PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus JUN KDM2B 17704768 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM2B SIN3A 17704768 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 KDM2B 22825849 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM2B ACBD3 26344197 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CEBPE KDM2B 20211142 biogrid exp G G G G G G G G G G G G G G G G G G EZH2 KDM2B 19202064 biogrid exp G G G G G G G G G G G G ECM29 KDM2B 20682791 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL1 KDM2B 17704768 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM2B KDM2B 22825849 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J KDM2B 22825849 biogrid exp G G G G G G G G PCGF3 KDM2B 22325352 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LZTR1 KDM2B 20211142 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM2B RNF2 24457600,26496610,23395003,22325352,25533466, 25402006, 21836163 innatedb,biogrid,intact exp, ortho, pred G BCOR KDM2B 16943429,26496610,25533466, 25402006, 21836163 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G SKP1 KDM2B 16943429,17704768,17463251,25533466, 25402006, 21836163 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM2B PCGF1 16943429,23395003,22325352,25533466, 25402006, 21836163 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G YAF2 KDM2B 22325352, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G RYBP KDM2B 26186194,23395003,22325352, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CSNK2A2 KDM2B ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EED KDM2B ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSPA8 KDM2B ortho CTBP2 KDM2B ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR5 KDM2B ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CSNK2A1 KDM2B ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBBP4 KDM2B ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CBX3 KDM2B 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BMI1 KDM2B 25402006 ortho, pred CTBP1 KDM2B 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 KDM2B 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM2B CBX8 25402006 ortho, pred KDM1A KDM2B 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM2B KDM2A 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM7A KDM2B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BCL6 KDM2B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PHF2 KDM2B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SP1 KDM2B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96ST3 Q8NHM5 affinity chromatography technology 17704768 physical association X 2 A0A087WW00 Q8NHM5 enzymatic study 22825849 direct interaction X 2 Q8N488 Q8NHM5 affinity chromatography technology 22325352 physical association X 2 Q8N488 Q8NHM5 affinity chromatography technology 23395003 physical association X 2 A0A090N7U0 Q8NHM5 affinity chromatography technology 17704768 physical association X 2 Q8NHM5 affinity chromatography technology 22325352 physical association X 2 Q8NHM5 Q15744 two hybrid 20211142 direct interaction X 2 Q8N653 Q8NHM5 two hybrid 20211142 direct interaction X 2 P61956-2 Q8NHM5 affinity chromatography technology 21693764 physical association X 2 P61956-2 Q8NHM5 affinity chromatography technology 19471022 physical association X 2 Q6W2J9-4 Q8NHM5 affinity chromatography technology 16943429 physical association X 2 Q6W2J9-4 Q8NHM5 affinity chromatography technology 16943429 physical association X 2 P55854 Q8NHM5 affinity chromatography technology 25391492 physical association X 2 P0CG48 Q8NHM5 affinity chromatography technology 21139048 physical association X 2 P63208 Q8NHM5 affinity chromatography technology 17463251 physical association X 2 P63208 Q8NHM5 pull down 16943429 direct interaction X 2 P63208 Q8NHM5 affinity chromatography technology 17704768 physical association X 2 P68431 Q8NHM5 enzymatic study 22825849 direct interaction X 2 P68431 Q8NHM5 pull down 22825849 direct interaction X 2 Q8NHM5 Q9BSM1 affinity chromatography technology 22325352 physical association X 2 Q8NHM5 Q9BSM1 affinity chromatography technology 22325352 physical association X 2 Q8NHM5 Q8NHM5 enzymatic study 22825849 direct interaction X 2 Q8NHM5 Q9BSM1 affinity chromatography technology 23395003 physical association X 2 Q8NHM5 Q9BSM1 affinity chromatography technology 16943429 physical association X 2 Q8NHM5 affinity chromatography technology 19202064 physical association X 2 Q8NHM5 P05412 affinity chromatography technology 17704768 physical association X 2 J3KN16 Q8NHM5 affinity chromatography technology 20682791 physical association X 2 Q3KNV8 Q8NHM5 affinity chromatography technology 22325352 physical association X 2 Q99496 Q8NHM5 affinity chromatography technology 22325352 physical association X 2 Q99496 Q8NHM5 affinity chromatography technology 23395003 physical association X 2 Q99496 Q8NHM5 affinity chromatography technology 24457600 physical association X 2 Q8NHM5 coimmunoprecipitation 16943429 association C 8 Q6W2J9 Q8NHM5 anti bait coimmunoprecipitation 16943429 physical association X 2 Q6W2J9 Q8NHM5 anti tag coimmunoprecipitation 16943429 physical association X 2 P63208 Q8NHM5 pull down 16943429 physical association X 2 Q8NHM5 pull down 16943429 association C 8

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL1 KDM2B MI:0004(affinity chromatography technology) 17704768 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_185198 prey bait RYBP KDM2B MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22325352,23395003 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_191993|BIOGRID_280477 bait|prey prey|bait KDM2B SIN3A MI:0004(affinity chromatography technology) 17704768 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_185201 bait prey BCOR KDM2B MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16943429 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_85398|UniProt_85401|BIOGRID_122944|BIOGRID_122923 prey|bait|prey|bait bait|prey|bait|prey SUMO2 KDM2B MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19471022,21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_165606|BIOGRID_183472 bait|bait prey|prey EZH2 KDM2B MI:0004(affinity chromatography technology) 19202064 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_126037 prey bait KDM2B RNF2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22325352,23395003,24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_191896|BIOGRID_306549|BIOGRID_280475 prey|prey|bait bait|bait|prey ECM29 KDM2B MI:0018(two hybrid) 20682791 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199737 bait prey SKP1 KDM2B MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16943429,17463251,17704768 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_85396|BIOGRID_273740|BIOGRID_185200|BIOGRID_122943 prey|prey|prey|prey bait|bait|bait|bait CEBPE KDM2B MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128323 bait prey YAF2 KDM2B MI:0004(affinity chromatography technology) 22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_192019 bait prey KDM2B PCGF1 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16943429,22325352,23395003 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_85388|BIOGRID_122930|BIOGRID_191798|BIOGRID_280476|BIOGRID_192036 prey|prey|prey|bait|prey bait|bait|bait|prey|bait PCGF3 KDM2B MI:0004(affinity chromatography technology) 22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_191821 bait prey UBC KDM2B MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_169656 bait prey HIST1H3A KDM2B MI:0415(enzymatic study)|MI:0415(enzymatic study) 22825849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_201756|BIOGRID_197671 prey|prey bait|bait LZTR1 KDM2B MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128780 bait prey c-Jun KDM2B MI:0004(affinity chromatography technology) 17704768 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_185196 prey bait UBE2D1 KDM2B MI:0415(enzymatic study) 22825849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225915 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SKP1 KDM2B 26725323,17704768,17463251,25533466,16943429 0004,0004,0004,0004,0096 LC CUL1 KDM2B 26725323,17704768 0004,0004 LC BCOR KDM2B 16943429,26496610,26496610,16943429,25533466,26687479,16943429 0007,0004,0007,0004,0004,0004,0006 LC,HT RYBP KDM2B 22325352,23395003,26186194 0004,0004,0004 LC,HT KDM2B RNF2 26496610,26496610,24457600,25533466,22325352,23395003 0004,0007,0004,0004,0004,0004 HT,LC KDM2B PCGF1 16943429,25533466,22325352,26687479,23395003,16943429,26687479 0004,0004,0004,0004,0004,0096,0401 LC KDM2B ACBD3 26344197 0401 HT BCOR KDM2B 26496610,26496610 0004,0007 HT RYBP KDM2B 26186194 0004 HT KDM2B RNF2 26496610,26496610 0004,0007 HT KDM2B ACBD3 26344197 0401 HT SKP1 KDM2B 26725323,17704768,17463251,25533466,16943429 0004,0004,0004,0004,0096 LC CUL1 KDM2B 26725323,17704768 0004,0004 LC BCOR KDM2B 16943429,16943429,25533466,26687479,16943429 0007,0004,0004,0004,0006 LC RYBP KDM2B 22325352,23395003 0004,0004 LC KDM2B RNF2 24457600,25533466,22325352,23395003 0004,0004,0004,0004 LC KDM2B PCGF1 16943429,25533466,22325352,26687479,23395003,16943429,26687479 0004,0004,0004,0004,0004,0096,0401 LC FOS KDM2B 26725323,26725323 0415,0004 LC UBE2D1 KDM2B 22825849 0415 LC SKP1 KDM2B 27568929 0114 LC HIST1H3A|HIST1H3B|HIST1H3C|HIST1H3D|HIST1H3E|HIST1H3F|HIST1H3G|HIST1H3H|HIST1H3I|HIST1H3J KDM2B 22825849,22825849 0096,0415 LC CEBPE KDM2B 20211142 0018 HT BCORL1 KDM2B 27568929 0114 LC LZTR1 KDM2B 20211142 0018 HT KDM2B KDM2B PDB_4O64,22825849 0114,0415 LC KDM2B PCGF1 27568929,26687479,26687479 0114,0004,0401 LC KDM2B ACBD3 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NHM5 Q5VYK3 KDM2B ECM29 0.126 20682791 Q8NHM5 Q8N653 KDM2B LZTR1 0.183 20211142 Q9H9S0 Q8NHM5 NANOG KDM2B 0.126 26687479 Q9HC52 Q8NHM5 CBX8 KDM2B 0.126 27705803 Q8NHM5 P05412 KDM2B JUN 0.21 17704768 Q8NHM5 P62877 KDM2B RBX1 0.21 26725323 Q8NHM5 Q15910 KDM2B EZH2 0.21 19202064 Q8NHM5 Q8N488 KDM2B RYBP 0.472 27705803,26186194,22325352,23395003 Q8NHM5 Q8NHM5 KDM2B KDM2B 0.332 22825849 Q96ST3 Q8NHM5 SIN3A KDM2B 0.21 17704768 Q9H3P7 Q8NHM5 ACBD3 KDM2B 0.081 26344197 Q8NHM5 P01100 KDM2B FOS 0.569 26725323 Q9WTX5 Q8NHM5 SKP1 KDM2B 0.236 26496610 Q8NHM5 P68431 KDM2B HIST1H3J 0.523 22825849 Q9BSM1 Q8NHM5 PCGF1 KDM2B 0.78 27505670,27705803,26687479,22325352,23395003,16943429,25533466 Q8NHM5 Q6W2J9 KDM2B BCOR 0.712 27505670,26687479,26496610,16943429,25533466 Q99496 Q8NHM5 RNF2 KDM2B 0.583 27705803,25533466,26496610,23395003 Q8R023 Q8NHM5 PCGF1 KDM2B 0.236 26496610 Q8NHM5 Q8IY57 KDM2B YAF2 0.236 22325352,27705803 Q8NHM5 Q13616 KDM2B CUL1 0.507 26725323,17704768 Q8NHM5 P63208 KDM2B SKP1 0.765 27705803,17463251,17704768,26725323,16943429,25533466 Q8NHM5 Q01860 KDM2B POU5F1 0.126 26687479 Q8NHM5 Q15744 KDM2B CEBPE 0.183 20211142 Q8NHM5 O00257 KDM2B CBX4 0.126 27705803 Q8NHM5 Q06587 KDM2B RING1 0.126 27705803

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 KDM1A KDM2B MI:0362 inference MI:0461 interaction database EED KDM2B MI:0362 inference MI:0461 interaction database FOS KDM2B MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2AB KDM2B MI:0362 inference MI:0461 interaction database JUN KDM2B MI:0045 experimental interaction detection MI:0461 interaction database H2AFZ KDM2B MI:0362 inference MI:0461 interaction database HIST1H2AG KDM2B MI:0362 inference MI:0461 interaction database UBC KDM2B MI:0045 experimental interaction detection MI:0461 interaction database HSPA8 KDM2B MI:0362 inference MI:0461 interaction database H2AFX KDM2B MI:0362 inference MI:0461 interaction database CSNK2A2 KDM2B MI:0362 inference MI:0461 interaction database HIST1H2AD KDM2B MI:0362 inference MI:0461 interaction database BMI1 KDM2B MI:0362 inference MI:0461 interaction database UBE2D1 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database CTBP2 KDM2B MI:0362 inference MI:0461 interaction database SUMO2 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database WDR5 KDM2B MI:0362 inference MI:0461 interaction database RBX1 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database SKP1 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A1 KDM2B MI:0362 inference MI:0461 interaction database HIST1H3A KDM2B MI:0045 experimental interaction detection MI:0461 interaction database POU5F1 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database RING1 KDM2B MI:0362 inference MI:0461 interaction database RBBP4 KDM2B MI:0362 inference MI:0461 interaction database CBX3 KDM2B MI:0362 inference MI:0461 interaction database CTBP1 KDM2B MI:0362 inference MI:0461 interaction database CUL1 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database CEBPE KDM2B MI:0045 experimental interaction detection MI:0461 interaction database EZH2 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database HIST2H2AC KDM2B MI:0362 inference MI:0461 interaction database PCGF3 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database ECM29 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database HIST2H2AA3 KDM2B MI:0362 inference MI:0461 interaction database BCOR KDM2B MI:0045 experimental interaction detection MI:0461 interaction database HIST3H2A KDM2B MI:0362 inference MI:0461 interaction database WDR5B KDM2B MI:0362 inference MI:0461 interaction database HIST2H2AB KDM2B MI:0362 inference MI:0461 interaction database YAF2 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database RYBP KDM2B MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 KDM2B MI:0045 experimental interaction detection MI:0461 interaction database KDM2B HIST1H2AC MI:0362 inference MI:0461 interaction database KDM2B HIST1H2AH MI:0362 inference MI:0461 interaction database KDM2B HIST1H2AA MI:0362 inference MI:0461 interaction database KDM2B SIN3A MI:0045 experimental interaction detection MI:0461 interaction database KDM2B RNF2 MI:0045 experimental interaction detection MI:0461 interaction database KDM2B HIST1H2AJ MI:0362 inference MI:0461 interaction database KDM2B PCGF1 MI:0045 experimental interaction detection MI:0461 interaction database KDM2B H2AFJ MI:0362 inference MI:0461 interaction database KDM2B NANOG MI:0045 experimental interaction detection MI:0461 interaction database KDM2B CBX8 MI:0362 inference MI:0461 interaction database