PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus AIRE RAVER1 23443559 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE PIK3R1 17474147 intact exp P P P P P GP P P P P P P P P P P P P P AIRE PLCG1 17474147 innatedb,intact exp P P P P P GP P P P P P P P P P P P P P AIRE GIGYF2 23443559 biogrid exp P P P P GP P P P P P P P P P P AIRE TMPRSS13 23443559 biogrid exp P P P AIRE HDAC2 20185822 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE SRRM2 23443559 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE HIST3H3 20953165 biogrid exp P P P P P P P P P P P P P P P P P P P AIRE HSPA5 23443559,15150263 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE TUBA1C 23443559 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE HSPA8 23443559 biogrid exp P P P P P P P P P P P P P P P AIRE ATP4A 17255364 biogrid exp P P P P P P P P AIRE ABL1 17474147 intact exp P P P P P GP P P P P P P P P P P P P P AIRE CCDC87 23443559 biogrid exp P P P P P P P P AIRE GRB2 17474147 intact exp P P P P P GP P P P P P P P P P P P P P AIRE FAT1 23443559 biogrid exp P P P P GP P P P P P P P P P P P P P AIRE UBAC1 16310047 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE DAXX 20185822 biogrid,intact exp P P P P P GP P P P P P P P P P P P P P AIRE HIST1H2BO 20085707 biogrid exp AIRE TUBB4B 23443559 biogrid exp P P P G P P P P P P P P P P P AIRE HIST1H2BB 18292755 intact exp AIRE HSP90AB1 23443559 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE SRC 17474147 intact exp P P P G P P P P P P P P AIRE HSPA1L 23443559 biogrid exp P P P AIRE UBB 23443559 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE HSPA1A, HSPA1B 23443559 biogrid exp P P P P P P P P P P P P P P P P P P P AIRE CRK 17474147 intact exp P P P GP P P P P P P P AIRE EIF4EBP3 23443559 biogrid exp P P P P P P P P P P P P P P P P P P AIRE HIST2H2BE 18292755 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE TUBB 23443559 biogrid exp P P P P P GP P P P P P P P P P P P P P AIRE HIST1H2AC 20085707 biogrid exp, ortho P P P P P GP P P P P P P P P P P P P P AIRE AIRE 12929931,20185822,11533054,10748110 hprd,biogrid,i2d,intact exp, ortho P P P P P GP P P P P P P P P P P P P P AIRE CHD6 20085707 biogrid exp, ortho P P G P P AIRE H2AFX 20085707 intact exp, ortho P P P P P GP P P P P P P P P P P P P P AIRE EFTUD2 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE NASP 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P AIRE LMNB1 20085707, 25402006 biogrid,intact exp, ortho, pred P P P P P P P P P P P P P P P P P P P AIRE PCNA 20085707, 25402006 biogrid exp, ortho, pred P P P P G P P P P P P P P P P AIRE MCM5 20085707, 25402006 biogrid exp, ortho, pred P P P G P P P P P P P AIRE RAD21 20085707, 25402006 biogrid,intact exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE SNRPD3 20085707, 25402006 biogrid exp, ortho, pred P P P P P G P P P P P P P P P P P P P AIRE SMC3 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P AIRE PRKDC 20085707, 25402006 biogrid,intact exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE IPO7 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P AIRE SNRPB 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE POLR2B 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE GEMIN5 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE KPNB1 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE TRIM28 20085707, 25402006 biogrid,intact exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE SMC1A 20085707, 25402006 biogrid exp, ortho, pred P P P P P G P P P P P P P P P P P P P AIRE SRSF3 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE MCM6 20085707, 25402006 biogrid exp, ortho, pred P P P P P G P P P P P P P P P P P P AIRE MCM2 20085707, 25402006 biogrid exp, ortho, pred P P P G P P P P P P P P P AIRE DDX5 20085707, 25402006 biogrid,intact exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE PARP1 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE PABPC1 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P XPO1 AIRE 20085707, 25402006 biogrid exp, ortho, pred P P P P P G P P P P P P P P P P P P P AIRE MYBBP1A 20085707, 25402006 biogrid exp, ortho, pred P P P P P G P P P P P P P P P P P AIRE MSH6 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE SRSF2 20085707, 25402006 biogrid,intact exp, ortho, pred P P P P P P P P P P P P P P P P P P P AIRE SRSF1 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE RUVBL2 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P NOP56 AIRE 20085707, 25402006 biogrid exp, ortho, pred P P P P P AIRE DDX17 20085707, 25402006 biogrid exp, ortho, pred P P P P G P P P P P P P P P P P P P AIRE RANBP9 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE NUP93 20085707, 25402006 biogrid,intact exp, ortho, pred P P P P P P P P P P P P P P P AIRE POLR2A 20085707, 25402006 biogrid exp, ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE TOP2A 20085707, 25402006 biogrid,intact exp, ortho, pred P P P P P P P P P P P P AIRE MSH2 20085707, 25402006 biogrid exp, ortho, pred P P P P P P P P P P P P P P P P P P P AIRE XRCC5 20085707, 25402006 intact exp, pred P P P P P G P P P P P P P P P P P P P AIRE HSPA4 15150263, 21836163 biogrid exp, pred P P P P P GP P P P P P P P P P P P P P AIRE NCK1 17474147, 25402006 intact exp, pred P P P P P GP P P P P P P P P P P P P P AIRE SSRP1 20085707, 25402006 biogrid exp, pred P P G P P P P P P P P AIRE RANBP2 20085707, 25402006 biogrid exp, pred P P P P P GP P P P P P P P P P P P P P AIRE CREBBP 12929931,10748110, 25402006 hprd,biogrid,i2d exp, pred P P P P P GP P P P P P P P P P P P P P AIRE HDAC1 20185822, 25402006 biogrid exp, pred P P P P P GP P P P P P P P P P P P P P AIRE FYN 17474147, 23023127 intact exp, pred P P P P GP P P P AIRE HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J 18292755, 25402006 biogrid,mint,intact exp, pred P P P P P P P P P P P P P P P P P P P XPOT AIRE 20085707, 25402006 biogrid exp, pred P P P P P GP P P P P P P P P P AIRE HIST1H2AD ortho P P P P P P P P P P P P P P P P P P P AIRE GCN1L1 ortho P P P P P GP P P P P P P P P P P P P P AIRE SUPT16H 25402006 ortho, pred P P P P P GP P P P P P P P P P P P P P AIRE HIST2H2BF 25402006 ortho, pred P P P P P P P P P P P P P P P P P P P AIRE CAND1 25402006 ortho, pred P P GP P P P P P AIRE C1QBP 25402006 ortho, pred P P P P P G P P P P P P P P P P P P P AIRE STAG1 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE SREK1 25402006 pred P P P P P GP P P P P P P P P P P P AIRE EP300 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE STAG2 25402006 pred P P P P GP P P P P P P P P P P P P P AIRE CD46 23023127 pred P P P GP P P P P P P P P P P P P AIRE SH2D1A 23023127 pred AIRE RIPK3 25402006 pred P P P P P P P P P P P P P P P P P P P AIRE HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 25402006 pred P P P P P P P P P P P P P P P P P P P AIRE RELA 25402006 pred P P P P P GP P P P P P P P P P P P P P C21orf2 AIRE 21836163 pred P P P P P GP P P P P P P P P P P P P P AIRE CCL2 23023127 pred P P P P P GP P P P P P P P P P P P P P AIRE C1R 23023127 pred P P P GP P P P P P P P P P P AIRE MYC 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE C2 23023127 pred P G P P AIRE PRKCA 25402006 pred P P P P G P P P P P P P P AIRE HPX 23023127 pred P GP P P P AIRE U2AF1 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE NR2E3 25402006 pred AIRE C8A 23023127 pred G AIRE NKX2-1 25402006 pred P AIRE CBX3 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE ASF1A 25402006 pred G AIRE C8G 23023127 pred P P GP P P P P P P P P P P HDAC3 AIRE 25402006 pred P P P P P G P P P P P P P P P P P P P AIRE PRKCG 25402006 pred P G P AIRE PHF8 25402006 pred P P P P P G P P P P P P P P P P P P P FOXN1 AIRE 21836163 pred P P P P P P P P P P P P P P P P P P AIRE NCKIPSD 25402006 pred P P P P P GP P P P P P P P P P P P P AIRE C1RL 23023127 pred P P P P G P P P P P P P AIRE HIST1H2AB, HIST1H2AE 25402006 pred AIRE NEK9 25402006 pred P P G P P P P P P P P P AIRE MAP3K14 25402006 pred G AIRE KIF13B 16082366 pred P P P P P GP P P P P P P P P P P P AIRE MAP3K3 25402006 pred P P P G P P P P P P P P AIRE ATM 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE SMAD3 25402006 pred P P G P P P P P AIRE MCM4 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE NR4A1 25402006 pred G AIRE KHDRBS1 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE LMNA 25402006 pred P P P P P GP P P P P P P P P P P P P P CHUK AIRE 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE IKBKG 25402006 pred G AIRE L3MBTL1 25402006 pred AIRE CIR1 25402006 pred P P P P G P P P P P P P AIRE PRKCB 25402006 pred P P P P P G P P P P P P P P P P AIRE NCOA6 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE TOP1 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE PDS5A 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE CSNK2A1 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE CASP6 25402006 pred P P P P G P P P P P P P P P AIRE SETDB1 25402006 pred P P P P P G P P P P P P P P P P AIRE CHAF1B 25402006 pred P P P P P P P AIRE POLDIP3 25402006 pred P P P P GP P P P P P P P P P AIRE CHRNA1 21836163 pred P P P P P P P P P P P P P P P P P SMAD7 AIRE 16082366 pred P P P P P GP P P P P P P P P P P P P P AIRE LTBR 21836163 pred P P P P G P P P P P P P P P P AIRE IRF7 16082366 pred P P P P P GP P P P P P P P P P P P P P AIRE HNF4A 25402006 pred P P GP P P P P P RIMBP2 AIRE 23023127 pred P P P P P P P P P P P P P P P P P AIRE C4BPA 23023127 pred P P P GP P AIRE NCOA2 25402006 pred G AIRE MASP1 23023127 pred GP P P AIRE TMPO 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE SMARCA5 25402006 pred P P P P P G P P P P P P P P P P P P P AIRE ESR1 25402006 pred P G AIRE DMBT1 23023127 pred P P G P P P P P AIRE BRCA1 25402006 pred P P P P P P P P P P P P P P P P P P P AIRE TRAPPC10 21836163 pred G AIRE TDRD6 21836163 pred G AIRE IRF8 21836163, 16082366 pred P G P P P AIRE RELB 21836163 pred P P P P GP P P P P P P P P AIRE WAPAL 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE MYB 25402006 pred P P P P P P P P P P P P P P P P P P P AIRE CBX1 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE NCOA3 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE NFKB2 25402006 pred P P P P P G P P P P P P P P P P P AIRE CHAF1A 25402006 pred P P P P GP P P P P P P P P P P P P AIRE RAE1 25402006 pred P P P P P G P P P P P P P P P P P AIRE DHX30 25402006 pred P P P GP P P P P P P P P P P AIRE SMAD2 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE CFB 23023127 pred GP P P P P AIRE PPARG 25402006 pred P P P P P P P P P P P P P P AIRE DDX21 25402006 pred P P P P P GP P P P P P P P P P P P P AIRE RGPD4 25402006 pred P P P P P P P P P P P P P P P P P AIRE NUP205 25402006 pred P G P P P AIRE PNKP 16082366 pred P P P P P GP P P P P P P P P P P P P P AIRE XRCC6 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE LTA 21836163 pred AIRE PAX3 25402006 pred P P P P P P P P P P P P P P P P AIRE BLNK 23023127 pred P P P P P G P P P P P P P P P P AIRE POLR1A 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE CDK1 25402006 pred P P P P P P P P P P P P P P P AIRE NR3C1 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE KMT2A 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE CBX5 25402006 pred P P P P P G P P P P P P P P P P P P P AIRE NCOA1 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE NUDT11 21836163 pred P P P P AIRE C1S 23023127 pred G AIRE CFD 23023127 pred P P G P P P P AIRE RBBP4 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE PDS5B 25402006 pred P P P P P P P P P P P P P P P P P P P AIRE HIST1H2BC, HIST1H2BE, HIST1H2BF, HIST1H2BG, HIST1H2BI 25402006 pred P P P P P GP P P P P P P P P P P P P P AIRE CTNNB1 25402006 pred P P P P P GP P P P P P P P P P P P AIRE EPS8L2 23023127 pred P P P P GP P P P P P P P P P P P AIRE NBN 16082366 pred P P P P P GP P P P P P P P P P P P P P AIRE AR 25402006 pred P G P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O43918 O43918 - 10748110,11533054 - X 2 O43918 O43918 - 10748110,11533054 - X 2 O43918 - 10748110 - X 2 B1AHB0 O43918 affinity chromatography technology 20085707 physical association X 2 A0A024R3T8 O43918 affinity chromatography technology 20085707 physical association X 2 Q9UQ35 O43918 affinity chromatography technology 23443559 physical association X 2 P49792 O43918 affinity chromatography technology 20085707 physical association X 2 Q53HF2 O43918 affinity chromatography technology 23443559 physical association X 2 Q13263 O43918 affinity chromatography technology 20085707 physical association X 2 Q13263 O43918 affinity chromatography technology 20085707 physical association X 2 P62318 O43918 affinity chromatography technology 20085707 physical association X 2 Q6Y7W6-3 O43918 affinity chromatography technology 23443559 physical association X 2 Q16695 O43918 affinity chromatography technology 20953165 physical association X 2 Q92769 O43918 affinity chromatography technology 20185822 physical association X 2 P17844 O43918 affinity chromatography technology 20085707 physical association X 2 P17844 O43918 affinity chromatography technology 20085707 physical association X 2 B2R6F3 O43918 affinity chromatography technology 20085707 physical association X 2 Q14683 O43918 affinity chromatography technology 20085707 physical association X 2 Q14683 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 O43918 affinity chromatography technology 20185822 physical association X 2 O43918 A0A024RD80 affinity chromatography technology 23443559 physical association X 2 O43918 Q9BYE2-4 affinity chromatography technology 23443559 physical association X 2 O43918 O43918 two hybrid 10748110 direct interaction X 2 O43918 O43918 pull down 10748110 direct interaction X 2 O43918 far western blotting 10748110 direct interaction X 2 O43918 O43918 pull down 12929931 direct interaction X 2 O43918 O43918 two hybrid 12929931 direct interaction X 2 O43918 far western blotting 12929931 direct interaction X 2 O43918 two hybrid 12929931 direct interaction X 2 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 B4DZT3 affinity chromatography technology 20085707 physical association X 2 O43918 O14980 affinity chromatography technology 20085707 physical association X 2 O43918 Q8N1F7-2 affinity chromatography technology 20085707 physical association X 2 O43918 P14678 affinity chromatography technology 20085707 physical association X 2 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 B4DZT3 affinity chromatography technology 20085707 physical association X 2 O43918 Q8N1F7-2 affinity chromatography technology 20085707 physical association X 2 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 two hybrid 10748110 direct interaction X 2 P43246 O43918 affinity chromatography technology 20085707 physical association X 2 Q14517 O43918 affinity chromatography technology 23443559 physical association X 2 Q9BQE3 O43918 affinity chromatography technology 23443559 physical association X 2 Q14974 O43918 affinity chromatography technology 20085707 physical association X 2 A0A024R4Z6 O43918 affinity chromatography technology 20085707 physical association X 2 A0A024R4Z6 O43918 affinity chromatography technology 20085707 physical association X 2 A0A024R017 O43918 affinity chromatography technology 20085707 physical association X 2 P12004 O43918 affinity chromatography technology 20085707 physical association X 2 P07437 O43918 affinity chromatography technology 23443559 physical association X 2 O43592 O43918 affinity chromatography technology 20085707 physical association X 2 O95373 O43918 affinity chromatography technology 20085707 physical association X 2 P20648 O43918 affinity chromatography technology 17255364 physical association X 2 E9PAU2 O43918 affinity chromatography technology 23443559 physical association X 2 P49736 O43918 affinity chromatography technology 20085707 physical association X 2 A0A024R9C1 O43918 affinity chromatography technology 20085707 physical association X 2 Q14566 O43918 affinity chromatography technology 20085707 physical association X 2 P0CG47 O43918 affinity chromatography technology 23443559 physical association X 2 O43918 affinity chromatography technology 20085707 physical association X 2 O00567 O43918 affinity chromatography technology 20085707 physical association X 2 P34932 O43918 affinity chromatography technology 15150263 physical association X 2 P34931 O43918 affinity chromatography technology 23443559 physical association X 2 A0A024QZW3 O43918 affinity chromatography technology 20085707 physical association X 2 P68371 O43918 affinity chromatography technology 23443559 physical association X 2 Q53FN0 O43918 affinity chromatography technology 20085707 physical association X 2 Q53FN0 O43918 affinity chromatography technology 20085707 physical association X 2 Q16778 O43918 pull down 18292755 direct interaction X 2 A8K5I0 O43918 affinity chromatography technology 23443559 physical association X 2 O60516 O43918 affinity chromatography technology 23443559 physical association X 2 P11021 O43918 affinity chromatography technology 23443559 physical association X 2 P11021 O43918 affinity chromatography technology 15150263 physical association X 2 Q9Y230 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 Q9BSL1 two hybrid 16310047 direct interaction X 2 O43918 two hybrid 20185822 direct interaction X 2 O43918 affinity chromatography technology 20185822 physical association X 2 O43918 P23527 affinity chromatography technology 20085707 physical association X 2 O43918 Q9UQE7 affinity chromatography technology 20085707 physical association X 2 O43918 Q15029-3 affinity chromatography technology 20085707 physical association X 2 O43918 P68431 pull down 18292755 direct interaction X 2 O43918 P68431 unspecified method 18292755 direct interaction X 2 O43918 P68431 affinity chromatography technology 18292755 physical association X 2 O43918 P68431 x-ray crystallography 18292755 association X 2 P78527-2 O43918 affinity chromatography technology 20085707 physical association X 2 P78527-2 O43918 affinity chromatography technology 20085707 physical association X 2 A0A024R9J0 O43918 affinity chromatography technology 20085707 physical association X 2 A0A024R9J0 O43918 affinity chromatography technology 20085707 physical association X 2 P11388 O43918 affinity chromatography technology 20085707 physical association X 2 P11388 O43918 affinity chromatography technology 20085707 physical association X 2 P52701 O43918 affinity chromatography technology 20085707 physical association X 2 Q9NVE4 O43918 affinity chromatography technology 23443559 physical association X 2 P30876 O43918 affinity chromatography technology 20085707 physical association X 2 Q13547 O43918 affinity chromatography technology 20185822 physical association X 2 Q8TD26 O43918 affinity chromatography technology 20085707 physical association X 2 O43918 O43918 two hybrid 10748110 association Y 1 O43918 O43918 coimmunoprecipitation 10748110 association Y 1 O43918 two hybrid 10748110 - X 2 O43918 in vitro 10748110 - X 2 O43918 two hybrid 10748110 - X 2 O43918 in vitro 10748110 - X 2 O43918 O43918 in vivo 10748110,11533054 - X 2 O43918 O43918 in vitro 10748110,11533054 - X 2 O43918 O43918 two hybrid 10748110,11533054 - X 2 O43918 pull down 18292755 association C 3 P12931 O43918 peptide array 17474147 physical association X 2 Q13263 O43918 anti bait coimmunoprecipitation 20085707 physical association X 2 L7RT18 O43918 peptide array 17474147 physical association X 2 P17844 O43918 anti bait coimmunoprecipitation 20085707 physical association X 2 O43918 P27986 peptide array 17474147 physical association X 2 O43918 O43918 anti tag coimmunoprecipitation 20185822 physical association X 2 P06241 O43918 peptide array 17474147 physical association X 2 P78527 O43918 anti bait coimmunoprecipitation 20085707 physical association X 2 O43918 anti bait coimmunoprecipitation 20085707 association C 6 O43918 anti bait coimmunoprecipitation 20085707 association C 5 O43918 anti bait coimmunoprecipitation 20085707 association C 5 O43918 anti tag coimmunoprecipitation 20085707 association C 5 A0A024R8U5 O43918 anti bait coimmunoprecipitation 20085707 physical association X 2 P20700 O43918 anti tag coimmunoprecipitation 20085707 physical association X 2 P16333 O43918 peptide array 17474147 physical association X 2 P16333 O43918 peptide array 17474147 physical association X 2 O43918 A0A024R8E2 peptide array 17474147 physical association X 2 O43918 P19174 peptide array 17474147 physical association X 2 O43918 P68431 pull down 18292755 physical association X 2 O43918 P68431 pull down 18292755 direct interaction X 2 O43918 P68431 fluorescence technology 18292755 direct interaction X 2 O43918 P68431 fluorescence technology 18292755 direct interaction X 2 O43918 P68431 fluorescence technology 18292755 direct interaction X 2 O43918 P68431 fluorescence technology 18292755 direct interaction X 2 O43918 P68431 fluorescence technology 18292755 direct interaction X 2 O43918 P68431 fluorescence technology 18292755 direct interaction X 2 O43918 P68431 nuclear magnetic resonance 18292755 direct interaction X 2 O43918 P68431 nuclear magnetic resonance 18292755 direct interaction X 2 O43918 P68431 nuclear magnetic resonance 18292755 direct interaction X 2 O43918 P68431 pull down 18292755 direct interaction X 2 O43918 P68431 nuclear magnetic resonance 18292755 direct interaction X 2 O43918 P68431 isothermal titration calorimetry 18292755 direct interaction X 2 O43918 P68431 isothermal titration calorimetry 18292755 direct interaction X 2 O43918 P68431 isothermal titration calorimetry 18292755 direct interaction X 2 O43918 P68431 isothermal titration calorimetry 18292755 direct interaction X 2 O43918 P68431 pull down 18292755 direct interaction X 2 O43918 P68431 pull down 18292755 direct interaction X 2 O43918 Q8N1F7 anti bait coimmunoprecipitation 20085707 physical association X 2 O43918 Q7TPV4 anti tag coimmunoprecipitation 20085707 physical association X 2 Q99MD9 O43918 anti tag coimmunoprecipitation 20085707 physical association X 2 A0A024R9J0 O43918 anti tag coimmunoprecipitation 20085707 physical association X 2 B0LPF3 O43918 peptide array 17474147 physical association X 2 A0A024RCS3 O43918 two hybrid 20185822 physical association X 2 A0A024RCS3 O43918 two hybrid 20185822 physical association X 2 A0A024RCS3 O43918 confocal microscopy 20185822 colocalization X 2 A0A024RCS3 O43918 two hybrid 20185822 physical association X 2 A0A024RCS3 O43918 anti tag coimmunoprecipitation 20185822 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B AIRE SMC3 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122690 bait prey AIRE TRIM28 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid) BIOGRID_122692|UniProt_104242|BIOGRID_122718 bait|prey|prey prey|bait|bait AIRE HDAC1 MI:0018(two hybrid) 20185822 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_214744 bait prey AIRE MSH2 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122686 bait prey AIRE GEMIN5 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122708 bait prey AIRE CHD6 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122691 bait prey AIRE SNRPB MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122707 bait prey XPOT AIRE MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122697 prey bait AIRE RAD21 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(intact) BIOGRID_122688|UniProt_170244|BIOGRID_122719|UniProt_104251 bait|prey|prey|prey prey|bait|bait|bait AIRE DAXX MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 20185822 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_214742|BIOGRID_214741|UniProt_104271|UniProt_104270|UniProt_104275|UniProt_104272|UniProt_104268 bait|bait|bait|neutral component|bait|bait|bait prey|prey|prey|neutral component|prey|prey|prey AIRE ATP4A MI:0004(affinity chromatography technology) 17255364 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_284704 prey bait AIRE LMNB1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(biogrid) BIOGRID_122693|UniProt_104248|UniProt_170241|BIOGRID_122712 bait|prey|prey|prey prey|bait|bait|bait AIRE HIST1H3A MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18292755 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) UniProt_95772|MINT_35924|MINT_64978|UniProt_95779|UniProt_95778|UniProt_95777|UniProt_95776|UniProt_95775|UniProt_95774|MINT_35950|UniProt_95773|UniProt_95771|MINT_64977|UniProt_95789|MINT_64975|UniProt_95786|UniProt_95785|UniProt_95788|UniProt_95787|MINT_35926|UniProt_95781|UniProt_95782|UniProt_95783|MINT_35925|UniProt_95784|MINT_65000|MINT_65001|MINT_35923|MINT_65003|MINT_35921|UniProt_95780|MINT_65004|BIOGRID_146401|BIOGRID_146402|BIOGRID_146403|MINT_35928|MINT_35929|MINT_64980|MINT_64982|MINT_64983|UniProt_95790|MINT_64989|MINT_64979|MINT_35935|MINT_35938|MINT_35937|MINT_35939|MINT_64991|MINT_64992|MINT_64995|MINT_64993|BIOGRID_146399|MINT_64994|MINT_64999|MINT_64997|MINT_64998|MINT_35941|MINT_35940|MINT_35945|MINT_35944|MINT_35943|MINT_35949|MINT_35947|MINT_35946 bait|bait|bait|neutral component|neutral component|neutral component|prey|prey|prey|neutral component|bait|bait|bait|neutral component|bait|neutral component|neutral component|neutral component|neutral component|neutral component|bait|bait|bait|prey|bait|neutral component|neutral component|bait|neutral component|bait|neutral component|neutral component|bait|bait|bait|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|prey|neutral component|prey|bait|prey|bait|prey|bait|prey|bait|bait|neutral component|bait|neutral component|bait|bait|neutral component|neutral component|bait|neutral component|neutral component|neutral component prey|prey|prey|neutral component|neutral component|neutral component|bait|bait|bait|neutral component|prey|prey|prey|neutral component|prey|neutral component|neutral component|neutral component|neutral component|neutral component|prey|prey|prey|bait|prey|neutral component|neutral component|prey|neutral component|prey|neutral component|neutral component|prey|prey|prey|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|bait|neutral component|bait|prey|bait|prey|bait|prey|bait|prey|prey|neutral component|prey|neutral component|prey|prey|neutral component|neutral component|prey|neutral component|neutral component|neutral component AIRE HIST1H2AC MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122684 bait prey AIRE RUVBL2 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122672 bait prey AIRE MCM5 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122681 bait prey AIRE SRC MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint) MINT_42603|UniProt_91364|MINT_72646 bait|bait|bait prey|prey|prey AIRE MCM2 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122680 bait prey AIRE RANBP2 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122698 bait prey AIRE NASP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_122687|BIOGRID_122714 bait|prey prey|bait AIRE PCNA MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122678 bait prey AIRE SRSF1 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122702 bait prey AIRE HDAC2 MI:0018(two hybrid) 20185822 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_214745 bait prey AIRE DDX17 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122671 bait prey AIRE CREBBP MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0096(pull down)|MI:0096(pull down) 10748110,12929931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_92574|BIOGRID_77672|HPRD_6397|BIOGRID_100208|BIOGRID_100209 prey|prey|-|prey|prey bait|bait|-|bait|bait AIRE TOP2A MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(biogrid) UniProt_170240|UniProt_104246|BIOGRID_122711|BIOGRID_122673 prey|prey|prey|bait bait|prey|bait|prey AIRE HSPA4 MI:0004(affinity chromatography technology) 15150263 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_135455 bait prey AIRE PIK3R1 MI:0081(peptide array)|MI:0081(peptide array)|MI:0096(pull down) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_73193|MINT_43150|UniProt_92130 bait|bait|bait prey|prey|prey AIRE PABPC1 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122703 bait prey NOP56 AIRE MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122669 prey bait AIRE HSPA5 MI:0004(affinity chromatography technology) 15150263 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_135454 bait prey AIRE FYN MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint) MINT_72786|UniProt_91504|MINT_42743 bait|bait|bait prey|prey|prey AIRE SRSF2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_122704|BIOGRID_122716|UniProt_104241 bait|prey|prey prey|bait|bait AIRE SSRP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_122710|BIOGRID_122675 prey|bait bait|prey AIRE HIST1H2BO MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122685 bait prey AIRE PLCG1 MI:0081(peptide array)|MI:0081(peptide array)|MI:0096(pull down) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_73301|MINT_43258|UniProt_92238 bait|bait|bait prey|prey|prey AIRE SRSF3 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122701 bait prey XPO1 AIRE MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122695 prey bait AIRE HIST3H3 MI:0004(affinity chromatography technology) 20953165 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_259601 prey bait AIRE HIST2H2BE MI:0096(pull down) 18292755 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_146400 bait prey AIRE POLR2A MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122677 bait prey AIRE IPO7 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122696 bait prey AIRE PRKDC MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(biogrid) BIOGRID_122709|UniProt_104238|BIOGRID_122674 prey|prey|bait bait|bait|prey AIRE UBAC1 MI:0018(two hybrid) 16310047 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_207917 bait prey AIRE MYBBP1A MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_122668|BIOGRID_122717 bait|prey prey|bait AIRE MSH6 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122683 bait prey AIRE SNRPD3 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122705 bait prey AIRE RANBP9 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122699 bait prey AIRE DDX5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_122670|BIOGRID_122715|UniProt_104240 bait|prey|prey prey|bait|bait AIRE GRB2 MI:0096(pull down)|MI:0081(peptide array)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint) UniProt_91700|MINT_43303|MINT_73346 bait|bait|bait prey|prey|prey AIRE EFTUD2 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122706 bait prey AIRE NUP93 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_122700|BIOGRID_122713|UniProt_104239 bait|prey|prey prey|bait|bait AIRE POLR2B MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122679 bait prey AIRE ABL1 MI:0081(peptide array)|MI:0081(peptide array)|MI:0096(pull down) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_42547|MINT_72590|UniProt_91191 bait|bait|bait prey|prey|prey AIRE KPNB1 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122694 bait prey AIRE SMC1A MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_122689|BIOGRID_122720 bait|prey prey|bait AIRE MCM6 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122682 bait prey AIRE NCK1 MI:0096(pull down)|MI:0081(peptide array)|MI:0081(peptide array)|MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint) UniProt_91826|MINT_43074|MINT_73117|MINT_72893|UniProt_91985|MINT_42850 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey AIRE CRK MI:0081(peptide array)|MI:0081(peptide array)|MI:0096(pull down) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_43398|MINT_73441|UniProt_91347 bait|bait|bait prey|prey|prey AIRE PARP1 MI:0004(affinity chromatography technology) 20085707 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_122676 bait prey

PPI - HINT Gene A Gene B PMID Method Quality AIRE AIRE 10748110,12929931,10748110,12929931,10748110,10748110,20185822,10748110,20185822 0045,0018,0096,0096,0019,0018,0004,0004,0007 LC AIRE EIF4EBP3 23443559 0004 HT AIRE TUBB 23443559 0004 HT AIRE HSP90AB1 23443559 0004 HT AIRE UBB 23443559 0004 HT AIRE HSPA1B 23443559 0004 HT AIRE HSPA1L 23443559 0004 HT AIRE TUBB4B 23443559 0004 HT AIRE FAT1 23443559 0004 HT AIRE GIGYF2 23443559 0004 HT AIRE RAVER1 23443559 0004 HT AIRE TUBA1C 23443559 0004 HT AIRE TMPRSS13 23443559 0004 HT AIRE CCDC87 23443559 0004 HT AIRE SRRM2 23443559 0004 HT AIRE HEL-S-72P 23443559 0004 HT AIRE HEL-S-89N 15150263,23443559 0004,0004 LC,HT AIRE EIF4EBP3 23443559 0004 HT AIRE TUBB 23443559 0004 HT AIRE HSP90AB1 23443559 0004 HT AIRE UBB 23443559 0004 HT AIRE HSPA1B 23443559 0004 HT AIRE HSPA1L 23443559 0004 HT AIRE TUBB4B 23443559 0004 HT AIRE FAT1 23443559 0004 HT AIRE GIGYF2 23443559 0004 HT AIRE RAVER1 23443559 0004 HT AIRE TUBA1C 23443559 0004 HT AIRE TMPRSS13 23443559 0004 HT AIRE CCDC87 23443559 0004 HT AIRE SRRM2 23443559 0004 HT AIRE HEL-S-72P 23443559 0004 HT AIRE HEL-S-89N 23443559 0004 HT AIRE AIRE 10748110,12929931,10748110,12929931,10748110,10748110,20185822,10748110,20185822 0045,0018,0096,0096,0019,0018,0004,0004,0007 LC AIRE HEL-S-89N 15150263 0004 LC AIRE AIRE 10748110,12929931,11533054,11533054,11533054,10748110,12929931,10748110,10748110,10748110 0045,0018,0045,0018,0019,0096,0096,0019,0018,0004 LC AIRE ABL1 17474147 0081 HT AIRE FYN 17474147 0081 HT AIRE SRC 17474147 0081 HT AIRE NCK1 17474147 0081 HT AIRE PLCG1 17474147 0081 HT AIRE PIK3R1 17474147 0081 HT AIRE CRK 17474147 0081 HT AIRE GRB2 17474147 0081 HT AIRE HIST1H3A|HIST1H3B|HIST1H3C|HIST1H3D|HIST1H3E|HIST1H3F|HIST1H3G|HIST1H3H|HIST1H3I|HIST1H3J 18292755,18292755,18292755,18292755,18292755,18292755 0114,0004,0051,0077,0096,0065 LC AIRE CREBBP 10748110,12929931,12929931,10748110,10748110 0045,0018,0047,0018,0047 LC AIRE UBAC1 16310047 0018 LC AIRE DAXX 20185822,20185822,20185822,20185822 0663,0004,0018,0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID O43918 O00567 AIRE NOP56 0.126 20085707 O43918 O14980 AIRE XPO1 0.126 20085707 O43918 O43592 AIRE XPOT 0.126 20085707 O60216 O43918 RAD21 AIRE 0.332 20085707 O60516 O43918 EIF4EBP3 AIRE 0.126 23443559 O95373 O43918 IPO7 AIRE 0.126 20085707 P00519 O43918 ABL1 AIRE 0.236 17474147 P06241 O43918 FYN AIRE 0.126 17474147 P07437 O43918 TUBB AIRE 0.126 23443559 P08238 O43918 HSP90AB1 AIRE 0.126 23443559 P09874 O43918 PARP1 AIRE 0.126 20085707 P0CG47 O43918 UBB AIRE 0.126 23443559 P0DMV8 O43918 HSPA1A AIRE 0.126 23443559 P0DMV9 O43918 HSPA1B {ECO:0000312|HGNC:HGNC:5233} AIRE 0.126 23443559 P11142 O43918 HSPA8 AIRE 0.126 23443559 P11388 O43918 TOP2A AIRE 0.416 20085707 P11940 O43918 PABPC1 AIRE 0.126 20085707 P12004 O43918 PCNA AIRE 0.126 20085707 P12931 O43918 SRC AIRE 0.236 17474147 P13010 O43918 XRCC5 AIRE 0.236 20085707 P14678 O43918 SNRPB AIRE 0.126 20085707 P16104 O43918 H2AFX AIRE 0.236 20085707 P16333 O43918 NCK1 AIRE 0.236 17474147 P23527 O43918 HIST1H2BO AIRE 0.126 20085707 P24928 O43918 POLR2A AIRE 0.126 20085707 P27986 O43918 PIK3R1 AIRE 0.126 17474147 P30876 O43918 POLR2B AIRE 0.126 20085707 P33778 O43918 HIST1H2BB AIRE 0.21 18292755 P33992 O43918 MCM5 AIRE 0.126 20085707 P34931 O43918 HSPA1L AIRE 0.126 23443559 P34932 O43918 HSPA4 AIRE 0.21 15150263 P43246 O43918 MSH2 AIRE 0.126 20085707 P49736 O43918 MCM2 AIRE 0.126 20085707 P49792 O43918 RANBP2 AIRE 0.126 20085707 P52701 O43918 MSH6 AIRE 0.126 20085707 P62318 O43918 SNRPD3 AIRE 0.126 20085707 P68371 O43918 TUBB4B AIRE 0.126 23443559 P84103 O43918 SRSF3 AIRE 0.126 20085707 Q07955 O43918 SRSF1 AIRE 0.126 20085707 Q13547 O43918 HDAC1 AIRE 0.21 20185822 Q14517 O43918 FAT1 AIRE 0.126 23443559 Q14566 O43918 MCM6 AIRE 0.126 20085707 Q14974 O43918 KPNB1 AIRE 0.126 20085707 Q15029 O43918 EFTUD2 AIRE 0.126 20085707 Q16778 O43918 HIST2H2BE AIRE 0.309 18292755 Q6Y7W6 O43918 GIGYF2 AIRE 0.126 23443559 Q8IY67 O43918 RAVER1 AIRE 0.126 23443559 Q8TD26 O43918 CHD6 AIRE 0.126 20085707 Q8TEQ6 O43918 GEMIN5 AIRE 0.126 20085707 Q92769 O43918 HDAC2 AIRE 0.21 20185822 Q92841 O43918 DDX17 AIRE 0.126 20085707 Q93077 O43918 HIST1H2AC AIRE 0.126 20085707 Q96S59 O43918 RANBP9 AIRE 0.126 20085707 Q99MD9 O43918 NASP AIRE 0.126 20085707 Q9BQE3 O43918 TUBA1C AIRE 0.126 23443559 Q9BSL1 O43918 UBAC1 AIRE 0.309 16310047 Q9BYE2 O43918 TMPRSS13 AIRE 0.126 23443559 Q9NVE4 O43918 CCDC87 AIRE 0.126 23443559 Q9UQ35 O43918 SRRM2 AIRE 0.126 23443559 Q9UQE7 O43918 SMC3 AIRE 0.126 20085707 Q9Y230 O43918 RUVBL2 AIRE 0.126 20085707 Q7TPV4 O43918 MYBBP1A AIRE 0.126 20085707 Q8N1F7 O43918 NUP93 AIRE 0.416 20085707 P78527 O43918 PRKDC AIRE 0.416 20085707 P20700 O43918 LMNB1 AIRE 0.416 20085707 Q01130 O43918 SRSF2 AIRE 0.416 20085707 Q9UBQ0 O43918 VPS29 AIRE 0.236 unassigned1304 Q9BYR6 O43918 KRTAP3-3 AIRE 0.236 unassigned1304 O43918 B8A4K4 AIRE CYSRT1 {ECO:0000313|ENSEMBL:ENSP00000386453} 0.236 unassigned1304 P11021 O43918 HSPA5 AIRE 0.309 15150263,23443559 O95833 O43918 CLIC3 AIRE 0.236 unassigned1304 Q5TD97 O43918 FHL5 AIRE 0.236 unassigned1304 Q16134 O43918 ETFDH AIRE 0.236 unassigned1304 Q9UER7 O43918 DAXX AIRE 0.82 20185822 P68431 O43918 HIST1H3J AIRE 0.982 18292755 Q92793 O43918 CREBBP AIRE 0.772 10748110,12929931 O43918 O43918 AIRE AIRE 0.884 10748110,12929931,20185822 Q9BQG0 O43918 MYBBP1A AIRE 0.236 20085707 P46108 O43918 CRK AIRE 0.126 17474147 P17844 O43918 DDX5 AIRE 0.332 20085707 P62993 O43918 GRB2 AIRE 0.126 17474147 P49321 O43918 NASP AIRE 0.236 20085707 Q14683 O43918 SMC1A AIRE 0.236 20085707 P19174 O43918 PLCG1 AIRE 0.236 17474147 Q13263 O43918 TRIM28 AIRE 0.332 20085707 P20648 O43918 ATP4A AIRE 0.126 17255364 Q16695 O43918 HIST3H3 AIRE 0.21 20953165 Q08945 O43918 SSRP1 AIRE 0.236 20085707

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 RGPD3 AIRE MI:0362 inference MI:0461 interaction database NOP56 AIRE MI:0045 experimental interaction detection MI:0461 interaction database RGPD8 AIRE MI:0362 inference MI:0461 interaction database XPO1 AIRE MI:0045 experimental interaction detection MI:0461 interaction database XPOT AIRE MI:0045 experimental interaction detection MI:0461 interaction database AIRE RAD21 MI:0045 experimental interaction detection MI:0461 interaction database AIRE EIF4EBP3 MI:0045 experimental interaction detection MI:0461 interaction database AIRE IPO7 MI:0045 experimental interaction detection MI:0461 interaction database AIRE ABL1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST1H2AB MI:0362 inference MI:0461 interaction database AIRE FYN MI:0045 experimental interaction detection MI:0461 interaction database AIRE TUBB MI:0045 experimental interaction detection MI:0461 interaction database AIRE HSP90AB1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE PARP1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE H2AFZ MI:0362 inference MI:0461 interaction database AIRE HIST1H2AG MI:0362 inference MI:0461 interaction database AIRE UBB MI:0045 experimental interaction detection MI:0461 interaction database AIRE RGPD1 MI:0362 inference MI:0461 interaction database AIRE RGPD2 MI:0362 inference MI:0461 interaction database AIRE HSPA1A MI:0045 experimental interaction detection MI:0461 interaction database AIRE HSPA1B MI:0045 experimental interaction detection MI:0461 interaction database AIRE HSPA5 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HSPA8 MI:0045 experimental interaction detection MI:0461 interaction database AIRE TOP2A MI:0045 experimental interaction detection MI:0461 interaction database AIRE PABPC1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE PCNA MI:0045 experimental interaction detection MI:0461 interaction database AIRE SRC MI:0045 experimental interaction detection MI:0461 interaction database AIRE XRCC5 MI:0045 experimental interaction detection MI:0461 interaction database AIRE SNRPB MI:0045 experimental interaction detection MI:0461 interaction database AIRE H2AFX MI:0045 experimental interaction detection MI:0461 interaction database AIRE NCK1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE DDX5 MI:0045 experimental interaction detection MI:0461 interaction database AIRE PLCG1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE ATP4A MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST1H2AD MI:0362 inference MI:0461 interaction database AIRE LMNB1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST1H2BO MI:0045 experimental interaction detection MI:0461 interaction database AIRE POLR2A MI:0045 experimental interaction detection MI:0461 interaction database AIRE PIK3R1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE POLR2B MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST1H2BB MI:0045 experimental interaction detection MI:0461 interaction database AIRE MCM5 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HSPA1L MI:0045 experimental interaction detection MI:0461 interaction database AIRE HSPA4 MI:0045 experimental interaction detection MI:0461 interaction database AIRE MSH2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE CRK MI:0045 experimental interaction detection MI:0461 interaction database AIRE NASP MI:0045 experimental interaction detection MI:0461 interaction database AIRE MCM2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE RANBP2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE MSH6 MI:0045 experimental interaction detection MI:0461 interaction database AIRE SNRPD3 MI:0045 experimental interaction detection MI:0461 interaction database AIRE GRB2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE TUBB4B MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST1H3A MI:0045 experimental interaction detection MI:0461 interaction database AIRE PRKDC MI:0045 experimental interaction detection MI:0461 interaction database AIRE SRSF3 MI:0045 experimental interaction detection MI:0461 interaction database AIRE SRSF2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE TOP2B MI:0362 inference MI:0461 interaction database AIRE C1QBP MI:0362 inference MI:0461 interaction database AIRE SRSF1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE SSRP1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE TRIM28 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HDAC1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE FAT1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE MCM6 MI:0045 experimental interaction detection MI:0461 interaction database AIRE SMC1A MI:0045 experimental interaction detection MI:0461 interaction database AIRE KPNB1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE EFTUD2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST3H3 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST2H2AC MI:0362 inference MI:0461 interaction database AIRE HIST2H2BE MI:0045 experimental interaction detection MI:0461 interaction database AIRE PABPC1L MI:0362 inference MI:0461 interaction database AIRE PABPC1L2A MI:0362 inference MI:0461 interaction database AIRE HIST2H2BF MI:0362 inference MI:0461 interaction database AIRE HIST2H2AA3 MI:0362 inference MI:0461 interaction database AIRE GIGYF2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST3H2A MI:0362 inference MI:0461 interaction database AIRE RGPD4 MI:0362 inference MI:0461 interaction database AIRE CAND1 MI:0362 inference MI:0461 interaction database AIRE HIST2H2AB MI:0362 inference MI:0461 interaction database AIRE RAVER1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE NUP93 MI:0045 experimental interaction detection MI:0461 interaction database AIRE CHD6 MI:0045 experimental interaction detection MI:0461 interaction database AIRE GEMIN5 MI:0045 experimental interaction detection MI:0461 interaction database AIRE GCN1 MI:0362 inference MI:0461 interaction database AIRE HDAC2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE CREBBP MI:0045 experimental interaction detection MI:0461 interaction database AIRE DDX17 MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST1H2AC MI:0045 experimental interaction detection MI:0461 interaction database AIRE HIST1H2AH MI:0362 inference MI:0461 interaction database AIRE HIST1H2AA MI:0362 inference MI:0461 interaction database AIRE RANBP9 MI:0045 experimental interaction detection MI:0461 interaction database AIRE RGPD5 MI:0362 inference MI:0461 interaction database AIRE HIST1H2AJ MI:0362 inference MI:0461 interaction database AIRE TUBA1C MI:0045 experimental interaction detection MI:0461 interaction database AIRE MYBBP1A MI:0045 experimental interaction detection MI:0461 interaction database AIRE UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE H2AFJ MI:0362 inference MI:0461 interaction database AIRE TMPRSS13 MI:0045 experimental interaction detection MI:0461 interaction database AIRE PABPC3 MI:0362 inference MI:0461 interaction database AIRE CCDC87 MI:0045 experimental interaction detection MI:0461 interaction database AIRE DAXX MI:0045 experimental interaction detection MI:0461 interaction database AIRE SRRM2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE SMC3 MI:0045 experimental interaction detection MI:0461 interaction database AIRE RUVBL2 MI:0045 experimental interaction detection MI:0461 interaction database AIRE SUPT16H MI:0362 inference MI:0461 interaction database