PTM - CPLM Gene Name UniProt ID Type Position Code KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Acetylation 758 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Acetylation 765 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Sumoylation 890 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Ubiquitination 117 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Ubiquitination 129 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Ubiquitination 111 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Ubiquitination 210 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Ubiquitination 1111 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Ubiquitination 147 K KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 Ubiquitination 1187 K

PTM - dbPAF Gene Name UniProt ID Position Type Species KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 1015 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 1018 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 1024 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 1029 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 1031 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 124 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 134 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 145 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 149 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 223 Y Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 229 Y Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 440 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 443 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 444 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 445 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 447 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 449 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 472 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 474 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 477 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 480 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 483 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 484 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 485 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 490 Y Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 493 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 495 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 497 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 50 Y Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 500 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 503 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 57 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 593 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 739 Y Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 741 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 746 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 768 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 795 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 823 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 824 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 827 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 828 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 829 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 832 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 840 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 842 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 847 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 848 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 850 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 904 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 907 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 910 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 912 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 913 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 914 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 916 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 920 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 921 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 94 Y Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 947 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 951 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 961 T Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 964 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 975 S Homo sapiens(Human) KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 Q8NHM5 979 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 rs35367851 ACG->ATG T->M 114 T VDVMDVNTQKGTEMS 145 Phosphorylation TypeIII- KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2 rs35367851 ACG->ATG T->M 145 T VDVMDVNTQKGTEMS 145 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q8NHM5 K758-ac Acetylation QKMNRDNkEGQEPAk Q8NHM5 K765-ac Acetylation kEGQEPAkRRsECEE Q8NHM5 K890-m1 Methylation NKPLRRFkQEPEDEL Q8NHM5 R1231-m1 Methylation DITDASLrLIIRHMP Q8NHM5 Y50-p Phosphorylation RPIDRQRyDENEDLs Q8NHM5 S57-p Phosphorylation yDENEDLsDVEEIVS Q8NHM5 Y94-p Phosphorylation MEGKDFNyEYVQREA Q8NHM5 T124-p Phosphorylation KMPDPDFtVRDVKLL Q8NHM5 S134-p Phosphorylation DVKLLVGsRRLVDVM Q8NHM5 T145-p Phosphorylation VDVMDVNtQKGtEMS Q8NHM5 T149-p Phosphorylation DVNtQKGtEMSMSQF Q8NHM5 Y223-p Phosphorylation NAIAEMKyPKVKKyC Q8NHM5 Y229-p Phosphorylation KyPKVKKyCLMSVKG Q8NHM5 T440-p Phosphorylation DRAPKPPtDGstsPt Q8NHM5 S443-p Phosphorylation PKPPtDGstsPtStP Q8NHM5 T444-p Phosphorylation KPPtDGstsPtStPS Q8NHM5 S445-p Phosphorylation PPtDGstsPtStPSE Q8NHM5 T447-p Phosphorylation tDGstsPtStPSEDQ Q8NHM5 T449-p Phosphorylation GstsPtStPSEDQEA Q8NHM5 T472-p Phosphorylation ALRFLKRtLsNEsEE Q8NHM5 S474-p Phosphorylation RFLKRtLsNEsEEsV Q8NHM5 S477-p Phosphorylation KRtLsNEsEEsVKST Q8NHM5 S480-p Phosphorylation LsNEsEEsVKSTTLA Q8NHM5 T493-p Phosphorylation LAVDYPKtPtGsPAt Q8NHM5 T495-p Phosphorylation VDYPKtPtGsPAtEV Q8NHM5 S497-p Phosphorylation YPKtPtGsPAtEVsA Q8NHM5 T500-p Phosphorylation tPtGsPAtEVsAKWT Q8NHM5 S503-p Phosphorylation GsPAtEVsAKWTHLT Q8NHM5 S593-p Phosphorylation KGKLGPAsAVKLAAN Q8NHM5 Y739-p Phosphorylation KRGPGFKyAsNLPGs Q8NHM5 S741-p Phosphorylation GPGFKyAsNLPGsLL Q8NHM5 S746-p Phosphorylation yAsNLPGsLLKEQKM Q8NHM5 S768-p Phosphorylation QEPAkRRsECEEAPR Q8NHM5 S795-p Phosphorylation DGLLRRKsDDVHLRK Q8NHM5 S813-p Phosphorylation YEKPQELsGRKRASs Q8NHM5 S820-p Phosphorylation sGRKRASsLQTsPGs Q8NHM5 S824-p Phosphorylation RASsLQTsPGsSSHL Q8NHM5 S827-p Phosphorylation sLQTsPGsSSHLsPR Q8NHM5 S832-p Phosphorylation PGsSSHLsPRPPLGS Q8NHM5 S840-p Phosphorylation PRPPLGSsLsPWWRS Q8NHM5 S842-p Phosphorylation PPLGSsLsPWWRSSL Q8NHM5 T850-p Phosphorylation PWWRSSLtYFQQQLK Q8NHM5 S912-p Phosphorylation RESDHSRsssPtAGP Q8NHM5 S913-p Phosphorylation ESDHSRsssPtAGPS Q8NHM5 S914-p Phosphorylation SDHSRsssPtAGPST Q8NHM5 T916-p Phosphorylation HSRsssPtAGPSTEG Q8NHM5 S947-p Phosphorylation RLPNKELsRELsKEL Q8NHM5 S951-p Phosphorylation KELsRELsKELNHEI Q8NHM5 S975-p Phosphorylation ENQQPIKsEPEsEGE Q8NHM5 S979-p Phosphorylation PIKsEPEsEGEEPKR Q8NHM5 S1015-p Phosphorylation LRHQLGPsLRsPPRV Q8NHM5 S1018-p Phosphorylation QLGPsLRsPPRVISR Q8NHM5 S1029-p Phosphorylation VISRPPPsVsPPKCI Q8NHM5 S1031-p Phosphorylation SRPPPsVsPPKCIQM Q8NHM5 K890-sm Sumoylation NKPLRRFkQEPEDEL

PTM - dbPTM UniProt ID Position Code Type Resources References Q8NHM5 223 Y Phosphorylation Swiss-Prot 1010711 17924679 Q8NHM5 474 S Phosphorylation Swiss-Prot 1010711 15302935;19690332 Q8NHM5 493 T Phosphorylation Swiss-Prot 1010711 19690332 Q8NHM5 497 S Phosphorylation Swiss-Prot 1010711 15302935 Q8NHM5 975 S Phosphorylation Swiss-Prot 1010711 19690332 Q8NHM5 979 S Phosphorylation Swiss-Prot 1010711 19690332 Q8NHM5 474 S Phosphorylation PhosphoELM.10011 15302935 Q8NHM5 497 S Phosphorylation PhosphoELM.10011 15302935 Q8NHM5 832 S Phosphorylation PhosphoELM.10011 18669648 Q8NHM5 842 S Phosphorylation PhosphoELM.10011 18669648 Q8NHM5 912 S Phosphorylation PhosphoELM.10011 18669648 Q8NHM5 914 S Phosphorylation PhosphoELM.10011 18669648 Q8NHM5 1031 S Phosphorylation PhosphoELM.10011 18669648 Q8NHM5 823 T Phosphorylation PhosphoELM.10011 18669648 Q8NHM5 890 K Sumoylation Phosphositeplus.1010730 20797634 Q8NHM5 758 K Acetylation Phosphositeplus.1010730 20167786 Q8NHM5 765 K Acetylation Phosphositeplus.1010730 20167786 Q8NHM5 1029 S Phosphorylation Phosphositeplus.1010730 20363803 Q8NHM5 1031 S Phosphorylation Phosphositeplus.1010730 20363803;22115753 Q8NHM5 134 S Phosphorylation Phosphositeplus.1010730 16674116 Q8NHM5 443 S Phosphorylation Phosphositeplus.1010730 19664995 Q8NHM5 474 S Phosphorylation Phosphositeplus.1010730 15302935;19690332;20164059;20363803;21406692;22115753 Q8NHM5 477 S Phosphorylation Phosphositeplus.1010730 20164059;20363803;21406692 Q8NHM5 480 S Phosphorylation Phosphositeplus.1010730 20164059;20363803 Q8NHM5 497 S Phosphorylation Phosphositeplus.1010730 15302935;19664995;19690332;20363803;21406692;22115753 Q8NHM5 57 S Phosphorylation Phosphositeplus.1010730 19664994;19690332;21406692;21659604;22115753 Q8NHM5 795 S Phosphorylation Phosphositeplus.1010730 21406692 Q8NHM5 912 S Phosphorylation Phosphositeplus.1010730 19664995 Q8NHM5 913 S Phosphorylation Phosphositeplus.1010730 19664995 Q8NHM5 914 S Phosphorylation Phosphositeplus.1010730 19664994;19664995 Q8NHM5 975 S Phosphorylation Phosphositeplus.1010730 19690332;20363803;21406692;21659604;22115753 Q8NHM5 979 S Phosphorylation Phosphositeplus.1010730 19690332;20363803;21406692;21659604;22115753 Q8NHM5 145 T Phosphorylation Phosphositeplus.1010730 16674116 Q8NHM5 447 T Phosphorylation Phosphositeplus.1010730 19276368 Q8NHM5 493 T Phosphorylation Phosphositeplus.1010730 19690332;20363803;21406692;22115753 Q8NHM5 495 T Phosphorylation Phosphositeplus.1010730 19690332 Q8NHM5 916 T Phosphorylation Phosphositeplus.1010730 19664995 Q8NHM5 223 Y Phosphorylation Phosphositeplus.1010730 20068231 Q8NHM5 50 Y Phosphorylation Phosphositeplus.1010730 19690332 Q8NHM5 739 Y Phosphorylation Phosphositeplus.1010730 18083107;18180459 Q8NHM5 57 S Phosphorylation HPRD 9.0 19664994 Q8NHM5 443 S Phosphorylation HPRD 9.0 15302935 Q8NHM5 443 S Phosphorylation HPRD 9.0 19664995 Q8NHM5 445 S Phosphorylation HPRD 9.0 18452278,20068231 Q8NHM5 474 S Phosphorylation HPRD 9.0 15302935 Q8NHM5 497 S Phosphorylation HPRD 9.0 15302935,19664995 Q8NHM5 832 S Phosphorylation HPRD 9.0 18669648 Q8NHM5 842 S Phosphorylation HPRD 9.0 18669648 Q8NHM5 910 S Phosphorylation HPRD 9.0 18452278 Q8NHM5 912 S Phosphorylation HPRD 9.0 18669648,19664995 Q8NHM5 913 S Phosphorylation HPRD 9.0 19664995,19413330 Q8NHM5 914 S Phosphorylation HPRD 9.0 18669648,19664995,19664994,19413330 Q8NHM5 975 S Phosphorylation HPRD 9.0 18452278 Q8NHM5 979 S Phosphorylation HPRD 9.0 18452278 Q8NHM5 1029 S Phosphorylation HPRD 9.0 20068231 Q8NHM5 1031 S Phosphorylation HPRD 9.0 18669648,19651622,18452278 Q8NHM5 444 T Phosphorylation HPRD 9.0 18452278 Q8NHM5 823 T Phosphorylation HPRD 9.0 18669648 Q8NHM5 916 T Phosphorylation HPRD 9.0 19664995 Q8NHM5 223 Y Phosphorylation HPRD 9.0 17924679,20068231 Q8NHM5 474 S Phosphorylation SysPTM 1.1 15302935 Q8NHM5 497 S Phosphorylation SysPTM 1.1 15302935

PTM - HPRD Symbol Position Code Type References KDM2B 1029 S Phosphorylation 20068231 KDM2B 1031 S Phosphorylation 18669648,19651622,18452278 KDM2B 192 Y Phosphorylation 17924679,20068231 KDM2B 223 Y Phosphorylation 17924679,20068231 KDM2B 26 S Phosphorylation 19664994 KDM2B 412 S Phosphorylation 19664995 KDM2B 413 T Phosphorylation 18452278 KDM2B 414 S Phosphorylation 18452278,20068231 KDM2B 443 S Phosphorylation 15302935 KDM2B 443 S Phosphorylation 19664995 KDM2B 444 T Phosphorylation 18452278 KDM2B 445 S Phosphorylation 18452278,20068231 KDM2B 466 S Phosphorylation 15302935,19664995 KDM2B 474 S Phosphorylation 15302935 KDM2B 497 S Phosphorylation 15302935,19664995 KDM2B 57 S Phosphorylation 19664994 KDM2B 823 T Phosphorylation 18669648 KDM2B 832 S Phosphorylation 18669648 KDM2B 842 S Phosphorylation 18669648 KDM2B 843 S Phosphorylation 18669648,19664995 KDM2B 844 S Phosphorylation 19664995,19413330 KDM2B 845 S Phosphorylation 18669648,19664995,19664994,19413330 KDM2B 847 T Phosphorylation 19664995 KDM2B 906 S Phosphorylation 18452278 KDM2B 910 S Phosphorylation 18452278 KDM2B 912 S Phosphorylation 18669648,19664995 KDM2B 913 S Phosphorylation 19664995,19413330 KDM2B 914 S Phosphorylation 18669648,19664995,19664994,19413330 KDM2B 916 T Phosphorylation 19664995 KDM2B 960 S Phosphorylation 20068231 KDM2B 962 S Phosphorylation 18669648,19651622,18452278 KDM2B 975 S Phosphorylation 18452278 KDM2B 979 S Phosphorylation 18452278

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q8NHM5 832 S 18669648 HTP Phosphorylation Q8NHM5 912 S 18669648 HTP Phosphorylation Q8NHM5 842 S 18669648 HTP Phosphorylation Q8NHM5 1031 S 18669648 HTP Phosphorylation Q8NHM5 497 S 15302935 HTP Phosphorylation Q8NHM5 474 S 15302935 HTP Phosphorylation Q8NHM5 823 T 18669648 HTP Phosphorylation Q8NHM5 914 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q8NHM5 57 Phosphoserine 23186163 Q8NHM5 474 Phosphoserine 21406692;23186163 Q8NHM5 477 Phosphoserine 21406692 Q8NHM5 493 Phosphothreonine 19690332;21406692 Q8NHM5 497 Phosphoserine 21406692 Q8NHM5 951 Phosphoserine 23186163 Q8NHM5 975 Phosphoserine 19690332;23186163 Q8NHM5 979 Phosphoserine 19690332;23186163 Q8NHM5 1018 Phosphoserine 23186163 Q8NHM5 1031 Phosphoserine 23186163