PTM - CPLM Gene Name UniProt ID Type Position Code ESR1; ESR; NR3A1 P03372 Acetylation 8 K ESR1; ESR; NR3A1 P03372 Acetylation 266 K ESR1; ESR; NR3A1 P03372 Acetylation 268 K ESR1; ESR; NR3A1 P03372 Acetylation 299 K ESR1; ESR; NR3A1 P03372 Acetylation 302 K ESR1; ESR; NR3A1 P03372 Acetylation 303 K ESR1; ESR; NR3A1 P03372 Acetylation 472 K ESR1; ESR; NR3A1 P03372 Methylation 302 K ESR1; ESR; NR3A1 P03372 Sumoylation 266 K ESR1; ESR; NR3A1 P03372 Sumoylation 268 K ESR1; ESR; NR3A1 P03372 Sumoylation 299 K ESR1; ESR; NR3A1 P03372 Sumoylation 302 K ESR1; ESR; NR3A1 P03372 Sumoylation 303 K ESR1; ESR; NR3A1 P03372 Ubiquitination 302 K

PTM - dbPAF Gene Name UniProt ID Position Type Species ESR1; ESR; NR3A1 P03372 10 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 102 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 104 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 106 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 118 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 154 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 167 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 2 T Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 201 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 212 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 219 Y Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 236 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 282 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 294 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 305 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 311 T Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 341 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 4 T Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 46 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 47 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 485 T Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 52 Y Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 537 Y Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 554 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 559 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 576 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 578 S Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 594 T Homo sapiens(Human) ESR1; ESR; NR3A1 P03372 7 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P03372 K32-ac Acetylation PLNRPQLkIPLERPL P03372 K171-ac Acetylation RLAsTNDkGSMAMES P03372 K244-ac Acetylation CQACRLRkCYEVGMM P03372 K252-ac Acetylation CYEVGMMkGGIRKDR P03372 K266-ac Acetylation RrGGRMLkHkRQRDD P03372 K268-ac Acetylation GGRMLkHkRQRDDGE P03372 K299-ac Acetylation WPsPLMIkRSkkNsL P03372 K302-ac Acetylation PLMIkRSkkNsLALS P03372 K303-ac Acetylation LMIkRSkkNsLALSL P03372 K472-ac Acetylation TLKSLEEkDHIHRVL P03372 K171-m2 Methylation RLAsTNDkGSMAMES P03372 K171-m1 Methylation RLAsTNDkGSMAMES P03372 K180-m2 Methylation SMAMESAkETRYCAV P03372 R260-m2 Methylation GGIRKDRrGGRMLkH P03372 K266-m1 Methylation RrGGRMLkHkRQRDD P03372 R277-m2 Methylation QRDDGEGrGEVGsAG P03372 K302-me Methylation PLMIkRSkkNsLALS P03372 K302-m1 Methylation PLMIkRSkkNsLALS P03372 K401-m2 Methylation RSMEHPGkLLFAPNL P03372 T7-p Phosphorylation _MTMTLHtKAsGMAL P03372 S10-p Phosphorylation MTLHtKAsGMALLHQ P03372 S46-p Phosphorylation LGEVYLDssKPAVyN P03372 S47-p Phosphorylation GEVYLDssKPAVyNY P03372 Y52-p Phosphorylation DssKPAVyNYPEGAA P03372 S102-p Phosphorylation GGFPPLNsVsPsPLM P03372 S104-p Phosphorylation FPPLNsVsPsPLMLL P03372 S106-p Phosphorylation PLNsVsPsPLMLLHP P03372 S118-p Phosphorylation LHPPPQLsPFLQPHG P03372 S154-p Phosphorylation PAFYRPNsDNRRQGG P03372 S167-p Phosphorylation GGRERLAsTNDkGSM P03372 S212-p Phosphorylation CKAFFKRsIQGHNDy P03372 Y219-p Phosphorylation sIQGHNDyMCPATNQ P03372 S236-p Phosphorylation IDKNRRKsCQACRLR P03372 S282-p Phosphorylation EGrGEVGsAGDMRAA P03372 S294-p Phosphorylation RAANLWPsPLMIkRS P03372 S305-p Phosphorylation IkRSkkNsLALSLtA P03372 T311-p Phosphorylation NsLALSLtADQMVSA P03372 S341-p Phosphorylation TRPFSEAsMMGLLTN P03372 T485-p Phosphorylation VLDKITDtLIHLMAK P03372 Y537-p Phosphorylation CKNVVPLyDLLLEML P03372 S554-p Phosphorylation HRLHAPTsRGGAsVE P03372 S559-p Phosphorylation PTsRGGAsVEETDQS P03372 S576-p Phosphorylation ATAGSTSsHsLQKYY P03372 S578-p Phosphorylation AGSTSsHsLQKYYIT P03372 T594-p Phosphorylation EAEGFPAtV______ P03372 K171-sm Sumoylation RLAsTNDkGSMAMES P03372 K180-sm Sumoylation SMAMESAkETRYCAV P03372 K266-sm Sumoylation RrGGRMLkHkRQRDD P03372 K268-sm Sumoylation GGRMLkHkRQRDDGE P03372 K299-sm Sumoylation WPsPLMIkRSkkNsL P03372 K472-sm Sumoylation TLKSLEEkDHIHRVL P03372 K302-ub Ubiquitination PLMIkRSkkNsLALS

PTM - dbPTM UniProt ID Position Code Type Resources References P03372 7 T Phosphorylation Swiss-Prot 1010711 18187866 P03372 10 S Phosphorylation Swiss-Prot 1010711 18187866 P03372 104 S Phosphorylation Swiss-Prot 1010711 10428798 P03372 106 S Phosphorylation Swiss-Prot 1010711 10428798 P03372 260 R Methylation Swiss-Prot 1010711 18657504 P03372 118 S Phosphorylation Swiss-Prot 1010711 - P03372 167 S Phosphorylation Swiss-Prot 1010711 - P03372 537 Y Phosphorylation Swiss-Prot 1010711 - P03372 46 S Phosphorylation PhosphoELM.10011 20043841 P03372 47 S Phosphorylation PhosphoELM.10011 20043841 P03372 154 S Phosphorylation PhosphoELM.10011 18984578 P03372 212 S Phosphorylation PhosphoELM.10011 18984578 P03372 282 S Phosphorylation PhosphoELM.10011 20043841 P03372 294 S Phosphorylation PhosphoELM.10011 20043841;18984578 P03372 554 S Phosphorylation PhosphoELM.10011 18984578 P03372 559 S Phosphorylation PhosphoELM.10011 20043841;18984578 P03372 104 S Phosphorylation PhosphoELM.10011 20043841;16741565;18984578;8308015;10428798;10949034;16076840;10949034 P03372 106 S Phosphorylation PhosphoELM.10011 20043841;16741565;18984578;10949034;8308015;10428798;16076840 P03372 102 S Phosphorylation PhosphoELM.10011 18984578;16076840 P03372 118 S Phosphorylation PhosphoELM.10011 20043841;16741565;18984578;15528270;9528769;12118371;12093745;7838153;7491495;15059947;16076840;12118371;15461668;10949034 P03372 305 S Phosphorylation PhosphoELM.10011 17627277;16452229;16741565;15193262;12374744 P03372 236 S Phosphorylation PhosphoELM.10011 16741565;18984578;9891036 P03372 167 S Phosphorylation PhosphoELM.10011 16741565;18984578;9528769;11432835;7838153;11139588 P03372 311 T Phosphorylation PhosphoELM.10011 16741565;12138194;12138194 P03372 52 Y Phosphorylation PhosphoELM.10011 20101225 P03372 219 Y Phosphorylation PhosphoELM.10011 20101225 P03372 537 Y Phosphorylation PhosphoELM.10011 16741565;7539106;7539106 P03372 266 K Sumoylation Phosphositeplus.1010730 15961505 P03372 268 K Sumoylation Phosphositeplus.1010730 15961505 P03372 302 K Ubiquitylation Phosphositeplus.1010730 17392432;19887647 P03372 244 K Acetylation Phosphositeplus.1010730 16497729 P03372 252 K Acetylation Phosphositeplus.1010730 16497729 P03372 266 K Acetylation Phosphositeplus.1010730 16497729;19887647;20167786 P03372 268 K Acetylation Phosphositeplus.1010730 16497729;19887647 P03372 299 K Acetylation Phosphositeplus.1010730 11279135;16497729 P03372 302 K Acetylation Phosphositeplus.1010730 11279135;19887647 P03372 303 K Acetylation Phosphositeplus.1010730 11279135;15604293;18471979;19887647 P03372 472 K Acetylation Phosphositeplus.1010730 18984578 P03372 302 K Methylation Phosphositeplus.1010730 18471979;19208734 P03372 10 S Phosphorylation Phosphositeplus.1010730 18187866 P03372 102 S Phosphorylation Phosphositeplus.1010730 10949034;16076840;18984578 P03372 104 S Phosphorylation Phosphositeplus.1010730 10428798;10949034;11108261;12118371;12714702;12856811;14718389;16076840;16741565;17068199;18367407;18372406;18984578;19104930;20043841;20418363;20531297;8308015 P03372 106 S Phosphorylation Phosphositeplus.1010730 10428798;10949034;11108261;12118371;12714702;12856811;14718389;16076840;16741565;17068199;18367407;18372406;18984578;19104930;20043841;20418363;20531297;8308015 P03372 118 S Phosphorylation Phosphositeplus.1010730 10428798;10949034;11083859;11108261;11139588;11145737;12093745;12118371;12466266;12714702;12775708;12856811;14718389;14764652;14977836;15059947;15355923;15461668;15528270;15778291;15784730;15808510;15831449;15879307;15913882;15919818;16076840;16113102;16168121;16223974;16452229;16455819;16740736;16741565;16778166;17047081;17068199;17108142;17157789;17158758;17237269;17384676;17466625;17615152;18367407;18372406;18922467;18941890;18984578;19104930;19169277;19326083;19339517;19377875;19887647;19940281;20043841;20103631;20418363;20471474;20531297;20696772;21356307;21602804;7476978;7491495;8308015;9528769 P03372 154 S Phosphorylation Phosphositeplus.1010730 18367407;18984578 P03372 167 S Phosphorylation Phosphositeplus.1010730 10949034;11108261;11139588;11432835;11507039;15528270;15778291;16113102;16168121;16455819;16741565;17068199;17157789;17158758;18367407;18941890;18984578;19104930;19112174;19574224;19887647;19925796;19940156;20418363;20531297;21602804;7838153;9337862;9528769 P03372 212 S Phosphorylation Phosphositeplus.1010730 18984578;22266331 P03372 236 S Phosphorylation Phosphositeplus.1010730 16741565;17068199;18984578;22266331;9891036 P03372 282 S Phosphorylation Phosphositeplus.1010730 19104930;20043841;20418363 P03372 294 S Phosphorylation Phosphositeplus.1010730 15778291;18984578;19104930;20043841;20418363;22431515 P03372 305 S Phosphorylation Phosphositeplus.1010730 12374744;15193262;15604293;16452229;16741565;16778166;17068199;17627277;18521086;19205871;20101208;20179234 P03372 46 S Phosphorylation Phosphositeplus.1010730 20043841 P03372 47 S Phosphorylation Phosphositeplus.1010730 20043841 P03372 554 S Phosphorylation Phosphositeplus.1010730 18984578 P03372 559 S Phosphorylation Phosphositeplus.1010730 18984578;19104930;20043841;20418363 P03372 2 T Phosphorylation Phosphositeplus.1010730 18187866 P03372 311 T Phosphorylation Phosphositeplus.1010730 12138194;16741565;17068199;19104930;20418363 P03372 4 T Phosphorylation Phosphositeplus.1010730 18187866 P03372 7 T Phosphorylation Phosphositeplus.1010730 18187866 P03372 219 Y Phosphorylation Phosphositeplus.1010730 20101225 P03372 52 Y Phosphorylation Phosphositeplus.1010730 20101225 P03372 537 Y Phosphorylation Phosphositeplus.1010730 10571988;11145737;16741565;17068199;7539106;9500442 P03372 537 Y Dephosphorylation HPRD 9.0 7539106 P03372 537 Y Dephosphorylation HPRD 9.0 7539106 P03372 10 S O-linked Glycosylation HPRD 9.0 11226831 P03372 167 S Phosphorylation (AKT1) HPRD 9.0 11139588 P03372 167 S Phosphorylation (AKT2) HPRD 9.0 11507039,11139588,11432835,9528769 P03372 118 S Phosphorylation (CDK7) HPRD 9.0 15461668 P03372 118 S Phosphorylation (MAPK1) HPRD 9.0 12093745,9528769,10409727 P03372 102 S Phosphorylation (MNAT1) HPRD 9.0 10949034 P03372 104 S Phosphorylation (MNAT1) HPRD 9.0 10949034,8308015 P03372 106 S Phosphorylation (MNAT1) HPRD 9.0 10949034,8308015 P03372 305 S Phosphorylation (PAK1) HPRD 9.0 12374744 P03372 118 S Phosphorylation (RPS6KA1) HPRD 9.0 12093745,9528769 P03372 167 S Phosphorylation (RPS6KA1) HPRD 9.0 11507039,11139588,11432835,9528769 P03372 167 S Phosphorylation (RPS6KA3) HPRD 9.0 11507039,11139588,11432835,9528769 P03372 311 T Phosphorylation (MAPK14) HPRD 9.0 12138194 P03372 537 Y Phosphorylation (LCK) HPRD 9.0 7539106 P03372 537 Y Phosphorylation (SRC) HPRD 9.0 7539106

PTM - HPRD Symbol Position Code Type References ESR1 10 S Glycosylation 11226831 ESR1 102 S Phosphorylation 10949034 ESR1 104 S Phosphorylation 10949034,8308015 ESR1 106 S Phosphorylation 10949034,8308015 ESR1 118 S Phosphorylation 12093745,9528769 ESR1 118 S Phosphorylation 12093745,9528769,10409727 ESR1 118 S Phosphorylation 15461668 ESR1 167 S Phosphorylation 11139588 ESR1 167 S Phosphorylation 11507039,11139588,11432835,9528769 ESR1 305 S Phosphorylation 12374744 ESR1 311 T Phosphorylation 12138194 ESR1 537 Y Dephosphorylation 7539106 ESR1 537 Y Phosphorylation 7539106

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P03372 282 S 20043841 LTP Phosphorylation P03372 52 Y 20101225 LTP Phosphorylation P03372 294 S 20043841 LTP Phosphorylation P03372 294 S 18984578 LTP Phosphorylation P03372 167 S 16741565 LTP Phosphorylation P03372 167 S 18984578 LTP Phosphorylation P03372 167 S 9528769 LTP Phosphorylation P03372 167 S 11432835 RSK_group LTP Phosphorylation P03372 167 S 7838153 RSK_group LTP Phosphorylation P03372 167 S 11139588 PKB_beta LTP Phosphorylation P03372 554 S 18984578 LTP Phosphorylation P03372 106 S 20043841 LTP Phosphorylation P03372 106 S 16741565 LTP Phosphorylation P03372 106 S 18984578 LTP Phosphorylation P03372 106 S 10949034 LTP Phosphorylation P03372 106 S 8308015 LTP Phosphorylation P03372 106 S 10428798 CDK_group LTP Phosphorylation P03372 106 S 16076840 GSK-3_beta LTP Phosphorylation P03372 305 S 17627277 LTP Phosphorylation P03372 305 S 16452229 LTP Phosphorylation P03372 305 S 16741565 LTP Phosphorylation P03372 305 S 15193262 LTP Phosphorylation P03372 305 S 12374744 PAK1 LTP Phosphorylation P03372 46 S 20043841 LTP Phosphorylation P03372 311 T 16741565 LTP Phosphorylation P03372 311 T 12138194 MAPK_group LTP Phosphorylation P03372 311 T 12138194 MAPK14 LTP Phosphorylation P03372 102 S 18984578 LTP Phosphorylation P03372 102 S 16076840 GSK-3_beta LTP Phosphorylation P03372 559 S 20043841 LTP Phosphorylation P03372 559 S 18984578 LTP Phosphorylation P03372 118 S 20043841 LTP Phosphorylation P03372 118 S 16741565 LTP Phosphorylation P03372 118 S 18984578 LTP Phosphorylation P03372 118 S 15528270 LTP Phosphorylation P03372 118 S 9528769 LTP Phosphorylation P03372 118 S 12118371 MAPK_group LTP Phosphorylation P03372 118 S 12093745 MAPK_group LTP Phosphorylation P03372 118 S 7838153 RSK_group LTP Phosphorylation P03372 118 S 7491495 MAPK3 LTP Phosphorylation P03372 118 S 15059947 MAPK1 LTP Phosphorylation P03372 118 S 16076840 GSK-3_beta LTP Phosphorylation P03372 118 S 12118371 CDK7 LTP Phosphorylation P03372 118 S 15461668 CDK7 LTP Phosphorylation P03372 118 S 10949034 CDK7 LTP Phosphorylation P03372 537 Y 16741565 LTP Phosphorylation P03372 537 Y 7539106 Lck LTP Phosphorylation P03372 537 Y 7539106 SRC LTP Phosphorylation P03372 219 Y 20101225 LTP Phosphorylation P03372 154 S 18984578 LTP Phosphorylation P03372 212 S 18984578 LTP Phosphorylation P03372 47 S 20043841 LTP Phosphorylation P03372 236 S 16741565 LTP Phosphorylation P03372 236 S 18984578 LTP Phosphorylation P03372 236 S 9891036 PKA_group LTP Phosphorylation P03372 104 S 20043841 LTP Phosphorylation P03372 104 S 16741565 LTP Phosphorylation P03372 104 S 18984578 LTP Phosphorylation P03372 104 S 8308015 LTP Phosphorylation P03372 104 S 10428798 CDK_group LTP Phosphorylation P03372 104 S 10949034 CDK_group LTP Phosphorylation P03372 104 S 16076840 GSK-3_beta LTP Phosphorylation P03372 104 S 10949034 GSK-3_beta LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P03372 104 Phosphoserine; by CDK2 10428798 P03372 106 Phosphoserine; by CDK2 10428798 P03372 118 Phosphoserine 14764652 P03372 167 Phosphoserine; by CK2 7838153 P03372 260 Asymmetric dimethylarginine; by PRMT1 18657504 P03372 537 Phosphotyrosine; by Tyr-kinases 7539106

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 2099 108403 - K Ubiquitination 17418098 2099 108403 - K Ubiquitination 16314411 2099 108403 - K Sumoylation 15961505 2099 108403 - K Ubiquitination 15538384 2099 108403 - K Ubiquitination 14702340 2099 108403 - K Ubiquitination 12917323 2099 108403 - K Ubiquitination 21503962 2099 108403 - K Ubiquitination 20060929 2099 108403 - K Ubiquitination 19383985 2099 108403 - K Ubiquitination 19887647 2099 108403 - K Ubiquitination 21572428 2099 108403 - K Ubiquitination 22865929 2099 108403 - K Ubiquitination 17311814 2099 108403 - K Ubiquitination 18388150 2099 108403 - K Ubiquitination 17545634 2099 108403 - K Ubiquitination 12554766 2099 108403 - K Ubiquitination 19122208 2099 108403 - K Ubiquitination 18414007 2099 108403 - K Ubiquitination 23041672 2099 108403 - K Ubiquitination 24441041 2099 108403 - K Ubiquitination 12615709