PTM - CPLM Gene Name UniProt ID Type Position Code UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 610 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 794 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 801 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 951 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 964 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 989 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1106 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1189 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1203 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 702 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 443 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 827 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1169 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1056 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1058 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1150 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1132 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1210 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 575 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1180 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1143 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 442 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1205 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 1217 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 972 K UBE4B; HDNB1; KIAA0684; UFD2 O95155 Ubiquitination 558 K

PTM - dbPAF Gene Name UniProt ID Position Type Species UBE4B; HDNB1; KIAA0684; UFD2 O95155 101 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1026 Y Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 103 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1034 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1044 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 105 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 116 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 118 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 124 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1249 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1256 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1265 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1267 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1274 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 1278 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 141 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 143 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 148 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 149 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 154 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 22 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 224 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 23 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 238 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 254 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 259 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 26 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 262 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 27 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 30 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 307 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 31 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 311 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 323 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 327 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 352 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 383 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 392 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 393 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 61 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 64 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 65 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 76 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 78 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 79 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 798 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 803 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 807 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 83 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 84 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 86 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 87 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 88 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 90 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 92 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 929 Y Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 95 T Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 969 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 97 S Homo sapiens(Human) UBE4B; HDNB1; KIAA0684; UFD2 O95155 99 S Homo sapiens(Human)

PTM - PhosSNP Gene Name dbSNP ID Gene Mutation AA Mutation Mutation Position Code Peptide Score Modification Type UBE4B; HDNB1; KIAA0684; UFD2 rs15191 CCC->ACC P->T 1265 S ILRHLLNSPTDPFNR 1265 Phosphorylation TypeIII- UBE4B; HDNB1; KIAA0684; UFD2 rs15191 CCC->ACC P->T 1136 S ILRHLLNSPTDPFNR 1265 Phosphorylation TypeIII-

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O95155 R10-m1 Methylation ELSADEIrRRRLARL O95155 T22-p Phosphorylation ARLAGGQtsQPttPL O95155 S23-p Phosphorylation RLAGGQtsQPttPLt O95155 T26-p Phosphorylation GGQtsQPttPLtsPQ O95155 T27-p Phosphorylation GQtsQPttPLtsPQR O95155 T30-p Phosphorylation sQPttPLtsPQRENP O95155 S31-p Phosphorylation QPttPLtsPQRENPP O95155 T61-p Phosphorylation GLNVHNMtPAtsPIG O95155 T64-p Phosphorylation VHNMtPAtsPIGASG O95155 S65-p Phosphorylation HNMtPAtsPIGASGV O95155 S76-p Phosphorylation ASGVAHRsQssEGVs O95155 S78-p Phosphorylation GVAHRsQssEGVssL O95155 S79-p Phosphorylation VAHRsQssEGVssLs O95155 S83-p Phosphorylation sQssEGVssLsssPs O95155 S84-p Phosphorylation QssEGVssLsssPsN O95155 S86-p Phosphorylation sEGVssLsssPsNsL O95155 S87-p Phosphorylation EGVssLsssPsNsLE O95155 S88-p Phosphorylation GVssLsssPsNsLEt O95155 S90-p Phosphorylation ssLsssPsNsLEtQS O95155 S92-p Phosphorylation LsssPsNsLEtQSQs O95155 T95-p Phosphorylation sPsNsLEtQSQsLsR O95155 S99-p Phosphorylation sLEtQSQsLsRsQsM O95155 S101-p Phosphorylation EtQSQsLsRsQsMDI O95155 S103-p Phosphorylation QSQsLsRsQsMDIDG O95155 S105-p Phosphorylation QsLsRsQsMDIDGVS O95155 S116-p Phosphorylation DGVSCEKsMsQVDVD O95155 S118-p Phosphorylation VSCEKsMsQVDVDsG O95155 S124-p Phosphorylation MsQVDVDsGIENMEV O95155 S141-p Phosphorylation NDRREKRsLsDKEPS O95155 S143-p Phosphorylation RREKRsLsDKEPSsG O95155 S149-p Phosphorylation LsDKEPSsGPEVsEE O95155 S154-p Phosphorylation PSsGPEVsEEQALQL O95155 S224-p Phosphorylation RDENPFAsLTATSQP O95155 S238-p Phosphorylation PIAAAARsPDRNLLL O95155 S307-p Phosphorylation ASQLAVPsTPLSPHS O95155 S352-p Phosphorylation SILSSSPsPPALASS O95155 S383-p Phosphorylation GPPLPPAsPSATSRR O95155 T705-p Phosphorylation STKIkLEtVDPtyIF O95155 T709-p Phosphorylation kLEtVDPtyIFHPRC O95155 Y710-p Phosphorylation LEtVDPtyIFHPRCR O95155 S798-p Phosphorylation EDLkNNEsQWkDsPL O95155 S803-p Phosphorylation NEsQWkDsPLAtRHR O95155 T807-p Phosphorylation WkDsPLAtRHREMLK O95155 Y929-p Phosphorylation QNYIRNPyLVAKLVE O95155 S969-p Phosphorylation STkLLVPsLMKFYTD O95155 Y1026-p Phosphorylation SGKQFVRyINMLIND O95155 T1034-p Phosphorylation INMLINDtTFLLDES O95155 S1249-p Phosphorylation TDPVRLPsGTIMDRs O95155 S1256-p Phosphorylation sGTIMDRsIILRHLL O95155 S1265-p Phosphorylation ILRHLLNsPtDPFNR O95155 T1267-p Phosphorylation RHLLNsPtDPFNRQt O95155 T1274-p Phosphorylation tDPFNRQtLTEsMLE O95155 S1278-p Phosphorylation NRQtLTEsMLEPVPE O95155 K558-ub Ubiquitination LCETKFGkTHPVCNL O95155 K575-ub Ubiquitination SLRLWLPkSLSPGCG O95155 K610-ub Ubiquitination DDVKVVEkYFSGPAI O95155 K702-ub Ubiquitination QQLSTKIkLEtVDPt O95155 K794-ub Ubiquitination NRTVEDLkNNEsQWk O95155 K801-ub Ubiquitination kNNEsQWkDsPLAtR O95155 K827-ub Ubiquitination LKKLVRCkACADAGL O95155 K951-ub Ubiquitination AVQPRTQkFFEMIEN O95155 K964-ub Ubiquitination ENHPLSTkLLVPsLM O95155 K989-ub Ubiquitination ATSEFYDkFTIRYHI O95155 K1056-ub Ubiquitination HEVQEEMkNkEQWDQ O95155 K1058-ub Ubiquitination VQEEMkNkEQWDQLP O95155 K1106-ub Ubiquitination ILTKQVQkPFLRPEL O95155 K1189-ub Ubiquitination LFEEVISkMRKAGIK O95155 K1203-ub Ubiquitination KSTIAIEkFkLLAEk O95155 K1205-ub Ubiquitination TIAIEkFkLLAEkVE O95155 K1210-ub Ubiquitination kFkLLAEkVEEIVAk O95155 K1217-ub Ubiquitination kVEEIVAkNARAEID

PTM - dbPTM UniProt ID Position Code Type Resources References O95155 22 T Phosphorylation Swiss-Prot 1010711 18669648 O95155 26 T Phosphorylation Swiss-Prot 1010711 18669648 O95155 31 S Phosphorylation Swiss-Prot 1010711 18669648;18691976 O95155 84 S Phosphorylation Swiss-Prot 1010711 19690332 O95155 87 S Phosphorylation Swiss-Prot 1010711 19413330 O95155 88 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 O95155 90 S Phosphorylation Swiss-Prot 1010711 18669648;19413330;19690332 O95155 92 S Phosphorylation Swiss-Prot 1010711 19413330 O95155 95 T Phosphorylation Swiss-Prot 1010711 19413330 O95155 101 S Phosphorylation Swiss-Prot 1010711 18669648;19690332 O95155 105 S Phosphorylation Swiss-Prot 1010711 15302935;19413330 O95155 803 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;18691976 O95155 1265 S Phosphorylation Swiss-Prot 1010711 17081983;18220336 O95155 31 S Phosphorylation PhosphoELM.10011 18669648 O95155 84 S Phosphorylation PhosphoELM.10011 18669648 O95155 88 S Phosphorylation PhosphoELM.10011 18669648;17081983 O95155 90 S Phosphorylation PhosphoELM.10011 18669648 O95155 99 S Phosphorylation PhosphoELM.10011 18669648 O95155 101 S Phosphorylation PhosphoELM.10011 18669648 O95155 105 S Phosphorylation PhosphoELM.10011 18669648;15302935 O95155 224 S Phosphorylation PhosphoELM.10011 18669648 O95155 392 S Phosphorylation PhosphoELM.10011 17081983 O95155 798 S Phosphorylation PhosphoELM.10011 18669648 O95155 803 S Phosphorylation PhosphoELM.10011 18669648;18220336;17081983 O95155 1265 S Phosphorylation PhosphoELM.10011 18669648;18220336;17081983 O95155 22 T Phosphorylation PhosphoELM.10011 18669648 O95155 26 T Phosphorylation PhosphoELM.10011 18669648 O95155 1056 K Ubiquitylation Phosphositeplus.1010730 21906983 O95155 1058 K Ubiquitylation Phosphositeplus.1010730 21906983 O95155 1106 K Ubiquitylation Phosphositeplus.1010730 21890473 O95155 1189 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O95155 1203 K Ubiquitylation Phosphositeplus.1010730 21890473 O95155 1217 K Ubiquitylation Phosphositeplus.1010730 21906983 O95155 610 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O95155 702 K Ubiquitylation Phosphositeplus.1010730 21906983 O95155 794 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O95155 801 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O95155 951 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O95155 964 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 O95155 989 K Ubiquitylation Phosphositeplus.1010730 21890473 O95155 101 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;19690332;22115753 O95155 103 S Phosphorylation Phosphositeplus.1010730 19664995;21406692;22115753 O95155 105 S Phosphorylation Phosphositeplus.1010730 15302935;18669648;19362540;19664995;20562096;22115753 O95155 124 S Phosphorylation Phosphositeplus.1010730 21406692;22115753 O95155 1265 S Phosphorylation Phosphositeplus.1010730 18220336;18669648;19276368;20068231;22115753 O95155 23 S Phosphorylation Phosphositeplus.1010730 16964243 O95155 31 S Phosphorylation Phosphositeplus.1010730 17446864;18669648;18691976 O95155 803 S Phosphorylation Phosphositeplus.1010730 18220336;18669648;18691976;19276368;20068231;21406692;22115753 O95155 84 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;19690332 O95155 87 S Phosphorylation Phosphositeplus.1010730 19690332 O95155 88 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;19276368;19664994;19664995;19690332;21406692 O95155 90 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;19664995;19690332;20058876 O95155 969 S Phosphorylation Phosphositeplus.1010730 21406692 O95155 99 S Phosphorylation Phosphositeplus.1010730 16964243 O95155 27 T Phosphorylation Phosphositeplus.1010730 16964243 O95155 929 Y Phosphorylation Phosphositeplus.1010730 20068231 O95155 23 S Phosphorylation HPRD 9.0 16964243 O95155 31 S Phosphorylation HPRD 9.0 15345747,18669648,18691976,16964243,20068231 O95155 31 S Phosphorylation HPRD 9.0 18669648,18691976,16964243,20068231 O95155 83 S Phosphorylation HPRD 9.0 19651622 O95155 84 S Phosphorylation HPRD 9.0 18669648 O95155 86 S Phosphorylation HPRD 9.0 17081983 O95155 87 S Phosphorylation HPRD 9.0 17081983,19413330 O95155 88 S Phosphorylation HPRD 9.0 17081983,18669648,19413330,19664995,19651622,19664994 O95155 90 S Phosphorylation HPRD 9.0 18669648,19413330,19664995,19651622,20058876 O95155 92 S Phosphorylation HPRD 9.0 17322306,19413330 O95155 99 S Phosphorylation HPRD 9.0 18669648 O95155 101 S Phosphorylation HPRD 9.0 15345747,18669648,19651622,20068231 O95155 101 S Phosphorylation HPRD 9.0 18669648,19651622,20068231 O95155 103 S Phosphorylation HPRD 9.0 19664995,19651622 O95155 105 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,19664995,18767875 O95155 105 S Phosphorylation HPRD 9.0 15302935,18669648,19413330,19664995,18767875 O95155 224 S Phosphorylation HPRD 9.0 18669648 O95155 238 S Phosphorylation HPRD 9.0 17322306 O95155 259 S Phosphorylation HPRD 9.0 20068231 O95155 393 S Phosphorylation HPRD 9.0 20068231 O95155 798 S Phosphorylation HPRD 9.0 17081983,18669648,18767875,20068231 O95155 803 S Phosphorylation HPRD 9.0 17322306,18669648,19651622,18767875,18691976,20068231 O95155 1044 S Phosphorylation HPRD 9.0 18452278 O95155 1265 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,20068231 O95155 22 T Phosphorylation HPRD 9.0 18669648 O95155 26 T Phosphorylation HPRD 9.0 18669648 O95155 27 T Phosphorylation HPRD 9.0 16964243 O95155 95 T Phosphorylation HPRD 9.0 19413330 O95155 929 Y Phosphorylation HPRD 9.0 20068231 O95155 1026 Y Phosphorylation HPRD 9.0 18452278 O95155 109 D Proteolytic Cleavage HPRD 9.0 11802788 O95155 123 D Proteolytic Cleavage HPRD 9.0 11802788 O95155 109 D Proteolytic Cleavage HPRD 9.0 11802788 O95155 123 D Proteolytic Cleavage HPRD 9.0 11802788 O95155 23 S Phosphorylation SysPTM 1.1 16964243 O95155 31 S Phosphorylation SysPTM 1.1 16964243;18669648;18691976 O95155 84 S Phosphorylation SysPTM 1.1 16964243 O95155 88 S Phosphorylation SysPTM 1.1 18669648;16964243 O95155 90 S Phosphorylation SysPTM 1.1 18669648 O95155 99 S Phosphorylation SysPTM 1.1 16964243 O95155 101 S Phosphorylation SysPTM 1.1 16964243;18669648 O95155 105 S Phosphorylation SysPTM 1.1 15302935 O95155 803 S Phosphorylation SysPTM 1.1 18669648;18691976 O95155 798 S Phosphorylation SysPTM 1.1 17081983 O95155 803 S Phosphorylation SysPTM 1.1 17081983 O95155 1265 S Phosphorylation SysPTM 1.1 17081983 O95155 22 T Phosphorylation SysPTM 1.1 18669648 O95155 26 T Phosphorylation SysPTM 1.1 18669648 O95155 27 T Phosphorylation SysPTM 1.1 16964243

PTM - HPRD Symbol Position Code Type References UBE4B 101 S Phosphorylation 15345747,18669648,19651622,20068231 UBE4B 101 S Phosphorylation 18669648,19651622,20068231 UBE4B 1026 Y Phosphorylation 18452278 UBE4B 103 S Phosphorylation 19664995,19651622 UBE4B 1044 S Phosphorylation 18452278 UBE4B 105 S Phosphorylation 15302935,18669648,19413330,19664995,18767875 UBE4B 105 S Phosphorylation 17322306,18669648,19413330,19664995,18767875 UBE4B 109 D Proteolytic Cleavage 11802788 UBE4B 1136 S Phosphorylation 17081983,18669648,19651622,20068231 UBE4B 123 D Proteolytic Cleavage 11802788 UBE4B 1265 S Phosphorylation 17081983,18669648,19651622,20068231 UBE4B 22 T Phosphorylation 18669648 UBE4B 224 S Phosphorylation 18669648 UBE4B 23 S Phosphorylation 16964243 UBE4B 238 S Phosphorylation 17322306 UBE4B 259 S Phosphorylation 20068231 UBE4B 26 T Phosphorylation 18669648 UBE4B 27 T Phosphorylation 16964243 UBE4B 31 S Phosphorylation 15345747,18669648,18691976,16964243,20068231 UBE4B 31 S Phosphorylation 18669648,18691976,16964243,20068231 UBE4B 393 S Phosphorylation 20068231 UBE4B 669 S Phosphorylation 17081983,18669648,18767875,20068231 UBE4B 674 S Phosphorylation 17322306,18669648,19651622,18767875,18691976,20068231 UBE4B 798 S Phosphorylation 17081983,18669648,18767875,20068231 UBE4B 800 Y Phosphorylation 20068231 UBE4B 803 S Phosphorylation 17322306,18669648,19651622,18767875,18691976,20068231 UBE4B 83 S Phosphorylation 19651622 UBE4B 84 S Phosphorylation 18669648 UBE4B 86 S Phosphorylation 17081983 UBE4B 87 S Phosphorylation 17081983,19413330 UBE4B 88 S Phosphorylation 17081983,18669648,19413330,19664995,19651622,19664994 UBE4B 897 Y Phosphorylation 18452278 UBE4B 90 S Phosphorylation 18669648,19413330,19664995,19651622,20058876 UBE4B 915 S Phosphorylation 18452278 UBE4B 92 S Phosphorylation 17322306,19413330 UBE4B 929 Y Phosphorylation 20068231 UBE4B 95 T Phosphorylation 19413330 UBE4B 99 S Phosphorylation 18669648

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O95155 1265 S 18669648 HTP Phosphorylation O95155 1265 S 18220336 HTP Phosphorylation O95155 1265 S 17081983 HTP Phosphorylation O95155 224 S 18669648 HTP Phosphorylation O95155 798 S 18669648 HTP Phosphorylation O95155 101 S 18669648 HTP Phosphorylation O95155 803 S 18669648 HTP Phosphorylation O95155 803 S 18220336 HTP Phosphorylation O95155 803 S 17081983 HTP Phosphorylation O95155 99 S 18669648 HTP Phosphorylation O95155 88 S 18669648 HTP Phosphorylation O95155 88 S 17081983 HTP Phosphorylation O95155 392 S 17081983 HTP Phosphorylation O95155 22 T 18669648 HTP Phosphorylation O95155 84 S 18669648 HTP Phosphorylation O95155 105 S 18669648 HTP Phosphorylation O95155 105 S 15302935 HTP Phosphorylation O95155 31 S 18669648 HTP Phosphorylation O95155 90 S 18669648 HTP Phosphorylation O95155 26 T 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O95155 1 N-acetylmethionine 22223895;22814378 O95155 23 Phosphoserine 23186163 O95155 31 Phosphoserine 16964243;18669648;23186163 O95155 84 Phosphoserine 19690332 O95155 88 Phosphoserine 18669648;19690332;24275569 O95155 90 Phosphoserine 18669648;19690332 O95155 101 Phosphoserine 18669648;19690332;23186163 O95155 103 Phosphoserine 21406692 O95155 105 Phosphoserine 23186163 O95155 124 Phosphoserine 23186163 O95155 238 Phosphoserine 23186163 O95155 383 Phosphoserine 23186163 O95155 803 Phosphoserine 17081983;18669648;18691976;20068231;21406692;23186163 O95155 1265 Phosphoserine 20068231;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type UBE4B IPI00005715 S 1265 LRHLLNpSPTDPFN phosphorylation UBE4B IPI00005715 S 31 PTTPLTpSPQRENP phosphorylation UBE4B IPI00005715 S 392 ATSRRPpSSLRISP phosphorylation UBE4B IPI00005715 S 803 ESQWKDpSPLATRH phosphorylation UBE4B IPI00005715 S 88 VSSLSSpSPSNSLE phosphorylation UBE4B IPI00005715 S 969 TKLLVPpSLMKFYT phosphorylation UBE4B IPI00005715 Y 929 NYIRNPpYLVAKLV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 10277 115566 - K Ubiquitination 21987572 10277 115566 - K Ubiquitination 21963094 10277 115566 - K Ubiquitination 21139048 10277 115566 - K Ubiquitination 21890473 10277 115566 - K Ubiquitination 21906983 10277 115566 - K Ubiquitination 22505724 10277 115566 - K Ubiquitination 23000965 10277 115566 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID UBE4B Homo sapiens (Human) 835; 822; 665; 1074; 977; 481; 1060; 672; 860 "835,NHPLSTKLLVPSL; 822,VQPRTQKFFEMIE; 665,RTVEDLKNNESQW; 1074,STIAIEKFKLLAE; 977,LTKQVQKPFLRPE; 481,DVKVVEKYFSGPA; 1060,FEEVISKMRKAGI; 672,NNESQWKDSPLAT; 860,TSEFYDKFTIRYH" 835:21890473; 822:21890473; 665:21890473; 1074:21890473; 977:21890473; 481:21890473; 1060:21890473; 672:21890473; 860:21890473 UBE4B Homo sapiens (Human) 610; 1217; 1189; 989; 1058; 1056; 951; 794; 702; 1203; 801; 964; 1106 "610,DVKVVEKYFSGPA; 1217,VEEIVAKNARAEI; 1189,FEEVISKMRKAGI; 989,TSEFYDKFTIRYH; 1058,QEEMKNKEQWDQL; 1056,EVQEEMKNKEQWD; 951,VQPRTQKFFEMIE; 794,RTVEDLKNNESQW; 702,QLSTKIKLETVDP; 1203,STIAIEKFKLLAE; 801,NNESQWKDSPLAT; 964,NHPLSTKLLVPSL; 1106,LTKQVQKPFLRPE" "610:21890473,21906983; 1217:21906983; 1189:21890473,21906983; 989:21890473; 1058:21906983; 1056:21906983; 951:21890473,21906983; 794:21890473,21906983; 702:21906983; 1203:21890473; 801:21890473,21906983; 964:21890473,21906983; 1106:21890473" UBE4B Homo sapiens (Human) 927; 822; 977; 1088; 1060; 672; 860; 835; 665; 1074; 573; 929; 481 "927,EVQEEMKNKEQWD; 822,VQPRTQKFFEMIE; 977,LTKQVQKPFLRPE; 1088,VEEIVAKNARAEI; 1060,FEEVISKMRKAGI; 672,NNESQWKDSPLAT; 860,TSEFYDKFTIRYH; 835,NHPLSTKLLVPSL; 665,RTVEDLKNNESQW; 1074,STIAIEKFKLLAE; 573,QLSTKIKLETVDP; 929,QEEMKNKEQWDQL; 481,DVKVVEKYFSGPA" "927:21906983; 822:21890473,21906983; 977:21890473; 1088:21906983; 1060:21890473,21906983; 672:21890473,21906983; 860:21890473; 835:21890473,21906983; 665:21890473,21906983; 1074:21890473; 573:21906983; 929:21906983; 481:21890473,21906983" UBE4B Homo sapiens (Human) 958; 549; 744; 457; 719; 972; 365; 813; 556; 706; 944; 861; 811 "958,STIAIEKFKLLAE; 549,RTVEDLKNNESQW; 744,TSEFYDKFTIRYH; 457,QLSTKIKLETVDP; 719,NHPLSTKLLVPSL; 972,VEEIVAKNARAEI; 365,DVKVVEKYFSGPA; 813,QEEMKNKEQWDQL; 556,NNESQWKDSPLAT; 706,VQPRTQKFFEMIE; 944,FEEVISKMRKAGI; 861,LTKQVQKPFLRPE; 811,EVQEEMKNKEQWD" "958:21890473; 549:21890473,21906983; 744:21890473; 457:21906983; 719:21890473,21906983; 972:21906983; 365:21890473,21906983; 813:21906983; 556:21890473,21906983; 706:21890473,21906983; 944:21890473,21906983; 861:21890473; 811:21906983" UBE4B Homo sapiens (Human) 835; 822; 665; 1074; 977; 481; 1060; 672; 860 "835,NHPLSTKLLVPSL; 822,VQPRTQKFFEMIE; 665,RTVEDLKNNESQW; 1074,STIAIEKFKLLAE; 977,LTKQVQKPFLRPE; 481,DVKVVEKYFSGPA; 1060,FEEVISKMRKAGI; 672,NNESQWKDSPLAT; 860,TSEFYDKFTIRYH" 835:21890473; 822:21890473; 665:21890473; 1074:21890473; 977:21890473; 481:21890473; 1060:21890473; 672:21890473; 860:21890473 UBE4B Homo sapiens (Human) 1202; 609; 800; 988; 1188; 963; 950; 1105; 793 "1202,STIAIEKFKLLAE; 609,DVKVVEKYFSGPA; 800,NNESQWKDSPLAT; 988,TSEFYDKFTIRYH; 1188,FEEVISKMRKAGI; 963,NHPLSTKLLVPSL; 950,VQPRTQKFFEMIE; 1105,LTKQVQKPFLRPE; 793,RTVEDLKNNESQW" 1202:21890473; 609:21890473; 800:21890473; 988:21890473; 1188:21890473; 963:21890473; 950:21890473; 1105:21890473; 793:21890473