PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PLCG1 TRAIP 17474147 innatedb,i2d,mint,intact exp P P P P P P P P P P P P P P P P P P P P P GP TRAIP POLK 24553286 biogrid exp G RNF4 TRAIP 22493164 biogrid,intact exp P P P P P P P P P P P P GP TRAIP TRAIP 17544371 biogrid exp P P P P P P P P P P P P P P P P P P P P P GP MAPRE2 TRAIP 25416956 biogrid,intact exp P P P P P P P P P P P P P P UBE2D1 TRAIP 17544371 biogrid exp P P P P P P P P P P P P P P P P GP UBE2H TRAIP 19549727 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P GP TRIM23 TRAIP 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P GP TSG101 TRAIP 19549727 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P GP UBE2D2 TRAIP 17544371 biogrid exp P P P P P P P P P P P P P P P P GP TRAIP RNF114 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P GP USP2 TRAIP 23105109 biogrid exp P P P P P P P P P P P P P P P P P P P P GP UBE2D3 TRAIP 17544371 biogrid exp P P P P P P P P P P P P P P P P GP SYK TRAIP 19151749 biogrid exp P P P P P P P P P P P P P GP RAD21 TRAIP 22145905 biogrid exp P P P P P P P P P P P P P P P P P P P P P GP UBE2K TRAIP 19549727 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P GP TRAIP POLH 24553286 biogrid exp P P P P P P P P P P P P P P P P P P P GP FLII TRAIP 9671805 hprd,biogrid exp P P P P P P P P P P P P P P P P P P P P P GP APP TRAIP 21832049 biogrid exp P P P P P P P P P P GP TRAIP UBE2Z 19549727 biogrid,intact exp P P P P P P P P P P P P P P P P P P P GP UBOX5 TRAIP 22493164 biogrid,intact exp P P P P P P P P P P P P P P G GRB2 TRAIP 17474147 i2d,intact exp P P P P P P P P P P P P P P P P P P P P GP FYN TRAIP 17474147 i2d,intact exp P P P P P P P P P G NCK1 TRAIP 17474147 i2d,intact exp P P P P P P P P P P P P P P P P P P P P GP UBE2U TRAIP 19690564 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P GP TRIM41 TRAIP 22493164 biogrid,intact exp P P P P P P P P P P P P P P P P P P GP TRAIP TBK1 22945920 biogrid exp, ortho P P P P P P P P P P P P P P P P P P P P GP TRAF2 TRAIP 9104814,25716317,17544371, 25402006 hprd,biogrid,bci exp, ortho, pred P P P P P P P P P P P P P P P P P P P P P P TRAIP TRAF6 17544371, 25402006 biogrid exp, ortho, pred P P P P P P P P P P P P P P P P GP TNFRSF1B TRAIP 9104814, 25402006 hprd,biogrid,bci exp, pred P P P P P P P P P P P P P P P P P P P P P P TRAF5 TRAIP 17544371, 25402006 biogrid exp, pred P P P P P P P P P P P P P P P P P P P P GP TRAF1 TRAIP 9104814,17544371, 25402006, 21836163 hprd,biogrid,bci exp, pred P P P P P P P G TRAIP CYLD 14676304, 21836163 hprd,biogrid,i2d,bci exp, pred P P P P P P P P P P P P P P P P P P P P P GP TNFRSF8 TRAIP 9104814, 25402006 biogrid exp, pred P P P P G TRAF3 TRAIP 22945920,17544371, 25402006 biogrid exp, pred P P P P P P P P P P P P P P P GP TRAIP SPATA2 25402006 pred P P P P P P P P P P P P P P P P GP HSPA1L TRAIP 25402006 pred P P P GP TRADD TRAIP 25402006 pred P P P P P P P P P P P P P P GP CFLAR TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP EGFR TRAIP 25402006 pred P P P P P P P P P P P P P GP TRAIP LRRFIP2 25402006 pred P P P P P P P P P P P P P P P P P P P GP TICAM1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P SPOP TRAIP 25402006 pred P P P P P P P P P P P P GP TRAIP MAP4K5 25402006 pred P P P P P P P P P P GP EDARADD TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P MAP3K14 TRAIP 25402006 pred G PLK1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP CD40 TRAIP 25402006 pred P P G BIRC2 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P GP TNFRSF1A TRAIP 21836163 pred P P P P P P P P P P P P P P P P P P P P P GP NXNL1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P HSPA8 TRAIP 25402006 pred P P P P P P P P P P P P P P P P TRAIP NT5DC2 25402006 pred P P P P P P P P P P P P P P P P P P GP RPS3 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P GP HSPA9 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP TUBB4A TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP TUBB TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP HSP90AA1 TRAIP 25402006 pred P P P P P P GP ACTL6A TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP BIRC3 TRAIP 25402006 pred P P P P P P P P P P P P P GP TUBA3C, TUBA3D TRAIP 25402006 pred P P P P P P P P P P P P P P TNFRSF9 TRAIP 25402006 pred P P P P P P P P P P P P GP HIVEP3 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P P TNFAIP3 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P GP LRRFIP1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P G ERN1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP PPIB TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P GP SLC25A5 TRAIP 25402006 pred P P P P P P P P P P P GP APIP TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P GP IKBKE TRAIP 25402006 pred G TRAIP TNFRSF12A 25402006 pred P P P P P P P P P P P P P P P P P P P GP TRAIP ECT2 25402006 pred G BAG2 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P GP CHAF1A TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P GP ISG15 TRAIP 21836163 pred P P P P P P P P P P P P P P P P P P P P P GP ACTG1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP NAP1L1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP TNFSF9 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP TRAIP TNFRSF11A 25402006 pred P P P P P P P P P P P P P P P P P CASP8 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP TRPA1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P MAP3K1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP DNAJA1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P GP TNFRSF4 TRAIP 25402006 pred P P P TRAIP HDAC6 25402006 pred P P P P P P P P P P P P P P P P P P P P GP MAVS TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP ARHGEF7 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P GP PKN2 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P GP MAP3K7 TRAIP 25402006 pred P P P P P P P P P P P GP TRAIP TNFRSF18 25402006 pred P P P P P P P P P P P GP PAK1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP RIPK1 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P GP TRAIP TPX2 25402006 pred P P P P P P P P P P P P P P P P GP TRAIP TNIK 25402006 pred P P P P P P P P P P P P P P P P P P P GP MAP3K8 TRAIP 25402006 pred P P P P P P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9NQC7 Q9BWF2 - 14676304 - X 2 Q9BWF2 P61077-3 pull down 17544371 direct interaction X 2 Q9BWF2 O75604-2 two hybrid 23105109 direct interaction X 2 Q9BWF2 Q8WV44-2 two hybrid 22493164 direct interaction X 2 Q9BWF2 P28908-3 affinity chromatography technology 9104814 physical association X 2 Q9BWF2 Q99816 two hybrid 19549727 direct interaction X 2 Q9BWF2 two hybrid 19549727 direct interaction X 2 Q9BWF2 O00463 affinity chromatography technology 17544371 physical association X 2 Q9BWF2 Q9Y4K3 affinity chromatography technology 17544371 physical association X 2 A0A087WW00 Q9BWF2 pull down 17544371 direct interaction X 2 Q13114-2 Q9BWF2 affinity chromatography technology 22945920 physical association X 2 Q13114-2 Q9BWF2 affinity chromatography technology 17544371 physical association X 2 A0A024RAP4 Q9BWF2 two hybrid 24553286 direct interaction X 2 A0A024R9J0 Q9BWF2 affinity chromatography technology 22145905 physical association X 2 Q13077-2 Q9BWF2 two hybrid 9104814 direct interaction X 2 Q13077-2 Q9BWF2 pull down 9104814 direct interaction X 2 Q13077-2 Q9BWF2 affinity chromatography technology 17544371 physical association X 2 P78317 Q9BWF2 two hybrid 22493164 direct interaction X 2 Q9BWF2 P62837 pull down 17544371 direct interaction X 2 Q9BWF2 P05067-7 pull down 21832049 direct interaction X 2 Q9BWF2 P36406 two hybrid 22493164 direct interaction X 2 Q9BWF2 O94941-2 two hybrid 22493164 direct interaction X 2 Q9BWF2 A0A024RD62 two hybrid 24553286 direct interaction X 2 Q9BWF2 A0A024RD62 affinity chromatography technology 24553286 physical association X 2 Q9BWF2 A0A024RD62 affinity chromatography technology 24553286 physical association X 2 Q9BWF2 A0A024RD62 imaging technique 24553286 colocalization X 2 Q9BWF2 A0A024RC33 two hybrid 25416956 direct interaction X 2 Q9BWF2 Q13045 pull down 9671805 direct interaction X 2 Q9BWF2 P20333 affinity chromatography technology 9104814 physical association X 2 Q9BWF2 two hybrid 19690564 direct interaction X 2 Q9BWF2 Q9H832 two hybrid 19549727 direct interaction X 2 Q9BWF2 A0A024R6T1 two hybrid 14676304 direct interaction X 2 Q9BWF2 A0A024R6T1 far western blotting 14676304 direct interaction X 2 Q9BWF2 Q9BWF2 enzymatic study 17544371 direct interaction X 2 Q9BWF2 Q13045 two hybrid 9671805 direct interaction X 2 Q9Y508 Q9BWF2 two hybrid 22493164 direct interaction X 2 A0A024R244 Q9BWF2 two hybrid 19151749 direct interaction X 2 A0A024R244 Q9BWF2 affinity chromatography technology 19151749 physical association X 2 A0A024R244 Q9BWF2 affinity chromatography technology 19151749 physical association X 2 Q9UHD2 Q9BWF2 affinity chromatography technology 22945920 physical association X 2 A0A024R8H5 Q9BWF2 two hybrid 9104814 direct interaction X 2 A0A024R8H5 Q9BWF2 pull down 9104814 direct interaction X 2 A0A024R8H5 Q9BWF2 affinity chromatography technology 17544371 physical association X 2 P61086 Q9BWF2 two hybrid 19549727 direct interaction X 2 P0CG48 Q9BWF2 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9BWF2 affinity chromatography technology 17544371 physical association X 2 P0CG48 Q9BWF2 affinity chromatography technology 21906983 physical association X 2 Q13077 Q9BWF2 in vitro 9104814 - X 2 Q13077 Q9BWF2 in vivo 9104814 - X 2 Q13077 Q9BWF2 two hybrid 9104814 - X 2 Q13077 Q9BWF2 in vitro 9104814 - X 2 Q13077 Q9BWF2 in vivo 9104814 - X 2 Q13077 Q9BWF2 two hybrid 9104814 - X 2 Q9BWF2 in vivo 9104814 - C 3 Q9BWF2 in vivo 9104814 - C 3 Q9BWF2 in vivo 9104814 - C 3 Q9BWF2 in vivo 9104814 - X 2 Q9BWF2 in vitro 9104814 - X 2 Q9BWF2 two hybrid 9104814 - X 2 Q9BWF2 Q13045 two hybrid 9671805 - X 2 Q9BWF2 Q13045 in vitro 9671805 - X 2 Q9BWF2 A0A024R6T1 in vitro 14676304 - X 2 Q9BWF2 A0A024R6T1 in vivo 14676304 - X 2 Q9BWF2 A0A024R6T1 two hybrid 14676304 - X 2 Q9BWF2 in vivo 9104814 - X 2 Q9BWF2 in vitro 9104814 - X 2 Q9BWF2 two hybrid 9104814 - X 2 Q9BWF2 Q13045 in vitro 9671805 - X 2 Q9BWF2 Q13045 two hybrid 9671805 - X 2 Q9BWF2 A0A024R6T1 two hybrid 14676304 - X 2 Q9BWF2 A0A024R6T1 in vitro 14676304 - X 2 Q9BWF2 A0A024R6T1 in vivo 14676304 - X 2 A0A024R8H5 Q9BWF2 in vivo 9104814 - X 2 A0A024R8H5 Q9BWF2 in vitro 9104814 - X 2 A0A024R8H5 Q9BWF2 two hybrid 9104814 - X 2 A0A024R8H5 Q9BWF2 two hybrid 9104814 - X 2 A0A024R8H5 Q9BWF2 in vivo 9104814 - X 2 A0A024R8H5 Q9BWF2 in vitro 9104814 - X 2 Q9BWF2 Q99816 two hybrid array 19549727 physical association X 2 Q9BWF2 A4D1L5 two hybrid array 19549727 physical association X 2 Q9BWF2 Q5VVX9 two hybrid array 19690564 physical association X 2 P16333 Q9BWF2 peptide array 17474147 physical association X 2 P16333 Q9BWF2 peptide array 17474147 physical association X 2 P16333 Q9BWF2 peptide array 17474147 physical association X 2 P06241 Q9BWF2 peptide array 17474147 physical association X 2 B0LPF3 Q9BWF2 peptide array 17474147 physical association X 2 P78317 Q9BWF2 two hybrid array 22493164 physical association X 2 Q9BWF2 P19174 peptide array 17474147 physical association X 2 Q9BWF2 Q9H832 two hybrid array 19549727 physical association X 2 Q9BWF2 P36406 two hybrid array 22493164 physical association X 2 Q9BWF2 O94941 two hybrid array 22493164 physical association X 2 Q9BWF2 A0A024RC33 two hybrid prey pooling approach 25416956 physical association X 2 Q9BWF2 A0A024RC33 two hybrid array 25416956 physical association X 2 Q9BWF2 A0A024RC33 validated two hybrid 25416956 physical association X 2 Q9Y508 Q9BWF2 two hybrid array 22493164 physical association X 2 Q8WV44 Q9BWF2 two hybrid array 22493164 physical association X 2 B3KSH4 Q9BWF2 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TSG101 TRAIP MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124056|UniProt_100986 bait|bait prey|prey UBE2U TRAIP MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102661|BIOGRID_123672 bait|bait prey|prey APP TRAIP MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228624 prey bait UBE2D3 TRAIP MI:0096(pull down) 17544371 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225938 prey bait UBOX5 TRAIP MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284165|UniProt_122524 prey|prey bait|bait FLII TRAIP MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 9671805 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_6865|BIOGRID_109307|BIOGRID_77701 -|prey|prey -|bait|bait UBC TRAIP MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 17544371,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_141910|BIOGRID_265999|BIOGRID_179614|BIOGRID_141908 prey|bait|bait|prey bait|prey|prey|bait SYK TRAIP MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 19151749 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_210156|BIOGRID_210154|BIOGRID_210155 prey|bait|bait bait|prey|prey TRAIP UBE2Z MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124297|UniProt_101507 prey|prey bait|bait USP2 TRAIP MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248162 bait prey TRIM23 TRAIP MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122464|BIOGRID_284134 bait|bait prey|prey TRAF3 TRAIP MI:0096(pull down)|MI:0004(affinity chromatography technology) 17544371,22945920 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_141913|BIOGRID_209119 prey|prey bait|bait GRB2 TRAIP MI:0096(pull down)|MI:0081(peptide array)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|MI:0471(mint)|MI:0471(mint) UniProt_91621|MINT_43331|MINT_73374 prey|prey|prey bait|bait|bait TRAF1 TRAIP MI:0096(pull down)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid) 17544371,9104814 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_141911|HPRD_9626|BIOGRID_77808|BIOGRID_114940 prey|-|prey|prey bait|-|bait|bait NCK1 TRAIP MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array)|MI:0081(peptide array)|MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint) MINT_73064|UniProt_91818|MINT_72904|MINT_43021|MINT_42861|UniProt_91998|MINT_73109|UniProt_91928|MINT_43066 prey|prey|prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait|bait|bait SIRT2 TRAIP MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_193359 bait prey TRAIP POLH MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 24553286 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_307787|BIOGRID_307789|BIOGRID_307790|BIOGRID_307792 bait|bait|prey|bait prey|prey|bait|prey TRAIP RNF114 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284142|UniProt_122525 bait|bait prey|prey TRAIP TRAF6 MI:0096(pull down) 17544371 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_141915 bait prey PLCG1 TRAIP MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint) MINT_43216|UniProt_92197|MINT_73259 prey|prey|prey bait|bait|bait UBE2K TRAIP MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124296 bait prey RNF4 TRAIP MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_283962|UniProt_122490 bait|prey prey|bait TRAF5 TRAIP MI:0096(pull down) 17544371 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_141914 prey bait TRAIP HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101196 prey bait FYN TRAIP MI:0081(peptide array)|MI:0096(pull down)|MI:0081(peptide array) 17474147 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint) MINT_42674|UniProt_91435|MINT_72717 prey|prey|prey bait|bait|bait TRAIP CYLD MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo) 14676304 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_132812|BIOGRID_132811|HPRD_20266 prey|prey|- bait|bait|- UBE2D1 TRAIP MI:0096(pull down) 17544371 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225936 prey bait TRAF2 TRAIP MI:0493(in vivo)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0493(in vivo) 17544371,9104814 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|- MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) HPRD_9995|BIOGRID_77820|BIOGRID_141912|BIOGRID_114941|HPRD_40293 -|prey|prey|prey|- -|bait|bait|bait|- TRAIP TBK1 MI:0004(affinity chromatography technology) 22945920 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_209118 bait prey UBE2D2 TRAIP MI:0096(pull down) 17544371 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225937 prey bait TRAIP POLK MI:0018(two hybrid) 24553286 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_307788 bait prey RAD21 TRAIP MI:0018(two hybrid) 22145905 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_182011 bait prey TRIM41 TRAIP MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122526|BIOGRID_284147 bait|prey prey|bait TNFRSF8 TRAIP MI:0018(two hybrid)|MI:0493(in vivo) 9104814 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_114943|HPRD_40293 bait|- prey|- UBE2H TRAIP MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101339|BIOGRID_124295 bait|bait prey|prey TNFRSF1B TRAIP MI:0493(in vivo)|MI:0018(two hybrid) 9104814 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_4639|BIOGRID_114942 -|bait -|prey

PPI - HINT Gene A Gene B PMID Method Quality TRAF2 TRAIP 25716317,9104814,9104814,17544371 0004,0018,0096,0004 LC TRAF1 TRAIP 9104814,9104814,17544371 0018,0096,0004 LC TRAF3 TRAIP 22945920,17544371 0004,0004 LC TRAF2 TRAIP 25716317,9104814,9104814,17544371 0004,0018,0096,0004 LC TRAF1 TRAIP 9104814,9104814,17544371 0018,0096,0004 LC TRAF3 TRAIP 22945920,17544371 0004,0004 LC HIP2 TRAIP 19549727 0397 HT USP2 TRAIP 23105109 0018 LC UBOX5 TRAIP 22493164,22493164 0018,0397 HT FYN TRAIP 17474147 0081 HT PCNA TRAIP 26711499,26711499,26711499 0114,0096,0004 LC NCK1 TRAIP 17474147 0081 HT PLCG1 TRAIP 17474147 0081 HT TNFRSF1B TRAIP 9104814,9104814 0004,0018 LC TRIM23 TRAIP 22493164,22493164 0018,0397 HT SYK TRAIP 19151749,19151749 0018,0004 LC UBE2K TRAIP 19549727 0018 HT UBE2H TRAIP 19549727,19549727 0397,0018 HT GRB2 TRAIP 17474147 0081 HT RNF4 TRAIP 22493164,22493164 0018,0397 HT TRAF2 TRAIP 9104814,9104814 0018,0096 LC FLII TRAIP 9671805,9671805 0018,0096 LC TRAF1 TRAIP 9104814,9104814 0018,0096 LC MAPRE2 TRAIP 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBE2U TRAIP 19690564,19690564 0397,0018 HT TRIM41 TRAIP 22493164,22493164 0018,0397 HT TSG101 TRAIP 19549727,19549727 0397,0018 HT TRAIP TRAIP 17544371 0415 LC TRAIP UBE2Z 19549727,19549727 0397,0018 HT TRAIP MAGEF1 25590999 0018 LC TRAIP CYLD 14676304,14676304,14676304 0047,0018,0019 LC TRAIP POLK 24553286 0018 LC TRAIP POLH 24553286,24553286,24553286 0018,0428,0004 LC TRAIP RNF114 22493164,22493164 0018,0397 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BWF2 P61086 TRAIP UBE2K 0.183 19549727 Q9HAY2 Q9BWF2 MAGEF1 TRAIP 0.309 25590999 Q9BWF2 O60216 TRAIP RAD21 0.126 22145905 Q9Y253 Q9BWF2 POLH TRAIP 0.623 24553286 Q9BWF2 O75604 TRAIP USP2 0.183 23105109 Q9NQC7 Q9BWF2 CYLD TRAIP 0.523 14676304 Q9BWF2 Q96LK0 TRAIP CEP19 0.236 unassigned1304 Q9BWF2 Q9BS40 TRAIP LXN 0.236 unassigned1304 Q9BWF2 Q15555 TRAIP MAPRE2 0.583 25416956,unassigned1304 Q9BWF2 Q13114 TRAIP TRAF3 0.376 17544371,22945920 Q9BWF2 O94941 TRAIP UBOX5 0.286 22493164 Q9BWF2 Q13045 TRAIP FLII 0.523 9671805 Q9Y508 Q9BWF2 RNF114 TRAIP 0.286 22493164 Q9BWF2 Q99816 TRAIP TSG101 0.286 19549727 Q9BWF2 P36406 TRAIP TRIM23 0.286 22493164 Q9BWF2 P12004 TRAIP PCNA 0.623 26711499 Q9BWF2 Q13077 TRAIP TRAF1 0.623 9104814,17544371 Q9BWF2 Q9BWF2 TRAIP TRAIP 0.757 17544371,unassigned1304,26093298 Q9BWF2 Q8WV44 TRAIP TRIM41 0.286 22493164 Q9BWF2 P28908 TRAIP TNFRSF8 0.21 9104814 Q9BWF2 B3KSH4 TRAIP HIP2 0.236 19549727 Q9BWF2 O00463 TRAIP TRAF5 0.21 17544371 Q9BWF2 P05067 TRAIP APP 0.183 21832049 Q9BWF2 P06241 TRAIP FYN 0.236 17474147 Q9BWF2 P16333 TRAIP NCK1 0.236 17474147 Q9BWF2 P19174 TRAIP PLCG1 0.126 17474147 Q9BWF2 P43405 TRAIP SYK 0.569 19151749 Q9BWF2 P62256 TRAIP UBE2H 0.376 19549727 Q9BWF2 P62993 TRAIP GRB2 0.236 17474147 Q9BWF2 P78317 TRAIP RNF4 0.286 22493164 Q9BWF2 Q5VVX9 TRAIP UBE2U 0.286 19690564 Q9H832 Q9BWF2 UBE2Z TRAIP 0.286 19549727 Q9UBT6 Q9BWF2 POLK TRAIP 0.309 24553286 Q9UHD2 Q9BWF2 TBK1 TRAIP 0.21 22945920 Q9Y4K3 Q9BWF2 TRAF6 TRAIP 0.21 17544371 Q9BWF2 Q12933 TRAIP TRAF2 0.702 9104814,17544371,25716317 Q9BWF2 P20333 TRAIP TNFRSF1B 0.21 9104814

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TRAF5 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database NTN3 TRAIP MI:0362 inference MI:0461 interaction database RAD21 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database USP2 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database UBOX5 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database NTN1 TRAIP MI:0362 inference MI:0461 interaction database APP TRAIP MI:0045 experimental interaction detection MI:0461 interaction database FYN TRAIP MI:0045 experimental interaction detection MI:0461 interaction database UBC TRAIP MI:0045 experimental interaction detection MI:0461 interaction database PCNA TRAIP MI:0045 experimental interaction detection MI:0461 interaction database RAC2 TRAIP MI:0362 inference MI:0461 interaction database NCK1 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database PLCG1 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database TNFRSF1B TRAIP MI:0045 experimental interaction detection MI:0461 interaction database TNFRSF8 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database TRIM23 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database HNF4A TRAIP MI:0045 experimental interaction detection MI:0461 interaction database SYK TRAIP MI:0045 experimental interaction detection MI:0461 interaction database NOTCH1 TRAIP MI:0362 inference MI:0461 interaction database UBE2D1 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database RAC3 TRAIP MI:0362 inference MI:0461 interaction database UBE2D3 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database UBE2K TRAIP MI:0045 experimental interaction detection MI:0461 interaction database UBE2N TRAIP MI:0362 inference MI:0461 interaction database UBE2H TRAIP MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database GRB2 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database RAC1 TRAIP MI:0362 inference MI:0461 interaction database RNF4 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database GPSM2 TRAIP MI:0362 inference MI:0461 interaction database NOTCH2 TRAIP MI:0362 inference MI:0461 interaction database RBL2 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database FLII TRAIP MI:0045 experimental interaction detection MI:0461 interaction database TRAF1 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database TRAF3 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database ARHGEF7 TRAIP MI:0362 inference MI:0461 interaction database ARHGEF6 TRAIP MI:0362 inference MI:0461 interaction database MAPRE2 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database E2F4 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database ESCO2 TRAIP MI:0362 inference MI:0461 interaction database ESCO1 TRAIP MI:0362 inference MI:0461 interaction database RALGPS1 TRAIP MI:0362 inference MI:0461 interaction database UBE2NL TRAIP MI:0362 inference MI:0461 interaction database UBE2U TRAIP MI:0045 experimental interaction detection MI:0461 interaction database RALGPS2 TRAIP MI:0362 inference MI:0461 interaction database RHOT1 TRAIP MI:0362 inference MI:0461 interaction database VPS52 TRAIP MI:0362 inference MI:0461 interaction database TRIM41 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database YIPF5 TRAIP MI:0362 inference MI:0461 interaction database DGCR14 TRAIP MI:0362 inference MI:0461 interaction database TSG101 TRAIP MI:0045 experimental interaction detection MI:0461 interaction database MCMBP TRAIP MI:0362 inference MI:0461 interaction database TRAIP CRNKL1 MI:0362 inference MI:0461 interaction database TRAIP DRC3 MI:0362 inference MI:0461 interaction database TRAIP UBE2Z MI:0045 experimental interaction detection MI:0461 interaction database TRAIP MAGEF1 MI:0045 experimental interaction detection MI:0461 interaction database TRAIP CYLD MI:0045 experimental interaction detection MI:0461 interaction database TRAIP SMOX MI:0362 inference MI:0461 interaction database TRAIP POLK MI:0045 experimental interaction detection MI:0461 interaction database TRAIP TBK1 MI:0045 experimental interaction detection MI:0461 interaction database TRAIP NOTCH3 MI:0362 inference MI:0461 interaction database TRAIP POLI MI:0362 inference MI:0461 interaction database TRAIP POLH MI:0045 experimental interaction detection MI:0461 interaction database TRAIP COG6 MI:0362 inference MI:0461 interaction database TRAIP TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database TRAIP RNF114 MI:0045 experimental interaction detection MI:0461 interaction database