ESR1
Drug & target - TTD
NameType of TargetSynonymsDiseaseDrugsInhibitorAntibody
Estrogen receptorImprecisely defined successful target type 1 (ambiguous subtype/subunit)Estradiol receptor;Estrogen receptor alpha;Oestrogen receptor;Oestrogen receptor alpha;ER;ERalpha;ER-alphaPostmenopausal symptoms;Breast cancer;Coronary atherosclerosis;Osteoporosis;Cardiovascular disease;Endocrine independent cancer;Neurodegenerative diseases;Brain injuryOspemifene;Ospemifene;Fulvestrant;Raloxifene;RAD-1901;NP-50301;Synthetic conjugated estrogen;Tamoxifen;Acolbifene;Conjugated estrogens a;Premarin/Trimegestone;SR-90067;ARN-810;Estriol;Estriol;Premarin/Pravachol;4-HYDROXYTAMOXIFEN;Estrogen;Quinestrol;Quinestrol;ERA-923;ATD transdermal gel;Estropipate;Estetrol;BITHIONOL;Conjugated estrogens b;Danazol;Danazol;Estrone;SERM-3339;GTx-758;GTx-758;Estradiol;Estradiol;Fosfestrol;Androgen restored contraceptive;NPC-01;Diethylstilbestrol;Diethylstilbestrol;Trimegestone/ethinyl estradiol;Mitotane;Miproxifene;Panomifene;Toremifene;Mestranol;Cenestin;Afimoxifene;Estratab;CC-8490;Bazedoxifene;ARZOXIFENE;Esterified estrogens;Gestrinone;Ethinyl Estradiol;HEXESTROL;ONAPRISTONE;Endoxifen;Chlorotrianisene;Chlorotrianisene;IoGen;Nomegestrol acetate;HRT;Estrogen receptor beta-selective phytoestrogenic formulation;Cyclofenil;Clomifene;CHF-4227;Droloxifene;Dienestrol;Dienestrol;Lasofoxifene;Levormeloxifene non-steroidal;EM-800;Idoxifene;MX-4509;PromestrieneANDROSTENEDIOL;2-(4-Hydroxy-phenyl)-7-vinyl-benzooxazol-5-ol;NAFOXIDINE;3-chloro-4-(4-hydroxyphenyl)salicylaldoxime;3-ETHYL-2-(4-HYDROXYPHENYL)-2H-INDAZOL-5-OL;Estrogen platinum(II) hybrid derivative;4-(6-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol;1-Fluoro-6-(4-hydroxy-phenyl)-naphthalen-2-ol;17-METHYL-17-ALPHA-DIHYDROEQUILENIN;ZK-119010;JNJ-17148066;CP-409069;5-Chloro-2-(4-hydroxy-phenyl)-quinolin-6-ol;4-[1,2-bis(4-hydroxyphenyl)pent-1-enyl]phenol;6-(4-Hydroxy-phenyl)-naphthalen-1-ol;3-(5-Hydroxy-benzooxazol-2-yl)-benzene-1,2-diol;GSK-5182;7-Chloro-2-(4-hydroxy-phenyl)-benzofuran-5-ol;LY-117018;2-(4-Hydroxy-phenyl)-4-vinyl-quinolin-6-ol;SNG-8033;Doxorubicin-Formaldehyde Conjugate;2-phenyl-1,2'-spirobi[1H-indene]-5'-ol;3,8-dihydroxy-7-methyl-6H-benzo[c]chromen-6-one;N-butyl-4-hydroxy-N-phenylbenzenesulfonamide;4-(7-chloro-1-cyclohexyl-1H-indazol-3-yl)phenol;8-n-pentylnaringenin;8-(2,2-dimethylpropyl)naringenin;SNG-163;2-Naphthalen-1-yl-benzooxazol-6-ol;6-(4-Hydroxy-phenyl)-1-phenyl-naphthalen-2-ol;6-(3-Hydroxy-phenyl)-naphthalen-1-ol;4-(1-cyclopentyl-7-fluoro-1H-indazol-3-yl)phenol;4,6,7,10-tetramethyl-6H-benzo[c]chromene-3,8-diol;8-methylnaringenin;3-(4-Hydroxyphenyl)-7-isobutoxychromen-4-one;6-ethyl-2,4-diisobutylaminopyrimidine;COUMESTROL;6-(4-Hydroxy-phenyl)-naphthalen-2-ol;4-HYDROXYTAMOXIFEN;1-Bromo-6-(4-hydroxy-phenyl)-naphthalen-2-ol;Dicarba-closo-dodecaborane derivative;ERA-923;5-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol;8-n-nonylnaringenin;2-(3-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol;CP-394531;7-(3-Hydroxy-phenyl)-naphthalen-2-ol;1,8-Dichloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol;ATD transdermal gel;2-(4-Hydroxy-phenyl)-7-propyl-benzooxazol-5-ol;4-Bromo-2-(4-hydroxy-phenyl)-quinolin-6-ol;2-(5-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol;2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE;4-[1-(4-hydroxyphenyl)-2-phenylprop-1-enyl]phenol;Compound 4-D;1-Chloro-6-(4-hydroxy-phenyl)-naphthalen-2-ol;ICI-164384;Compound 15;2-(2-Chloro-4-hydroxy-phenyl)-benzooxazol-5-ol;N-cyclohexyl-4-hydroxy-N-phenylbenzenesulfonamide;2-(4-Hydroxy-phenyl)-4-methoxy-quinolin-6-ol;4-Benzo[d]isoxazol-3-yl-benzene-1,3-diol;4,6,6,7-tetramethyl-6H-benzo[c]chromene-3,8-diol;6-(4-Hydroxy-2-methoxy-phenyl)-naphthalen-2-ol;BITHIONOL;Tamoxifen ethyl bromide;DIHYDRORALOXIFENE;7-Ethyl-2-(4-hydroxy-phenyl)-benzooxazol-5-ol;6-(2,5-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol;2-(3-Fluoro-4-hydroxy-phenyl)-benzooxazol-6-ol;8-n-propylnaringenin;4-[1,2-bis(4-hydroxyphenyl)but-1-enyl]phenol;8-n-heptylnaringenin;Compound 16;4-(7-chloro-1-cyclopentyl-1H-indazol-3-yl)phenol;8-benzylnaringenin;ZK-164015;6-(2,6-Difluoro-4-hydroxy-phenyl)-naphthalen-2-ol;6-ethyl-4,7-dimethyl-6H-benzo[c]chromene-3,8-diol;6-(2-Chloro-4-hydroxy-phenyl)-naphthalen-2-ol;4,10-dimethyl-6H-benzo[c]chromene-3,8-diol;Pipendoxifene;N-ethyl-4-hydroxy-N-phenylbenzenesulfonamide;4-Naphthalen-2-yl-phenol;2-(3-hydroxyphenyl)-1,2'-spirobi[1H-indene]-5-ol;2-(4-Hydroxy-phenyl)-7-isopropyl-benzooxazol-5-ol;2-(4-Hydroxy-phenyl)-benSNG-8023
Estrogen receptor alphaClinical trial targetEstrogen receptor;ER;ERalpha;Estradiol receptor;Nuclear receptor subfamily 3 group A member 1;ESR1Pain;Hyperlipidemia;Leukemia;Contraception;Breast cancer;Osteoporosis;Menopause;Cancer;Brain cancerSR 16234
Drug & target - GRAC
Estrogen receptor-α nhr 96 3A. Estrogen receptors 620 6q25.1
Drug & target - PDTD
Ensembl_gene_ID UniProt ID PDB Code
ENSG00000091831.21 P03372 1PCG
ENSG00000091831.21 P03372 1QKT
ENSG00000091831.21 P03372 1UOM
ENSG00000091831.21 P03372 3ERT