 Ubiquitination 141 K AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 Ubiquitination 250 K

PTM - dbPAF Gene Name UniProt ID Position Type Species AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 10 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 104 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 116 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 148 Y Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 16 T Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 197 Y Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 199 Y Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 212 Y Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 226 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 266 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 278 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 284 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 287 T Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 288 T Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 292 T Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 295 Y Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 342 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 369 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 391 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 4 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 41 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 51 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 53 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 54 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 66 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 67 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 83 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 89 S Homo sapiens(Human) AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 O14965 98 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 rs2230743 TCG->TTG S->L 104 S KSKQPLPSAPENNPE 104 Phosphorylation: Aurora A TypeI- AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 rs2230743 TCG->TTG S->L 98 S PLNNTQKSKQPLPSA 98 Phosphorylation: Aurora A TypeIII- AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 rs33923703 ATG->GTG M->V 369 S RLLKHNPSQRPMLRE 369 Phosphorylation TypeIII- AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 rs45533839 GTA->GCA V->A 83 S QKQLQATSVPHPVSR 83 Phosphorylation: Aurora A TypeIII- AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 rs45557632 TTC->TTA F->L 342 S QETYKRISRVEFTFP 342 Phosphorylation: Aurora A TypeIII- AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6 rs6069717 GGA->AGA G->R 10 S RSKENCISGPVKATA 10 Phosphorylation: Aurora A TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O14965 S4-p Phosphorylation ____MDRsKENCIsG O14965 S10-p Phosphorylation RsKENCIsGPVKAtA O14965 T16-p Phosphorylation IsGPVKAtAPVGGPK O14965 S41-p Phosphorylation QNPLPVNsGQAQRVL O14965 S51-p Phosphorylation AQRVLCPsNssQRVP O14965 S53-p Phosphorylation RVLCPsNssQRVPLQ O14965 S54-p Phosphorylation VLCPsNssQRVPLQA O14965 S66-p Phosphorylation LQAQKLVssHKPVQN O14965 S67-p Phosphorylation QAQKLVssHKPVQNQ O14965 S83-p Phosphorylation QKQLQATsVPHPVsR O14965 S89-p Phosphorylation TsVPHPVsRPLNNTQ O14965 S98-p Phosphorylation PLNNTQKsKQPLPsA O14965 S104-p Phosphorylation KsKQPLPsAPENNPE O14965 S116-p Phosphorylation NPEEELAsKQKNEES O14965 Y148-p Phosphorylation KGkFGNVyLAREKQS O14965 S226-p Phosphorylation YRELQKLsKFDEQRT O14965 S266-p Phosphorylation PENLLLGsAGELKIA O14965 S278-p Phosphorylation KIADFGWsVHAPSsR O14965 S284-p Phosphorylation WsVHAPSsRRttLCG O14965 T287-p Phosphorylation HAPSsRRttLCGtLD O14965 T288-p Phosphorylation APSsRRttLCGtLDy O14965 T292-p Phosphorylation RRttLCGtLDyLPPE O14965 Y295-p Phosphorylation tLCGtLDyLPPEMIE O14965 S342-p Phosphorylation QETYKRIsRVEFTFP O14965 S369-p Phosphorylation RLLKHNPsQRPMLRE O14965 S391-p Phosphorylation TANSSKPsNCQNKES O14965 K143-ub Ubiquitination GRPLGKGkFGNVyLA

PTM - dbPTM UniProt ID Position Code Type Resources References O14965 41 S Phosphorylation Swiss-Prot 1010711 18691976 O14965 51 S Phosphorylation Swiss-Prot 1010711 17229885;18691976;19007248 O14965 53 S Phosphorylation Swiss-Prot 1010711 19369195 O14965 83 S Phosphorylation Swiss-Prot 1010711 18691976 O14965 287 T Phosphorylation Swiss-Prot 1010711 14580337;19668197 O14965 288 T Phosphorylation Swiss-Prot 1010711 11039908;13678582;14580337;14990569;16246726;18662907;19668197 O14965 342 S Phosphorylation Swiss-Prot 1010711 16246726 O14965 369 S Phosphorylation Swiss-Prot 1010711 17525332 O14965 369 S Phosphorylation PhosphoELM.10011 17525332 O14965 10 S Phosphorylation PhosphoELM.10011 16083426 O14965 41 S Phosphorylation PhosphoELM.10011 16083426 O14965 67 S Phosphorylation PhosphoELM.10011 16083426 O14965 83 S Phosphorylation PhosphoELM.10011 16083426 O14965 98 S Phosphorylation PhosphoELM.10011 16083426 O14965 104 S Phosphorylation PhosphoELM.10011 16083426 O14965 226 S Phosphorylation PhosphoELM.10011 16083426 O14965 266 S Phosphorylation PhosphoELM.10011 16083426 O14965 278 S Phosphorylation PhosphoELM.10011 16083426 O14965 342 S Phosphorylation PhosphoELM.10011 16083426 O14965 391 S Phosphorylation PhosphoELM.10011 16083426 O14965 16 T Phosphorylation PhosphoELM.10011 16083426 O14965 287 T Phosphorylation PhosphoELM.10011 16083426 O14965 288 T Phosphorylation PhosphoELM.10011 11039908;16083426 O14965 148 Y Phosphorylation PhosphoELM.10011 16083426 O14965 10 S Phosphorylation Phosphositeplus.1010730 16083426 O14965 104 S Phosphorylation Phosphositeplus.1010730 16083426 O14965 116 S Phosphorylation Phosphositeplus.1010730 20068231 O14965 226 S Phosphorylation Phosphositeplus.1010730 16083426 O14965 266 S Phosphorylation Phosphositeplus.1010730 16083426 O14965 278 S Phosphorylation Phosphositeplus.1010730 16083426 O14965 284 S Phosphorylation Phosphositeplus.1010730 16785988 O14965 342 S Phosphorylation Phosphositeplus.1010730 16083426;16246726 O14965 369 S Phosphorylation Phosphositeplus.1010730 17525332 O14965 391 S Phosphorylation Phosphositeplus.1010730 16083426 O14965 41 S Phosphorylation Phosphositeplus.1010730 16083426;18691976 O14965 51 S Phosphorylation Phosphositeplus.1010730 17229885;17895985;18691976 O14965 67 S Phosphorylation Phosphositeplus.1010730 16083426 O14965 83 S Phosphorylation Phosphositeplus.1010730 16083426;18691976 O14965 89 S Phosphorylation Phosphositeplus.1010730 22451695 O14965 98 S Phosphorylation Phosphositeplus.1010730 16083426 O14965 16 T Phosphorylation Phosphositeplus.1010730 16083426 O14965 287 T Phosphorylation Phosphositeplus.1010730 15173575;16083426;22094468;22322096;22451695 O14965 288 T Phosphorylation Phosphositeplus.1010730 11039908;15173575;16082213;16083426;16222244;16246726;16785988;17545617;17895985;18032922;19531483;20603326;21099343;21785464;21788394;21878642;22094468;22322096;22451695 O14965 292 T Phosphorylation Phosphositeplus.1010730 22322096 O14965 148 Y Phosphorylation Phosphositeplus.1010730 16083426;18691976 O14965 197 Y Phosphorylation Phosphositeplus.1010730 18083107 O14965 199 Y Phosphorylation Phosphositeplus.1010730 18083107 O14965 212 Y Phosphorylation Phosphositeplus.1010730 18083107 O14965 4 S Phosphorylation HPRD 9.0 18691976 O14965 41 S Phosphorylation HPRD 9.0 18691976 O14965 51 S Phosphorylation HPRD 9.0 18691976,19007248 O14965 53 S Phosphorylation HPRD 9.0 18691976 O14965 66 S Phosphorylation HPRD 9.0 18691976 O14965 83 S Phosphorylation HPRD 9.0 18691976 O14965 116 S Phosphorylation HPRD 9.0 20068231 O14965 369 S Phosphorylation HPRD 9.0 17525332 O14965 287 T Phosphorylation HPRD 9.0 18691976 O14965 288 T Phosphorylation (PRKACA) HPRD 9.0 11039908 O14965 41 S Phosphorylation SysPTM 1.1 18691976 O14965 51 S Phosphorylation SysPTM 1.1 18691976 O14965 83 S Phosphorylation SysPTM 1.1 18691976

PTM - HPRD Symbol Position Code Type References AURKA 116 S Phosphorylation 20068231 AURKA 287 T Phosphorylation 18691976 AURKA 288 T Phosphorylation 11039908 AURKA 369 S Phosphorylation 17525332 AURKA 4 S Phosphorylation 18691976 AURKA 41 S Phosphorylation 18691976 AURKA 51 S Phosphorylation 18691976,19007248 AURKA 53 S Phosphorylation 18691976 AURKA 66 S Phosphorylation 18691976 AURKA 83 S Phosphorylation 18691976

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O14965 226 S 16083426 Aurora A LTP Phosphorylation O14965 98 S 16083426 Aurora A LTP Phosphorylation O14965 342 S 16083426 Aurora A LTP Phosphorylation O14965 67 S 16083426 Aurora A LTP Phosphorylation O14965 148 Y 16083426 LTP Phosphorylation O14965 391 S 16083426 Aurora A LTP Phosphorylation O14965 369 S 17525332 HTP Phosphorylation O14965 104 S 16083426 Aurora A LTP Phosphorylation O14965 288 T 11039908 PKA_group LTP Phosphorylation O14965 288 T 16083426 Aurora A LTP Phosphorylation O14965 41 S 16083426 Aurora A LTP Phosphorylation O14965 266 S 16083426 Aurora A LTP Phosphorylation O14965 10 S 16083426 Aurora A LTP Phosphorylation O14965 278 S 16083426 Aurora A LTP Phosphorylation O14965 16 T 16083426 Aurora A LTP Phosphorylation O14965 287 T 16083426 Aurora A LTP Phosphorylation O14965 83 S 16083426 Aurora A LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O14965 41 Phosphoserine 18691976 O14965 51 Phosphoserine 17229885 O14965 287 Phosphothreonine 14580337;19668197 O14965 288 Phosphothreonine 11039908;13678582;14580337;14990569;16246726;18662907;19668197 O14965 342 Phosphoserine; by PKA and PAK 16246726

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type AURKA IPI00298940 S 41 NPLPVNpSGQAQRV phosphorylation AURKA IPI00298940 S 51 QRVLCPpSNSSQRV phosphorylation AURKA IPI00298940 S 83 KQLQATpSVPHPVS phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 6790 112666 - K Ubiquitination 21139048 6790 112666 - K Ubiquitination 21906983 6790 112666 - K Ubiquitination 21890637 6790 112666 - K Ubiquitination 21986944 6790 112666 - K Ubiquitination 22513362 6790 112666 - K Ubiquitination 22505724 6790 112666 - K Ubiquitination 22014574 6790 112666 - K Ubiquitination 21890473 6790 112666 - K Ubiquitination 21963094 6790 112666 - K Ubiquitination 21987572 6790 112666 - K Ubiquitination 23539442 6790 112666 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID AURKA Homo sapiens (Human) 19 "19,RPLGKGKFGNVYL" "19:21906983,21890473" AURKA Homo sapiens (Human) 143 "143,RPLGKGKFGNVYL" 143:21906983 AURKA Homo sapiens (Human) 143 "143,RPLGKGKFGNVYL" 143:21890473