PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TXN2 SHARPIN 21988832 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G SHARPIN NOD2 23818254,22607974 biogrid exp P G G P P P GP P P P P P P P P P GP P ITGAL SHARPIN 24210817 biogrid exp G G G G G G G G G GP GP G G G G G G G G G GP G G ITGB1 SHARPIN 21947080 intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G UBA52 SHARPIN 21455181 dip exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G BDKRB2 SHARPIN 24211782 intact exp GP GP G G GP G G G G P G G GP P G GP G GP P G TNFAIP3 SHARPIN 23032186 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP G GP GP G CHUK SHARPIN 21455180 biogrid,dip exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G TNFRSF1A SHARPIN 23746843 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G ITGAD SHARPIN 24210817 biogrid exp GP P G G G GP GP P P G G G P GP G G P P GP GP ITGA2 SHARPIN 21947080 biogrid,intact exp GP GP GP G GP GP G GP GP GP G G GP GP GP P G GP GP P GP GP GP P G AURKB SHARPIN 23443559 biogrid exp P G G P G GP P P P GP P P P GP P GP P OTULIN SHARPIN 24726323,23746843 biogrid exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP P G GP GP GP GP G TNF SHARPIN 23104095,23032187,23032186,23955153 biogrid,intact,dip exp G G G G G GP G G GP G G G GP G GP GP G P G G G GP G GP G G PTEN SHARPIN 25152374,20458142 biogrid exp GP GP G G G GP G G GP G GP G GP GP G GP GP G P G P G GP G GP GP GP GP G TFAP2C SHARPIN 24835590 intact exp GP P G GP GP G P P G P G GP G P P P G IL1A SHARPIN 21947080 intact exp P P P P P P P P P P P P P P P P P P P P GP LIPF SHARPIN 26186194 biogrid exp G G P G G G G GP P ITGA1 SHARPIN 21947080 biogrid exp GP GP P P P P P P G P P P P P GP P P GP G GP P LTBR SHARPIN 26186194 biogrid exp GP G G G P G G G GP G GP GP G GP P G G P G GP G GP GP GP GP G ITGAM SHARPIN 24210817 biogrid exp G G G G G GP G G G G G G GP GP G G GP G G G G G G GP G G IKBKB SHARPIN 21455180 biogrid,dip exp GP GP G G G GP G G GP G GP G GP GP G GP GP GP P G P GP GP G GP GP GP GP G ITGA5 SHARPIN 21947080 biogrid,intact exp, ortho G G G G G G G G G G GP G G G G G G G P G G G G G G G G RNF31 SHARPIN 24726327,21455180,23746843,23104095,23032186 biogrid,intact,dip exp, ortho P P G G G GP P P G GP GP GP P GP GP P P G P P P GP GP GP P GP SHARPIN IKBKG 21455180,23986494,21709223,23032186 innatedb,biogrid,mint,intact,dip exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G SHARPIN SHARPIN 11178875 hprd,biogrid exp, ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G RBCK1 SHARPIN 21455180,24726327,21455181,21709223,23032186 innatedb,biogrid,intact,dip exp, ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G SHARPIN SHANK1 11178875,12753155, 25402006, 21836163 hprd,biogrid exp, ortho, pred P G P P P P P P P P P P P P P P P P SHARPIN SHANK2 23897824, 21836163 biogrid exp, pred P G GP G GP G GP GP GP P G GP GP P G P G G P GP GP GP P TEKT4 SHARPIN ortho P P P P P P P P P P P P P P P P UCHL1 SHARPIN ortho G G G G G GP G G GP G GP G G G G G GP G P G G G G G G G GP G ADCYAP1 SHARPIN ortho G G G G G G G G G G G G G G G G G G G EYA1 SHARPIN ortho G G G G ASAP2 SHARPIN ortho GP GP G G G GP G G GP G GP GP GP GP G GP GP GP P G P GP GP G GP P GP GP G CEBPA SHARPIN ortho GP G G G G GP G GP G G GP G GP G G GP GP G P G P GP G G GP G GP GP G SHARPIN SCN11A ortho G GP G G P G GP GP GP GP GP GP GP G P P GP GP GP G P GP G EYA2 SHARPIN ortho GP P P G P P GP P P P G P P P P P GP GP P P P GP GP G RNF20 SHARPIN ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G FYB SHARPIN ortho G G G G G G G G G G G GP G G G G G G G GP G PSMD1 SHARPIN ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G SHARPIN STK24 ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G SHARPIN ZNF106 ortho GP GP G G G GP G GP GP G GP G G GP G GP GP G P G P G GP GP GP GP GP GP G CAPN13 SHARPIN ortho GP GP G G G GP G P GP G GP GP GP P G GP GP GP P G P GP GP G GP P GP GP SHANK3 SHARPIN ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G AIFM1 SHARPIN ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP G P G P GP GP G GP GP GP GP G SURF6 SHARPIN ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G KMT2D SHARPIN ortho G GP G G G GP G G GP G GP G GP G G G GP G P G P GP G G G G G GP G TRAF2 SHARPIN 25402006 ortho, pred P P P P P P P P P P P P P P P P P P GP GP P DLG4 SHARPIN 25402006 ortho, pred G GP G G G G GP G G G G G G G SHARPIN GRIP1 25402006 ortho, pred P P G GP G P GP G GP P P P G P GP P G P GP GP P P GP GP P SSTR2 SHARPIN 25402006 pred GP GP G G G GP G GP GP G GP GP P G P GP GP P G P GP GP P G GP GP GPAA1 SHARPIN 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G DNM2 SHARPIN 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G P G P GP GP G GP GP GP GP G SHARPIN BAIAP2 25402006 pred P P G G G GP G GP P G GP GP GP GP P GP GP P G P GP P P P P GP GP G DLGAP1 SHARPIN 25402006 pred P GP G GP P P G P P P P GP P P G P P GP P P GP ANK1 SHARPIN 21836163 pred G G G GP G G G P GP G P GP G P P SHARPIN PUF60 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G GP GP G GP G GP GP G MAP3K1 SHARPIN 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G LPHN1 SHARPIN 25402006 pred GP GP G G G GP G G GP G GP GP GP G G GP GP GP P G GP GP G GP G GP G G ARHGEF7 SHARPIN 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP G GP GP GP GP GP G SHARPIN VPS28 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P17301 Q9H0F6 affinity chromatography technology 21947080 physical association X 2 P17301 Q9H0F6 pull down 21947080 direct interaction X 2 Q9H0F6 P56199 affinity chromatography technology 21947080 physical association X 2 Q9H0F6 P56199 pull down 21947080 direct interaction X 2 Q9H0F6 Q96EP0 affinity chromatography technology 23032186 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 22053931 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 23000965 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 23746843 physical association X 2 Q9H0F6 Q96BN8 affinity chromatography technology 23746843 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 23986494 physical association X 2 Q9H0F6 Q9UPX8-4 unspecified method 23897824 direct interaction X 2 Q9H0F6 Q96EP0 affinity chromatography technology 24726327 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 24726327 physical association X 2 Q9H0F6 Q96BN8 affinity chromatography technology 24726323 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 Q96EP0 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 25015289 physical association X 2 Q9H0F6 B2RAL6 affinity chromatography technology 24210817 physical association X 2 Q9H0F6 B2RAL6 pull down 24210817 direct interaction X 2 Q9H0F6 B2RAL6 far western blotting 24210817 direct interaction X 2 Q9H0F6 B2RAL6 unspecified method 24210817 direct interaction X 2 Q9H0F6 P0CG48 affinity chromatography technology 25147182 physical association X 2 Q9H0F6 Q9Y566 two hybrid 11178875 direct interaction X 2 Q9H0F6 Q9Y566 affinity chromatography technology 11178875 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 21987572 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q9H0F6 P0CG48 affinity chromatography technology 21906983 physical association X 2 P21580 Q9H0F6 affinity chromatography technology 23032186 physical association X 2 P21580 Q9H0F6 affinity chromatography technology 23032186 physical association X 2 Q9H0F6 Q9HC29 affinity chromatography technology 22607974 physical association X 2 Q9H0F6 F6KD01 affinity chromatography technology 20458142 physical association X 2 Q9H0F6 F6KD01 affinity chromatography technology 20458142 physical association X 2 Q9H0F6 P08648 affinity chromatography technology 21947080 physical association X 2 Q9H0F6 P01375 affinity chromatography technology 23032187 physical association X 2 Q9H0F6 affinity chromatography technology 23032186 physical association X 2 Q9H0F6 affinity chromatography technology 23032186 physical association X 2 Q9H0F6 P01375 affinity chromatography technology 23032186 physical association X 2 Q9H0F6 affinity chromatography technology 21709223 physical association X 2 Q9H0F6 P19438 affinity chromatography technology 23746843 physical association X 2 Q9H0F6 Q9HC29 affinity chromatography technology 23818254 physical association X 2 Q9H0F6 Q99757 two hybrid 21988832 direct interaction X 2 Q9H0F6 affinity chromatography technology 23986494 physical association X 2 Q9H0F6 affinity chromatography technology 24726327 physical association X 2 Q9H0F6 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 Q96GD4 affinity chromatography technology 23443559 physical association X 2 Q9H0F6 unspecified method 24210817 direct interaction X 2 Q9H0F6 Q13349 unspecified method 24210817 direct interaction X 2 Q9H0F6 F6KD01 affinity chromatography technology 25152374 physical association X 2 Q9H0F6 F6KD01 affinity chromatography technology 25152374 physical association X 2 Q9H0F6 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 O15111 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 affinity chromatography technology 21455180 physical association X 2 Q9H0F6 Q9H0F6 affinity chromatography technology 11178875 physical association X 2 Q9H0F6 pull down 23955153 - C 8 Q9H0F6 anti tag coimmunoprecipitation 21455180 - C 4 Q9H0F6 anti bait coimmunoprecipitation 21455180 - C 4 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455181 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 two hybrid 22158122 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455181 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 24141947 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455181 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455181 direct interaction X 2 Q9H0F6 Q96EP0 pull down 21455181 direct interaction X 2 Q9H0F6 Q96EP0 anti tag coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 21455180 direct interaction X 2 Q9H0F6 Q96EP0 pull down 21455180 direct interaction X 2 Q9H0F6 Q96EP0 pull down 21455180 direct interaction X 2 Q9H0F6 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti tag coimmunoprecipitation 21455181 physical association X 2 Q9H0F6 Q9BYM8 anti tag coimmunoprecipitation 21455181 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 pull down 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti tag coimmunoprecipitation 21455181 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti tag coimmunoprecipitation 21455181 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti tag coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9BYM8 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 anti tag coimmunoprecipitation 21709223 - C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 - C 5 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 pull down 21455180 physical association C 3 Q9H0F6 molecular sieving 21455180 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455181 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 pull down 21455180 physical association C 3 Q9H0F6 molecular sieving 21455180 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 pull down 21455180 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455181 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 24141947 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455180 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455181 physical association C 3 Q9H0F6 anti tag coimmunoprecipitation 21455180 - C 3 Q9H0F6 anti bait coimmunoprecipitation 21455180 - C 5 Q9H0F6 anti bait coimmunoprecipitation 21455180 - C 6 Q9H0F6 P62987 pull down 21455181 direct interaction X 2 Q9H0F6 P62987 pull down 21455181 direct interaction X 2 Q9H0F6 P62987 pull down 21455181 direct interaction X 2 Q9H0F6 P62987 isothermal titration calorimetry 21455181 direct interaction X 2 Q9H0F6 P62987 pull down 22158122 direct interaction X 2 Q9H0F6 P62987 pull down 22158122 direct interaction X 2 Q9H0F6 Q9Y6K9 anti tag coimmunoprecipitation 21709223 physical association X 2 Q9H0F6 Q9Y6K9 anti tag coimmunoprecipitation 21709223 physical association X 2 Q9H0F6 Q9Y6K9 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9Y6K9 anti tag coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9Y6K9 anti tag coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9Y6K9 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9Y6K9 anti tag coimmunoprecipitation 21709223 physical association X 2 Q9H0F6 Q9Y6K9 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 Q9Y6K9 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 O15111 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 O15111 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 O14920 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 O14920 anti bait coimmunoprecipitation 21455180 physical association X 2 Q9H0F6 P01375 pull down 23955153 physical association X 2 Q9H0F6 Q9Y566 two hybrid 11178875,12753155 - X 2 Q9H0F6 Q9Y566 in vitro 11178875,12753155 - X 2 Q9H0F6 Q9Y566 in vivo 11178875,12753155 - X 2 Q9H0F6 Q9Y566 in vitro 11178875,12753155 - X 2 Q9H0F6 Q9Y566 two hybrid 11178875,12753155 - X 2 Q9H0F6 Q9Y566 in vivo 11178875,12753155 - X 2 Q9H0F6 Q9H0F6 in vitro 11178875 - X 2 Q9H0F6 Q9H0F6 in vivo 11178875 - X 2 Q9H0F6 anti bait coimmunoprecipitation 23032186 association C 4 Q9H0F6 anti bait coimmunoprecipitation 23032186 association C 5 Q9H0F6 anti tag coimmunoprecipitation 23032186 association C 6 Q9H0F6 anti bait coimmunoprecipitation 21947080 association C 3 Q9H0F6 anti bait coimmunoprecipitation 21947080 association C 3 P17301 Q9H0F6 pull down 21947080 direct interaction X 2 P17301 Q9H0F6 anti bait coimmunoprecipitation 21947080 physical association X 2 P17301 Q9H0F6 pull down 21947080 physical association X 2 P17301 Q9H0F6 fluorescence polarization spectroscopy 21947080 direct interaction X 2 Q9H0F6 Q9WMX2 two hybrid prey pooling approach 18985028 physical association X 2 Q9H0F6 Q9WMX2 two hybrid prey pooling approach 18985028 physical association X 2 Q9H0F6 P05556 confocal microscopy 21947080 colocalization X 2 Q9H0F6 Q96EP0 anti bait coimmunoprecipitation 23104095 physical association X 2 Q9H0F6 anti tag coimmunoprecipitation 23032186 association C 4 Q9H0F6 anti bait coimmunoprecipitation 23032186 association C 4 Q9H0F6 pull down 23104095 association C 4 Q9H0F6 anti bait coimmunoprecipitation 23032186 association C 3 Q9H0F6 P08648 anti bait coimmunoprecipitation 21947080 physical association X 2 Q9H0F6 P08648 anti tag coimmunoprecipitation 21947080 physical association X 2 Q9H0F6 P08648 fluorescent resonance energy transfer 21947080 physical association X 2 Q9H0F6 P01583 anti bait coimmunoprecipitation 21947080 physical association X 2 Q9H0F6 Q9Y6K9 anti bait coimmunoprecipitation 23032186 physical association X 2 Q9H0F6 P30411-2 two hybrid 24211782 physical association X 2 Q9H0F6 Q92754 two hybrid 24835590 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TNFRSF1A SHARPIN MI:0415(enzymatic study) 23746843 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281125 prey bait SHARPIN SHANK2 MI:0686(unspecified method) 23897824 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_307712 prey bait TXN2 SHARPIN MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_285396|UniProt_120119 prey|unspecified role bait|unspecified role FAM105B SHARPIN MI:0415(enzymatic study) 23746843 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_281124 prey bait ITGA2 SHARPIN MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy) 21947080 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(intact)|(intact) UniProt_116095|UniProt_175106|UniProt_116105|UniProt_116109|BIOGRID_217914|BIOGRID_217911|UniProt_116102|UniProt_116106 neutral component|bait|bait|bait|bait|bait|bait|bait neutral component|prey|prey|prey|prey|prey|prey|prey IL1A SHARPIN MI:0053(fluorescence polarization spectroscopy) 21947080 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_116108 bait prey UBC SHARPIN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 21139048,21890473,21906983,21963094,21987572,22053931,22253853,23000965,23986494 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_174483|BIOGRID_268222|BIOGRID_264523|BIOGRID_223154|BIOGRID_201081|BIOGRID_179519|BIOGRID_266965|BIOGRID_289204|BIOGRID_163113 bait|bait|bait|bait|prey|bait|bait|prey|bait prey|prey|prey|prey|bait|prey|prey|bait|prey ITGA1 SHARPIN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21947080 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_217913|BIOGRID_217910 bait|bait prey|prey ITGA5 SHARPIN MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy)|MI:0053(fluorescence polarization spectroscopy)|MI:0004(affinity chromatography technology)|MI:0053(fluorescence polarization spectroscopy) 21947080 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(intact)|(biogrid)|(intact) UniProt_116104|UniProt_116098|UniProt_116103|BIOGRID_217912|UniProt_116107 bait|fluorescence accept|bait|bait|bait prey|fluorescence donor|prey|prey|prey TNF SHARPIN MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 23032186,23032187,23104095 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_219091|BIOGRID_218367|UniProt_124328|UniProt_125831 bait|bait|bait|bait prey|prey|prey|prey ITGB1 SHARPIN MI:0053(fluorescence polarization spectroscopy) 21947080 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (intact) UniProt_116101 neutral component neutral component SHARPIN NOD2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22607974,23818254 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_187981|BIOGRID_282696 prey|prey bait|bait RBCK1 SHARPIN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 23032186,24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_310386|BIOGRID_219086|UniProt_125826|UniProt_125832 prey|prey|prey|prey bait|bait|bait|prey RNF31 SHARPIN MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 22253853,23032186,23104095,23746843,24726327 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact) BIOGRID_201083|UniProt_124323|BIOGRID_201082|BIOGRID_310385|BIOGRID_281123|BIOGRID_219087|BIOGRID_310374|UniProt_125826|UniProt_125832 bait|bait|prey|prey|prey|prey|bait|prey|prey prey|prey|bait|bait|bait|bait|prey|bait|prey NFKBIA SHARPIN MI:0004(affinity chromatography technology) 22605335 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_192127 prey bait TNFAIP3 SHARPIN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 23032186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_219128|BIOGRID_219085|UniProt_125826|UniProt_125832 bait|prey|prey|bait prey|bait|bait|prey SHARPIN SHANK1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 11178875,12753155 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_103415|BIOGRID_103417|HPRD_13413 prey|prey|- bait|bait|- SHARPIN IKBKG MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 21709223,23032186,23986494 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (intact)|(intact)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact) UniProt_125829|UniProt_125827|BIOGRID_219084|BIOGRID_289213|UniProt_125830|BIOGRID_220042|UniProt_125825 prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait PTEN SHARPIN MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20458142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_200526|BIOGRID_200527 prey|bait bait|prey

PPI - HINT Gene A Gene B PMID Method Quality TNF SHARPIN 26670046,23032187,23032186,23032186,23955153,23104095 0004,0004,0007,0004,0096,0096 LC LIPF SHARPIN 26186194 0004 HT UBC SHARPIN 21455181,22158122,21455181 0096,0096,0065 LC ITGAL SHARPIN 26600301,26600301,24210817,24210817,26600301,24210817 0096,0047,0004,0047,0004,0096 LC LTBR SHARPIN 26186194 0004 HT PTEN SHARPIN 25152374,20458142 0004,0004 LC OTULIN SHARPIN 26670046,23746843,24726323 0004,0004,0004 LC RNF31 SHARPIN 26670046,24141947,26600301,21455181,26600301,23032186,21455181,21455180,21455180,23032186,22791023,21455180,26600301,24726327,21455180,23746843,23104095 0004,0007,0096,0096,0047,0006,0007,0007,0096,0004,0096,0006,0004,0004,0004,0004,0006 LC AURKB SHARPIN 23443559 0004 HT RBCK1 SHARPIN 26670046,21455181,23032186,21455180,23032186,21455180,21455180,24726327,21455180 0004,0007,0006,0096,0004,0007,0006,0004,0004 LC SHARPIN SHARPIN 11178875 0004 LC SHARPIN NOD2 26670046,22607974,23818254 0004,0004,0004 LC SHARPIN IKBKG 23986494,21709223,21709223,23032186,23032186,21455180,21455180,21455180 0096,0004,0007,0006,0004,0007,0006,0004 LC LIPF SHARPIN 26186194 0004 HT LTBR SHARPIN 26186194 0004 HT AURKB SHARPIN 23443559 0004 HT TNF SHARPIN 26670046,23032187,23032186,23032186,23955153,23104095 0004,0004,0007,0004,0096,0096 LC UBC SHARPIN 21455181,22158122,21455181 0096,0096,0065 LC ITGAL SHARPIN 26600301,26600301,24210817,24210817,26600301,24210817 0096,0047,0004,0047,0004,0096 LC PTEN SHARPIN 25152374,20458142 0004,0004 LC OTULIN SHARPIN 26670046,23746843,24726323 0004,0004,0004 LC RNF31 SHARPIN 26670046,24141947,26600301,21455181,26600301,23032186,21455181,21455180,21455180,23032186,22791023,21455180,26600301,24726327,21455180,23746843,23104095 0004,0007,0096,0096,0047,0006,0007,0007,0096,0004,0096,0006,0004,0004,0004,0004,0006 LC RBCK1 SHARPIN 26670046,21455181,23032186,21455180,23032186,21455180,21455180,24726327,21455180 0004,0007,0006,0096,0004,0007,0006,0004,0004 LC SHARPIN SHARPIN 11178875 0004 LC SHARPIN NOD2 26670046,22607974,23818254 0004,0004,0004 LC SHARPIN IKBKG 23986494,21709223,21709223,23032186,23032186,21455180,21455180,21455180 0096,0004,0007,0006,0004,0007,0006,0004 LC ITGB2 SHARPIN 26600301,26600301 0096,0047 LC ITGA5 SHARPIN 21947080,21947080,21947080,21947080,26600301 0006,0007,0004,0055,0055 LC UBC SHARPIN 21455181,21455181 0096,0065 LC ITGA2 SHARPIN 21947080,21947080,21947080,21947080 0006,0004,0053,0096 LC ITGAL SHARPIN 26600301,26600301,24210817,24210817,26600301,24210817 0096,0047,0004,0047,0004,0096 LC NFKBIA SHARPIN 22605335 0415 LC BDKRB2 SHARPIN 24211782 0018 LC UBA52 SHARPIN 21455181,21455181 0065,0096 LC TFAP2C SHARPIN 24835590 0018 LC RNF31 SHARPIN 26600301,26600301,22158122,26600301 0096,0047,0018,0004 LC TXN2 SHARPIN 21988832 0018 HT SHARPIN SHARPIN 22549881 0114 LC SHARPIN SHANK1 11178875,12753155,11178875 0018,0018,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NQC7 Q9H0F6 CYLD SHARPIN 0.376 26670046 Q9H0F6 Q96BN8 SHARPIN OTULIN 0.507 23746843,26670046,24726323 Q9H0F6 Q13490 SHARPIN BIRC2 0.21 27070702 Q9H0F6 P01583 SHARPIN IL1A 0.21 21947080 Q9H0F6 O95999 SHARPIN BCL10 0.21 27070702 Q9H0F6 O14920 SHARPIN IKBKB 0.21 21455180 Q9H0F6 O15111 SHARPIN CHUK 0.21 21455180 Q9H0F6 Q92754 SHARPIN TFAP2C 0.183 24835590 Q9H0F6 P19438 SHARPIN TNFRSF1A 0.21 23746843 Q9H0F6 P05107 SHARPIN ITGB2 0.523 26600301 Q9H0F6 P05556 SHARPIN ITGB1 0.126 21947080 Q9H0F6 Q13489 SHARPIN BIRC3 0.21 27070702 Q9UDY8 Q9H0F6 MALT1 SHARPIN 0.21 27070702 Q9H0F6 Q9H0F6 SHARPIN SHARPIN 0.236 11178875 Q9Y6K9 Q9H0F6 IKBKG SHARPIN 0.757 23032186,21709223,21455180 Q9H0F6 P11215 SHARPIN ITGAM 0.309 24210817 Q9H0F6 P07098 SHARPIN LIPF 0.126 26186194 Q9Y566 Q9H0F6 SHANK1 SHARPIN 0.454 11178875 Q9WV60 Q9H0F6 GSK3B SHARPIN 0.236 26496610 Q9H0F6 A0A0C4DGF1 SHARPIN ZBTB32 {ECO:0000313|ENSEMBL:ENSP00000433657} 0.236 unassigned1304 Q9H0F6 P08648 SHARPIN ITGA5 0.787 21947080,26600301 Q9H0F6 P17301 SHARPIN ITGA2 0.872 21947080 Q9H0F6 P21580 SHARPIN TNFAIP3 0.61 23032186 Q9H0F6 P60484 SHARPIN PTEN 0.61 25152374,20458142 Q9H0F6 Q15645 SHARPIN TRIP13 0.236 unassigned1304 Q9H0F6 Q70EL1 SHARPIN USP54 0.236 unassigned1304 Q9H0F6 P56199 SHARPIN ITGA1 0.454 21947080 Q9HC29 Q9H0F6 NOD2 SHARPIN 0.507 26670046,22607974,23818254 Q9H0F6 P20701 SHARPIN ITGAL 0.932 24210817,26600301 Q9H0F6 Q9BYM8 SHARPIN RBCK1 0.61 26670046,23032186,24726327 Q9H0F6 P01375 SHARPIN TNF 0.61 26670046,23032186,23032187 Q9H0F6 Q96EP0 SHARPIN RNF31 0.96 23746843,26670046,23032186,26600301,24726327,22791023 Q9H0F6 P36941 SHARPIN LTBR 0.126 26186194 Q9H0F6 P30411 SHARPIN BDKRB2 0.523 24211782 Q9H0F6 Q96GD4 SHARPIN AURKB 0.126 23443559 Q9H0F6 Q99757 SHARPIN TXN2 0.332 21988832 Q9UPX8 Q9H0F6 SHANK2 SHARPIN 0.309 23897824 Q9H0F6 Q13349 SHARPIN ITGAD 0.309 24210817 Q9H0F6 Q13077 SHARPIN TRAF1 0.376 25996949

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 EYA2 SHARPIN MI:0362 inference MI:0461 interaction database STK25 SHARPIN MI:0362 inference MI:0461 interaction database IKBKB SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CHUK SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FYB SHARPIN MI:0362 inference MI:0461 interaction database ASAP2 SHARPIN MI:0362 inference MI:0461 interaction database SURF6 SHARPIN MI:0362 inference MI:0461 interaction database AIFM1 SHARPIN MI:0362 inference MI:0461 interaction database BCL10 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database TNF SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database IL1A SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database ITGB2 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database LIPF SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database ITGA5 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database UCHL1 SHARPIN MI:0362 inference MI:0461 interaction database UBB SHARPIN MI:0362 inference MI:0461 interaction database UBC SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database ITGAM SHARPIN MI:0362 inference MI:0461 interaction database ITGA2 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database ADCYAP1 SHARPIN MI:0362 inference MI:0461 interaction database TNFRSF1A SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ITGAL SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database TNFAIP3 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database BDKRB2 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database LTBR SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database CUX1 SHARPIN MI:0362 inference MI:0461 interaction database CEBPA SHARPIN MI:0362 inference MI:0461 interaction database GSK3B SHARPIN MI:0362 inference MI:0461 interaction database ITGA1 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database PTEN SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database RPS27A SHARPIN MI:0362 inference MI:0461 interaction database UBA52 SHARPIN MI:0362 inference MI:0461 interaction database DLG4 SHARPIN MI:0362 inference MI:0461 interaction database TRAF2 SHARPIN MI:0362 inference MI:0461,MI:1106 interaction database,pathways database TRAF1 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database ITGAD SHARPIN MI:0362 inference MI:0461 interaction database BIRC3 SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database BIRC2 SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RIPK1 SHARPIN MI:0362 inference MI:0461,MI:1106 interaction database,pathways database TRADD SHARPIN MI:0362 inference MI:0461,MI:1106 interaction database,pathways database RNF20 SHARPIN MI:0362 inference MI:0461 interaction database CAPN13 SHARPIN MI:0362 inference MI:0461 interaction database TEKT4 SHARPIN MI:0362 inference MI:0461 interaction database TFAP2C SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database OTULIN SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF31 SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database AURKB SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database NSD1 SHARPIN MI:0362 inference MI:0461 interaction database PSMD1 SHARPIN MI:0362 inference MI:0461 interaction database EYA1 SHARPIN MI:0362 inference MI:0461 interaction database TXN2 SHARPIN MI:0045 experimental interaction detection MI:0461 interaction database SHANK3 SHARPIN MI:0362 inference MI:0461,MI:1106 interaction database,pathways database RBCK1 SHARPIN MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SHARPIN NOD2 MI:0045 experimental interaction detection MI:0461 interaction database SHARPIN CYLD MI:0045 experimental interaction detection MI:0461 interaction database SHARPIN MALT1 MI:0045 experimental interaction detection MI:0461 interaction database SHARPIN SCN11A MI:0362 inference MI:0461 interaction database SHARPIN SHANK2 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SHARPIN GRIP1 MI:0362 inference MI:0461 interaction database SHARPIN SHANK1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SHARPIN STK24 MI:0362 inference MI:0461 interaction database SHARPIN IKBKG MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database