PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus RING1 ELAC2 9199346 hprd exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G RING1 ZFP42 21530438 biogrid exp P P P P P P P P P P P P P P P P P P CSNK2A2 RING1 26186194,23455922 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 USP7 20800574,26496610,20601937 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CBX6 RING1 21282530,22325352 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G RING1 PHC3 22325352 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RB1 RING1 11583618 hprd,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 SNW1 20467437 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 MOV10 20543829 dip exp G G G G G G G G G G G G G G G G G G G G G G RING1 PCGF1 22493164,16943429,22325352 biogrid,intact exp P GP G GP GP G GP P P GP P G P GP GP GP G GP GP GP GP GP P GP GP G RING1 FBXO38 21988832 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RING1 CBX3 12004135 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOP2A RING1 19956605 biogrid exp P P G GP GP P GP GP G P P GP GP GP GP RING1 BCOR 16943429,26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G RING1 HECW2 24163370 biogrid exp GP GP G G GP GP G GP GP G GP G GP G G P GP P GP G GP GP GP GP GP G GP GP RING1 AUTS2 25519132 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RING1 TERF2 20811636 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SNAI1 RING1 24903147 biogrid exp GP GP G GP P P P P P GP P P P P P GP P P GP P P P P RING1 HIST3H3 20850016 biogrid exp P P P P P P P P P P P P P P P P P P P P P P JUN RING1 25609649 intact exp GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G NOTCH1 RING1 23022380 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBC RING1 20601937 mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 SMARCAD1 21549307 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G TERF1 RING1 20811636 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 PCGF5 22493164,26186194,22325352 biogrid,intact exp GP G G G G GP G G G G GP G G G G GP GP G G G G G G GP GP G GP GP G RING1 HDAC1 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RING1 PCGF6 22493164,22325352,12167161 biogrid,intact exp G G G G G G G G G G GP GP G G G G G G G G G G G G G G G G G WDR5 RING1 22325352 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AIM2 RING1 25665578 intact exp GP GP G GP GP G GP GP G P GP GP GP G GP GP G GP G GP P GP GP GP GP GP GP G CSNK2A1 RING1 25852190 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 MED23 25281560 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G YY1 RING1 16624538 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 YAF2 25416956,21516116,22325352 biogrid,mint,intact exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G E2F1 RING1 11583618 biogrid exp P GP G G GP GP G GP GP G GP GP GP GP GP GP GP GP G P P GP P GP P GP GP G RING1 PIK3R3 18624398 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP G GP G GP GP GP GP G YY2 RING1 21530438 biogrid exp P P P P P P P P P P P P P P P P P P P P RING1 PCGF3 22493164,22325352 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G APP RING1 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G GP G GP GP G G GP G G GP G KDM5C RING1 17468742 biogrid,dip exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XPO1 RING1 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CENPA RING1 15009096 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G G GP GP GP GP GP G RING1 RNF2 21596310,16943429,24457600,15386022,26496610,16359901,22325352,12183370, 25402006, 23023127, 21836163, 21836163 innatedb,hprd,biogrid,intact exp, ortho, pred P P P P GP P P P P P P P P P P P RING1 PHC2 15386022,22325352, 25402006, 21836163, 21836163 biogrid,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 CBX8 25416956,10825164,21282530,26496610, 25402006, 23023127 hprd,biogrid,intact exp, ortho, pred P P P P P P P P P P P P P P P P P P P P RING1 CBX2 10369680,22325352, 25402006 biogrid exp, ortho, pred P P GP P P G P G P P P GP G G CBX7 RING1 14647293,19636380,21282530, 25402006 hprd,biogrid,intact exp, ortho, pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BMI1 RING1 19451220,22493164,24457600,16751658,15386022,19636380,16359901,20601937,22897849,25416956,9858531,22325352,9199346, 25402006, 23023127, 21836163, 21836163 innatedb,hprd,biogrid,i2d,intact exp, ortho, pred P P P P P P P P P P P P P P P P P P P P P P RING1 RING1 19956605,9858531, 21836163 hprd,biogrid,i2d exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PCGF2 RING1 22493164,19636380,21516116,20601937,22325352,17936708, 25402006 biogrid,intact exp, ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EED RING1 24457600, 21836163 biogrid exp, ortho, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP GP GP GP G E2F6 RING1 11171983, 25402006 hprd,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 RING1 19549727, 25402006, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G PHC1 RING1 22325352,9199346, 25402006 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP GP G GP GP GP G G GP GP GP G UBE2K RING1 19549727, 25402006, 23023127 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 RYBP 25416956,16943429,10369680,16189514,26186194,22325352,17070805, 25402006 hprd,biogrid,mint,intact exp, pred GP G G G G G G G G G GP G GP G G GP G G GP G GP GP G GP GP G GP GP G UBE2D3 RING1 19549727, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G TP53 RING1 22907436, 25402006 biogrid exp, pred G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G USP11 RING1 20601937, 21836163 biogrid,mint,intact exp, pred G GP G G G GP G G GP G GP G G G G G GP G G G G G G G G G G GP G RING1 UBE2E3 19549727, 23023127 biogrid,intact exp, pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G RING1 UBE2E2 19549727, 23023127 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2E1 RING1 19549727, 23023127, 21836163 biogrid,intact exp, pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G RING1 UBE2D4 19549727, 23023127 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G CBX4 RING1 9858531,21282530,26496610,22325352,22078878,9199346, 25402006, 21836163, 21836163 hprd,biogrid,i2d,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBE2D1 RING1 19956605,19549727, 25402006, 23023127, 21836163 biogrid,intact exp, pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G RING1 FHL1 14999091,15710417, 25402006 hprd,biogrid,i2d exp, pred G G G G G G G GP GP G GP G GP G G G G GP GP G GP G G GP G G G G G RUNX1 RING1 ortho P P P P P P P P P P P P P P P P P P P P YWHAE RING1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 KDM2B 25402006 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 UBE2S 23023127 pred G G G G G G G G GP G G G GP G G G G G G G G G G G GP G TUBB RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KMT2D RING1 21836163, 21836163 pred RING1 CTBP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HLA-C RING1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DDAH2 RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP P G RING1 CASP10 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G G GP GP GP GP G RING1 RNF139 23023127 pred G GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G SOD1 RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 TOMM7 21836163 pred RING1 HIST2H2AB 21836163 pred P P P P P P P P P P P P P P P P P P P P P P RING1 RNF157 23023127 pred GP P G P GP G GP GP G GP P P GP G GP GP P P G P P GP GP P GP LRP6 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CCND2 RING1 25402006 pred GP GP G G G GP G GP GP G GP GP G G G GP GP G GP G G G G GP GP G GP G G RING1 UBE2NL 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 HIST2H2AC 25402006 pred P P P P P P P P P P P P P P P P P P P P P P BANF1 RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 SIRT3 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MLLT3 RING1 25402006 pred GP GP G G GP GP G GP GP G GP P GP GP G GP GP GP GP G GP GP GP G GP GP GP P G HOXA1 RING1 21836163, 21836163 pred P P P P P P P P P P P P P P P P P RPL15 RING1 21836163 pred G G G G G GP G G GP G GP G GP GP G GP GP G GP G GP G G G GP G GP GP G UBE2N RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RING1 VSX1 23023127 pred SSR2 RING1 21836163 pred G G G G G GP G GP GP G GP GP GP G G GP GP G GP G G G GP G GP G GP GP G RBPJ RING1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DSCAM RING1 23023127 pred G G G G GP G G GP G P G GP G GP G G P G G G G G UBE2A RING1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NF1 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 UBE2F 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RING1 MYLIP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 KAT5 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 HUWE1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 IHH 23023127 pred P P P P P GP P GP P P GP P P P P GP P GP GP P GP P G RING1 TMEM147 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 RNF167 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP G G GP G GP GP G RING1 NACA2 21836163 pred G PEX10 RING1 23023127 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G GP G RING1 RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G RING1 TFCP2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPL24 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMAD3 RING1 23023127 pred GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G RING1 STUB1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 RNF215 23023127 pred P GP P P GP GP P P P P G GP P GP G P P P GP GP P GP P G GDI1 RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CTBP2 RING1 25402006 pred GP G G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G SP1 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 ANAPC11 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BRD1 RING1 23023127 pred G G G G G GP G G G G G G G G G G GP G G G G G G G G G G GP G RING1 MBD2 21836163, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RING1 RLIM 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 EPC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SCAMP3 RING1 21836163 pred G G G G G GP G GP G G GP G GP GP G G GP G GP G G G G GP G G GP GP G RING1 KDM5B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 CHFR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 TRIM26 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZEB1 RING1 23023127 pred P P P P P P P P P P P ARF5 RING1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM16 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 SCML2 21836163, 21836163 pred GP G G G G GP G G G G G G GP G G G GP G G G G G G G G G G GP G PRC1 RING1 21836163, 21836163 pred GP P G G GP GP G GP GP G P P P GP G GP GP G GP GP P P P GP GP G GP GNB1 RING1 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G G GP G GP G GP GP G RING1 VPS72 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RPS4X RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G H3F3A, H3F3B RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G AHRR RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G UBE2B RING1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PPP2R1A RING1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SET RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NCL RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 SUZ12 21836163, 21836163 pred G G G G GP G G G GP G GP G G GP G GP G G G G GP G G G GP G GP G G RING1 RBM4 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CALM1, CALM2, CALM3 RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 RRAGA 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MLLT1 RING1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP G GP G GP GP GP GP G G GP GP G MGRN1 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2L6 RING1 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G NRIP1 RING1 25402006 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 UBE4A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G LMX1B RING1 23023127 pred RING1 RNF5 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G SIX3 RING1 23023127 pred G G G G G SOX2 RING1 23023127 pred P P G P GP G P GP G P P GP P GP GP P G P GP P GP P GP GP G RING1 DTX3L 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP G GP GP GP GP GP GP G HIST1H2AG, HIST1H2AI, HIST1H2AK, HIST1H2AL, HIST1H2AM RING1 25402006 pred GP GP G GP GP GP GP GP P P GP G P GP P P G P GP GP P P GP GP GP RING1 LRSAM1 23023127 pred P GP G P GP G P GP G GP GP P GP P GP GP GP G P GP P P P GP P P G RPLP0 RING1 21836163 pred GP GP G G G GP G G GP G G G GP G G GP GP G GP G GP G GP G GP GP GP GP G RAG1 RING1 23023127 pred RING1 MBD1 21836163, 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DVL2 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 EGLN3 21836163, 21836163 pred P P G G G GP G G G G G G G G G G G G G G G G RPL8 RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ATF4 RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G VSX2 RING1 23023127 pred P P P P P P P P P P P P P RING1 TRAF7 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G G G G G GP GP GP G GP GP G RING1 TRAF6 23023127 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G RING1 KAT8 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 BARD1 21836163, 21836163 pred P G GP P P GP P P P GP G GP P G P P GP P GP P GP GP GP G GABARAP RING1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SP3 RING1 23023127 pred GP G G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP GP GP GP GP GP GP GP G RING1 UBE2T 23023127 pred G G G GP G GP P P P GP GP P GP P G GP P GP G EIF4B RING1 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF103 RING1 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G G GP G G GP G GP GP G RING1 TFDP1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RING1 TRIM17 23023127 pred P P P P P P P P P P P P P P P P P P GP RING1 KIF20B 21836163, 21836163 pred GP P G G GP GP G P GP P P P G GP GP GP P P G GP GP P G GP GP RING1 EZH2 25402006, 21836163, 21836163 pred GP P G GP GP P GP G GP G P P P GP GP GP GP GATA4 RING1 23023127 pred P P P P GP P P GP P P GP P GP GP GP P P P GP P GP GP RING1 BIRC7 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP GP G RING1 RNF182 23023127 pred P G G GP GP P G P GP P P GP P G G GP P P P GP RING1 TFDP2 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ERP29 RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KDM6A RING1 21836163, 21836163 pred GP G G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP G G GP GP GP GP G RNF8 RING1 23023127 pred GP GP G G G GP G GP GP G GP G G G G GP GP G GP G G G GP G GP G GP GP G RING1 E2F2 25402006 pred GP GP G G G GP G G G P P G G G GP GP G P P G G G GP GP RING1 EIF3C 21836163 pred P GP P P P GP GP GP P GP GP P GP P P GP GP P P GP GP GP G RING1 PFDN5 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RPL29 RING1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 USP20 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KMT2A RING1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 WHSC1L1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ABL1 RING1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2L3 RING1 23023127 pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G RPS3A RING1 21836163 pred P P P P P P P P P P P P P P P P P P P P P RING1 RNF41 23023127 pred GP GP G G G GP G GP GP G GP P G G GP GP P P G P G P GP GP GP GP P RING1 UBE2R2 23023127 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP GP G G RPL13A RING1 21836163 pred P P P P P P P P P P P P P P P P P P P P EPHB1 RING1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G CLTA RING1 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G UBE2G1 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2I RING1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RING1 AP2M1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP G G G GP G GP GP G TMBIM6 RING1 21836163 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP G GP GP GP GP GP GP G TRIM21 RING1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G E2F3 RING1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G RING1 RNF144B 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP G G G GP G G GP G ACADVL RING1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 CHD7 23023127 pred GP G G G G GP G G GP G GP G G GP G GP GP G GP G G GP G GP GP G GP GP G UBOX5 RING1 23023127 pred GP GP G G G GP G GP P G G G GP GP G P GP G G G G G GP P GP GP GP G G COX7A2 RING1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 SP8 23023127 pred G G G G GP GP G G GP GP G GP G GP G G RING1 HYOU1 21836163 pred G G G G G GP G G GP G G G G GP G GP GP G GP G GP G GP G GP G GP GP G RING1 RSPRY1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G CABP4 RING1 23023127 pred G GP G G GP GP G G GP G GP G GP G G G GP G G G GP G G GP G G GP GP G SKI RING1 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 BIRC2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G RING1 EP300 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G2 RING1 23023127 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G MDM2 RING1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 MEX3D 23023127 pred GP GP G G GP GP G GP GP G GP GP GP P G GP GP GP GP G GP GP GP P GP GP GP GP G PEX12 RING1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RING1 RNF185 23023127 pred G G G G G GP G G GP G G G G G G G GP G G G G G G GP G G GP GP G RAC1 RING1 21836163 pred GP GP G G GP G G G GP G G G GP G G GP G G GP G GP GP G GP GP G GP GP G YWHAB RING1 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RING1 MIB1 23023127 pred GP GP G G GP GP G G GP G GP GP G GP G GP GP GP GP G GP GP GP G GP G GP GP G ABCB1 RING1 25402006 pred G GP G G G GP G G GP G GP GP G G G GP GP G G G G G G G GP G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q06587 - 15386022 - C 4 Q06587 Q13642-1 - 15710417 - X 2 Q15554 Q06587 affinity chromatography technology 20811636 physical association X 2 P61077-3 Q06587 two hybrid 19549727 direct interaction X 2 A0A024R1Q2 Q06587 affinity chromatography technology 21282530 physical association X 2 A0A024R1Q2 Q06587 affinity chromatography technology 21282530 physical association X 2 A0A024R1Q2 Q06587 pull down 21282530 direct interaction X 2 A0A024R1Q2 Q06587 pull down 14647293 direct interaction X 2 A0A024R1Q2 Q06587 affinity chromatography technology 14647293 physical association X 2 A0A024R1Q2 Q06587 affinity chromatography technology 19636380 physical association X 2 P78364 Q06587 affinity chromatography technology 22325352 physical association X 2 P78364 Q06587 affinity chromatography technology 9199346 physical association X 2 P51784 Q06587 affinity chromatography technology 20601937 physical association X 2 A4D177 Q06587 affinity chromatography technology 12004135 physical association X 2 Q16695 Q06587 unspecified method 20850016 direct interaction X 2 Q9P2P5 Q06587 affinity chromatography technology 24163370 physical association X 2 Q969T4 Q06587 two hybrid 19549727 direct interaction X 2 P61086 Q06587 two hybrid 19549727 direct interaction X 2 O95503 Q06587 affinity chromatography technology 22325352 physical association X 2 O95503 Q06587 affinity chromatography technology 21282530 physical association X 2 O95503 Q06587 affinity chromatography technology 21282530 physical association X 2 O95503 Q06587 pull down 21282530 direct interaction X 2 P19784 Q06587 affinity chromatography technology 23455922 physical association X 2 Q06587 A0A024R1V6 affinity chromatography technology 22325352 physical association X 2 Q06587 Q86SE9 affinity chromatography technology 22325352 physical association X 2 Q06587 O00257 affinity chromatography technology 22325352 physical association X 2 Q06587 Q8N488 affinity chromatography technology 22325352 physical association X 2 Q06587 Q8N488 two hybrid 16189514 direct interaction X 2 Q06587 Q8N488 affinity chromatography technology 22325352 physical association X 2 Q06587 A0A024R1V6 affinity chromatography technology 22325352 physical association X 2 Q06587 O00257 two hybrid 9858531 direct interaction X 2 Q06587 P04637-7 affinity chromatography technology 22907436 physical association X 2 Q06587 A0A024R1V6 two hybrid 22493164 direct interaction X 2 Q06587 Q86SE9 two hybrid 22493164 direct interaction X 2 Q06587 Q8N488 two hybrid 25416956 direct interaction X 2 Q06587 O00257 two hybrid 9199346 direct interaction X 2 Q06587 O00257 affinity chromatography technology 9199346 physical association X 2 Q06587 O00257 affinity chromatography technology 9199346 physical association X 2 Q06587 Q06587 two hybrid 9858531 direct interaction X 2 Q06587 O00257 pull down 9858531 direct interaction X 2 Q06587 Q06587 pull down 9858531 direct interaction X 2 Q06587 Q01094 affinity chromatography technology 11583618 physical association X 2 Q06587 Q8N488 two hybrid 10369680 direct interaction X 2 Q06587 Q8N488 affinity chromatography technology 10369680 physical association X 2 Q06587 Q8N488 affinity chromatography technology 10369680 physical association X 2 Q06587 Q8N488 pull down 10369680 direct interaction X 2 Q06587 P41229-3 affinity chromatography technology 17468742 physical association X 2 Q06587 A0A024R1V6 affinity chromatography technology 17936708 physical association X 2 Q06587 Q6W2J9-4 affinity chromatography technology 16943429 physical association X 2 Q06587 Q8N488 pull down 16943429 direct interaction X 2 Q06587 A0A024R2K3 two hybrid 19549727 direct interaction X 2 Q06587 A0A024R2Q2 two hybrid 19549727 direct interaction X 2 Q06587 A0A024R1V6 affinity chromatography technology 19636380 physical association X 2 Q06587 P49450 biochemical 15009096 association X 2 Q06587 Q9H4L7-3 affinity chromatography technology 21549307 physical association X 2 P54274-2 Q06587 affinity chromatography technology 20811636 physical association X 2 P25490 Q06587 affinity chromatography technology 16624538 physical association X 2 P61964 Q06587 affinity chromatography technology 22325352 physical association X 2 Q06587 two hybrid 9199346 direct interaction X 2 Q8NDX5-7 Q06587 affinity chromatography technology 22325352 physical association X 2 Q93009 Q06587 affinity chromatography technology 20601937 physical association X 2 Q93009 Q06587 pull down 20800574 direct interaction X 2 Q06587 affinity chromatography technology 22325352 physical association X 2 Q06587 affinity chromatography technology 22325352 physical association X 2 Q06587 pull down 10369680 direct interaction X 2 A0A087WW00 Q06587 two hybrid 19549727 direct interaction X 2 Q6AZE0 Q06587 two hybrid 21988832 direct interaction X 2 O15391 Q06587 affinity chromatography technology 21530438 physical association X 2 Q96MM3 Q06587 affinity chromatography technology 21530438 physical association X 2 Q9HC52 Q06587 affinity chromatography technology 21282530 physical association X 2 Q9HC52 Q06587 affinity chromatography technology 21282530 physical association X 2 Q9HC52 Q06587 pull down 21282530 direct interaction X 2 Q9HC52 Q06587 two hybrid 25416956 direct interaction X 2 Q9HC52 Q06587 two hybrid 10825164 direct interaction X 2 Q9HC52 Q06587 affinity chromatography technology 10825164 physical association X 2 P30658 Q06587 biochemical 12167701 association X 2 P30658 Q06587 affinity chromatography technology 12167701 physical association X 2 O95863 Q06587 affinity chromatography technology 24903147 physical association X 2 O95863 Q06587 affinity chromatography technology 24903147 physical association X 2 O95863 Q06587 imaging technique 24903147 colocalization X 2 O95863 Q06587 imaging technique 24903147 colocalization X 2 P0CG48 Q06587 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q06587 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q06587 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q06587 affinity chromatography technology 21890473 physical association X 2 Q3KNV8 Q06587 affinity chromatography technology 22325352 physical association X 2 Q3KNV8 Q06587 two hybrid 22493164 direct interaction X 2 P11388 Q06587 affinity chromatography technology 19956605 physical association X 2 Q06587 Q9BSM1 affinity chromatography technology 22325352 physical association X 2 Q06587 P35226 affinity chromatography technology 22325352 physical association X 2 Q06587 Q99496 affinity chromatography technology 22325352 physical association X 2 Q06587 affinity chromatography technology 22325352 physical association X 2 Q06587 affinity chromatography technology 22325352 physical association X 2 Q06587 Q99496 affinity chromatography technology 22325352 physical association X 2 Q06587 P35226 affinity chromatography technology 22325352 physical association X 2 Q06587 Q9BSM1 affinity chromatography technology 22325352 physical association X 2 Q06587 affinity chromatography technology 22325352 physical association X 2 Q06587 P35226 pull down 19451220 direct interaction X 2 Q06587 A2AEX7 affinity chromatography technology 15710417 physical association X 2 Q06587 P05067-7 pull down 21832049 direct interaction X 2 Q06587 P46531 affinity chromatography technology 23022380 physical association X 2 Q06587 Q13642-1 two hybrid 14999091 direct interaction X 2 Q06587 Q13642-1 pull down 14999091 direct interaction X 2 Q06587 Q13642-1 affinity chromatography technology 14999091 physical association X 2 Q06587 P35226 affinity chromatography technology 22897849 physical association X 2 Q06587 P25916 two hybrid 12589020 direct interaction X 2 Q06587 Q9BSM1 two hybrid 22493164 direct interaction X 2 Q06587 P35226 two hybrid 22493164 direct interaction X 2 Q06587 P35226 two hybrid 25416956 direct interaction X 2 Q06587 two hybrid 25416956 direct interaction X 2 Q06587 E9PJK2 affinity chromatography technology 24457600 physical association X 2 Q06587 Q99496 affinity chromatography technology 24457600 physical association X 2 Q06587 P35226 affinity chromatography technology 24457600 physical association X 2 Q06587 E9PJK2 imaging technique 24457600 colocalization X 2 Q06587 E9PJK2 affinity chromatography technology 24457600 physical association X 2 Q06587 P25916 biochemical 12167701 association X 2 Q06587 P25916 affinity chromatography technology 12167701 physical association X 2 Q06587 P35226 affinity chromatography technology 9199346 physical association X 2 Q06587 P35226 affinity chromatography technology 9199346 physical association X 2 Q06587 P35226 two hybrid 9858531 direct interaction X 2 Q06587 P35226 pull down 9858531 direct interaction X 2 Q06587 A0A024RDV3 affinity chromatography technology 11583618 physical association X 2 Q06587 P35226 biochemical 16359901 association X 2 Q06587 P35226 pull down 16359901 direct interaction X 2 Q06587 Q99496 pull down 16359901 direct interaction X 2 Q06587 Q9BSM1 affinity chromatography technology 16943429 physical association X 2 Q06587 Q9BSM1 pull down 16943429 direct interaction X 2 Q06587 Q99496 pull down 16943429 direct interaction X 2 Q06587 P62837 two hybrid 19549727 direct interaction X 2 Q06587 A0A024RA90 two hybrid 19549727 direct interaction X 2 Q06587 P35226 affinity chromatography technology 19636380 physical association X 2 Q06587 P35226 affinity chromatography technology 16751658 physical association X 2 Q06587 Q99496 affinity chromatography technology 15386022 physical association X 2 Q06587 P35226 affinity chromatography technology 15386022 physical association X 2 Q06587 affinity chromatography technology 15386022 physical association X 2 Q06587 B4DXM8 two hybrid 18624398 direct interaction X 2 Q06587 Q99496 pull down 21596310 direct interaction X 2 Q9BYE7 Q06587 affinity chromatography technology 22325352 physical association X 2 Q9BYE7 Q06587 two hybrid 12167161 direct interaction X 2 Q9BYE7 Q06587 two hybrid 22493164 direct interaction X 2 O75461 Q06587 affinity chromatography technology 11171983 physical association X 2 O75461 Q06587 affinity chromatography technology 11171983 physical association X 2 O75461 Q06587 pull down 11171983 direct interaction X 2 O75461 Q06587 pull down 11171983 direct interaction X 2 Q06587 anti bait coimmunoprecipitation 15009096 association C 37 Q06587 chromatin immunoprecipitation assay 15009096 association C 37 Q06587 molecular sieving 15386022 association C 4 Q06587 ion exchange chromatography 15386022 association C 4 Q06587 affinity chromatography technology 12167701 association C 13 Q06587 anti bait coimmunoprecipitation 9199346 association C 4 Q06587 anti tag coimmunoprecipitation 14999091 association C 3 Q06587 coimmunoprecipitation 16943429 association C 8 Q06587 anti tag coimmunoprecipitation 12004135 association C 12 Q06587 mass spectrometry studies of complexes 12004135 association C 12 Q06587 affinity chromatography technology 12167701 association C 12 Q06587 anti bait coimmunoprecipitation 20543829 - C 4 Q8VDS3 Q06587 tandem affinity purification 20543829 physical association X 2 Q06587 Q9HCE1 anti bait coimmunoprecipitation 20543829 physical association X 2 Q06587 P41229 tandem affinity purification 17468742 physical association X 2 Q06587 tandem affinity purification 17468742 - C 14 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 Q06587 in vivo 12167701 - C 11 A0A024R1Q2 Q06587 in vitro 14647293 - X 2 A0A024R1Q2 Q06587 in vivo 14647293 - X 2 A0A024R1Q2 Q06587 in vivo 14647293 - X 2 A0A024R1Q2 Q06587 in vitro 14647293 - X 2 P78364 Q06587 in vivo 9199346 - X 2 P78364 Q06587 in vivo 9199346 - X 2 Q06587 Q8N488 in vivo 10369680 - X 2 Q06587 Q06587 in vitro 9858531 - X 2 Q06587 Q06587 two hybrid 9858531 - X 2 Q06587 O00257 two hybrid 9199346,9858531 - X 2 Q06587 O00257 in vivo 9199346,9858531 - X 2 Q06587 O00257 in vivo 9199346,9858531 - X 2 Q06587 O00257 two hybrid 9199346,9858531 - X 2 Q06587 Q8N488 in vivo 10369680 - X 2 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q06587 in vivo 12004135 - C 6 Q9HC52 Q06587 two hybrid 10825164 - X 2 Q9HC52 Q06587 in vivo 10825164 - X 2 Q9HC52 Q06587 in vivo 10825164 - X 2 Q9HC52 Q06587 two hybrid 10825164 - X 2 Q06587 P35226 in vitro 9199346,9858531 - X 2 Q06587 P35226 in vivo 9199346,9858531 - X 2 Q06587 A0A024RDV3 in vivo 11583618 - X 2 Q06587 Q13642-1 in vivo 15710417 - X 2 Q06587 A0A024RDV3 in vivo 11583618 - X 2 Q06587 Q13642-1 in vivo 15710417 - X 2 Q06587 P35226 in vivo 9199346,9858531 - X 2 Q06587 P35226 in vitro 9199346,9858531 - X 2 Q06587 Q9BQ52 two hybrid 9199346 - X 2 Q06587 Q99496 in vitro 12183370 - X 2 Q06587 Q99496 in vivo 12183370 - X 2 Q06587 Q9BQ52 two hybrid 9199346 - X 2 Q06587 Q99496 in vitro 12183370 - X 2 Q06587 Q99496 in vivo 12183370 - X 2 Q6Q9Z5 Q06587 in vitro 11171983 - X 2 Q6Q9Z5 Q06587 in vivo 11171983 - X 2 Q6Q9Z5 Q06587 in vivo 11171983 - X 2 Q6Q9Z5 Q06587 in vitro 11171983 - X 2 Q06587 cosedimentation 20601937 colocalization C 7 Q06587 tandem affinity purification 19636380 association C 9 Q06587 anti bait coimmunoprecipitation 22078878 association C 5 Q06587 anti bait coimmunoprecipitation 15386022 association C 3 Q06587 anti bait coimmunoprecipitation 15386022 association C 4 Q06587 pull down 16943429 association C 5 Q06587 anti tag coimmunoprecipitation 12167701 association C 11 Q06587 anti tag coimmunoprecipitation 12167701 association C 11 Q06587 tandem affinity purification 21282530 association C 54 Q06587 tandem affinity purification 21282530 association C 60 Q06587 tandem affinity purification 21282530 association C 16 Q06587 tandem affinity purification 19636380 association C 10 A0A024R1Q2 Q06587 pull down 21282530 direct interaction X 2 A0A024R1Q2 Q06587 anti tag coimmunoprecipitation 21282530 physical association X 2 P51784 Q06587 pull down 20601937 direct interaction X 2 P51784 Q06587 anti tag coimmunoprecipitation 20601937 physical association X 2 P51784 Q06587 anti tag coimmunoprecipitation 20601937 physical association X 2 A0A024QZJ2 Q06587 two hybrid array 19549727 physical association X 2 Q6PIJ6 Q06587 two hybrid array 21988832 physical association X 2 Q8D053 Q06587 two hybrid pooling approach 20711500 physical association X 2 Q969T4 Q06587 two hybrid array 19549727 physical association X 2 O95503 Q06587 pull down 21282530 direct interaction X 2 O95503 Q06587 anti tag coimmunoprecipitation 21282530 physical association X 2 Q06587 Q8N488 two hybrid pooling approach 16189514 physical association X 2 Q06587 Q8N488 pull down 16943429 physical association X 2 Q06587 Q8N488 anti tag coimmunoprecipitation 17070805 physical association X 2 Q06587 A0A024R2K3 two hybrid array 19549727 physical association X 2 Q06587 A0A024R2Q2 two hybrid array 19549727 physical association X 2 Q06587 A0A024R1V6 anti tag coimmunoprecipitation 19636380 physical association X 2 Q06587 Q86SE9 two hybrid array 22493164 physical association X 2 Q06587 A0A024R1V6 anti tag coimmunoprecipitation 22493164 physical association X 2 Q06587 Q86SE9 anti tag coimmunoprecipitation 22493164 physical association X 2 Q06587 A0A024R1V6 two hybrid array 22493164 physical association X 2 Q06587 Q8N488 mammalian protein protein interaction trap 25416956 physical association X 2 Q06587 Q8N488 two hybrid prey pooling approach 25416956 physical association X 2 Q06587 Q8N488 two hybrid prey pooling approach 25416956 physical association X 2 Q06587 Q8N488 two hybrid array 25416956 physical association X 2 Q06587 Q8N488 two hybrid array 25416956 physical association X 2 Q06587 Q8N488 validated two hybrid 25416956 physical association X 2 B3KSH4 Q06587 two hybrid array 19549727 physical association X 2 Q06587 pull down 16943429 association C 8 Q06587 tandem affinity purification 19636380 association C 7 Q06587 tandem affinity purification 20601937 association C 13 Q06587 tandem affinity purification 23455922 association C 63 Q06587 anti tag coimmunoprecipitation 20601937 physical association C 3 Q06587 anti tag coimmunoprecipitation 12167701 association C 11 Q06587 tandem affinity purification 20601937 association C 16 Q06587 anti tag coimmunoprecipitation 12167701 association C 7 Q06587 anti tag coimmunoprecipitation 12167701 association C 5 A0A024RDH2 Q06587 two hybrid array 19549727 physical association X 2 Q93009 Q06587 pull down 20601937 direct interaction X 2 Q93009 Q06587 anti tag coimmunoprecipitation 20601937 physical association X 2 Q93009 Q06587 anti tag coimmunoprecipitation 20601937 physical association X 2 P97447 Q06587 anti tag coimmunoprecipitation 15710417 physical association X 2 P97447 Q06587 anti tag coimmunoprecipitation 15710417 physical association X 2 Q9HC52 Q06587 pull down 21282530 direct interaction X 2 Q9HC52 Q06587 anti tag coimmunoprecipitation 21282530 physical association X 2 Q9HC52 Q06587 two hybrid prey pooling approach 25416956 physical association X 2 Q9HC52 Q06587 two hybrid array 25416956 physical association X 2 Q9HC52 Q06587 validated two hybrid 25416956 physical association X 2 P0CG48 Q06587 pull down 20601937 physical association X 2 Q3KNV8 Q06587 anti tag coimmunoprecipitation 22493164 physical association X 2 Q3KNV8 Q06587 two hybrid array 22493164 physical association X 2 Q06587 Q99496 ion exchange chromatography 15386022 physical association X 2 Q06587 Q99496 molecular sieving 15386022 physical association X 2 Q06587 Q99496 pull down 16943429 physical association X 2 Q06587 Q9BSM1 pull down 16943429 physical association X 2 Q06587 Q92569 two hybrid 18624398 physical association X 2 Q06587 P62837 two hybrid array 19549727 physical association X 2 Q06587 A0A024RA90 two hybrid array 19549727 physical association X 2 Q06587 Q8IY57 two hybrid 21516116 physical association X 2 Q06587 P35226 two hybrid array 22493164 physical association X 2 Q06587 Q9BSM1 two hybrid array 22493164 physical association X 2 Q06587 Q9BSM1 anti tag coimmunoprecipitation 22493164 physical association X 2 Q06587 P35226 anti tag coimmunoprecipitation 22493164 physical association X 2 Q06587 Q9BSM1 two hybrid array 22493164 physical association X 2 Q06587 P35226 anti bait coimmunoprecipitation 22897849 physical association X 2 Q06587 P35226 anti bait coimmunoprecipitation 22897849 physical association X 2 Q06587 P35226 anti bait coimmunoprecipitation 22897849 physical association X 2 Q06587 P35226 anti bait coimmunoprecipitation 22897849 physical association X 2 Q06587 P35226 two hybrid prey pooling approach 25416956 physical association X 2 Q06587 Q8IY57 two hybrid prey pooling approach 25416956 physical association X 2 Q06587 P35226 two hybrid array 25416956 physical association X 2 Q06587 Q8IY57 two hybrid array 25416956 physical association X 2 Q06587 P35226 validated two hybrid 25416956 physical association X 2 Q06587 Q8IY57 validated two hybrid 25416956 physical association X 2 Q9BYE7 Q06587 two hybrid array 22493164 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B APP RING1 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229344 prey bait RING1 PCGF3 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0397(two hybrid array) 22325352,22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(intact) UniProt_122632|BIOGRID_191814|BIOGRID_284063|UniProt_122420 bait|prey|prey|bait prey|bait|bait|prey RING1 SMARCAD1 MI:0004(affinity chromatography technology) 21549307 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_165234 prey bait CBX4 RING1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0006(anti bait coimmunoprecipitation)|MI:0493(in vivo) 12167701,22078878,22325352,9199346,9858531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0914(association)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(intact)|MI:0468(hprd) BIOGRID_92613|BIOGRID_92612|BIOGRID_92626|BIOGRID_191959|BIOGRID_77827|BIOGRID_92615|HPRD_10231|UniProt_120679|HPRD_39356 bait|bait|prey|bait|prey|prey|-|bait|- prey|prey|bait|prey|bait|bait|-|prey|- PCGF2 RING1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 10,17936708,19636380,20601937,22325352,22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(intact) MINT_47098|UniProt_109351|MINT_78893|UniProt_169938|UniProt_100287|MINT_79352|MINT_47489|BIOGRID_118875|BIOGRID_283988|UniProt_100292|BIOGRID_191801|UniProt_122418|UniProt_122629|BIOGRID_128022|BIOGRID_192053|UniProt_109370 neutral component|neutral component|neutral component|bait|bait|bait|bait|bait|bait|prey|bait|prey|prey|bait|prey|bait neutral component|neutral component|neutral component|prey|prey|prey|prey|prey|prey|bait|prey|bait|bait|prey|bait|prey RING1 HECW2 MI:0004(affinity chromatography technology) 24163370 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_293874 prey bait RING1 USP7 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0415(enzymatic study)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 10,20601937,20800574 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|(biogrid)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint) MINT_47098|UniProt_109351|MINT_78893|MINT_78887|UniProt_109330|MINT_47092|BIOGRID_138745|UniProt_109366|UniProt_109339|MINT_47482|MINT_47506|MINT_47088|MINT_79345|UniProt_173381|BIOGRID_139359|UniProt_109328|MINT_79380|MINT_78883 neutral component|neutral component|neutral component|bait|bait|bait|prey|prey|prey|prey|prey|bait|prey|prey|prey|bait|prey|bait neutral component|neutral component|neutral component|prey|prey|prey|bait|bait|bait|bait|bait|prey|bait|bait|bait|prey|bait|prey RING1 PCGF5 MI:0415(enzymatic study)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 22325352,22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|(intact)|(biogrid) BIOGRID_284023|UniProt_122630|UniProt_122445|BIOGRID_191843 prey|bait|bait|prey bait|prey|prey|bait UBE2D1 RING1 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124298|UniProt_101223 bait|bait prey|prey USP11 RING1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 10,20601937 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint) MINT_47481|MINT_47090|MINT_79344|BIOGRID_138750|MINT_47098|UniProt_109351|MINT_78893|MINT_78887|UniProt_109330|MINT_47092|MINT_47507|UniProt_109365|UniProt_109331|UniProt_109340|UniProt_173380|MINT_78885|MINT_79381 bait|prey|bait|bait|neutral component|neutral component|neutral component|bait|prey|bait|bait|bait|prey|bait|bait|prey|bait prey|bait|prey|prey|neutral component|neutral component|neutral component|bait|bait|bait|prey|prey|bait|prey|prey|bait|prey RING1 YAF2 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21516116,22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_114691|BIOGRID_192051|BIOGRID_192007 prey|bait|prey bait|prey|bait TERF1 RING1 MI:0004(affinity chromatography technology) 20811636 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_140858 bait prey RING1 PHC2 MI:0226(ion exchange chromatography)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12167701,15386022,22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|- (intact)|(biogrid)|(biogrid)|MI:0468(hprd) UniProt_77670|BIOGRID_191921|BIOGRID_135007|HPRD_39356 bait|prey|bait|- prey|bait|prey|- RING1 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101444|BIOGRID_124300 prey|prey bait|bait UBE2D3 RING1 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101274|BIOGRID_124299 bait|bait prey|prey RB1 RING1 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 11583618 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_92781|HPRD_2609 prey|- bait|- TOP2A RING1 MI:0004(affinity chromatography technology) 19956605 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_146717 bait prey PHC1 RING1 MI:0493(in vivo)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 12167701,22325352,9199346 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|MI:0915(physical association)|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|(biogrid)|(biogrid) HPRD_39356|HPRD_10237|BIOGRID_92621|BIOGRID_191907 -|-|prey|bait -|-|bait|prey RING1 BCOR MI:0004(affinity chromatography technology)|MI:0096(pull down) 16943429 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_122925|UniProt_85389 prey|prey bait|bait KDM5C RING1 MI:0004(affinity chromatography technology) 17468742 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_118675 bait prey RING1 FBXO38 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_285601|UniProt_118123 prey|unspecified role bait|unspecified role RING1 FHL1 MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14999091,15710417 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_17715|BIOGRID_247371|BIOGRID_247372|BIOGRID_247373 -|prey|prey|prey -|bait|bait|bait RING1 CBX3 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 12004135 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_118072|HPRD_40298 prey|- bait|- RING1 UBE2E3 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101424|BIOGRID_124302 prey|prey bait|bait BMI1 RING1 MI:0226(ion exchange chromatography)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0018(two hybrid)|MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0401(biochemical)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0493(in vivo) 10,12167701,15386022,16359901,16751658,19451220,19636380,20601937,22325352,22493164,22897849,24457600,9199346,9858531 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association)|- (intact)|(intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd) UniProt_77670|UniProt_109369|MINT_47098|UniProt_109351|MINT_78893|UniProt_169939|UniProt_100288|BIOGRID_92614|BIOGRID_118394|BIOGRID_128030|BIOGRID_192047|BIOGRID_92624|UniProt_122631|UniProt_124402|UniProt_124411|BIOGRID_284042|BIOGRID_129782|BIOGRID_118395|BIOGRID_135006|UniProt_122389|BIOGRID_307165|UniProt_124396|HPRD_39128|BIOGRID_210524|BIOGRID_92618|BIOGRID_92628|BIOGRID_191830|BIOGRID_259544|UniProt_124418|MINT_79351|MINT_47488|HPRD_39356 prey|bait|neutral component|neutral component|neutral component|bait|bait|bait|bait|bait|prey|prey|prey|bait|bait|prey|bait|prey|prey|bait|bait|bait|-|bait|prey|prey|bait|bait|bait|bait|bait|- bait|prey|neutral component|neutral component|neutral component|prey|prey|prey|prey|prey|bait|bait|bait|prey|prey|bait|prey|bait|bait|prey|prey|prey|-|prey|bait|bait|prey|prey|prey|prey|prey|- RING1 PCGF1 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 16943429,22325352,22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association) (biogrid)|(biogrid)|(intact)|(intact)|(biogrid)|(intact)|(intact)|(biogrid)|(biogrid)|(intact) BIOGRID_284022|BIOGRID_192048|UniProt_122622|UniProt_122428|BIOGRID_122938|UniProt_85391|UniProt_122628|BIOGRID_122932|BIOGRID_191791|UniProt_85388 prey|bait|prey|bait|prey|prey|bait|prey|prey|prey bait|prey|bait|prey|bait|bait|prey|bait|bait|bait EED RING1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid) BIOGRID_307446|BIOGRID_306102|BIOGRID_307461 bait|bait|bait prey|prey|prey UBE2D2 RING1 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101023|BIOGRID_124057 bait|bait prey|prey RING1 ELAC2 MI:0493(in vivo) 9199346 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10232 - - p53 RING1 MI:0004(affinity chromatography technology) 22907436 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_244611 prey bait RING1 PCGF6 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0397(two hybrid array) 12167161,22325352,22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(intact) BIOGRID_284013|BIOGRID_191854|BIOGRID_213979|UniProt_122421 prey|prey|prey|bait bait|bait|bait|prey RING1 TERF2 MI:0004(affinity chromatography technology) 20811636 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_140955 prey bait RING1 CBX2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 10369680,22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_192050|BIOGRID_191948|BIOGRID_92789 bait|prey|prey prey|bait|bait E2F1 RING1 MI:0004(affinity chromatography technology) 11583618 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_92782 prey bait NOTCH1 RING1 MI:0004(affinity chromatography technology) 23022380 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_246714 bait prey RING1 RYBP MI:0018(two hybrid)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0065(isothermal titration calorimetry)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0493(in vivo) 10369680,16189514,16943429,17070805,22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|MI:0468(hprd) BIOGRID_81237|UniProt_85393|BIOGRID_122940|BIOGRID_192049|BIOGRID_191982|MINT_84411|MINT_84410|BIOGRID_92786|BIOGRID_92785|MINT_69682|BIOGRID_92788|BIOGRID_92787|UniProt_89228|MINT_84413|UniProt_89225|UniProt_89226|MINT_51951|MINT_51952|MINT_51954|MINT_40309|UniProt_154059|HPRD_10234 bait|prey|prey|bait|prey|null|null|bait|bait|bait|prey|prey|null|null|null|null|null|null|null|bait|unspecified role|- prey|bait|bait|prey|bait|bait|bait|prey|prey|prey|bait|bait|neutral component|neutral component|bait|bait|bait|bait|neutral component|prey|unspecified role|- UBE2E1 RING1 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124301|UniProt_101298 bait|bait prey|prey RING1 ZFP42 MI:0018(two hybrid) 21530438 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_166874 prey bait RING1 UBE2E2 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101318|BIOGRID_124304 prey|prey bait|bait CSNK2A2 RING1 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 23455922 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_276331|UniProt_127595 bait|bait prey|prey RING1 PHC3 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 12167701,22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_39356|BIOGRID_191936 -|prey -|bait CENPA RING1 MI:0401(biochemical) 15009096 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association) (biogrid) BIOGRID_135986 bait prey YY1 RING1 MI:0004(affinity chromatography technology) 16624538 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_270650 prey bait UBC RING1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 10,20601937,21139048,21890473,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint)|(intact)|(biogrid) BIOGRID_168264|MINT_79350|BIOGRID_269410|MINT_47487|UniProt_109374|BIOGRID_174073 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey YY2 RING1 MI:0018(two hybrid) 21530438 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_166876 bait prey CBX6 RING1 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21282530,22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_111846|UniProt_111875|BIOGRID_263177|UniProt_111849|BIOGRID_191969|BIOGRID_263195|BIOGRID_262988 bait|bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey|prey WDR5 RING1 MI:0004(affinity chromatography technology) 22325352 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_192052 prey bait RING1 HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101190 prey bait UBE2K RING1 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124303 bait prey RING1 RNF2 MI:0226(ion exchange chromatography)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0226(ion exchange chromatography)|MI:0401(biochemical)|MI:0226(ion exchange chromatography)|MI:0493(in vivo) 12167701,12183370,15386022,16359901,16943429,21596310,22325352,24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- (intact)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(intact)|(biogrid)|(intact)|MI:0468(hprd) UniProt_77670|BIOGRID_192046|UniProt_85395|BIOGRID_306509|BIOGRID_164841|BIOGRID_122942|BIOGRID_191873|BIOGRID_135005|HPRD_10233|UniProt_77669|BIOGRID_118396|UniProt_77668|HPRD_39356 bait|bait|bait|prey|bait|bait|prey|bait|-|neutral component|bait|unspecified role|- prey|prey|prey|bait|prey|prey|bait|prey|-|neutral component|prey|unspecified role|- E2F6 RING1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0493(in vivo) 11171983,12004135 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|MI:0468(hprd) BIOGRID_92645|BIOGRID_92647|BIOGRID_92646|HPRD_10230|BIOGRID_92648|HPRD_40298 bait|prey|prey|-|bait|- prey|bait|bait|-|prey|- CBX7 RING1 MI:0676(tandem affinity purification)|MI:0676(tandem affinity purification)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 14647293,19636380,21282530 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(intact)|MI:0468(hprd)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_111847|UniProt_111850|HPRD_10235|BIOGRID_263179|BIOGRID_128011|UniProt_111883|BIOGRID_263203|BIOGRID_87342|BIOGRID_87341|BIOGRID_263007 bait|bait|-|bait|bait|bait|bait|bait|bait|bait prey|prey|-|prey|prey|prey|prey|prey|prey|prey RING1 CBX8 MI:0676(tandem affinity purification)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0676(tandem affinity purification)|MI:0493(in vivo)|MI:0676(tandem affinity purification)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 10,10825164,20601937,21282530 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|MI:0468(hprd)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_111848|MINT_47098|UniProt_109351|MINT_78893|UniProt_111851|HPRD_10236|UniProt_111891|BIOGRID_92640|BIOGRID_263211|BIOGRID_263058|BIOGRID_263181|BIOGRID_92639 prey|neutral component|neutral component|neutral component|prey|-|prey|bait|prey|prey|prey|bait bait|neutral component|neutral component|neutral component|bait|-|bait|prey|bait|bait|bait|prey RING1 PIK3R3 MI:0018(two hybrid)|MI:0018(two hybrid) 18624398 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_155210|UniProt_96567 prey|prey bait|bait

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q06587 O14862 RING1 AIM2 0.126 25665578 Q06587 P61086 RING1 UBE2K 0.376 unassigned1304,19549727 Q06587 P61964 RING1 WDR5 0.332 22325352,27705803 Q06587 O15391 RING1 YY2 0.21 21530438 Q8IXK0 Q06587 PHC2 RING1 0.396 27705803,15386022 Q9H4L7 Q06587 SMARCAD1 RING1 0.126 21549307 Q6P5F9 Q06587 XPO1 RING1 0.126 26673895 Q06587 P11388 RING1 TOP2A 0.21 19956605 Q06587 P03428 RING1 PB2 0.126 unassigned1333 Q06587 P05412 RING1 JUN 0.126 25609649 Q06587 P06932 RING1 E7 {ECO:0000255|HAMAP-RULE:MF_04004} 0.126 22810586 Q9Y2X8 Q06587 UBE2D4 RING1 0.523 19549727,unassigned1304 Q8R023 Q06587 PCGF1 RING1 0.236 26496610 Q8VDS3 Q06587 CBX7 RING1 0.236 26496610 Q99496 Q06587 RNF2 RING1 0.826 16359901,15386022,21596310,22325352,26496610,24457600,16943429 Q06587 O95863 RING1 SNAI1 0.523 24903147 Q06587 Q01094 RING1 E2F1 0.309 11583618,27705803 Q06587 P51668 RING1 UBE2D1 0.623 19549727,19956605,unassigned1304 Q9BYE7 Q06587 PCGF6 RING1 0.623 27705803,22493164,12167161 Q06587 P30658 RING1 CBX2 0.376 12167701 Q6PIJ6 Q06587 FBXO38 RING1 0.286 21988832 Q06587 O55187 RING1 CBX4 0.236 26496610 Q06587 O75530 RING1 EED 0.196 24457600 Q86SE9 Q06587 PCGF5 RING1 0.681 27705803,26186194,unassigned1304,22493164 Q13642 Q06587 FHL1 RING1 0.623 14999091 Q06587 O75461 RING1 E2F6 0.772 11171983,27705803 Q06587 Q06587 RING1 RING1 0.702 19956605,9858531 Q06587 P25916 RING1 BMI1 0.569 12589020,12167701 Q8IY57 Q06587 YAF2 RING1 0.837 25416956,27705803,unassigned1304,22325352,21516116 Q06587 O00257 RING1 CBX4 0.891 27705803,9199346,26496610,22078878,9858531 Q9BSM1 Q06587 PCGF1 RING1 0.867 27505670,27705803,26687479,22493164,22325352,16943429 Q06587 P35227 RING1 PCGF2 0.876 27705803,22493164,19636380,17936708,22325352,20601937,21516116,unassigned1304 Q9HC52 Q06587 CBX8 RING1 0.891 25416956,27705803,21282530,26496610,10825164,unassigned1304 Q8N488 Q06587 RYBP RING1 0.984 25416956,27705803,16189514,22325352,16943429,26186194,unassigned1304,10369680,17070805 Q06587 P35226 RING1 BMI1 0.995 25416956,16751658,19451220,15386022,22493164,20601937,22897849,9858531,16359901,27705803,9199346,19636380,22325352 Q969R5 Q06587 L3MBTL2 RING1 0.236 27705803 Q969T4 Q06587 UBE2E3 RING1 0.286 19549727 Q8WXX7 Q06587 AUTS2 RING1 0.309 25519132,27705803 Q923J1 Q06587 TRPM7 RING1 0.126 24855944 Q92569 Q06587 PIK3R3 RING1 0.332 18624398 Q96MM3 Q06587 ZFP42 RING1 0.21 21530438 Q9ERL0 Q06587 Q9ERL0 RING1 0.126 26496610 Q9P2P5 Q06587 HECW2 RING1 0.126 24163370 Q06587 P46531 RING1 NOTCH1 0.126 23022380 Q13547 Q06587 HDAC1 RING1 0.126 26496610 Q13573 Q06587 SNW1 RING1 0.126 20467437 Q06587 P41229 RING1 KDM5C 0.21 17468742 Q06587 P78364 RING1 PHC1 0.396 27705803,9199346 Q06587 P62837 RING1 UBE2D2 0.286 19549727 Q06587 P83916 RING1 CBX1 0.126 27705803 Q14186 Q06587 TFDP1 RING1 0.236 27705803 Q06587 P49450 RING1 CENPA 0.21 15009096 Q14781 Q06587 CBX2 RING1 0.472 27705803,10369680,22325352 Q15554 Q06587 TERF2 RING1 0.126 20811636 Q06587 P63208 RING1 SKP1 0.236 27705803 Q06587 P51965 RING1 UBE2E1 0.286 19549727 Q06587 B3KSH4 RING1 HIP2 0.236 19549727 Q06587 O95503 RING1 CBX6 0.523 27705803,21282530,22325352 Q06587 O95931 RING1 CBX7 0.765 27705803,21282530,19636380,14647293 Q06587 P04637 RING1 TP53 0.21 22907436 Q06587 P05067 RING1 APP 0.183 21832049 Q06587 P06400 RING1 RB1 0.21 11583618 Q06587 P0CG48 RING1 UBC 0.126 20601937 Q06587 P19784 RING1 CSNK2A2 0.49 27705803,23455922,26186194 Q06587 P25490 RING1 YY1 0.21 16624538 Q06587 P51784 RING1 USP11 0.454 20601937 Q06587 P61077 RING1 UBE2D3 0.376 19549727 Q06587 P61244 RING1 MAX 0.236 27705803 Q06587 P61962 RING1 DCAF7 0.236 27705803 Q06587 P67870 RING1 CSNK2B 0.126 27705803 Q06587 P68400 RING1 CSNK2A1 0.416 27705803,25852190 Q06587 P97447 RING1 FHL1 0.507 15710417 Q13185 Q06587 CBX3 RING1 0.396 12004135,27705803 Q3KNV8 Q06587 PCGF3 RING1 0.636 27705803,unassigned1304,22493164 Q5H9F3 Q06587 BCORL1 RING1 0.126 27705803 Q6W2J9 Q06587 BCOR RING1 0.539 27505670,27705803,16943429,26687479,26496610 Q8D053 Q06587 PQIB RING1 0.126 20711500 Q8IWI9 Q06587 MGA RING1 0.126 27705803 Q8NDX5 Q06587 PHC3 RING1 0.236 27705803 Q8NEZ4 Q06587 KMT2C RING1 0.126 27705803 Q8NHM5 Q06587 KDM2B RING1 0.126 27705803 Q93009 Q06587 USP7 RING1 0.671 20601937,26496610,20800574 Q96LR5 Q06587 UBE2E2 RING1 0.376 19549727 Q9HAH7 Q06587 FBRS RING1 0.126 27705803 Q9HCM7 Q06587 FBRSL1 RING1 0.126 27705803 Q9ULD2 Q06587 MTUS1 RING1 0.126 27705803 Q06587 P54274 RING1 TERF1 0.126 20811636 Q16695 Q06587 HIST3H3 RING1 0.183 20850016