PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus VPS11 RNF181 22493164 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G NPY5R RNF181 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRIM24 RNF181 22493164 biogrid,intact exp G G G G G G G G GP G G G GP GP G GP G GP G G GP GP GP G GP G GP GP G CLK4 RNF181 21988832 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP GP GP GP G ADIPOR2 RNF181 26186194 biogrid exp GP GP G G G G G GP GP G G G G G G GP G G GP G GP G GP G GP G GP GP G UBE2U RNF181 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P P P GP BIRC2 RNF181 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP G GP GP GP GP G UBE2E1 RNF181 19690564 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G G GP G GP GP G SHFM1 RNF181 24811749 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BTG1 RNF181 21988832 biogrid,intact exp GP GP G G GP GP G GP G G GP GP GP G G GP GP G GP G GP GP G G GP G GP GP G RBCK1 RNF181 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PSMB9 RNF181 26186194 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G UBE2E3 RNF181 19690564 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G G GP G GP GP G TRIM8 RNF181 22493164 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ZMYND10 RNF181 21988832 biogrid,intact exp P GP G GP GP G GP P G P GP GP P P GP GP GP G P P GP G P P P GP G PEG10 RNF181 21988832 biogrid,intact exp G GP G G G G G G G G G G G G G G G G GP G G G G G GP G RNF181 RNF181 18331836 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MRPS6 RNF181 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ITGA2B RNF181 15075326,18331836, 25402006 biogrid exp, pred G G G G GP G G G G G G G G G G G G G G G G G G G G G UBE2D2 RNF181 19690564, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G G G GP GP GP G RNF181 UBE2D4 19690564, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G G G GP GP GP G UBE2D1 RNF181 19690564,18331836, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G G G GP GP GP G UBE2D3 RNF181 19690564, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G G G GP GP GP G GRB2 RNF181 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RNF181 AUP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CALM1, CALM2, CALM3 RNF181 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CUL1 RNF181 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G RNF181 STUB1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ITGB3 RNF181 25402006 pred GP G G G GP GP G GP G G GP G GP G G G GP G G G G G G G G G GP G UBE2G2 RNF181 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G CUL4A RNF181 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL4B RNF181 23023127 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP GP GP GP G COL2A1 RNF181 25402006 pred G G G P P P G G P GP G G UBE2N RNF181 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G UBE2NL RNF181 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A087WXL6 Q9P0P0 two hybrid 22493164 direct interaction X 2 Q13490 Q9P0P0 two hybrid 22493164 direct interaction X 2 Q9BZR9 Q9P0P0 two hybrid 22493164 direct interaction X 2 P82932 Q9P0P0 two hybrid 21988832 direct interaction X 2 Q9P0P0 Q9P0P0 enzymatic study 18331836 direct interaction X 2 Q9P0P0 A0A024RA90 two hybrid 19690564 direct interaction X 2 A0A087WW00 Q9P0P0 pull down 18331836 direct interaction X 2 A0A087WW00 Q9P0P0 two hybrid 19690564 direct interaction X 2 Q969T4 Q9P0P0 two hybrid 19690564 direct interaction X 2 A0A024R2K3 Q9P0P0 two hybrid 19690564 direct interaction X 2 P0CG48 Q9P0P0 affinity chromatography technology 21139048 physical association X 2 Q15761 Q9P0P0 two hybrid 21988832 direct interaction X 2 P61077-3 Q9P0P0 two hybrid 19690564 direct interaction X 2 P62837 Q9P0P0 two hybrid 19690564 direct interaction X 2 O15164 Q9P0P0 two hybrid 22493164 direct interaction X 2 Q9P0P0 two hybrid 22493164 direct interaction X 2 Q9P0P0 O75800 two hybrid 21988832 direct interaction X 2 Q9P0P0 two hybrid 21988832 direct interaction X 2 Q9P0P0 two hybrid 19690564 direct interaction X 2 P62324 Q9P0P0 two hybrid 21988832 direct interaction X 2 P60896 Q9P0P0 affinity chromatography technology 24811749 physical association X 2 P60896 Q9P0P0 affinity chromatography technology 24811749 physical association X 2 P08514 Q9P0P0 pull down 15075326 direct interaction X 2 P08514 Q9P0P0 pull down 18331836 direct interaction X 2 P08514 Q9P0P0 affinity chromatography technology 18331836 physical association X 2 Q9HAZ1 Q9P0P0 two hybrid 21988832 direct interaction X 2 Q9BYM8 Q9P0P0 two hybrid array 22493164 physical association X 2 Q9P0P0 anti tag coimmunoprecipitation 24811749 association C 6 Q9P0P0 anti tag coimmunoprecipitation 24811749 association C 66 Q9H270 Q9P0P0 two hybrid array 22493164 physical association X 2 Q13490 Q9P0P0 two hybrid array 22493164 physical association X 2 Q9BZR9 Q9P0P0 two hybrid array 22493164 physical association X 2 P82932 Q9P0P0 two hybrid array 21988832 physical association X 2 Q9P0P0 A0A024RA90 two hybrid array 19690564 physical association X 2 Q969T4 Q9P0P0 two hybrid array 19690564 physical association X 2 A0A024R2K3 Q9P0P0 two hybrid array 19690564 physical association X 2 Q15761 Q9P0P0 two hybrid array 21988832 physical association X 2 Q9P0P0 anti tag coimmunoprecipitation 24811749 association C 10 A0A024RDH2 Q9P0P0 two hybrid array 19690564 physical association X 2 P62837 Q9P0P0 two hybrid array 19690564 physical association X 2 O15164 Q9P0P0 two hybrid array 22493164 physical association X 2 A0A024QZJ2 Q9P0P0 two hybrid array 19690564 physical association X 2 Q9P0P0 O75800 two hybrid array 21988832 physical association X 2 Q5VVX9 Q9P0P0 two hybrid array 19690564 physical association X 2 P62324 Q9P0P0 two hybrid array 21988832 physical association X 2 Q86TG7 Q9P0P0 two hybrid array 21988832 physical association X 2 Q9HAZ1 Q9P0P0 two hybrid array 21988832 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2D2 RNF181 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123447|UniProt_102436 bait|bait prey|prey TRIM24 RNF181 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284084|UniProt_122511 bait|prey prey|bait UBE2D1 RNF181 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102408|BIOGRID_123419 bait|bait prey|prey UBE2E1 RNF181 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102531|BIOGRID_123541 bait|bait prey|prey UBE2E3 RNF181 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123561|UniProt_102550 bait|bait prey|prey UBE2U RNF181 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102637|BIOGRID_123648 bait|bait prey|prey TRIM8 RNF181 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284073|UniProt_122550 prey|bait bait|prey NPY5R RNF181 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286842|UniProt_118001 bait|unspecified role prey|unspecified role PEG10 RNF181 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118337|BIOGRID_286843 unspecified role|bait unspecified role|prey RNF181 UBE2D4 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123513|UniProt_102502 prey|prey bait|bait CLK4 RNF181 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118400|BIOGRID_286844 unspecified role|bait unspecified role|prey MRPS6 RNF181 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118401|BIOGRID_286845 unspecified role|bait unspecified role|prey ITGA2B RNF181 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 15075326,18331836 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_118002|BIOGRID_118003|BIOGRID_118004 prey|prey|prey bait|bait|bait ZMYND10 RNF181 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_285571|UniProt_118399 prey|unspecified role bait|unspecified role RBCK1 RNF181 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284061|UniProt_122531 bait|prey prey|bait BIRC2 RNF181 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284131|UniProt_122457 bait|prey prey|bait UBE2D3 RNF181 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123481|UniProt_102471 bait|bait prey|prey UBC RNF181 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_170094 bait prey BTG1 RNF181 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_286841|UniProt_117351 bait|unspecified role prey|unspecified role VPS11 RNF181 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284141|UniProt_122549 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality ITGA2B RNF181 18331836,15075326,18331836 0096,0096,0004 LC PSMB9 RNF181 26186194 0004 HT UBE2D1 RNF181 18331836,26711259 0096,0096 LC ADIPOR2 RNF181 26186194 0004 HT PSMB9 RNF181 26186194 0004 HT ADIPOR2 RNF181 26186194 0004 HT ITGA2B RNF181 18331836,15075326,18331836 0096,0096,0004 LC UBE2D1 RNF181 18331836,26711259 0096,0096 LC TRIM24 RNF181 22493164,22493164 0018,0397 HT ZMYND10 RNF181 21988832,21988832 0397,0018 HT BCL10 RNF181 26711259 0415 LC UBC RNF181 26711259 0415 LC UBE2D1 RNF181 19690564,19690564 0397,0018 HT UBE2E1 RNF181 19690564,19690564 0397,0018 HT UBE2D3 RNF181 19690564,19690564 0397,0018 HT BTG1 RNF181 21988832,21988832 0397,0018 HT UBE2D2 RNF181 19690564,19690564 0397,0018 HT MRPS6 RNF181 21988832,21988832 0397,0018 HT BIRC2 RNF181 22493164,22493164 0018,0397 HT NPY5R RNF181 21988832,21988832 0397,0018 HT UBE2U RNF181 19690564,19690564 0397,0018 HT PEG10 RNF181 21988832,21988832 0397,0018 HT UBE2E3 RNF181 19690564,19690564 0397,0018 HT CARD11 RNF181 26711259,26711259 0004,0055 LC RBCK1 RNF181 22493164,22493164 0018,0397 HT TRIM8 RNF181 22493164,22493164 0018,0397 HT VPS11 RNF181 22493164,22493164 0018,0397 HT CLK4 RNF181 21988832,21988832 0397,0018 HT RNF181 RNF181 18331836 0415 LC RNF181 UBE2D4 19690564,19690564 0397,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9P0P0 P61077 RNF181 UBE2D3 0.507 19690564,26711259 Q9P0P0 Q86V24 RNF181 ADIPOR2 0.126 26186194 Q9P0P0 P13285 RNF181 LMP2 0.126 22810586 Q9P0P0 P51965 RNF181 UBE2E1 0.569 19690564,26711259 Q9P0P0 P62837 RNF181 UBE2D2 0.569 19690564,26711259 Q9P0P0 Q9HAZ1 RNF181 CLK4 0.286 21988832 Q9P0P0 Q9BYM8 RNF181 RBCK1 0.286 22493164 Q9P0P0 Q13490 RNF181 BIRC2 0.286 22493164 Q9P0P0 O15164 RNF181 TRIM24 0.286 22493164 Q9P0P0 Q5VVX9 RNF181 UBE2U 0.286 19690564 Q9P0P0 P51668 RNF181 UBE2D1 0.702 19690564,18331836,26711259 Q9P0P0 Q86TG7 RNF181 PEG10 0.286 21988832 Q9P0P0 P60896 RNF181 SHFM1 0.236 24811749 Q9P0P0 P08514 RNF181 ITGA2B 0.623 15075326,18331836 Q9P0P0 P28065 RNF181 PSMB9 0.126 26186194 Q9P0P0 Q9BXL7 RNF181 CARD11 0.454 26711259 Q9P0P0 Q9BZR9 RNF181 TRIM8 0.286 22493164 Q9P0P0 O75800 RNF181 ZMYND10 0.286 21988832 Q9P0P0 Q9H270 RNF181 VPS11 0.286 22493164 Q9P0P0 P0CG48 RNF181 UBC 0.309 26711259 Q9P0P0 O95999 RNF181 BCL10 0.309 26711259 Q9P0P0 P82932 RNF181 MRPS6 0.286 21988832 Q9P0P0 P61088 RNF181 UBE2N 0.309 26711259 Q9P0P0 P62324 RNF181 BTG1 0.286 21988832 Q9P0P0 Q15761 RNF181 NPY5R 0.286 21988832 Q9P0P0 Q969T4 RNF181 UBE2E3 0.376 19690564 Q9Y2X8 Q9P0P0 UBE2D4 RNF181 0.286 19690564 Q9P0P0 Q9P0P0 RNF181 RNF181 0.332 18331836

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TRIM24 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database ZMYND10 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database BCL10 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database ITGA2B RNF181 MI:0045 experimental interaction detection MI:0461 interaction database UBC RNF181 MI:0045 experimental interaction detection MI:0461 interaction database PSMB9 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database SHFM1 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N RNF181 MI:0045 experimental interaction detection MI:0461 interaction database BTG1 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database MRPS6 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database BIRC2 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database NPY5R RNF181 MI:0045 experimental interaction detection MI:0461 interaction database UBE2U RNF181 MI:0045 experimental interaction detection MI:0461 interaction database PEG10 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database ADIPOR2 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E3 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database CARD11 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database RBCK1 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database VPS11 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database CLK4 RNF181 MI:0045 experimental interaction detection MI:0461 interaction database RNF181 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database