Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change BLCA 2 85822917 85822917 + Missense_Mutation SNP G G A TCGA-KQ-A41R-01A-21D-A34U-08 TCGA-KQ-A41R-10G-01D-A34X-08 g.chr2:85822917G>A c.31G>A c.(31-33)Gag>Aag p.E11K BLCA 2 85823723 85823723 + Missense_Mutation SNP G G T TCGA-FD-A3N5-01A-11D-A21A-08 TCGA-FD-A3N5-10A-01D-A21A-08 g.chr2:85823723G>T c.168G>T c.(166-168)aaG>aaT p.K56N BLCA 2 85823747 85823747 + Silent SNP G G A TCGA-K4-A54R-01A-11D-A26M-08 TCGA-K4-A54R-10A-01D-A26K-08 g.chr2:85823747G>A c.192G>A c.(190-192)agG>agA p.R64R BLCA 2 85823766 85823766 + Nonsense_Mutation SNP C C T TCGA-LC-A66R-01A-41D-A30E-08 TCGA-LC-A66R-10A-01D-A30H-08 g.chr2:85823766C>T c.211C>T c.(211-213)Cag>Tag p.Q71* BLCA 2 85824037 85824037 + Silent SNP C C T TCGA-MV-A51V-01A-11D-A26M-08 TCGA-MV-A51V-10A-01D-A26K-08 g.chr2:85824037C>T c.310C>T c.(310-312)Ctg>Ttg p.L104L COAD 2 85824623 85824623 + Missense_Mutation SNP C C T TCGA-CK-5916-01A-11D-1650-10 TCGA-CK-5916-10A-01D-1650-10 g.chr2:85824623C>T c.458C>T c.(457-459)aCg>aTg p.T153M COADREAD 2 85824623 85824623 + Missense_Mutation SNP C C T TCGA-CK-5916-01A-11D-1650-10 TCGA-CK-5916-10A-01D-1650-10 g.chr2:85824623C>T c.458C>T c.(457-459)aCg>aTg p.T153M GBM 2 85824255 85824255 + Missense_Mutation SNP A A G TCGA-06-2563-01A-01D-1494-08 TCGA-06-2563-10A-01D-1494-08 g.chr2:85824255A>G c.356A>G c.(355-357)gAg>gGg p.E119G GBMLGG 2 85824255 85824255 + Missense_Mutation SNP A A G TCGA-06-2563-01A-01D-1494-08 TCGA-06-2563-10A-01D-1494-08 g.chr2:85824255A>G c.356A>G c.(355-357)gAg>gGg p.E119G HNSC 2 85824002 85824006 + Frame_Shift_Del DEL TGCCT TGCCT - TCGA-CV-7440-01A-11D-2129-08 TCGA-CV-7440-10A-01D-2129-08 g.chr2:85824002_85824006delTGCCT c.275_279delTGCCT c.(274-279)atgcctfs p.MP92fs KICH 2 85823695 85823695 + Missense_Mutation SNP A A G TCGA-KM-8440-01A-11D-2310-10 TCGA-KM-8440-10A-01D-2311-10 g.chr2:85823695A>G c.140A>G c.(139-141)gAc>gGc p.D47G KIPAN 2 85823695 85823695 + Missense_Mutation SNP A A G TCGA-KM-8440-01A-11D-2310-10 TCGA-KM-8440-10A-01D-2311-10 g.chr2:85823695A>G c.140A>G c.(139-141)gAc>gGc p.D47G KIPAN 2 85823986 85823987 + Missense_Mutation DNP GA GA AC TCGA-SX-A71U-01A-12D-A33Q-10 TCGA-SX-A71U-10A-01D-A33Q-10 g.chr2:85823986_85823987GA>AC c.259_260GA>AC c.(259-261)GAg>ACg p.E87T KIRP 2 85823986 85823987 + Missense_Mutation DNP GA GA AC TCGA-SX-A71U-01A-12D-A33Q-10 TCGA-SX-A71U-10A-01D-A33Q-10 g.chr2:85823986_85823987GA>AC c.259_260GA>AC c.(259-261)GAg>ACg p.E87T LUSC 2 85823972 85823972 + Missense_Mutation SNP A A T TCGA-43-2578-01A-01D-1522-08 TCGA-43-2578-11A-01D-1522-08 g.chr2:85823972A>T c.245A>T c.(244-246)gAa>gTa p.E82V PAAD 2 85822895 85822895 + Silent SNP C C T TCGA-3A-A9IS-01A-21D-A397-08 TCGA-3A-A9IS-10A-01D-A39A-08 g.chr2:85822895C>T c.9C>T c.(7-9)tcC>tcT p.S3S PAAD 2 85824016 85824016 + Missense_Mutation SNP C C T TCGA-Q3-A5QY-01A-12D-A32N-08 TCGA-Q3-A5QY-10A-01D-A32N-08 g.chr2:85824016C>T c.289C>T c.(289-291)Ctt>Ttt p.L97F PRAD 2 85822908 85822908 + Missense_Mutation SNP C C T TCGA-HC-7231-01A-11D-2114-08 TCGA-HC-7231-10A-01D-2115-08 g.chr2:85822908C>T c.22C>T c.(22-24)Cac>Tac p.H8Y SKCM 2 85824049 85824049 + Missense_Mutation SNP A A C TCGA-FS-A1ZK-06A-11D-A197-08 TCGA-FS-A1ZK-10A-01D-A199-08 g.chr2:85824049A>C c.322A>C c.(322-324)Agc>Cgc p.S108R SKCM 2 85824241 85824241 + Silent SNP C C T TCGA-D3-A2JD-06A-11D-A19A-08 TCGA-D3-A2JD-10A-01D-A19A-08 g.chr2:85824241C>T c.342C>T c.(340-342)ccC>ccT p.P114P

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BLCA-US 2 85820206 85820206 single base substitution C T upstream_gene_variant BLCA-US 2 85823723 85823723 single base substitution G T exon_variant BLCA-US 2 85823723 85823723 single base substitution G T missense_variant K38N 114G>T BLCA-US 2 85823723 85823723 single base substitution G T missense_variant K56N 168G>T BOCA-FR 2 85818467 85818467 single base substitution C T upstream_gene_variant BOCA-FR 2 85820264 85820264 single base substitution C A upstream_gene_variant BRCA-EU 2 85818976 85818976 single base substitution C G upstream_gene_variant BRCA-EU 2 85820248 85820248 single base substitution G A upstream_gene_variant BRCA-EU 2 85820578 85820578 single base substitution C T upstream_gene_variant BRCA-EU 2 85824986 85824986 single base substitution C G downstream_gene_variant BRCA-EU 2 85826477 85826477 single base substitution C T downstream_gene_variant BRCA-EU 2 85828362 85828362 single base substitution C T downstream_gene_variant BRCA-EU 2 85828986 85828986 single base substitution C T downstream_gene_variant BRCA-FR 2 85822749 85822749 single base substitution T G upstream_gene_variant BRCA-UK 2 85820111 85820122 deletion of <=200bp AGAAGTGCTGGG - upstream_gene_variant BRCA-US 2 85818859 85818859 single base substitution G T upstream_gene_variant BRCA-US 2 85824654 85824654 single base substitution C T 3_prime_UTR_variant BRCA-US 2 85824654 85824654 single base substitution C T downstream_gene_variant BRCA-US 2 85824654 85824654 single base substitution C T missense_variant S159F 476C>T BRCA-US 2 85826426 85826426 single base substitution C T downstream_gene_variant BRCA-US 2 85827041 85827041 single base substitution C G downstream_gene_variant BTCA-JP 2 85828968 85828968 single base substitution C G downstream_gene_variant CESC-US 2 85818882 85818882 single base substitution C T upstream_gene_variant CESC-US 2 85820264 85820264 single base substitution C G upstream_gene_variant CESC-US 2 85828196 85828196 single base substitution C T downstream_gene_variant COAD-US 2 85820078 85820078 deletion of <=200bp C - upstream_gene_variant COAD-US 2 85824623 85824623 single base substitution C T 3_prime_UTR_variant COAD-US 2 85824623 85824623 single base substitution C T downstream_gene_variant COAD-US 2 85824623 85824623 single base substitution C T missense_variant R149C 445C>T COAD-US 2 85824623 85824623 single base substitution C T missense_variant T153M 458C>T COAD-US 2 85826721 85826721 single base substitution G A downstream_gene_variant COCA-CN 2 85818905 85818905 single base substitution C T upstream_gene_variant COCA-CN 2 85820216 85820216 single base substitution G T upstream_gene_variant COCA-CN 2 85820260 85820260 single base substitution G A upstream_gene_variant COCA-CN 2 85820322 85820322 single base substitution C T upstream_gene_variant COCA-CN 2 85826367 85826367 single base substitution G A downstream_gene_variant COCA-CN 2 85826781 85826781 single base substitution G T downstream_gene_variant COCA-CN 2 85829038 85829038 single base substitution A C downstream_gene_variant EOPC-DE 2 85828347 85828347 single base substitution C T downstream_gene_variant ESAD-UK 2 85820417 85820417 single base substitution C T upstream_gene_variant ESAD-UK 2 85821723 85821723 single base substitution C T upstream_gene_variant ESAD-UK 2 85823829 85823829 single base substitution G A exon_variant ESAD-UK 2 85823829 85823829 single base substitution G A intron_variant ESAD-UK 2 85824833 85824833 single base substitution A G downstream_gene_variant ESAD-UK 2 85826835 85826835 single base substitution G C downstream_gene_variant ESAD-UK 2 85829557 85829557 single base substitution G A downstream_gene_variant ESCA-CN 2 85823766 85823766 single base substitution C G exon_variant ESCA-CN 2 85823766 85823766 single base substitution C G missense_variant Q53E 157C>G ESCA-CN 2 85823766 85823766 single base substitution C G missense_variant Q71E 211C>G ESCA-CN 2 85824251 85824251 single base substitution T C 3_prime_UTR_variant ESCA-CN 2 85824251 85824251 single base substitution T C downstream_gene_variant ESCA-CN 2 85824251 85824251 single base substitution T C missense_variant Y118H 352T>C ESCA-CN 2 85824251 85824251 single base substitution T C synonymous_variant A113A 339T>C GBM-US 2 85818867 85818867 single base substitution G A upstream_gene_variant GBM-US 2 85824255 85824255 single base substitution A G 3_prime_UTR_variant GBM-US 2 85824255 85824255 single base substitution A G downstream_gene_variant GBM-US 2 85824255 85824255 single base substitution A G missense_variant E119G 356A>G GBM-US 2 85824255 85824255 single base substitution A G missense_variant S115G 343A>G GBM-US 2 85828199 85828199 single base substitution C G downstream_gene_variant KIRC-US 2 85828149 85828149 single base substitution G T downstream_gene_variant KIRC-US 2 85828190 85828190 single base substitution C T downstream_gene_variant LAML-KR 2 85820027 85820027 single base substitution A G upstream_gene_variant LGG-US 2 85818866 85818866 single base substitution C T upstream_gene_variant LICA-FR 2 85818914 85818914 single base substitution T A upstream_gene_variant LICA-FR 2 85828227 85828241 deletion of <=200bp GGACCTGGCAGGCAG - downstream_gene_variant LINC-JP 2 85820149 85820149 single base substitution G A upstream_gene_variant LINC-JP 2 85822883 85822883 single base substitution A T 5_prime_UTR_premature_start_codon_gain_variant LINC-JP 2 85822883 85822883 single base substitution A T exon_variant LINC-JP 2 85822883 85822883 single base substitution A T upstream_gene_variant LINC-JP 2 85825238 85825238 single base substitution C A downstream_gene_variant LINC-JP 2 85827934 85827934 single base substitution A C downstream_gene_variant LIRI-JP 2 85817953 85817953 deletion of <=200bp T - upstream_gene_variant LIRI-JP 2 85817978 85817978 single base substitution T G upstream_gene_variant LIRI-JP 2 85819985 85819985 single base substitution C G upstream_gene_variant LIRI-JP 2 85820244 85820244 single base substitution C T upstream_gene_variant LIRI-JP 2 85821160 85821160 single base substitution G T upstream_gene_variant LIRI-JP 2 85821161 85821161 single base substitution G T upstream_gene_variant LIRI-JP 2 85821186 85821186 single base substitution C T upstream_gene_variant LIRI-JP 2 85825580 85825580 single base substitution T A downstream_gene_variant LIRI-JP 2 85825793 85825797 deletion of <=200bp AGAAA - downstream_gene_variant LIRI-JP 2 85826822 85826822 single base substitution C A downstream_gene_variant LIRI-JP 2 85828365 85828365 single base substitution C T downstream_gene_variant LIRI-JP 2 85828517 85828517 single base substitution A G downstream_gene_variant LIRI-JP 2 85829367 85829367 single base substitution C T downstream_gene_variant LUSC-KR 2 85820412 85820412 single base substitution C T upstream_gene_variant LUSC-KR 2 85823632 85823632 single base substitution C T intron_variant LUSC-KR 2 85824073 85824073 single base substitution T C downstream_gene_variant LUSC-KR 2 85824073 85824073 single base substitution T C exon_variant LUSC-KR 2 85824073 85824073 single base substitution T C intron_variant LUSC-KR 2 85824073 85824073 single base substitution T C splice_region_variant LUSC-KR 2 85824084 85824084 single base substitution G C downstream_gene_variant LUSC-KR 2 85824084 85824084 single base substitution G C exon_variant LUSC-KR 2 85824084 85824084 single base substitution G C intron_variant LUSC-KR 2 85824084 85824084 single base substitution G C missense_variant V58L 172G>C LUSC-KR 2 85824251 85824251 single base substitution T C 3_prime_UTR_variant LUSC-KR 2 85824251 85824251 single base substitution T C downstream_gene_variant LUSC-KR 2 85824251 85824251 single base substitution T C missense_variant Y118H 352T>C LUSC-KR 2 85824251 85824251 single base substitution T C synonymous_variant A113A 339T>C LUSC-KR 2 85824468 85824468 single base substitution C T 3_prime_UTR_variant LUSC-KR 2 85824468 85824468 single base substitution C T downstream_gene_variant LUSC-KR 2 85824468 85824468 single base substitution C T intron_variant LUSC-KR 2 85826132 85826132 single base substitution G A downstream_gene_variant LUSC-KR 2 85828014 85828014 single base substitution T G downstream_gene_variant LUSC-US 2 85820097 85820097 single base substitution G A upstream_gene_variant LUSC-US 2 85823972 85823972 single base substitution A T downstream_gene_variant LUSC-US 2 85823972 85823972 single base substitution A T exon_variant LUSC-US 2 85823972 85823972 single base substitution A T intron_variant LUSC-US 2 85823972 85823972 single base substitution A T missense_variant E82V 245A>T LUSC-US 2 85823972 85823972 single base substitution A T splice_region_variant LUSC-US 2 85826823 85826823 single base substitution C A downstream_gene_variant MALY-DE 2 85826845 85826845 single base substitution A G downstream_gene_variant MELA-AU 2 85818006 85818006 single base substitution C T upstream_gene_variant MELA-AU 2 85818011 85818011 single base substitution C T upstream_gene_variant MELA-AU 2 85818227 85818227 single base substitution T C upstream_gene_variant MELA-AU 2 85818761 85818761 single base substitution G A upstream_gene_variant MELA-AU 2 85819015 85819016 multiple base substitution (>=2bp and <=200bp) GG AA upstream_gene_variant MELA-AU 2 85819090 85819090 single base substitution G A upstream_gene_variant MELA-AU 2 85819514 85819514 single base substitution C T upstream_gene_variant MELA-AU 2 85821231 85821231 single base substitution A C upstream_gene_variant MELA-AU 2 85821760 85821760 single base substitution G A upstream_gene_variant MELA-AU 2 85822722 85822722 single base substitution G A upstream_gene_variant MELA-AU 2 85822739 85822739 single base substitution C T upstream_gene_variant MELA-AU 2 85822746 85822746 single base substitution C T upstream_gene_variant MELA-AU 2 85822747 85822747 single base substitution C T upstream_gene_variant MELA-AU 2 85822810 85822810 single base substitution C A upstream_gene_variant MELA-AU 2 85824858 85824858 single base substitution A G downstream_gene_variant MELA-AU 2 85825053 85825053 single base substitution G A downstream_gene_variant MELA-AU 2 85827612 85827612 single base substitution C T downstream_gene_variant MELA-AU 2 85828033 85828033 single base substitution A G downstream_gene_variant MELA-AU 2 85828154 85828154 single base substitution G C downstream_gene_variant ORCA-IN 2 85819603 85819603 single base substitution G A upstream_gene_variant ORCA-IN 2 85829252 85829252 single base substitution C G downstream_gene_variant OV-AU 2 85824045 85824045 single base substitution G C 3_prime_UTR_variant OV-AU 2 85824045 85824045 single base substitution G C downstream_gene_variant OV-AU 2 85824045 85824045 single base substitution G C exon_variant OV-AU 2 85824045 85824045 single base substitution G C intron_variant OV-AU 2 85824045 85824045 single base substitution G C missense_variant W106C 318G>C OV-AU 2 85827353 85827353 single base substitution G A downstream_gene_variant OV-AU 2 85829547 85829547 single base substitution G C downstream_gene_variant PACA-AU 2 85818791 85818791 single base substitution G A upstream_gene_variant PACA-AU 2 85818849 85818849 single base substitution C A upstream_gene_variant PACA-AU 2 85819830 85819830 single base substitution A T upstream_gene_variant PACA-AU 2 85819998 85819998 single base substitution G C upstream_gene_variant PACA-AU 2 85826213 85826213 single base substitution T A downstream_gene_variant PACA-AU 2 85828397 85828397 single base substitution G A downstream_gene_variant PACA-CA 2 85820138 85820138 single base substitution G A upstream_gene_variant PACA-CA 2 85820538 85820538 insertion of <=200bp - C upstream_gene_variant PACA-CA 2 85825202 85825202 single base substitution C T downstream_gene_variant PRAD-CA 2 85823763 85823763 single base substitution T G exon_variant PRAD-CA 2 85823763 85823763 single base substitution T G missense_variant S52A 154T>G PRAD-CA 2 85823763 85823763 single base substitution T G missense_variant S70A 208T>G PRAD-US 2 85818986 85818986 single base substitution G A upstream_gene_variant PRAD-US 2 85822908 85822908 single base substitution C T exon_variant PRAD-US 2 85822908 85822908 single base substitution C T missense_variant H8Y 22C>T PRAD-US 2 85822908 85822908 single base substitution C T upstream_gene_variant RECA-EU 2 85821815 85821815 single base substitution T A upstream_gene_variant RECA-EU 2 85827153 85827153 single base substitution G A downstream_gene_variant SKCA-BR 2 85818727 85818727 single base substitution G A upstream_gene_variant SKCA-BR 2 85818728 85818728 single base substitution G A upstream_gene_variant SKCA-BR 2 85821442 85821442 single base substitution C T upstream_gene_variant SKCA-BR 2 85821898 85821898 single base substitution C T upstream_gene_variant SKCA-BR 2 85827306 85827306 single base substitution T G downstream_gene_variant SKCA-BR 2 85829728 85829728 single base substitution A C downstream_gene_variant SKCM-US 2 85824049 85824049 single base substitution A C 3_prime_UTR_variant SKCM-US 2 85824049 85824049 single base substitution A C downstream_gene_variant SKCM-US 2 85824049 85824049 single base substitution A C exon_variant SKCM-US 2 85824049 85824049 single base substitution A C intron_variant SKCM-US 2 85824049 85824049 single base substitution A C missense_variant S108R 322A>C SKCM-US 2 85824241 85824241 single base substitution C T 3_prime_UTR_variant SKCM-US 2 85824241 85824241 single base substitution C T downstream_gene_variant SKCM-US 2 85824241 85824241 single base substitution C T missense_variant P110L 329C>T SKCM-US 2 85824241 85824241 single base substitution C T synonymous_variant P114P 342C>T SKCM-US 2 85826257 85826257 single base substitution C T downstream_gene_variant STAD-US 2 85818963 85818963 single base substitution G A upstream_gene_variant STAD-US 2 85827121 85827123 deletion of <=200bp GCA - downstream_gene_variant STAD-US 2 85827471 85827471 single base substitution T C downstream_gene_variant STAD-US 2 85829045 85829045 single base substitution G A downstream_gene_variant UCEC-US 2 85820104 85820104 single base substitution G A upstream_gene_variant UCEC-US 2 85823694 85823694 single base substitution G A exon_variant UCEC-US 2 85823694 85823694 single base substitution G A missense_variant D29N 85G>A UCEC-US 2 85823694 85823694 single base substitution G A missense_variant D47N 139G>A UCEC-US 2 85824144 85824144 single base substitution G A downstream_gene_variant UCEC-US 2 85824144 85824144 single base substitution G A intron_variant UCEC-US 2 85824144 85824144 single base substitution G A missense_variant E78K 232G>A UCEC-US 2 85824199 85824199 single base substitution G T downstream_gene_variant UCEC-US 2 85824199 85824199 single base substitution G T intron_variant UCEC-US 2 85824199 85824199 single base substitution G T missense_variant R96M 287G>T UCEC-US 2 85824228 85824228 insertion of <=200bp - A downstream_gene_variant UCEC-US 2 85824228 85824228 insertion of <=200bp - A frameshift_variant Q106T? UCEC-US 2 85824228 85824228 insertion of <=200bp - A frameshift_variant T110N? UCEC-US 2 85824228 85824228 insertion of <=200bp - A splice_region_variant UCEC-US 2 85826209 85826209 single base substitution G A downstream_gene_variant UCEC-US 2 85826690 85826690 single base substitution G A downstream_gene_variant UCEC-US 2 85827094 85827094 single base substitution G A downstream_gene_variant UCEC-US 2 85828166 85828166 single base substitution G A downstream_gene_variant

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand RH18C COSM4001770 c.352T>C p.Y118H Substitution - Missense 2:85597128-85597128 + TCGA-CK-5916-01 COSM1409795 c.458C>T p.T153M Substitution - Missense 2:85597500-85597500 + ESCC-237T COSM3939220 c.211C>G p.Q71E Substitution - Missense 2:85596643-85596643 + CSCC-55-T COSM4566984 c.51_52GG>AA p.E18K Substitution - Missense 2:85595814-85595815 + SNUH_G45_S1 COSM4001770 c.352T>C p.Y118H Substitution - Missense 2:85597128-85597128 + RMS66_ COSM4001770 c.352T>C p.Y118H Substitution - Missense 2:85597128-85597128 + SMYM-PRGP COSM3727666 c.40G>T p.D14Y Substitution - Missense 2:85595803-85595803 + ZZUFHECRKL-G019T COSM4001770 c.352T>C p.Y118H Substitution - Missense 2:85597128-85597128 + LUAD-QCHM7 COSM377198 c.250G>C p.E84Q Substitution - Missense 2:85596854-85596854 + CSCC-11-T COSM4519842 c.102G>A p.R34R Substitution - coding silent 2:85596534-85596534 + TCGA-06-2563-01 COSM3408013 c.356A>G p.E119G Substitution - Missense 2:85597132-85597132 + GC8_T COSM148887 c.87-10C>T p.? Unknown 2:85596509-85596509 + CPCG0357-F1 COSM4880083 c.208T>G p.S70A Substitution - Missense 2:85596640-85596640 + T3024 COSM4722061 c.62C>T p.T21I Substitution - Missense 2:85595825-85595825 + TCGA-FS-A1ZK-06 COSM3583762 c.322A>C p.S108R Substitution - Missense 2:85596926-85596926 + AOCS-145-1-6 COSM4141277 c.318G>C p.W106C Substitution - Missense 2:85596922-85596922 + TCGA-BS-A0UJ-01 COSM1023377 c.329_330insA p.N111fs*9 Insertion - Frameshift 2:85597105-85597106 + T20 COSM5619032 c.312G>A p.L104L Substitution - coding silent 2:85596916-85596916 + T3262 COSM4722062 c.395G>A p.R132Q Substitution - Missense 2:85597171-85597171 + TCGA-D3-A2JD-06 COSM3583763 c.342C>T p.P114P Substitution - coding silent 2:85597118-85597118 + H460 COSM1196904 c.5C>A p.A2E Substitution - Missense 2:85595768-85595768 + TCGA-HC-7231-01 COSM1471361 c.22C>T p.H8Y Substitution - Missense 2:85595785-85595785 + RH30SJ_ COSM4001770 c.352T>C p.Y118H Substitution - Missense 2:85597128-85597128 + SCMC_RM2_ COSM4001770 c.352T>C p.Y118H Substitution - Missense 2:85597128-85597128 + TCGA-43-2578-01 COSM723018 c.245A>T p.E82V Substitution - Missense 2:85596849-85596849 + NCI-H747 COSM2822677 c.372C>T p.D124D Substitution - coding silent 2:85597148-85597148 + TCGA-AP-A059-01 COSM1023376 c.139G>A p.D47N Substitution - Missense 2:85596571-85596571 + RMS105_ COSM4001770 c.352T>C p.Y118H Substitution - Missense 2:85597128-85597128 + 587376 COSM1223944 c.115G>T p.D39Y Substitution - Missense 2:85596547-85596547 + TCGA-FD-A3N5-01 COSM1307047 c.168G>T p.K56N Substitution - Missense 2:85596600-85596600 + 9096_T COSM5041575 c.379T>G p.Y127D Substitution - Missense 2:85597155-85597155 + LIM2405 COSM4613584 c.171_172delTG p.V58fs*2 Deletion - Frameshift 2:85596603-85596604 + Gp2D COSM4628106 c.37T>C p.S13P Substitution - Missense 2:85595800-85595800 +

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.356187 2p11.2 612490 2395144|CGAP|BC002803|A/G|coding|Leu104Leu|336|Validated; 1513569|dbSNP|BC002803|A/C|non-coding||12|Candidate; 1514000|dbSNP|BC002803|A/G|coding|Leu104Leu|336|Validated

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.S108R c.322A>C 2 85824049 CM A G Missense p.E119G c.356A>G 2 85824255 GBM AG TA IntronicBlockSubstitution . c.217+4_217+5delinsTA 2 85823776 CM A T Missense p.E82V c.245A>T 2 85823972 LUSC C T IntronicSNV . c.217+47C>T 2 85823819 NSCLC C T Missense p.H8Y c.22C>T 2 85822908 PRAD C T Synonymous p.P114P c.342C>T 2 85824241 CM G A Missense p.R20Q c.59G>A 2 85822945 CM G T Missense p.K56N c.168G>T 2 85823723 BLCA TGCCT - Frameshift p.C94Sfs*24 c.279_283delTTGCC 2 85824002 HNSC