PTM - CPLM Gene Name UniProt ID Type Position Code SHARPIN; SIPL1; PSEC0216 Q9H0F6 Ubiquitination 189 K SHARPIN; SIPL1; PSEC0216 Q9H0F6 Ubiquitination 318 K

PTM - dbPAF Gene Name UniProt ID Position Type Species SHARPIN; SIPL1; PSEC0216 Q9H0F6 129 S Homo sapiens(Human) SHARPIN; SIPL1; PSEC0216 Q9H0F6 131 S Homo sapiens(Human) SHARPIN; SIPL1; PSEC0216 Q9H0F6 146 S Homo sapiens(Human) SHARPIN; SIPL1; PSEC0216 Q9H0F6 152 T Homo sapiens(Human) SHARPIN; SIPL1; PSEC0216 Q9H0F6 165 S Homo sapiens(Human) SHARPIN; SIPL1; PSEC0216 Q9H0F6 170 T Homo sapiens(Human) SHARPIN; SIPL1; PSEC0216 Q9H0F6 224 T Homo sapiens(Human) SHARPIN; SIPL1; PSEC0216 Q9H0F6 309 T Homo sapiens(Human) SHARPIN; SIPL1; PSEC0216 Q9H0F6 312 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q9H0F6 R29-m1 Methylation LAVHAAVrPLGAGPD Q9H0F6 S131-p Phosphorylation QNGSKSNsPPALGPE Q9H0F6 S143-p Phosphorylation GPEACPVsLPsPPEA Q9H0F6 S146-p Phosphorylation ACPVsLPsPPEAStL Q9H0F6 T152-p Phosphorylation PsPPEAStLKGPPPE Q9H0F6 S165-p Phosphorylation PEADLPRsPGNLtER Q9H0F6 T170-p Phosphorylation PRsPGNLtEREELAG Q9H0F6 T224-p Phosphorylation GPIRLQVtLEDAASA Q9H0F6 S282-p Phosphorylation CLCVPERsLASYGVR Q9H0F6 S312-p Phosphorylation EAPATGPsPQHPQkM Q9H0F6 K189-ub Ubiquitination AIAGGDEkGAAQVAA Q9H0F6 K318-ub Ubiquitination PsPQHPQkMDGELGR

PTM - dbPTM UniProt ID Position Code Type Resources References Q9H0F6 165 S Phosphorylation Swiss-Prot 1010711 18669648 Q9H0F6 165 S Phosphorylation PhosphoELM.10011 18669648 Q9H0F6 189 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q9H0F6 318 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q9H0F6 165 S Phosphorylation Phosphositeplus.1010730 18669648 Q9H0F6 312 S Phosphorylation Phosphositeplus.1010730 20068231 Q9H0F6 165 S Phosphorylation HPRD 9.0 18669648 Q9H0F6 312 S Phosphorylation HPRD 9.0 20068231

PTM - HPRD Symbol Position Code Type References SHARPIN 165 S Phosphorylation 18669648 SHARPIN 312 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q9H0F6 165 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q9H0F6 165 Phosphoserine 18669648;23186163 Q9H0F6 312 Phosphoserine 20068231;23186163

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 81858 123608 - K Ubiquitination 21987572 81858 123608 - K Ubiquitination 21890473 81858 123608 - K Ubiquitination 21906983 81858 123608 - K Ubiquitination 22053931 81858 123608 - K Ubiquitination 21963094 81858 123608 - K Ubiquitination 21139048 81858 123608 - K Ubiquitination 23000965 81858 123608 - K Ubiquitination 25015289 81858 123608 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID SHARPIN Homo sapiens (Human) 189; 318 "189,IAGGDEKGAAQVA; 318,SPQHPQKMDGELG" "189:21890473,21906983; 318:21890473,21906983" SHARPIN Homo sapiens (Human) 189 "189,IAGGDEKGAAQVA" "189:21906983,21890473" SHARPIN Homo sapiens (Human) 189; 318 "189,IAGGDEKGAAQVA; 318,SPQHPQKMDGELG" 189:21906983; 318:21906983 SHARPIN Homo sapiens (Human) 189 "189,IAGGDEKGAAQVA" 189:22053931 SHARPIN Homo sapiens (Human) 51; 189 "51,IAGGDEKGAAQVA; 189,IAGGDEKGAAQVA" 51:21906983; 189:21890473 SHARPIN Homo sapiens (Human) 189; 318 "189,IAGGDEKGAAQVA; 318,SPQHPQKMDGELG" 189:21890473; 318:21890473