Protein Structure - PDB UniProt ID PDB ID Strain Moleculel Fragment Q8TBC4 1r4n B, D, F, H UBIQUITIN-LIKE PROTEIN NEDD8 Q8TBC4 2lq7 A NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT INTERACTION WITH UBE2M CORE DOMAIN RESIDUES 368-463 Q8TBC4 2nvu B NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT RESIDUES 33-463 Q8TBC4 3dbl B, D, F, H NEDD8 Q8TBC4 1y8x B UBIQUITIN-ACTIVATING ENZYME E1C Q8TBC4 3dbr B, D, F, H NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT UNP RESIDUES 33-463 Q8TBC4 3fn1 A NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT UBIQUITIN-ACTIVATING ENZYME E1C, RESIDUE 368-463 Q8TBC4 1r4m B, D, F, H UBIQUITIN-LIKE PROTEIN NEDD8 Q8TBC4 1tt5 B, D UBIQUITIN-ACTIVATING ENZYME E1C ISOFORM 1 RESIDUES 33-463 Q8TBC4 1yov B, D UBIQUITIN-ACTIVATING ENZYME E1C Q8TBC4 3dbh B, D, F, H NEDD8 Q8TBC4 3gzn B, D NEDD8

Protein Structure - MMDB UniProt ID PDB code Chain ID MMDB ID Resolution Method Acceptable Q8TBC4 1Y8X A 32042 2.40 X-ray Acceptable Q8TBC4 2NVU C 44074 2.80 X-ray Acceptable Q8TBC4 3FN1 B 70250 2.50 X-ray Acceptable Q8TBC4 1R4M I 25782 3.00 X-ray Acceptable Q8TBC4 1R4M J 25782 3.00 X-ray Acceptable Q8TBC4 1R4M K 25782 3.00 X-ray Acceptable Q8TBC4 1R4M L 25782 3.00 X-ray Acceptable Q8TBC4 1R4N I 25783 3.60 X-ray Acceptable Q8TBC4 1R4N J 25783 3.60 X-ray Acceptable Q8TBC4 1R4N K 25783 3.60 X-ray Acceptable Q8TBC4 1R4N L 25783 3.60 X-ray Acceptable Q8TBC4 3DBH I 66038 2.85 X-ray Acceptable Q8TBC4 3DBL I 66039 2.90 X-ray Acceptable Q8TBC4 3DBR I 66040 3.05 X-ray Acceptable Q8TBC4 2NVU I 44074 2.80 X-ray Acceptable Q8TBC4 2NVU J 44074 2.80 X-ray Acceptable Q8TBC4 3DBR L 66040 3.05 X-ray Acceptable Q8TBC4 3DBR J 66040 3.05 X-ray Acceptable Q8TBC4 3DBR K 66040 3.05 X-ray Acceptable Q8TBC4 3GZN J 79727 3.00 X-ray Acceptable Q8TBC4 3DBH J 66038 2.85 X-ray Acceptable Q8TBC4 3DBH K 66038 2.85 X-ray Acceptable Q8TBC4 3DBH L 66038 2.85 X-ray Acceptable Q8TBC4 3DBL J 66039 2.90 X-ray Acceptable Q8TBC4 3DBL K 66039 2.90 X-ray Acceptable Q8TBC4 3DBL L 66039 2.90 X-ray Acceptable Q8TBC4 3GZN I 79727 3.00 X-ray Acceptable Q8TBC4 2NVU B 44074 2.80 X-ray Acceptable Q8TBC4 3DBH D 66038 2.85 X-ray Acceptable Q8TBC4 3DBL D 66039 2.90 X-ray Acceptable Q8TBC4 3DBH B 66038 2.85 X-ray Acceptable Q8TBC4 3DBL B 66039 2.90 X-ray Acceptable Q8TBC4 3DBR B 66040 3.05 X-ray Acceptable Q8TBC4 3DBR D 66040 3.05 X-ray Acceptable Q8TBC4 3DBH F 66038 2.85 X-ray Acceptable Q8TBC4 3DBL F 66039 2.90 X-ray Acceptable Q8TBC4 3DBR F 66040 3.05 X-ray Acceptable Q8TBC4 3DBH H 66038 2.85 X-ray Acceptable Q8TBC4 3DBL H 66039 2.90 X-ray Acceptable Q8TBC4 3DBR H 66040 3.05 X-ray Acceptable Q8TBC4 1R4M B 25782 3.00 X-ray Acceptable Q8TBC4 1R4M D 25782 3.00 X-ray Acceptable Q8TBC4 1R4M F 25782 3.00 X-ray Acceptable Q8TBC4 1R4M H 25782 3.00 X-ray Acceptable Q8TBC4 1R4N B 25783 3.60 X-ray Acceptable Q8TBC4 1R4N D 25783 3.60 X-ray Acceptable Q8TBC4 1R4N F 25783 3.60 X-ray Acceptable Q8TBC4 1R4N H 25783 3.60 X-ray Acceptable Q8TBC4 3GZN D 79727 3.00 X-ray Acceptable Q8TBC4 3GZN B 79727 3.00 X-ray Acceptable Q8TBC4 1TT5 B 29476 2.60 X-ray Acceptable Q8TBC4 1YOV B 32530 2.60 X-ray Acceptable Q8TBC4 1YOV D 32530 2.60 X-ray Acceptable Q8TBC4 1TT5 D 29476 2.60 X-ray Acceptable Q8TBC4 2NVU A 44074 2.80 X-ray Acceptable Q8TBC4 1YOV A 32530 2.60 X-ray Acceptable Q8TBC4 1YOV C 32530 2.60 X-ray Acceptable Q8TBC4 3DBH A 66038 2.85 X-ray Acceptable Q8TBC4 3DBL A 66039 2.90 X-ray Acceptable Q8TBC4 1R4M A 25782 3.00 X-ray Acceptable Q8TBC4 1R4M C 25782 3.00 X-ray Acceptable Q8TBC4 1R4M E 25782 3.00 X-ray Acceptable Q8TBC4 1R4M G 25782 3.00 X-ray Acceptable Q8TBC4 1R4N A 25783 3.60 X-ray Acceptable Q8TBC4 1R4N C 25783 3.60 X-ray Acceptable Q8TBC4 1R4N E 25783 3.60 X-ray Acceptable Q8TBC4 1R4N G 25783 3.60 X-ray Acceptable Q8TBC4 3DBH C 66038 2.85 X-ray Acceptable Q8TBC4 3DBL C 66039 2.90 X-ray Acceptable Q8TBC4 3DBH E 66038 2.85 X-ray Acceptable Q8TBC4 3DBH G 66038 2.85 X-ray Acceptable Q8TBC4 3DBL G 66039 2.90 X-ray Acceptable Q8TBC4 3DBR A 66040 3.05 X-ray Acceptable Q8TBC4 3DBL E 66039 2.90 X-ray Acceptable Q8TBC4 3DBR E 66040 3.05 X-ray Acceptable Q8TBC4 3DBR C 66040 3.05 X-ray Acceptable Q8TBC4 1TT5 A 29476 2.60 X-ray Acceptable Q8TBC4 3DBR G 66040 3.05 X-ray Acceptable Q8TBC4 1TT5 C 29476 2.60 X-ray Acceptable Q8TBC4 3GZN A 79727 3.00 X-ray Acceptable Q8TBC4 3GZN C 79727 3.00 X-ray Acceptable Q8TBC4 1Y8X B 32042 2.40 X-ray Acceptable Q8TBC4 3FN1 A 70250 2.50 X-ray Acceptable Q8TBC4 1TT5 E 29476 2.60 X-ray Acceptable Q8TBC4 1TT5 F 29476 2.60 X-ray Acceptable

Protein Structure - SCOP UniProt BeginUni EndUni Domain Node PDB Chain BeginPDB EndPDB Q8TBC4 33 463 8003475 6000686 3DBH B 12 442 Q8TBC4 33 463 8003476 5000407 3DBH B 12 442 Q8TBC4 60 369 8003527 4000345 3DBH B 39 348 Q8TBC4 370 463 8003528 2000122 3DBH B 349 442 Q8TBC4 60 225 8003542 3000112 3DBH B 39 204 Q8TBC4 309 369 8003542 3000112 3DBH B 288 348 Q8TBC4 244 307 8003549 3000140 3DBH B 223 286 Q8TBC4 244 307 8003560 1100008 3DBH B 223 286 Q8TBC4 60 225 8003592 2000082 3DBH B 39 204 Q8TBC4 309 369 8003592 2000082 3DBH B 288 348 Q8TBC4 70 102 8003613 7000008 3DBH B 49 81 Q8TBC4 370 463 8003941 3000147 3DBH B 349 442 Q8TBC4 244 307 8004402 2000000 3DBH B 223 286