DNA & RNA Element - UTRdb Gene Name Type ASPicDB UTRaspic Refseq ID Genome VAV1 3'UTR ccda0ae083 BA118061 NM_005428 chr19:6808119-6808371:+ VAV1 3'UTR 9a0104ce2d BA118062 NM_005428 chr19:6808119-6808377:+ VAV1 3'UTR 4f8fa255ba BA118063 NM_005428 chr19:6808119-6808377:+ VAV1 3'UTR 0c9ff35174 BA118064 NM_005428 chr19:6808119-6808377:+ VAV1 3'UTR 4422f8f5ea BA118065 NM_005428 chr19:6808119-6808377:+ VAV1 3'UTR fff2aad02a BA118066 NM_005428 chr19:6808119-6808377:+ VAV1 3'UTR 836c66ae17 BA118067 NM_005428 chr19:6808119-6808377:+ VAV1 3'UTR 2f75626a72 BA118068 NM_005428 chr19:6777927-6778115:+ VAV1 3'UTR 72bd805280 BA118069 NM_005428 chr19:6777927-6778115:+ VAV1 3'UTR 055e057310 BA118070 NM_005428 chr19:6808119-6808377:+ VAV1 5'UTR ccda0ae083 CA185488 NM_005428 chr19:6723722-6723818:+ VAV1 5'UTR 9a0104ce2d CA185489 NM_005428 chr19:6735129-6735213:+ VAV1 5'UTR 4f8fa255ba CA185490 NM_005428 chr19:6723679-6723818:+ VAV1 5'UTR 0c9ff35174 CA185491 NM_005428 chr19:6723679-6723818:+ VAV1 5'UTR 4422f8f5ea CA185492 NM_005428 chr19:6779326-6779456:+ VAV1 5'UTR fff2aad02a CA185493 NM_005428 chr19:6779457-6779903:+ VAV1 5'UTR 836c66ae17 CA185494 NM_005428 chr19:6779457-6779903:+ VAV1 5'UTR 2f75626a72 CA185495 NM_005428 chr19:6723679-6723818:+ VAV1 5'UTR 72bd805280 CA185496 NM_005428 chr19:6735129-6735213:+ VAV1 5'UTR 055e057310 CA185497 NM_005428 chr19:6801445-6801711:+

DNA & RNA Element - AREsite Gene Name Motif CDS Area ARE Area Evidence VAV1; VAV ATTTA 98-2635 2805-2809;2866-2870 VAV1; VAV WWATTTAWW 98-2635 2803-2811 VAV1; VAV WWWATTTAWWW 98-2635 2802-2812

DNA & RNA Element - circBase circRNA ID Chrom Start End Strand hsa_circ_0048934 chr19 6836442 6854109 + hsa_circ_0048933 chr19 6826622 6829929 + hsa_circ_0048930 chr19 6822231 6825417 + hsa_circ_0048932 chr19 6825063 6857371 + hsa_circ_0048928 chr19 6820712 6825132 + hsa_circ_0048927 chr19 6772721 6773022 + hsa_circ_0048931 chr19 6825063 6825417 + hsa_circ_0048929 chr19 6821801 6825132 +

DNA & RNA Element - circRNADb circRNA ID Chrom Start End Strand Samples hsa_circ_18364 chr19 6850680 6854109 + leukemia hsa_circ_29965 chr19 6820712 6822525 + leukemia

DNA & RNA Element - CircNet Circ ID GITPosition Express Symbol Entrez Category Strand Refered Name hsa-circ-VAV1-overlap.3 NM_005428Tchr19:6825063-6857371 expressed VAV1 7409 protein-coding + hsa_circ_0048932 hsa-circ-VAV1.1 NM_005428Tchr19:6821801-6825132 none VAV1 7409 protein-coding + hsa_circ_0048929 hsa-circ-VAV1.11 NM_001258207Tchr19:6826622-6829929 none VAV1 7409 protein-coding + hsa_circ_0048933 hsa-circ-VAV1.12 NM_005428Tchr19:6825063-6825417 none VAV1 7409 protein-coding + hsa_circ_0048931 hsa-circ-VAV1.13 NM_005428Tchr19:6822231-6825417 expressed VAV1 7409 protein-coding + hsa_circ_0048930 hsa-circ-VAV1.18 NM_001258206Tchr19:6836442-6854109 expressed VAV1 7409 protein-coding + hsa_circ_0048934 hsa-circ-VAV1.2 NM_001258206Tchr19:6820712-6825132 expressed VAV1 7409 protein-coding + hsa_circ_0048928 hsa-circ-VAV1.20 NM_005428Tchr19:6832101-6837061 expressed VAV1 7409 protein-coding x chr19:6832101-6837061_GM12878_poly(A)- hsa-circ-VAV1.21 NM_001258206Tchr19:6820712-6820829 expressed VAV1 7409 protein-coding x chr19:6820712-6820829_GM12878_poly(A)- hsa-circ-VAV1.24 NM_001258206Tchr19:6843145-6850768 expressed VAV1 7409 protein-coding + not_available hsa-circ-VAV1.3 NM_001258207Tchr19:6820712-6825132 expressed VAV1 7409 protein-coding + hsa_circ_0048928 hsa-circ-VAV1.5 NM_001258207Tchr19:6821801-6825132 expressed VAV1 7409 protein-coding + hsa_circ_0048929 hsa-circ-VAV1.7 NM_005428Tchr19:6836442-6854109 none VAV1 7409 protein-coding + hsa_circ_0048934 hsa-circ-VAV1.9 NM_001258207Tchr19:6822231-6825417 expressed VAV1 7409 protein-coding + hsa_circ_0048930

DNA & RNA Element - miRTarBase Target Gene (Entrez ID) miRTarBase ID miRNA Species (miRNA) Target Gene Species (Target Gene) Experiments Support Type References (PMID) MIRT029179 hsa-miR-26b-5p Homo sapiens VAV1 7409 Homo sapiens Microarray Functional MTI (Weak) 19088304

DNA & RNA Element - microRNA Mirbase Acc miRNA Name Gene ID Gene Symbol miRNA Alignment Alignment Gene Alignment miRNA Start miRNA End Gene Start Gene End Genome Coordinates Conservation Align Score Seed Cat Energy mirSVR Score MIMAT0004612 hsa-miR-186* 7409 VAV1 ggguuuuuuaagugGAAACCCg ||||||| ccggcggguggagaCUUUGGGa 2 9 87 108 [hg19:19:6857205-6857226:+] 0.5797 140 7 -17.78 -0.6244 MIMAT0000705 hsa-miR-362-5p 7409 VAV1 ugAGUGUGGAUCCAAGGUUCCUAa |:|||::|| | |||||| ggUUACAUUUA--AUAAAAGGAUg 2 23 225 246 [hg19:19:6857343-6857364:+] 0.5449 127 6 -13.92 -0.1258 MIMAT0000716 hsa-miR-302c* 7409 VAV1 guCGUCCAUGGGG--GUA-CAAUUu | | ||:|||: ||| ||||| cgGGAUGUGCCCUGACAUGGUUAAu 2 21 147 171 [hg19:19:6857265-6857289:+] 0.6289 127 0 -18.19 -0.8177 MIMAT0004690 hsa-miR-379* 7409 VAV1 ucaaucaccugguaCAAUGUAu ||||||| cggggcucaaggggGUUACAUu 2 9 212 233 [hg19:19:6857330-6857351:+] 0.5449 140 7 -13.86 -0.1657 MIMAT0004694 hsa-miR-342-5p 7409 VAV1 aguuAGUGUCUAUCGUGGGGa | |: ||| |||||| ugguUAAUUUAUAACACCCCg 2 18 164 184 [hg19:19:6857282-6857302:+] 0.6289 125 6 -13.95 -0.1635 MIMAT0004773 hsa-miR-500 7409 VAV1 agaGUGGGUCCAUCGUUCCUAau ||:::| || |||||| uuaCAUUUA-AUA-AAAGGAUga 3 21 227 247 [hg19:19:6857345-6857365:+] 0.5449 124 0 -10.16 -0.1522 MIMAT0002872 hsa-miR-501-5p 7409 VAV1 agagugggucccugUUUCCUAa ||||||| gguuacauuuaauaAAAGGAUg 2 9 225 246 [hg19:19:6857343-6857364:+] 0.5449 140 7 -11.59 -1.0768 MIMAT0004784 hsa-miR-455-3p 7409 VAV1 cacauauacgggUACCUGACg |||||||| ggagacuuugggAUGGACUGg 2 10 96 116 [hg19:19:6857214-6857234:+] 0.5797 145 7 -13.06 -0.1003 MIMAT0003261 hsa-miR-593* 7409 VAV1 cgacucguuacggaccGACCACGGa |||||||| -------------gccCUGGUGCCu 2 10 1 12 [hg19:19:6857119-6857130:+] 0.6515 145 7 -20.05 -0.4119 MIMAT0003276 hsa-miR-608 7409 VAV1 ugccucgacaggguugugGUGGGGa |||||| gacaugguuaauuuauaaCACCCCg 2 8 160 184 [hg19:19:6857278-6857302:+] 0.6289 120 6 -17.35 -0.1635 MIMAT0003277 hsa-miR-609 7409 VAV1 ucucuacucucuUUGUGGGa ||||||| ugguuaauuuauAACACCCc 2 9 164 183 [hg19:19:6857282-6857301:+] 0.6289 140 7 -10.77 -0.9639 MIMAT0004813 hsa-miR-411* 7409 VAV1 ccaaucaccuggCACAAUGUAu | ||||||| cggggcucaaggGGGUUACAUu 2 11 212 233 [hg19:19:6857330-6857351:+] 0.5449 142 7 -12.96 -0.1657 MIMAT0005573 hsa-miR-1225-3p 7409 VAV1 gacccccgcCGUGU-CCCCGAGu ||| | ||||||| uccccucaaGCAGACGGGGCUCa 2 14 198 220 [hg19:19:6857316-6857338:+] 0.5449 148 7 -21.29 -0.3061 MIMAT0005905 hsa-miR-1254 7409 VAV1 ugacguccgaggucgaAGGUCCGa ||||||| cagagagacgagaaacUCCAGGCu 2 9 16 39 [hg19:19:6857134-6857157:+] 0.5979 140 7 -19.89 -0.1527 MIMAT0012734 hsa-miR-711 7409 VAV1 gaauGC-AGAGAGGGACCCAGGg || |:|| :|:||||||| acccCGAUUUCCUCUUGGGUCCc 2 19 179 201 [hg19:19:6857297-6857319:+] 0.6115 161 7 -29.49 -0.4344 MIMAT0014978 hsa-miR-3116 7409 VAV1 ucagggaugauacaAGGUCCGu ||||||| gagagacgagaaacUCCAGGCu 2 9 18 39 [hg19:19:6857136-6857157:+] 0.5979 140 7 -12.83 -0.1512 MIMAT0014988 hsa-miR-3125 7409 VAV1 agaGAGGUGUCGAAGGAGAu | || |: :||||||| uaaCACCCCGAUUUCCUCUu 2 18 175 194 [hg19:19:6857293-6857312:+] 0.6780 153 7 -17.84 -0.5481 MIMAT0014990 hsa-miR-3127 7409 VAV1 gaAGGGUAAGGUGUUCGGGACUa ||||: |:: ||||||| gcUCCCG--GGAUGUGCCCUGAc 2 22 142 162 [hg19:19:6857260-6857280:+] 0.5797 146 7 -21.92 -0.4673 MIMAT0015014 hsa-miR-3144-5p 7409 VAV1 gauaUAUA-GAGAAACCAGGGGa || | ||||| ||||||| cccgAUUUCCUCUUGGGUCCCCu 2 19 181 203 [hg19:19:6857299-6857321:+] 0.6115 165 7 -24.43 -0.6215 MIMAT0016884 hsa-miR-4254 7409 VAV1 cuCUACCACCUCAUCGAGGUCCg || | ||| | ||||||| caGAGAGACGAGAAACUCCAGGc 2 22 16 38 [hg19:19:6857134-6857156:+] 0.5979 157 7 -24.54 -0.3260 MIMAT0016925 hsa-miR-500b 7409 VAV1 uggguccaucgUUCCUAa |||||| acauuuaauaaAAGGAUg 2 8 229 246 [hg19:19:6857347-6857364:+] 0.5449 120 6 -5.87 -0.1283 MIMAT0000422 hsa-miR-124 7409 VAV1 ccguaaguGGCGCACGGAAu || ||||||| ------gcCCUGGUGCCUUg 2 13 1 14 [hg19:19:6857119-6857132:+] 0.6515 144 7 -16.51 -0.1433 MIMAT0002878 hsa-miR-506 7409 VAV1 agaugagucuucCCACGGAAu |||||||| -------gcccuGGUGCCUUg 2 10 1 14 [hg19:19:6857119-6857132:+] 0.6515 145 7 -15.12 -0.1433

DNA & RNA Element - TRANSFAC Accession AS Description Species Entrez Pubmed Binding Info G004620 MO000033147 VAV1 Homo sapiens 7409 11835402 -39 -22 R68630; HS$VAV1_04; Binding factors: c-Myb //-38 -25 R62519; HS$VAV1_02; Binding factors: c-Myb //-25 -3 R39268; HS$VAV1_01; Binding factors: PU.1 , PU.1 //-22 -5 R62520; HS$VAV1_03; Binding factors: Elf-1

DNA & RNA Element - miRWalk Gene Name miRNAname Entrez ID Pathways VAV1 hsa-miR-26b-5p 7409 hsa04062_Chemokine signaling pathway VAV1 hsa-miR-26b-5p 7409 hsa04510_Focal adhesion VAV1 hsa-miR-26b-5p 7409 hsa04650_Natural killer cell mediated cytotoxicity VAV1 hsa-miR-26b-5p 7409 hsa04660_T cell receptor signaling pathway VAV1 hsa-miR-26b-5p 7409 hsa04662_B cell receptor signaling pathway VAV1 hsa-miR-26b-5p 7409 hsa04664_Fc epsilon RI signaling pathway VAV1 hsa-miR-26b-5p 7409 hsa04666_Fc gamma R mediated phagocytosis VAV1 hsa-miR-26b-5p 7409 hsa04670_Leukocyte transendothelial migration VAV1 hsa-miR-26b-5p 7409 hsa04810_Regulation of actin cytoskeleton

DNA & RNA Element - RepTar Gene Name miRNA Begin End Profile VAV1 hsa-miR-501-5p beg:227 end:246 pic:3' AGAGTGGGTCCCTGTTTCCTAA 5'& ||...| ||||||| &5' ---CATTTAATA--AAAGGAT- 3' VAV1 hsa-miR-609 beg:173 end:183 pic:3' TCTCTACTCTCTTTGTGGGA 5'& ||||||| &5' ------------AACACCC- 3' VAV1 hsa-miR-920 beg:71 end:89 pic:3' ATGACGAAGGTGTCGAGGGG 5'& .|||. ||||||||| &5' -GCTGTG---ACAGCTCCC- 3' VAV1 ebv-miR-BART13 beg:211 end:232 pic:3' AGTCGGCA--GGGACCGTTCAATGT 5'& || |.| | ..|||||| &5' -----CGGGGCTCAAGGGGGTTACA 3' VAV1 ebv-miR-BART17-5p beg:179 end:196 pic:3' GAACATACGGACGCAGGAGAAT 5'& || |||||||. &5' --------CCGATTTCCTCTTG 3' VAV1 ebv-miR-BART5star beg:50 end:71 pic:3' TCCACTTGTCGCCG-GGTG 5'& .|| ..|||||| ||| &5' GGGCAGGCAGCGGAGCCA- 3' VAV1 hsa-miR-124 beg:1 end:15 pic:3' CCGTAAGTGGCGCACGGAAT 5'& |.| |||||||. &5' --------CTG-GTGCCTTG 3' VAV1 hsa-miR-506 beg:3 end:15 pic:3' AGATGAGTCTTCCCACGGAAT 5'& ||||||||. &5' ------------GGTGCCTTG 3' VAV1 hcmv-miR-US25-2-3p beg:79 end:99 pic:3' GGCGCCCTCGAGAGGT---TCACCTA 5'& ||||| ||. .||||| &5' -------AGCTC-CCGGCGGGTGGA- 3' VAV1 hiv1-miR-TAR-5p beg:1 end:24 pic:3' AGTCTAGACCA--GATTGGTCTCTCT 5'& ||||| || . |||||||| &5' ------CTGGTGCCTTGGCAGAGAGA 3' VAV1 hsa-miR-1202 beg:120 end:139 pic:3' GAGGGGGTGAC-GTCGACCGTG 5'& || .| ||||||||. &5' ----CCAGCGTCCAGCTGGCG- 3' VAV1 hsa-miR-1233 beg:204 end:221 pic:3' GACGCCCTCCTGTCCCGAGT 5'& || |||.||||||| &5' --GCA----GACGGGGCTCA 3' VAV1 hsa-miR-1238 beg:102 end:122 pic:3' CCCCGTCTG-TCTGCTCCTTC 5'& ||| .||| .|| |||| &5' GGGATGGACTGGAGGAGG--- 3' VAV1 hsa-miR-1251 beg:3 end:23 pic:3' TCGCGGAAACCGTCGATCTCA 5'& .|.||| ||||||| |||| &5' GGTGCC-TTGGCAG--AGAG- 3' VAV1 hsa-miR-1296 beg:22 end:44 pic:3' CCTCTACCTCGGTCCCGGGATT 5'& |||| ||| |||.||.| &5' -GAGAAACT-CCA-GGCTCTGA 3' VAV1 hsa-miR-1296 beg:143 end:162 pic:3' CCTCTACCTCGGTCC----CGGGATT 5'& ||.|| |||||.| &5' ----------CCGGGATGTGCCCTGA 3' VAV1 hsa-miR-1468 beg:44 end:67 pic:3' GTCGC-TTTGTCCGTTTGCCTC 5'& |.||| ...||||| |.||||| &5' CGGCGTGGGCAGGC-AGCGGAG 3' VAV1 hsa-miR-1471 beg:27 end:57 pic:3' TGTGGACCGAGG--TG---TGCGCCCG 5'& || || |||||. .| .||.|||| &5' ACTCCAGGCTCTGAGCCCGGCGTGGGC 3' VAV1 hsa-miR-149 beg:50 end:71 pic:3' CCCTCACT--TCTGT-GCCTCGGTCT 5'& |||. ||.|| ||||||||| &5' ----GTGGGCAGGCAGCGGAGCCAG- 3' VAV1 hsa-miR-1538 beg:50 end:78 pic:3' TCC--TTGTCGTCGTCGGG-CCCGGC 5'& .|| ..||||.| |||| ||||.| &5' GGGCAGGCAGCGG-AGCCAGGGGCTG 3' VAV1 hsa-miR-183star beg:152 end:176 pic:3' AATAC-CGGGAA---GCC-ATTAAGTG 5'& | ||||| .|| |||||.|. &5' ----GTGCCCTGACATGGTTAATTTAT 3' VAV1 hsa-miR-205 beg:97 end:121 pic:3' GTCTGAGGCC--ACCTTACTTCCT 5'& |||||..|| |||| ||.|||| &5' -AGACTTTGGGATGGACTGGAGGA 3' VAV1 hsa-miR-2114star beg:204 end:220 pic:3' TTCAGGGAACGAA--CTCCGAGC 5'& || |.||||| &5' ---------GCAGACGGGGCTC- 3' VAV1 hsa-miR-2117 beg:1 end:24 pic:3' GACA--GGAACCGTTTCTCTTGT 5'& ||| ||||||||.||||| &5' CTGGTGCCTTGGCAGAGAGA--- 3' VAV1 hsa-miR-218-1star beg:49 end:71 pic:3' GGTACCACGAAC--TGCCTTGGTA 5'& |.||| || | .||||.||| &5' -CGTGG-GCAGGCAGCGGAGCCA- 3' VAV1 hsa-miR-24 beg:29 end:47 pic:3' GACAAGGA-CGACTTGACTCGGT 5'& ||| ||| ||||||| &5' ----TCCAGGCT---CTGAGCC- 3' VAV1 hsa-miR-2861 beg:21 end:42 pic:3' GGCGGG-TGGCGGTCCGGGG 5'& || ||. ||||||.|. &5' -CGAGAAACT-CCAGGCTCT 3' VAV1 hsa-miR-2909 beg:145 end:163 pic:3' GGTTCTCTACAACCGGGATTG 5'& |.||||| |||||.|| &5' ----GGGATGT--GCCCTGAC 3' VAV1 hsa-miR-2909 beg:21 end:44 pic:3' GGTTCTCTACAA-CCGGGATTG 5'& |.||| |||.||.| &5' -CGAGAAACTCCAGGCTCTGA- 3' VAV1 hsa-miR-30dstar beg:108 end:120 pic:3' CGTCGTTTGTAGACTGACTTTC 5'& |||||.|.| &5' -------------GACTGGAGG 3' VAV1 hsa-miR-30estar beg:108 end:120 pic:3' CGACATTTGTAGGCTGACTTTC 5'& |||||.|.| &5' -------------GACTGGAGG 3' VAV1 hsa-miR-3125 beg:177 end:193 pic:3' AGAGAGGTGTCGAAGGAGAT 5'& || |. .||||||| &5' -----CCCCGATTTCCTCT- 3' VAV1 hsa-miR-3127 beg:141 end:162 pic:3' GAAGGGTAAGGTGTTCGGGACTA 5'& ||||. ||||||| &5' --TCCCGGGATGT--GCCCTGA- 3' VAV1 hsa-miR-3144-5p beg:187 end:204 pic:3' GATATATAGAGAAACCAGGGGA 5'& ||||| |||||||| &5' --------CTCTTGGGTCCCCT 3' VAV1 hsa-miR-3172 beg:15 end:36 pic:3' ATTC-CTGACGTTTTGGGGT 5'& .|| ||| .||||.||| &5' -GAGAGACGA-GAAACTCCA 3' VAV1 hsa-miR-3195 beg:33 end:54 pic:3' TTGGGCC-CGGGCCGCGC 5'& ..|.| | ||||||||.| &5' GGCTCTGAGCCCGGCGTG 3' VAV1 hsa-miR-346 beg:39 end:62 pic:3' TCTCCGTCCGTACGCCCGTCTGT 5'& ||| | ||| |.||||||.|| &5' -GAGCCCGGC--GTGGGCAGGCA 3' VAV1 hsa-miR-4253 beg:139 end:160 pic:3' TGGGGGACCTGTACGGGA 5'& .|.||| |||..|||||| &5' GCTCCCGGGATGTGCCCT 3' VAV1 hsa-miR-4254 beg:17 end:39 pic:3' CTCTACCACCTCATCGAGGTCCG 5'& |||| ||| |||||||| &5' GAGAGAC--GAGAAACTCCAGGC 3' VAV1 hsa-miR-4288 beg:192 end:213 pic:3' CCTTT--GAG-TCGTCTGTT 5'& ||. ||| |||||||. &5' GGGTCCCCTCAAGCAGACG- 3' VAV1 hsa-miR-4289 beg:147 end:168 pic:3' ACTAT-CGGGAC-GTGTTACG 5'& |||. |||||| || .| &5' -GATGTGCCCTGACATGGT-- 3' VAV1 hsa-miR-4300 beg:68 end:89 pic:3' CTTCATCAG-GTCGAGGGT 5'& |..| || |||||||| &5' GGGGCTGTGACAGCTCCC- 3' VAV1 hsa-miR-4308 beg:17 end:38 pic:3' TTCT--TCTTTGAGGTCCCT 5'& .||| |||||||||||| &5' GAGACGAGAAACTCCAGG-- 3' VAV1 hsa-miR-4313 beg:210 end:229 pic:3' CCCAAACCCCGG--TCCCCCGA 5'& |||||. ||||||.| &5' ------GGGGCTCAAGGGGGTT 3' VAV1 hsa-miR-455-3p beg:105 end:116 pic:3' CACATATACGGGTACCTGACG 5'& |||||||| &5' ------------ATGGACTG- 3' VAV1 hsa-miR-511 beg:3 end:25 pic:3' ACTGACGTC-TCGT-TTTCTGTG 5'& |. ||| .||| |.||||. &5' -GG-TGCCTTGGCAGAGAGACG- 3' VAV1 hsa-miR-516b beg:14 end:38 pic:3' TTTCACGAAGAATGGAGGTCTA 5'& |.|| | ||||||. &5' AGAGAGACGAGAAACTCCAGG- 3' VAV1 hsa-miR-525-3p beg:0 end:14 pic:3' GCGAGATTTCCCTTCGCGGAAG 5'& || || .|.||||| &5' -GCCCT-------GGTGCCTT- 3' VAV1 hsa-miR-554 beg:97 end:117 pic:3' TGACCGACTCAGTCCTGATCG 5'& ||| .||.| |||||.| &5' ACT--TTGGGAT-GGACTGG- 3' VAV1 hsa-miR-561 beg:89 end:106 pic:3' TGAAGTTCCTAGAATTTGAAAC 5'& ||.| |.|||||| &5' -------GGGTGG-AGACTTTG 3' VAV1 hsa-miR-572 beg:116 end:139 pic:3' AC-CCGGTGGCGGCTCGCCTG 5'& | ||||| ||.| ||| |.| &5' -GAGGCCAGCGTCCAGCTGGC 3' VAV1 hsa-miR-593star beg:0 end:13 pic:3' CGACTCGTTACGGACCGACCACGGA 5'& ||| ||||||||| &5' ----------GCC---CTGGTGCCT 3' VAV1 hsa-miR-609 beg:15 end:35 pic:3' TCTCTACT-CTCTTTGTGGGA 5'& ||||| || ||||||| || &5' AGAGA-GACGAGAAACTCC-- 3' VAV1 hsa-miR-627 beg:210 end:221 pic:3' AGGAGAAAAGAATCTCTGAGTG 5'& |.|.|||| &5' -------------GGGGCTCA- 3' VAV1 hsa-miR-632 beg:42 end:62 pic:3' AGGGTGTCCTTCGTCTGTG 5'& |||. | .||||.|| &5' -CCCGGCGTGGGCAGGCA- 3' VAV1 hsa-miR-639 beg:46 end:66 pic:3' TGTCGCGAGCGTTGGCGTCGCTA 5'& |.|||. |||. ||||||. &5' -CGGCGTGGGCAG--GCAGCGG- 3' VAV1 hsa-miR-662 beg:35 end:56 pic:3' GACGACCCGGTGTTGCACCCT 5'& || ||| ||| |..|||||| &5' CT-CTGAGCC-CGGCGTGGG- 3' VAV1 hsa-miR-711 beg:180 end:202 pic:3' GAATGC-AGAGAGGGACCCAGGG 5'& || |.|| |.|||||||| &5' ----CGATTTCCTCTTGGGTCCC 3' VAV1 hsa-miR-718 beg:80 end:100 pic:3' GCTGCGGGCCGCCCCGCCTTC 5'& .| |||||| |||.|||. &5' --GCTCCCGGC-GGGTGGAG- 3' VAV1 hsa-miR-744star beg:45 end:66 pic:3' TCCAACTCCA-ATCA--CCGTTGTC 5'& || |.| ||||.|.| &5' -------GGCGTGGGCAGGCAGCGG 3' VAV1 hsa-miR-760 beg:52 end:70 pic:3' AGGGGTGTCTGG-GTCTCGGC 5'& .|||.| |.||||| &5' -----GCAGGCAGCGGAGCC- 3' VAV1 hsa-miR-96star beg:149 end:169 pic:3' GTATAAC-CGTGACGTGTACTAA 5'& || || ||| |||||.|| &5' -----TGTGCCCTG-ACATGGTT 3' VAV1 hsv1-miR-H18 beg:78 end:98 pic:3' CCAGGGCCGCAGGCCGCCCGCCC 5'& | || ||||||||.|| &5' -----CAGCTCCCGGCGGGTGG- 3' VAV1 hsv2-miR-H13 beg:139 end:162 pic:3' GTCACGAGCGTGAA--ACGGGATT 5'& |||||| |. ||||||.| &5' --GTGCTCCCGGGATGTGCCCTGA 3'

DNA & RNA Element - miRcode Gene Name Type microRNA Seed Position Seed Type Total Cons% Tr Region VAV1 High_conserved miR-503 chr19:6822461 7-mer-m8 31 CDS VAV1 High_conserved miR-133abc chr19:6832135 7-mer-m8 42 CDS VAV1 High_conserved miR-138/138ab chr19:6852998 7-mer-A1 42 CDS VAV1 High_conserved miR-143/1721/4770 chr19:6843176 7-mer-m8 33 CDS VAV1 High_conserved miR-146ac/146b-5p chr19:6828097 7-mer-A1 42 CDS VAV1 High_conserved miR-146ac/146b-5p chr19:6828162 8-mer 13 CDS VAV1 High_conserved miR-153 chr19:6828152 7-mer-m8 16 CDS VAV1 High_conserved miR-155 chr19:6848125 8-mer 40 CDS VAV1 High_conserved miR-15abc/16/16abc/195/322/424/497/1907 chr19:6822464 7-mer-m8 47 CDS VAV1 High_conserved miR-15abc/16/16abc/195/322/424/497/1907 chr19:6833294 7-mer-m8 49 CDS VAV1 High_conserved miR-192/215 chr19:6773000 7-mer-A1 36 CDS, 5pUTR VAV1 High_conserved miR-192/215 chr19:6828661 7-mer-A1 51 CDS VAV1 High_conserved miR-192/215 chr19:6850698 7-mer-A1 51 CDS VAV1 High_conserved miR-205/205ab chr19:6825357 8-mer 51 CDS VAV1 High_conserved miR-205/205ab chr19:6848098 7-mer-A1 40 CDS VAV1 High_conserved miR-214/761/3619-5p chr19:6820757 7-mer-m8 38 CDS VAV1 High_conserved miR-214/761/3619-5p chr19:6828138 8-mer 33 CDS VAV1 High_conserved miR-214/761/3619-5p chr19:6857118 7-mer-A1 51 CDS VAV1 High_conserved miR-218/218a chr19:6850704 7-mer-m8 42 CDS VAV1 High_conserved miR-218/218a chr19:6853969 8-mer 13 CDS VAV1 High_conserved miR-223 chr19:6822505 7-mer-A1 7 CDS VAV1 High_conserved miR-24/24ab/24-3p chr19:6857122 7-mer-m8 18 3pUTR VAV1 High_conserved miR-24/24ab/24-3p chr19:6857165 7-mer-m8 22 3pUTR VAV1 High_conserved miR-103a/107/107ab chr19:6833293 7-mer-m8 49 CDS VAV1 High_conserved miR-124/124ab/506 chr19:6820725 8-mer 31 CDS VAV1 High_conserved miR-124/124ab/506 chr19:6857132 7-mer-m8 2 3pUTR VAV1 High_conserved miR-33ab/33-5p chr19:6772841 7-mer-m8 2 CDS VAV1 High_conserved miR-10abc/10a-5p chr19:6837046 7-mer-m8 31 CDS VAV1 High_conserved miR-451 chr19:6825090 7-mer-m8 24 CDS VAV1 High_conserved miR-490-3p chr19:6829894 7-mer-m8 47 CDS VAV1 Medium_conserved miR-543 chr19:6828094 7-mer-m8 49 CDS VAV1 Medium_conserved miR-544/544ab/544-3p chr19:6837003 7-mer-A1 7 CDS VAV1 Medium_conserved miR-615-3p chr19:6822324 7-mer-A1 20 CDS VAV1 Medium_conserved miR-615-3p chr19:6848065 7-mer-A1 22 CDS VAV1 Medium_conserved miR-873 chr19:6820719 7-mer-m8 36 CDS VAV1 Medium_conserved miR-873 chr19:6825094 8-mer 20 CDS VAV1 Medium_conserved miR-874 chr19:6772753 7-mer-m8 4 5pUTR VAV1 Medium_conserved miR-136 chr19:6828463 7-mer-A1 31 CDS VAV1 Medium_conserved miR-149 chr19:6857190 7-mer-m8 0 3pUTR VAV1 Medium_conserved miR-197 chr19:6828440 7-mer-A1 51 CDS VAV1 Medium_conserved miR-290-5p/292-5p/371-5p/293 chr19:6832204 8-mer 27 CDS VAV1 Medium_conserved miR-296-3p chr19:6836529 7-mer-m8 24 CDS VAV1 Medium_conserved miR-324-5p chr19:6848102 7-mer-A1 9 CDS VAV1 Medium_conserved miR-329/329ab/362-3p chr19:6772912 7-mer-m8 22 CDS VAV1 Medium_conserved miR-340-5p chr19:6857295 7-mer-A1 33 3pUTR VAV1 Medium_conserved miR-342-3p chr19:6820761 7-mer-A1 40 CDS VAV1 Medium_conserved miR-370 chr19:6853084 7-mer-m8 4 CDS VAV1 Medium_conserved miR-376abd/376b-3p chr19:6822307 7-mer-m8 27 CDS VAV1 Medium_conserved miR-376abd/376b-3p chr19:6833740 7-mer-A1 22 CDS VAV1 Medium_conserved miR-377 chr19:6772914 8-mer 22 CDS VAV1 Medium_conserved miR-379/1193-5p/3529 chr19:6825393 7-mer-A1 40 CDS VAV1 Medium_conserved miR-411 chr19:6837014 7-mer-A1 9 CDS VAV1 Medium_conserved miR-431 chr19:6825106 7-mer-A1 42 CDS VAV1 Medium_conserved miR-431 chr19:6832167 7-mer-A1 24 CDS VAV1 Medium_conserved miR-433 chr19:6850716 7-mer-m8 53 CDS VAV1 Medium_conserved miR-491-5p chr19:6821814 7-mer-m8 42 CDS VAV1 Medium_conserved miR-494 chr19:6836467 7-mer-A1 13 CDS VAV1 Medium_conserved miR-496 chr19:6825336 7-mer-A1 13 CDS

DNA & RNA Element - RAID2 Gene Name RAID ID Interactor 1 Category 1 ID 1 Interactor 2 Category 2 ID 2 Methods Score VAV1 RAID00268088 hsa-miR-6817-3p miRNA MIMAT0027535 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID00419982 hsa-mir-340 miRNA MI0000802 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID01040069 hsa-miR-3125 miRNA MIMAT0014988 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID01150725 hsa-miR-506-3p miRNA MIMAT0002878 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID01185419 hsa-miR-24-3p miRNA MIMAT0000080 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID01832325 hsa-miR-609 miRNA MIMAT0003277 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID02437425 hsa-miR-3916 miRNA MIMAT0018190 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID03218768 hsa-miR-1225-3p miRNA MIMAT0005573 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID03333897 hsa-miR-6859-5p miRNA MIMAT0027618 VAV1 mRNA 7409 Prediction 0.1828 VAV1 RAID03555375 hsa-miR-26b-5p miRNA MIMAT0000083 VAV1 mRNA 7409 Microarray 0.5483 VAV1 RAID03637920 hsa-miR-124-3p miRNA MIMAT0000422 VAV1 mRNA 7409 Prediction 0.1828