PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HMGA2 E4F1 14645522 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G E4F1 EHMT2 16189514 hprd,biogrid,mint exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 FOXB1 25609649 intact exp E4F1 UPF2 15231747 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDKN2A E4F1 12446718 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD9 E4F1 15231748 hprd,biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 LNX2 21666599 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KRTAP10-7 E4F1 25416956 biogrid,intact exp FHL2 E4F1 16652157 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 LNX1 21666599 mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G KRTAP10-4 E4F1 25416956 intact exp TP53 E4F1 17110336,10644996,16652157,12446718, 25402006, 21836163 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRKDC E4F1 10608806, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HDAC1 E4F1 21666599,12730668, 25402006 biogrid,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ANP32A E4F1 17557114, 25402006, 21836163 hprd,mint,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 RASSF1 14729613, 25402006, 21836163 hprd,biogrid,intact exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATR E4F1 10608806, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RB1 E4F1 10869426, 25402006 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATM E4F1 10608806, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NFE2 E4F1 ortho G G G E4F1 GMEB2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SATB1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 SIN3A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 THOC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TOP1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ETS1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRDM2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 PHF21A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL7 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 EID1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2F4 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EP300 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GLI3 E4F1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SP1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CSNK1D E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCNT2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDK9 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAPK8 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STAT1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NFKBIA E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2F3 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G TRIP11 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 TDP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MTA1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NFYA E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NBN E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TAL1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G CBX4 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MTA2 E4F1 25402006 pred G INS E4F1 25402006 pred G G G HDAC3 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 PA2G4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYOD1 E4F1 25402006 pred G G E4F1 USP7 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATMIN E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2F1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G CBX5 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XRCC6 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CCND2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BRCA1 E4F1 25402006 pred G G G G SIN3B E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBBP7 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SAP18 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 PRDM16 23023127 pred G G G G G G G G G G G G G HR E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 MBD1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SKP2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 RCHY1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CHEK2 E4F1 25402006 pred G G G G G G G G G G G G G G E4F1 GCM1 25402006 pred G E4F1 RCOR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LIG4 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G E4F1 DAXX 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BLM E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STK11 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PURA E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDK2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EIF4EBP1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G PIAS2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 RAD9A 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMARCB1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARID4A E4F1 25402006 pred G G G G G G G G G G G G G G G G G G E4F1 CDKN2A 21836163 pred MDM2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 CABLES1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CTBP2 E4F1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MECOM E4F1 23023127 pred G G G G G G G G G G G G G G G G G G G G G JUN E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NPM1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP1S E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TAF9 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MDM4 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBBP4 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAD51 E4F1 25402006 pred G G G G G G G G G G G G G SNAI1 E4F1 25402006 pred G G G G G G G PML E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HUS1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 KAT2B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIF1A E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIN1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G NFYB E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E2F2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G BCL6 E4F1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SAP30 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 PIAS4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G E4F1 PPP1R13L 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CTBP1 E4F1 25402006, 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPI1 E4F1 25402006 pred G G G G G CSNK2A1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAP1B E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EWSR1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NR4A1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIAS1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ESR1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 BRF1 25402006 pred G G G G G G G G G G G G G AR E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GPS2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 ING5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CEBPB E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NCOA6 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUV39H1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CHD3 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 SNAPC3 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CHD4 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PARP1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2I E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 AATF 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HTT E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 ING4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G MECP2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TP73 E4F1 25402006 pred G G G G G E4F1 TELO2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 KAT8 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 CHFR 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBL1 E4F1 25402006 pred G G G G G G G G CDC20 E4F1 25402006 pred G G G G G G G G G G ABL1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RAD17 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HRAS E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AXIN1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 RBBP8 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TGIF1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRMT2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G H2AFX E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 RYBP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 ADNP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NOTCH1 E4F1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAPK1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 CUL9 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G CDC25C E4F1 25402006 pred G G G G G G G MDC1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CHEK1 E4F1 25402006 pred G G G G E4F1 PADI4 25402006 pred G G MAPK9 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 CNKSR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 ING1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 ING2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ETHE1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GSK3B E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KDM5A E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 KDM5B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 HDAC2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 HIPK2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMARCA4 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 NABP2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G DNMT1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 RRM2B 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SET E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CREB1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 COPS5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CSNK2B E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STAT3 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 PLAGL1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 SMARCC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 L3MBTL1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G CUX1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMAD2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 NR2E3 25402006 pred CDKN1A E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AP1B1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HCFC1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TP53BP1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G STK4 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WRN E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G RRM2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDK7 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PHB E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G E4F1 CREBBP 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AGRN E4F1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TBP E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G YY1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RBL2 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRAF1 E4F1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q66K89 two hybrid 16189514 direct interaction X 2 Q66K89 A0A024R3Z2 affinity chromatography technology 15876874 physical association X 2 Q66K89 two hybrid 25416956 direct interaction X 2 Q66K89 P52926-4 pull down 14645522 direct interaction X 2 Q66K89 P52926-4 affinity chromatography technology 14645522 physical association X 2 Q66K89 P52926-4 far western blotting 14645522 direct interaction X 2 Q66K89 A0A0A0MSG2 two hybrid 16652157 direct interaction X 2 Q66K89 A0A0A0MSG2 pull down 16652157 direct interaction X 2 Q66K89 A0A0A0MSG2 affinity chromatography technology 16652157 physical association X 2 Q66K89 A0A0A0MSG2 affinity chromatography technology 16652157 physical association X 2 Q66K89 P78527-2 unspecified method 10608806 direct interaction X 2 Q66K89 Q8N726 two hybrid 12446718 direct interaction X 2 Q66K89 Q8N726 affinity chromatography technology 12446718 physical association X 2 Q9YHE8 Q66K89 affinity chromatography technology 21666599 physical association X 2 Q13547 Q66K89 affinity chromatography technology 21666599 physical association X 2 Q13547 Q66K89 affinity chromatography technology 12730668 physical association X 2 Q13547 Q66K89 pull down 12730668 direct interaction X 2 Q13547 Q66K89 affinity chromatography technology 12730668 physical association X 2 Q66K89 two hybrid 15231748 direct interaction X 2 Q66K89 Q9NS23-5 two hybrid 14729613 direct interaction X 2 Q66K89 Q9NS23-5 pull down 14729613 direct interaction X 2 Q66K89 Q9NS23-5 affinity chromatography technology 14729613 physical association X 2 Q66K89 Q9NS23-5 pull down 14729613 direct interaction X 2 Q66K89 P04637-7 affinity chromatography technology 16652157 physical association X 2 Q66K89 A0A024R3C7 unspecified method 10608806 direct interaction X 2 Q66K89 Q13535 unspecified method 10608806 direct interaction X 2 Q66K89 P04637-7 affinity chromatography technology 12446718 physical association X 2 Q66K89 A0A024RDV3 two hybrid 10869426 direct interaction X 2 Q66K89 A0A024RDV3 pull down 10869426 direct interaction X 2 Q66K89 A0A024RDV3 affinity chromatography technology 10869426 physical association X 2 Q66K89 P04637-7 two hybrid 10644996 direct interaction X 2 Q66K89 P04637-7 pull down 10644996 direct interaction X 2 Q66K89 P04637-7 affinity chromatography technology 10644996 physical association X 2 Q9HAU5 Q66K89 two hybrid 15231747 direct interaction X 2 Q66K89 two hybrid 25416956 direct interaction X 2 P04637-8 Q66K89 in vivo 10644996,12446718,17110336 - X 2 P04637-8 Q66K89 in vitro 10644996,12446718,17110336 - X 2 P04637-8 Q66K89 in vivo 10644996,12446718,17110336 - X 2 P04637-8 Q66K89 in vitro 10644996,12446718,17110336 - X 2 Q96KQ7-2 Q66K89 two hybrid 16189514 - X 2 Q96KQ7-2 Q66K89 two hybrid 16189514 - X 2 Q66K89 G3XAG3 in vivo 12446718 - X 2 Q66K89 G3XAG3 in vivo 12446718 - X 2 Q66K89 Q9NS23-7 in vitro 14729613 - X 2 Q66K89 Q9NS23-7 in vivo 14729613 - X 2 Q66K89 Q9NS23-7 two hybrid 14729613 - X 2 Q66K89 Q9NS23-7 in vitro 14729613 - X 2 Q66K89 Q9NS23-7 two hybrid 14729613 - X 2 Q66K89 Q9NS23-7 in vivo 14729613 - X 2 Q66K89 A0A024RDV3 two hybrid 10869426 - X 2 Q66K89 A0A024RDV3 in vivo 10869426 - X 2 Q66K89 A0A024RDV3 in vitro 10869426 - X 2 Q66K89 P39687 two hybrid 17557114 - X 2 Q66K89 P39687 in vivo 17557114 - X 2 Q66K89 A0A024RDV3 in vitro 10869426 - X 2 Q66K89 A0A024RDV3 in vivo 10869426 - X 2 Q66K89 A0A024RDV3 two hybrid 10869426 - X 2 Q66K89 P39687 two hybrid 17557114 - X 2 Q66K89 P39687 in vivo 17557114 - X 2 A0A024RDR3 Q66K89 two hybrid 15231748 - X 2 A0A024RDR3 Q66K89 two hybrid 15231748 - X 2 Q66K89 Q64770 two hybrid 12730668 physical association X 2 Q66K89 Q64770 coimmunoprecipitation 12730668 physical association X 2 Q66K89 Q64770 anti tag coimmunoprecipitation 12730668 physical association X 2 Q66K89 Q64770 pull down 12730668 physical association X 2 Q66K89 Q9NS23-2 two hybrid 14729613 physical association X 2 Q66K89 Q9NS23-2 pull down 14729613 direct interaction X 2 Q66K89 Q9NS23-2 anti bait coimmunoprecipitation 14729613 physical association X 2 Q66K89 Q9NS23-2 anti bait coimmunoprecipitation 14729613 physical association X 2 Q66K89 Q9NS23-2 anti bait coimmunoprecipitation 14729613 physical association X 2 Q66K89 Q9NS23-2 anti tag coimmunoprecipitation 14729613 direct interaction X 2 Q66K89 Q9NS23-2 anti tag coimmunoprecipitation 14729613 direct interaction X 2 Q66K89 Q8N448 anti tag coimmunoprecipitation 21666599 physical association X 2 Q9YHE8 Q66K89 anti tag coimmunoprecipitation 21666599 physical association X 2 Q9YHE8 Q66K89 anti tag coimmunoprecipitation 21666599 physical association X 2 A4VCF7 Q66K89 anti tag coimmunoprecipitation 21666599 physical association X 2 A4VCF7 Q66K89 anti tag coimmunoprecipitation 21666599 physical association X 2 A4VCF7 Q66K89 pull down 21666599 direct interaction X 2 O15198 Q66K89 two hybrid 15231748 physical association X 2 Q13547 Q66K89 anti tag coimmunoprecipitation 12730668 physical association X 2 Q13547 Q66K89 pull down 12730668 physical association X 2 Q13547 Q66K89 anti tag coimmunoprecipitation 12730668 physical association X 2 Q13547 Q66K89 anti tag coimmunoprecipitation 21666599 physical association X 2 Q13547 Q66K89 anti tag coimmunoprecipitation 21666599 physical association X 2 Q66K89 P39687 imaging technique 17557114 colocalization X 2 Q66K89 P39687 pull down 17557114 physical association X 2 Q66K89 P39687 anti tag coimmunoprecipitation 17557114 physical association X 2 Q66K89 Q8TBB1 anti tag coimmunoprecipitation 21666599 physical association X 2 Q8V1H6 Q66K89 two hybrid 16112766 physical association X 2 Q8V1H6 Q66K89 pull down 16112766 direct interaction X 2 Q8V1H6 Q66K89 pull down 16112766 direct interaction X 2 Q8V1H6 Q66K89 two hybrid 16112766 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B E4F1 UPF2 MI:0018(two hybrid) 15231747 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_290066 prey bait CDKN2A E4F1 MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid) 12446718 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid) BIOGRID_96395|HPRD_6439|BIOGRID_96394 prey|-|bait bait|-|prey E4F1 EHMT2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction) MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(biogrid) MINT_68486|MINT_39224|HPRD_22142|BIOGRID_80490 bait|bait|-|bait prey|prey|-|prey SMAD9 E4F1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint) UniProt_79094|HPRD_1205|BIOGRID_258702|MINT_61425|MINT_32577 bait|-|bait|bait|bait prey|-|prey|prey|prey E4F1 LNX1 MI:0007(anti tag coimmunoprecipitation) 21666599 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_115364 prey bait ATM E4F1 MI:0686(unspecified method) 10608806 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_85126 bait prey E4F1 RASSF1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid) 14729613 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0468(hprd)|(intact) UniProt_74103|UniProt_74111|UniProt_74110|UniProt_74108|UniProt_74109|UniProt_74106|HPRD_20001|UniProt_74107 prey|prey|prey|prey|prey|prey|-|bait null|null|null|null|null|null|-|null E4F1 LNX2 MI:0007(anti tag coimmunoprecipitation) 21666599 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_115365 prey bait ANP32A E4F1 MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0018(two hybrid)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique)|MI:0428(imaging technique) 17557114 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization) MI:0471(mint)|MI:0471(mint)|MI:0468(hprd)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint) MINT_55131|MINT_55119|HPRD_32876|UniProt_92465|MINT_57749|UniProt_92463|UniProt_92464|MINT_57776|MINT_57726|MINT_55097 bait|prey|-|bait|prey|neutral component|prey|bait|neutral component|neutral component prey|bait|-|prey|bait|neutral component|bait|prey|neutral component|neutral component SUMO1 E4F1 MI:0004(affinity chromatography technology) 15876874 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201643 bait prey PRKDC E4F1 MI:0686(unspecified method) 10608806 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_85128 bait prey E4F1 HDAC1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 21666599 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_115352|UniProt_115360 bait|bait prey|prey p53 E4F1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid) 10644996,12446718 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_103779|BIOGRID_103778|HPRD_4510|BIOGRID_103780|BIOGRID_96397 prey|bait|-|bait|bait bait|prey|-|prey|prey RB1 E4F1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 10869426 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_103521|BIOGRID_103522|BIOGRID_103523|HPRD_2619 bait|prey|prey|- prey|bait|bait|- ATR E4F1 MI:0686(unspecified method) 10608806 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_85127 bait prey HDAC1 E4F1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 12730668,21666599 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(intact)|(biogrid) UniProt_73076|UniProt_73073|BIOGRID_131826|MINT_37062|MINT_66234|BIOGRID_131827|MINT_37061|MINT_37060|MINT_66232|MINT_66233|BIOGRID_131825|UniProt_73071|BIOGRID_195252 prey|bait|bait|prey|prey|bait|bait|bait|bait|bait|prey|bait|prey bait|prey|prey|bait|bait|prey|prey|prey|prey|prey|bait|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality TP53 E4F1 10644996,10644996,12446718,10644996 0018,0096,0004,0004 LC HDAC1 E4F1 12730668,21666599,21666599,12730668,12730668 0004,0004,0007,0007,0096 LC Q53GA5 E4F1 10644996,10644996,16652157,12446718,10644996 0018,0096,0004,0004,0004 LC E4F1 FOXB1 25609649,25609649 0676,0004 HT E4F1 FOXB1 25609649,25609649 0676,0004 HT TP53 E4F1 10644996,10644996,12446718,10644996 0018,0096,0004,0004 LC HDAC1 E4F1 12730668,21666599,21666599,12730668,12730668 0004,0004,0007,0007,0096 LC Q53GA5 E4F1 10644996,10644996,16652157,12446718,10644996 0018,0096,0004,0004,0004 LC SMAD9 E4F1 15231748 0018 HT TP53 E4F1 10644996,10644996,10644996 0018,0096,0004 LC RB1 E4F1 10869426,10869426,10869426 0018,0096,0004 LC ANP32A E4F1 17557114,17557114,17557114,17557114 0428,0007,0018,0096 LC CDKN2A E4F1 12446718,12446718 0018,0004 LC HMGA2 E4F1 14645522,14645522,14645522 0096,0047,0004 LC KRTAP10-4 E4F1 25416956,25416956,25416956 1112,0397,1356 HT KRTAP10-7 E4F1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FHL2 E4F1 16652157,16652157,16652157 0004,0018,0096 LC Q53GA5 E4F1 10644996,10644996,10644996 0018,0096,0004 LC E4F1 EHMT2 16189514 0018 HT E4F1 UPF2 15231747 0018 HT E4F1 RASSF1 14729613,14729613,14729613,14729613,14729613 0096,0004,0006,0007,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N726 Q66K89 CDKN2A E4F1 0.454 12446718 Q9HAU5 Q66K89 UPF2 E4F1 0.183 15231747 Q8TBB1 Q66K89 LNX1 E4F1 0.21 21666599 Q9YHE8 Q66K89 TCF7L1A E4F1 0.376 21666599 Q66K89 P60409 E4F1 KRTAP10-7 0.183 25416956 Q8N448 Q66K89 LNX2 E4F1 0.21 21666599 Q96KQ7 Q66K89 EHMT2 E4F1 0.183 16189514 Q6IT96 Q66K89 HDAC1 E4F1 0.21 21666599 Q66K89 P06400 E4F1 RB1 0.623 10869426 Q8V1H6 Q66K89 Q8V1H6 E4F1 0.523 16112766 Q99853 Q66K89 FOXB1 E4F1 0.236 25609649 Q66K89 O15198 E4F1 SMAD9 0.332 15231748 Q66K89 A4VCF7 E4F1 LNX2B 0.454 21666599 Q66K89 P04637 E4F1 TP53 0.765 16652157,10644996,12446718 Q66K89 P39687 E4F1 ANP32A 0.554 17557114 Q66K89 Q13547 E4F1 HDAC1 0.832 12730668,21666599 Q66K89 P52926 E4F1 HMGA2 0.623 14645522 Q66K89 Q64770 E4F1 Q64770 0.659 12730668 Q9NS23 Q66K89 RASSF1 E4F1 0.946 14729613 Q66K89 P42771 E4F1 CDKN2A 0.454 12446718 Q66K89 Q13535 E4F1 ATR 0.183 10608806 Q66K89 P78527 E4F1 PRKDC 0.183 10608806 Q66K89 Q14192 E4F1 FHL2 0.702 16652157 Q66K89 Q13315 E4F1 ATM 0.183 10608806

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SMAD9 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database ANP32D E4F1 MI:0362 inference MI:0461 interaction database TP53 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database RB1 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database ANP32A E4F1 MI:0045 experimental interaction detection MI:0461 interaction database CDKN2A E4F1 MI:0045 experimental interaction detection MI:0461 interaction database HMGA2 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database KRTAP10-7 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database PRKDC E4F1 MI:0362 inference MI:0461 interaction database ATM E4F1 MI:0362 inference MI:0461 interaction database ATR E4F1 MI:0362 inference MI:0461 interaction database HDAC1 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database FHL2 E4F1 MI:0045 experimental interaction detection MI:0461 interaction database NFE2 E4F1 MI:0362 inference MI:0461 interaction database E4F1 LNX2 MI:0045 experimental interaction detection MI:0461 interaction database E4F1 CDKN2A MI:0045 experimental interaction detection MI:0461 interaction database E4F1 LNX1 MI:0045 experimental interaction detection MI:0461 interaction database E4F1 EHMT2 MI:0045 experimental interaction detection MI:0461 interaction database E4F1 FOXB1 MI:0045 experimental interaction detection MI:0461 interaction database E4F1 UPF2 MI:0045 experimental interaction detection MI:0461 interaction database E4F1 TCF7L1 MI:0362 inference MI:0461 interaction database E4F1 RASSF1 MI:0045 experimental interaction detection MI:0461 interaction database E4F1 GMEB2 MI:0362 inference MI:0461 interaction database