Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 19 6801953 rs332425 C A rs332425 0.0003872 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 A intron GWASdb_drug 19 6801953 rs332425 C A rs332425 3.87E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 A intron GWASdb_drug 19 6801966 rs332426 G A rs332426 0.0003814 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 A intron GWASdb_drug 19 6801966 rs332426 G A rs332426 3.81E-04 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 A intron GWASdb_drug 19 6807732 rs12978597 T A rs12978597 0.00000212 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 T intron GWASdb_drug 19 6807732 rs12978597 T A rs12978597 2.12E-06 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 T intron GWASdb_drug 19 6808547 rs12710098 T G rs12710098 0.00000203 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 T intron GWASdb_drug 19 6808547 rs12710098 T G rs12710098 2.03E-06 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 T intron GWASdb_drug 19 6808656 rs12610223 G A rs12610223 0.00000146 INFLIXIMAB|ADALIMUMAB|IMMUNOGLOBULIN G TUMOR NECROSIS FACTOR-ALPHA|ANTIRHEUMATIC AGENTS|ANTIBODIES, MONOCLONAL, HUMANIZED|TNFR-FC FUSION PROTEIN|ANTIBODIES, MONOCLONAL|RECEPTORS, TUMOR NECROSIS FACTOR Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G intron GWASdb_drug 19 6808656 rs12610223 G A rs12610223 1.46E-06 LEUCOVORIN|METHOTREXATE SLCO1B1 PROTEIN, HUMAN|ORGANIC ANION TRANSPORTERS Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G intron GWASdb_drug 19 6782052 rs811292 G A rs811292 9.85E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 G intron GWASdb_trait 19 6782498 rs479660 C T rs479660 9.94E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 A intron GWASdb_trait 19 6782574 rs568259 C T rs568259 8.89E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 A intron GWASdb_trait 19 6782701 rs2546143 G A rs2546143 2.26E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 C intron GWASdb_trait 19 6786271 rs691528 G A rs691528 9.74E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 T intron GWASdb_trait 19 6786503 rs579371 G A rs579371 9.72E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 T,C intron GWASdb_trait 19 6788939 rs659657 T C rs659657 9.08E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 C intron GWASdb_trait 19 6788979 rs472835 C T rs472835 9.10E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 G intron GWASdb_trait 19 6791475 rs2546124 G A rs2546124 9.79E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 A intron GWASdb_trait 19 6792286 rs2660485 T C rs2660485 7.91E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 C intron GWASdb_trait 19 6792315 rs2546128 A G rs2546128 8.35E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 G intron GWASdb_trait 19 6792843 rs2617809 T C rs2617809 8.77E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 C intron GWASdb_trait 19 6792868 rs2546129 A G rs2546129 8.26E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 G intron GWASdb_trait 19 6793829 rs2546131 T C rs2546131 7.02E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 C intron GWASdb_trait 19 6793918 rs2546132 G T rs2546132 6.68E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 G intron GWASdb_trait 19 6794942 rs2660487 G A rs2660487 5.95E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 G intron GWASdb_trait 19 6795147 rs2617815 A G rs2617815 5.43E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 G intron GWASdb_trait 19 6795389 rs2617816 A G rs2617816 5.78E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 A intron GWASdb_trait 19 6795472 rs4807900 G A rs4807900 5.68E-05 Major depressive disorder (broad) HPOID:0000716 DOID:1470 G intron GWASdb_trait 19 6801953 rs332425 C A rs332425 0.0003872 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 A intron GWASdb_trait 19 6801953 rs332425 C A rs332425 3.87E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 A intron GWASdb_trait 19 6801966 rs332426 G A rs332426 0.0003814 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 A intron GWASdb_trait 19 6801966 rs332426 G A rs332426 3.81E-04 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 A intron GWASdb_trait 19 6803250 rs12232870 G A rs12232870 0.00000233 LDL cholesterol HPOID:0010979 DOID:1936|DOID:3393 G intron GWASdb_trait 19 6806689 rs8108646 A G rs8108646 2.04E-25 Narcolepsy HPOID:0100786 DOID:8986 A intron GWASdb_trait 19 6807732 rs12978597 T A rs12978597 0.00000212 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 T intron GWASdb_trait 19 6807732 rs12978597 T A rs12978597 2.12E-06 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 T intron GWASdb_trait 19 6808547 rs12710098 T G rs12710098 0.00000203 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 T intron GWASdb_trait 19 6808547 rs12710098 T G rs12710098 2.03E-06 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 T intron GWASdb_trait 19 6808656 rs12610223 G A rs12610223 3.67E-05 Graves' disease HPOID:0100647 DOID:12361 G intron GWASdb_trait 19 6808656 rs12610223 G A rs12610223 0.00000146 Anti-TNF treatment response in rheumatoid arthritis (by DAS-28 score change at 3 months) HPOID:0001370 DOID:7148 G intron GWASdb_trait 19 6808656 rs12610223 G A rs12610223 1.46E-06 Methotrexate clearance (acute lymphoblastic leukemia) HPOID:0006721 DOID:9952|DOID:12603 G intron GWASdb_trait 19 6815948 rs4807101 C T rs4807101 1.06E-05 Alcohol dependence HPOID:0000707 DOID:0050741 C intron GWASdb_trait 19 6836689 rs10419349 C T rs10419349 4.36E-08 Triglycerides HPOID:0003119 DOID:3393|DOID:3146|DOID:2349 C intron GWASdb_trait

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000141968.7 VAV1 164875