PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus KIF5B SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 APPL1 23414517 intact exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G NCL SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 HYPK 26344197 biogrid exp G G G G G GP G G GP G G G GP GP G GP GP G G G GP G G G GP G G GP G SMAD2 SPG20 20195357 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 MED20 25281560 biogrid exp G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G HSPA5 SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KPNB1 SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 WWOX 24550385 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SPG20 DPH5 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G ACSL3 SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EPS15 SPG20 16036216 hprd,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 WWP1 19580544,19765186,19307600 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBB SPG20 19765186 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBC SPG20 16196087 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP2 SPG20 19307600 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G CETN2 SPG20 26638075 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G SPG20 SMURF2 15231748,20007894,19307600 hprd,biogrid,i2d,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ACSL4 SPG20 19765186 biogrid,intact exp G GP G G G GP G G GP G GP P GP GP G GP GP G P G GP GP GP G GP G GP GP G AIFM1 SPG20 19765186 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SEC16A SPG20 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SPG20 KLC2 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G VIM SPG20 19765186 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G G GP GP GP G G G G G G GP G GP G RAD23B SPG20 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G LMNB1 SPG20 19765186 biogrid,intact exp GP P G GP P P GP P P GP GP G GP P GP GP GP P P P GP GP GP P HSPD1 SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TUBA1A SPG20 16945107 hprd,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G COPA SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G HSPA9 SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 SMURF1 19307600 biogrid exp G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G GP G GP G HADHA SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZFYVE9 SPG20 15231748 hprd,biogrid,i2d,mint,intact exp G GP G G G GP G G GP G GP G G G G GP GP GP GP G GP GP G G GP GP GP GP G APP SPG20 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G CLTC SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G DYNC1H1 SPG20 19765186 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G PLIN3 SPG20 23890011,19307600 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HTT SPG20 23275563 intact exp GP GP G G GP GP G G GP G P GP P GP G GP GP GP P G GP GP GP G GP GP GP GP SPG20 ITCH 19580544,19765186,16055720,19307600,20504295, 25402006 biogrid,i2d,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAP3K1 SPG20 25260751, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TAX1BP1 SPG20 25402006 pred GP GP G G GP GP G GP GP G GP G G GP G G GP GP G G GP G GP GP G G GP GP G TNFRSF1A SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TG SPG20 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARRB1 SPG20 25402006 pred GP G G G GP GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G SPG20 RIPK3 25402006 pred GP P G GP P GP GP G P P GP GP G GP P P GP G GP GP GP GP GP GP GP P SPG20 CBLC 25402006 pred P P P P P P GP P P P P P P P P P TRAF2 SPG20 25402006 pred P P P P P P P P P P P P P P P P P P P GP GP P PRNP SPG20 25402006 pred G GP G G G GP G G GP G G G GP G G G GP G GP G G GP GP G G G G GP G SPG20 TAB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPG20 SAMD11 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G PPP1CB SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 SGK3 25402006 pred P P P P P P P P P P P P P P P P P P P P P P MVD SPG20 25402006 pred P P P P P P P P P P P P P P P P P P P P TP53 SPG20 25402006 pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G PAX8 SPG20 25402006 pred G GP G G G G G G GP G GP G GP G G GP G G G G G G G G GP G G G G SPG20 TANK 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARRB2 SPG20 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G FBL SPG20 25402006 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MLANA SPG20 25402006 pred G G G SPG20 USP9X 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G GRB2 SPG20 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NPM1 SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IKBKB SPG20 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RELA SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 MAP3K3 25402006 pred G G G G GP GP G GP G G GP G GP GP G GP GP G G G GP G G G GP GP GP G G CFTR SPG20 25402006 pred P P GP P P GP P GP P GP GP P SPG20 FERMT2 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G SSB SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MYBL1 SPG20 25402006 pred P G G P GP P G G G P P P P P P P G GP GP SPG20 RNF11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SASH1 SPG20 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP GP G TNFRSF1B SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GP GP GP P G NEDD4 SPG20 25402006 pred GP GP G GP P G GP GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G SPG20 SIL1 25402006 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP GP G GP GP GP GP GP GP GP G SPG20 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RIPK1 SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YWHAZ SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 TCEAL4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NFKB1 SPG20 25402006 pred GP G G G GP G G G GP G G G GP GP G GP G G G G GP GP GP G GP GP G GP G TOP1 SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 TBK1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 25402006 pred NUDT21 SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAP3K7 SPG20 25402006 pred GP GP G G G GP G G GP G G GP GP G G G GP G GP G GP GP G G G G GP GP G SPG20 SPAST 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CPSF6 SPG20 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NFKB2 SPG20 25402006 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP G GP G GP GP GP GP G RELB SPG20 25402006 pred GP GP G G GP GP GP G GP GP GP GP G GP GP G G G G G G G GP GP GP GP G SPG20 PA2G4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SPG20 TRAF6 25402006 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G SPG20 MAP3K14 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FOXO1 SPG20 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PPP2R2B SPG20 25402006 pred GP P G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP G GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ZFYVE9 SPG20 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|(intact) MINT_32544|BIOGRID_258919|MINT_61392|HPRD_617|UniProt_79065 bait|bait|bait|-|bait prey|prey|prey|-|prey SUMO2 SPG20 MI:0004(affinity chromatography technology) 19471022 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_183354 bait prey APP SPG20 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228446 prey bait SPG20 ITCH MI:0676(tandem affinity purification)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16055720,19307600,19580544,19765186,20504295 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) UniProt_103074|BIOGRID_197097|BIOGRID_148350|BIOGRID_153180|BIOGRID_297868|BIOGRID_153652|HPRD_39749 bait|bait|bait|bait|prey|bait|- prey|prey|prey|prey|bait|prey|- EPS15 SPG20 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 16036216 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_27724|BIOGRID_218124|BIOGRID_218125 -|prey|prey -|bait|bait HSPA9 SPG20 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_103075|UniProt_103074|BIOGRID_148366|BIOGRID_148348 prey|prey|prey|prey bait|bait|bait|bait AIFM1 SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148361 prey|prey bait|bait SPG20 SMURF2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748,19307600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd)|MI:0471(mint) MINT_61076|BIOGRID_259398|BIOGRID_197099|UniProt_78801|HPRD_39141|MINT_32239 prey|prey|bait|prey|-|prey bait|bait|prey|bait|-|bait SPG20 SMURF1 MI:0018(two hybrid) 19307600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_197098 bait prey UBC SPG20 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16196087,18781797,19307600,19580544,20504295,20972266,21139048,21890473,21906983,21963094,21987572,22053931,22118674,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_176315|BIOGRID_197104|BIOGRID_223732|BIOGRID_268559|BIOGRID_164286|BIOGRID_163886|BIOGRID_222185|BIOGRID_153651|BIOGRID_143267|BIOGRID_160652|BIOGRID_162217|BIOGRID_264812|BIOGRID_153179|BIOGRID_177995|BIOGRID_168636 bait|prey|bait|bait|bait|bait|bait|prey|bait|bait|bait|bait|prey|bait|bait prey|bait|prey|prey|prey|prey|prey|bait|prey|prey|prey|prey|bait|prey|prey ACSL4 SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148363 prey|prey bait|bait ACSL3 SPG20 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_148364|UniProt_103074 prey|prey bait|bait HADHA SPG20 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_148362|UniProt_103074 prey|prey bait|bait CLTC SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148357 prey|prey bait|bait TUBA1A SPG20 MI:0055(fluorescent resonance energy transfer)|MI:0492(in vitro) 16945107 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_81492|HPRD_32721 prey|- bait|- SPG20 KLC2 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148354 bait|bait prey|prey SPG20 WWP1 MI:0676(tandem affinity purification)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 19307600,19580544,19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_103074|BIOGRID_197102|BIOGRID_197101|BIOGRID_148351|BIOGRID_153181|BIOGRID_197105|BIOGRID_197095 bait|bait|bait|bait|bait|prey|bait prey|prey|prey|prey|prey|bait|prey VIM SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148355 prey|prey bait|bait PLIN3 SPG20 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 19307600,23890011 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_197103|BIOGRID_197100|BIOGRID_283716 prey|prey|bait bait|bait|prey SPG20 WWOX MI:0004(affinity chromatography technology) 24550385 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309163 prey bait NCL SPG20 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_103075|UniProt_103074|BIOGRID_148360|BIOGRID_148367 prey|prey|prey|prey bait|bait|bait|bait WWP2 SPG20 MI:0018(two hybrid) 19307600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_197096 prey bait DYNC1H1 SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148352 prey|prey bait|bait KPNB1 SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148359 prey|prey bait|bait COPA SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148356 prey|prey bait|bait HSPD1 SPG20 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_148349|UniProt_103074 prey|prey bait|bait KIF5B SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148353 prey|prey bait|bait HSPA5 SPG20 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_103075|UniProt_103074|BIOGRID_148365|BIOGRID_148347 prey|prey|prey|prey bait|bait|bait|bait LMNB1 SPG20 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_103074|BIOGRID_148358 prey|prey bait|bait SMAD2 SPG20 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104975 bait prey HTT SPG20 - 23275563 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_126554 bait prey SPG20 APPL1 MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_126842 prey bait

PPI - HINT Gene A Gene B PMID Method Quality SEC16A SPG20 26496610,26496610 0007,0004 HT PLIN3 SPG20 19307600,23890011,19307600 0004,0096,0018 LC COQ9 SPG20 27499296 0004 HT CISD3 SPG20 27499296 0004 HT UBC SPG20 20972266,20504295,19580544,22118674,19307600 0004,0004,0004,0004,0004 LC CETN2 SPG20 26638075,26638075 1314,1313 HT RAD23B SPG20 26344197 0401 HT SPG20 ITCH 16055720,19765186,20504295,16055720,19580544,19765186 0096,0004,0004,0004,0004,0676 LC SPG20 WWP1 19765186,19765186,19307600,19307600,19580544,19307600 0676,0004,0428,0018,0004,0004 LC SPG20 DPH5 26344197 0401 HT SPG20 HYPK 26344197 0401 HT SEC16A SPG20 26496610,26496610 0007,0004 HT COQ9 SPG20 27499296 0004 HT CISD3 SPG20 27499296 0004 HT CETN2 SPG20 26638075,26638075 1314,1313 HT RAD23B SPG20 26344197 0401 HT SPG20 DPH5 26344197 0401 HT SPG20 HYPK 26344197 0401 HT PLIN3 SPG20 19307600,23890011,19307600 0004,0096,0018 LC UBC SPG20 20972266,20504295,19580544,22118674,19307600 0004,0004,0004,0004,0004 LC SPG20 ITCH 16055720,19765186,20504295,16055720,19580544,19765186 0096,0004,0004,0004,0004,0676 LC SPG20 WWP1 19765186,19765186,19307600,19307600,19580544,19307600 0676,0004,0428,0018,0004,0004 LC WWP2 SPG20 19307600 0018 LC PLIN3 SPG20 19307600,19307600 0004,0018 LC ZFYVE9 SPG20 15231748 0018 HT EPS15 SPG20 16036216,16036216 0096,0018 LC HTT SPG20 23275563 0729 HT IST1 SPG20 25657007 0114 LC RAD23B SPG20 26344197 0401 LC MAP3K1 SPG20 25260751 0415 LC SMAD2 SPG20 20195357 0034 LC TUBA1A SPG20 16945107 0055 LC SPG20 ITCH 19307600 0018 LC SPG20 WWP1 19307600,19307600,19307600 0428,0018,0004 LC SPG20 DPH5 26344197 0401 LC SPG20 SMURF2 15231748,19307600 0018,0018 HT,LC SPG20 SMURF1 20804422,19307600 0415,0018 LC SPG20 HYPK 26344197 0401 LC SPG20 APPL1 23414517 0399 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N0X7 O15027 SPG20 SEC16A 0.126 26496610 Q8N0X7 O00308 SPG20 WWP2 0.309 19307600 Q8N0X7 P05067 SPG20 APP 0.183 21832049 Q8N0X7 P0CG47 SPG20 UBB 0.21 19765186 Q8N0X7 Q71U36 SPG20 TUBA1A 0.309 16945107 Q8N0X7 Q7CGJ4 SPG20 PAPC 0.126 20711500 Q9HAU4 Q8N0X7 SMURF2 SPG20 0.539 15231748,19307600 Q9HCE7 Q8N0X7 SMURF1 SPG20 0.436 20804422,19307600 Q8N0X7 O60664 SPG20 PLIN3 0.623 23890011,19307600 Q9H0M0 Q8N0X7 WWP1 SPG20 0.814 19580544,19307600,19765186 Q9NZC7 Q8N0X7 WWOX SPG20 0.126 24550385 Q8N0X7 O75208 SPG20 COQ9 0.126 27499296 Q8N0X7 Q62925 SPG20 MAP3K1 0.033 25260751 Q8N0X7 P0C7P0 SPG20 CISD3 0.126 27499296 Q8N0X7 Q7CJG1 SPG20 CPXR 0.126 20711500 Q8N0X7 P0CG48 SPG20 UBC 0.126 16196087 Q8N0X7 Q14974 SPG20 KPNB1 0.376 19765186 Q8N0X7 Q14204 SPG20 DYNC1H1 0.376 19765186 Q8N0X7 Q00610 SPG20 CLTC 0.376 19765186 Q8N0X7 P53621 SPG20 COPA 0.376 19765186 Q8N0X7 P42566 SPG20 EPS15 0.523 16036216 Q8N0X7 P08670 SPG20 VIM 0.376 19765186 Q8N0X7 O60488 SPG20 ACSL4 0.376 19765186 Q8N0X7 O95831 SPG20 AIFM1 0.376 19765186 Q8N0X7 O95573 SPG20 ACSL3 0.376 19765186 Q8N0X7 P40939 SPG20 HADHA 0.376 19765186 Q8N0X7 P10809 SPG20 HSPD1 0.376 19765186 Q8N0X7 P20700 SPG20 LMNB1 0.376 19765186 Q8N0X7 P33176 SPG20 KIF5B 0.376 19765186 Q8N0X7 Q6GQQ9 SPG20 OTUD7B 0.236 unassigned1304 Q9H0B6 Q8N0X7 KLC2 SPG20 0.376 19765186 Q96DC9 Q8N0X7 OTUB2 SPG20 0.236 unassigned1304 Q8N0X7 Q7TSI3 SPG20 PPP6R1 0.236 26496610 Q8N0X7 O95208 SPG20 EPN2 0.236 unassigned1304 Q8N0X7 O95405 SPG20 ZFYVE9 0.332 15231748 Q8N0X7 P41208 SPG20 CETN2 0.236 26638075 Q8N0X7 P19338 SPG20 NCL 0.507 19765186 Q8N0X7 P11021 SPG20 HSPA5 0.507 19765186 Q8N0X7 P38646 SPG20 HSPA9 0.507 19765186 Q96J02 Q8N0X7 ITCH SPG20 0.731 19580544,19307600,19765186,20504295 Q9UKG1 Q8N0X7 APPL1 SPG20 0.126 23414517 Q8N0X7 P42858 SPG20 HTT 0.126 23275563 Q8N0X7 Q15796 SPG20 SMAD2 0.126 20195357 Q8N0X7 Q13233 SPG20 MAP3K1 0.183 25260751 Q8N0X7 Q16659 SPG20 MAPK6 0.126 26972000

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 WWP2 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database SEC16A SPG20 MI:0045 experimental interaction detection MI:0461 interaction database ACSL4 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database PLIN3 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database COQ9 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database ZFYVE9 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database ACSL3 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database AIFM1 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database GAS8 SPG20 MI:0362 inference MI:0461 interaction database APP SPG20 MI:0045 experimental interaction detection MI:0461 interaction database VIM SPG20 MI:0045 experimental interaction detection MI:0461 interaction database CISD3 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database UBB SPG20 MI:0045 experimental interaction detection MI:0461 interaction database UBC SPG20 MI:0045 experimental interaction detection MI:0461 interaction database HSPD1 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database HSPA5 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database NCL SPG20 MI:0045 experimental interaction detection MI:0461 interaction database LMNB1 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database KIF5B SPG20 MI:0045 experimental interaction detection MI:0461 interaction database HSPA9 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database HADHA SPG20 MI:0045 experimental interaction detection MI:0461 interaction database CETN2 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database EPS15 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database HTT SPG20 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A SPG20 MI:0362 inference MI:0461 interaction database NOVA1 SPG20 MI:0362 inference MI:0461 interaction database COPA SPG20 MI:0045 experimental interaction detection MI:0461 interaction database IST1 SPG20 MI:0362 inference MI:0461 interaction database SUMO2 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database CLTC SPG20 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database SQSTM1 SPG20 MI:0362 inference MI:0461 interaction database DYNC1H1 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database KPNB1 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 SPG20 MI:0045 experimental interaction detection MI:0461 interaction database TUBA1A SPG20 MI:0045 experimental interaction detection MI:0461 interaction database SPG20 TBC1D15 MI:0362 inference MI:0461 interaction database SPG20 ITCH MI:0045 experimental interaction detection MI:0461 interaction database SPG20 SLC39A3 MI:0362 inference MI:0461 interaction database SPG20 KLC2 MI:0045 experimental interaction detection MI:0461 interaction database SPG20 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database SPG20 MED20 MI:0045 experimental interaction detection MI:0461 interaction database SPG20 SMURF2 MI:0045 experimental interaction detection MI:0461 interaction database SPG20 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database SPG20 WWOX MI:0045 experimental interaction detection MI:0461 interaction database SPG20 APPL1 MI:0045 experimental interaction detection MI:0461 interaction database SPG20 NOVA2 MI:0362 inference MI:0461 interaction database SPG20 PPP6R1 MI:0362 inference MI:0461 interaction database SPG20 NME7 MI:0362 inference MI:0461 interaction database