PTM - CPLM Gene Name UniProt ID Type Position Code VAV1; VAV P15498 Acetylation 222 K VAV1; VAV P15498 Acetylation 252 K VAV1; VAV P15498 Acetylation 716 K VAV1; VAV P15498 Acetylation 194 K VAV1; VAV P15498 Ubiquitination 222 K VAV1; VAV P15498 Ubiquitination 751 K VAV1; VAV P15498 Ubiquitination 815 K VAV1; VAV P15498 Ubiquitination 782 K VAV1; VAV P15498 Ubiquitination 788 K VAV1; VAV P15498 Ubiquitination 429 K VAV1; VAV P15498 Ubiquitination 307 K VAV1; VAV P15498 Ubiquitination 435 K VAV1; VAV P15498 Ubiquitination 374 K VAV1; VAV P15498 Ubiquitination 804 K VAV1; VAV P15498 Ubiquitination 272 K VAV1; VAV P15498 Ubiquitination 810 K VAV1; VAV P15498 Ubiquitination 208 K VAV1; VAV P15498 Ubiquitination 73 K VAV1; VAV P15498 Ubiquitination 577 K VAV1; VAV P15498 Ubiquitination 353 K VAV1; VAV P15498 Ubiquitination 410 K VAV1; VAV P15498 Ubiquitination 629 K VAV1; VAV P15498 Ubiquitination 194 K VAV1; VAV P15498 Ubiquitination 404 K VAV1; VAV P15498 Ubiquitination 444 K VAV1; VAV P15498 Ubiquitination 770 K VAV1; VAV P15498 Ubiquitination 85 K VAV1; VAV P15498 Ubiquitination 700 K VAV1; VAV P15498 Ubiquitination 335 K VAV1; VAV P15498 Ubiquitination 292 K VAV1; VAV P15498 Ubiquitination 345 K VAV1; VAV P15498 Ubiquitination 716 K VAV1; VAV P15498 Ubiquitination 188 K

PTM - dbPAF Gene Name UniProt ID Position Type Species VAV1; VAV P15498 110 Y Homo sapiens(Human) VAV1; VAV P15498 113 S Homo sapiens(Human) VAV1; VAV P15498 142 Y Homo sapiens(Human) VAV1; VAV P15498 160 Y Homo sapiens(Human) VAV1; VAV P15498 174 Y Homo sapiens(Human) VAV1; VAV P15498 180 S Homo sapiens(Human) VAV1; VAV P15498 192 Y Homo sapiens(Human) VAV1; VAV P15498 267 Y Homo sapiens(Human) VAV1; VAV P15498 280 Y Homo sapiens(Human) VAV1; VAV P15498 285 S Homo sapiens(Human) VAV1; VAV P15498 396 S Homo sapiens(Human) VAV1; VAV P15498 541 Y Homo sapiens(Human) VAV1; VAV P15498 574 T Homo sapiens(Human) VAV1; VAV P15498 603 Y Homo sapiens(Human) VAV1; VAV P15498 745 Y Homo sapiens(Human) VAV1; VAV P15498 780 S Homo sapiens(Human) VAV1; VAV P15498 783 Y Homo sapiens(Human) VAV1; VAV P15498 786 T Homo sapiens(Human) VAV1; VAV P15498 791 Y Homo sapiens(Human) VAV1; VAV P15498 826 Y Homo sapiens(Human) VAV1; VAV P15498 836 Y Homo sapiens(Human) VAV1; VAV P15498 841 Y Homo sapiens(Human) VAV1; VAV P15498 842 S Homo sapiens(Human) VAV1; VAV P15498 844 Y Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P15498 K194-ac Acetylation PKMTEyDkRCCCLRE P15498 K222-ac Acetylation sIQQHFLkPLQRFLK P15498 K252-ac Acetylation RVHTHFLkEMKEALG P15498 K345-ac Acetylation LLLQELVkHTQEAME P15498 K487-ac Acetylation QGYELFFkTRELKKK P15498 K716-ac Acetylation IKYNVEVkHIKIMTA P15498 K732-ac Acetylation GLYRITEkkAFRGLT P15498 K733-ac Acetylation LYRITEkkAFRGLTE P15498 Y110-p Phosphorylation QDFGKVIyTLsALSW P15498 S113-p Phosphorylation GKVIyTLsALSWTPI P15498 Y142-p Phosphorylation SVGDEDIySGLSDQI P15498 Y160-p Phosphorylation VEEDEDLyDCVENEE P15498 Y174-p Phosphorylation EAEGDEIyEDLMRsE P15498 S180-p Phosphorylation IyEDLMRsEPVSMPP P15498 Y192-p Phosphorylation MPPKMTEyDkRCCCL P15498 S215-p Phosphorylation KYTDTLGsIQQHFLk P15498 Y267-p Phosphorylation TPGAANLyQVFIKYK P15498 Y280-p Phosphorylation YKERFLVyGRYCsQV P15498 S285-p Phosphorylation LVyGRYCsQVESASk P15498 S396-p Phosphorylation SIENLDQsLAHYGRP P15498 Y541-p Phosphorylation MLLRGTFyQGYRCHR P15498 T574-p Phosphorylation HGQDFPGtMKKDKLH P15498 Y603-p Phosphorylation KMEVFQEyYGLPPPP P15498 Y745-p Phosphorylation LTELVEFyQQNSLkD P15498 S774-p Phosphorylation EPEkRTIsRPAVGsT P15498 S780-p Phosphorylation IsRPAVGsTKyFGtA P15498 Y783-p Phosphorylation PAVGsTKyFGtAkAR P15498 T786-p Phosphorylation GsTKyFGtAkARyDF P15498 Y791-p Phosphorylation FGtAkARyDFCARDR P15498 Y826-p Phosphorylation GWWRGEIyGRVGWFP P15498 Y836-p Phosphorylation VGWFPANyVEEDysE P15498 Y841-p Phosphorylation ANyVEEDysEyC___ P15498 S842-p Phosphorylation NyVEEDysEyC____ P15498 Y844-p Phosphorylation VEEDysEyC______ P15498 K73-ub Ubiquitination MSQFLCLkNIRTFLS P15498 K85-ub Ubiquitination FLSTCCEkFGLkRSE P15498 K89-ub Ubiquitination CCEkFGLkRSELFEA P15498 K194-ub Ubiquitination PKMTEyDkRCCCLRE P15498 K222-ub Ubiquitination sIQQHFLkPLQRFLK P15498 K292-ub Ubiquitination sQVESASkHLDRVAA P15498 K307-ub Ubiquitination AREDVQMkLEECSQR P15498 K335-ub Ubiquitination VPMQRVLkYHLLLQE P15498 K353-ub Ubiquitination HTQEAMEkENLRLAL P15498 K374-ub Ubiquitination AQCVNEVkRDNETLR P15498 K410-ub Ubiquitination PKIDGELkITSVERR P15498 K444-ub Ubiquitination RGDSYDLkDFVNLHS P15498 K555-ub Ubiquitination RCRASAHkECLGRVP P15498 K629-ub Ubiquitination GDIVELTkAEAEQNW P15498 K751-ub Ubiquitination FyQQNSLkDCFkSLD P15498 K755-ub Ubiquitination NSLkDCFkSLDTTLQ P15498 K770-ub Ubiquitination FPFKEPEkRTIsRPA P15498 K788-ub Ubiquitination TKyFGtAkARyDFCA

PTM - dbPTM UniProt ID Position Code Type Resources References P15498 222 K Acetylation Swiss-Prot 1010711 19608861 P15498 252 K Acetylation Swiss-Prot 1010711 19608861 P15498 716 K Acetylation Swiss-Prot 1010711 19608861 P15498 826 Y Phosphorylation Swiss-Prot 1010711 15592455 P15498 174 Y Phosphorylation PhosphoELM.10011 10669745;898671 P15498 844 Y Phosphorylation PhosphoELM.10011 16497976 P15498 142 Y Phosphorylation PhosphoELM.10011 16285729 P15498 160 Y Phosphorylation PhosphoELM.10011 15699036;16285729 P15498 222 K Ubiquitylation Phosphositeplus.1010730 21890473 P15498 307 K Ubiquitylation Phosphositeplus.1010730 21906983 P15498 335 K Ubiquitylation Phosphositeplus.1010730 21906983 P15498 353 K Ubiquitylation Phosphositeplus.1010730 21906983 P15498 374 K Ubiquitylation Phosphositeplus.1010730 21906983 P15498 410 K Ubiquitylation Phosphositeplus.1010730 21906983 P15498 444 K Ubiquitylation Phosphositeplus.1010730 21906983 P15498 751 K Ubiquitylation Phosphositeplus.1010730 21906983 P15498 222 K Acetylation Phosphositeplus.1010730 19608861 P15498 252 K Acetylation Phosphositeplus.1010730 19608861 P15498 716 K Acetylation Phosphositeplus.1010730 19608861 P15498 142 Y Phosphorylation Phosphositeplus.1010730 16285729;17050525 P15498 160 Y Phosphorylation Phosphositeplus.1010730 15699036;16285729;17050525 P15498 174 Y Phosphorylation Phosphositeplus.1010730 10636924;12881521;15699036;15708849;16285729;17050525;18587398;20028078;22679023 P15498 267 Y Phosphorylation Phosphositeplus.1010730 20090780 P15498 280 Y Phosphorylation Phosphositeplus.1010730 18083107 P15498 745 Y Phosphorylation Phosphositeplus.1010730 20028078 P15498 791 Y Phosphorylation Phosphositeplus.1010730 16493040 P15498 826 Y Phosphorylation Phosphositeplus.1010730 15592455;18083107;20457609 P15498 836 Y Phosphorylation Phosphositeplus.1010730 20457609 P15498 841 Y Phosphorylation Phosphositeplus.1010730 20457609 P15498 844 Y Phosphorylation Phosphositeplus.1010730 16464493;16493040;16497976;18083107;18180459;19605366;20457609;21394647 P15498 222 K Acetylation HPRD 9.0 19608861 P15498 252 K Acetylation HPRD 9.0 19608861 P15498 716 K Acetylation HPRD 9.0 19608861 P15498 826 Y Phosphorylation HPRD 9.0 15592455 P15498 836 Y Phosphorylation HPRD 9.0 16497976 P15498 841 Y Phosphorylation HPRD 9.0 16497976 P15498 844 Y Phosphorylation HPRD 9.0 16497976 P15498 142 Y Phosphorylation (LCK) HPRD 9.0 10669745 P15498 160 Y Phosphorylation (LCK) HPRD 9.0 10669745 P15498 174 Y Phosphorylation (LCK) HPRD 9.0 10669745

PTM - HPRD Symbol Position Code Type References VAV1 142 Y Phosphorylation 10669745 VAV1 160 Y Phosphorylation 10669745 VAV1 174 Y Phosphorylation 10669745 VAV1 222 K Acetylation 19608861 VAV1 252 K Acetylation 19608861 VAV1 716 K Acetylation 19608861 VAV1 826 Y Phosphorylation 15592455 VAV1 836 Y Phosphorylation 16497976 VAV1 841 Y Phosphorylation 16497976 VAV1 844 Y Phosphorylation 16497976

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P15498 160 Y 15699036 LTP Phosphorylation P15498 160 Y 16285729 Lck LTP Phosphorylation P15498 844 Y 16497976 HTP Phosphorylation P15498 142 Y 16285729 Lck LTP Phosphorylation P15498 174 Y 10669745 LTP Phosphorylation P15498 174 Y 898671 LTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P15498 826 Phosphotyrosine 15592455

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type VAV1 IPI00011696 K 222 IQQHFLaKPLQRFL acetylation VAV1 IPI00011696 K 252 VHTHFLaKEMKEAL acetylation VAV1 IPI00011696 K 716 KYNVEVaKHIKIMT acetylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7409 113252 - K Ubiquitination 12881521 7409 113252 - K Ubiquitination 16356860 7409 113252 - K Ubiquitination 21890473 7409 113252 - K Ubiquitination 21906983 7409 113252 - K Ubiquitination 20189481 7409 113252 - K Ubiquitination 10747851 7409 113252 - K Ubiquitination 22505724 7409 113252 - K Ubiquitination 24816145

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID VAV1 Homo sapiens (Human) 410; 222; 307; 374; 444; 751; 353; 335 "410,KIDGELKITSVER; 222,IQQHFLKPLQRFL; 307,REDVQMKLEECSQ; 374,QCVNEVKRDNETL; 444,GDSYDLKDFVNLH; 751,YQQNSLKDCFKSL; 353,TQEAMEKENLRLA; 335,PMQRVLKYHLLLQ" 410:21906983; 222:21890473; 307:21906983; 374:21906983; 444:21906983; 751:21906983; 353:21906983; 335:21906983 VAV1 Homo sapiens (Human) 222 "222,IQQHFLKPLQRFL" 222:21890473 VAV1 Homo sapiens (Human) 222 "222,IQQHFLKPLQRFL" 222:21890473 VAV1 Homo sapiens (Human) 222 "222,IQQHFLKPLQRFL" 222:21890473