PTM - CPLM Gene Name UniProt ID Type Position Code RING1; RNF1 Q06587 Acetylation 297 K RING1; RNF1 Q06587 Ubiquitination 12 K RING1; RNF1 Q06587 Ubiquitination 275 K RING1; RNF1 Q06587 Ubiquitination 297 K RING1; RNF1 Q06587 Ubiquitination 285 K RING1; RNF1 Q06587 Ubiquitination 62 K RING1; RNF1 Q06587 Ubiquitination 403 K

PTM - dbPAF Gene Name UniProt ID Position Type Species RING1; RNF1 Q06587 11 S Homo sapiens(Human) RING1; RNF1 Q06587 117 Y Homo sapiens(Human) RING1; RNF1 Q06587 129 S Homo sapiens(Human) RING1; RNF1 Q06587 139 S Homo sapiens(Human) RING1; RNF1 Q06587 140 S Homo sapiens(Human) RING1; RNF1 Q06587 163 S Homo sapiens(Human) RING1; RNF1 Q06587 166 T Homo sapiens(Human) RING1; RNF1 Q06587 168 T Homo sapiens(Human) RING1; RNF1 Q06587 170 S Homo sapiens(Human) RING1; RNF1 Q06587 187 S Homo sapiens(Human) RING1; RNF1 Q06587 188 S Homo sapiens(Human) RING1; RNF1 Q06587 19 Y Homo sapiens(Human) RING1; RNF1 Q06587 190 S Homo sapiens(Human) RING1; RNF1 Q06587 194 S Homo sapiens(Human) RING1; RNF1 Q06587 211 S Homo sapiens(Human) RING1; RNF1 Q06587 212 S Homo sapiens(Human) RING1; RNF1 Q06587 215 T Homo sapiens(Human) RING1; RNF1 Q06587 220 T Homo sapiens(Human) RING1; RNF1 Q06587 229 S Homo sapiens(Human) RING1; RNF1 Q06587 232 S Homo sapiens(Human) RING1; RNF1 Q06587 238 T Homo sapiens(Human) RING1; RNF1 Q06587 24 T Homo sapiens(Human) RING1; RNF1 Q06587 243 T Homo sapiens(Human) RING1; RNF1 Q06587 248 S Homo sapiens(Human) RING1; RNF1 Q06587 254 S Homo sapiens(Human) RING1; RNF1 Q06587 38 S Homo sapiens(Human) RING1; RNF1 Q06587 96 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q06587 K297-ac Acetylation ATVDHLSkYLALRIA Q06587 R202-m1 Methylation APGPAPKrPRGGGAG Q06587 T2-p Phosphorylation ______MttPANAQN Q06587 T3-p Phosphorylation _____MttPANAQNA Q06587 S11-p Phosphorylation PANAQNAskTWELSL Q06587 Y19-p Phosphorylation kTWELSLyELHRtPQ Q06587 T24-p Phosphorylation SLyELHRtPQEAIMD Q06587 T33-p Phosphorylation QEAIMDGtEIAVsPR Q06587 S38-p Phosphorylation DGtEIAVsPRSLHSE Q06587 S96-p Phosphorylation KKLVSKRsLRPDPNF Q06587 Y117-p Phosphorylation IYPSREEyEAHQDRV Q06587 S138-p Phosphorylation LHNQQALsssIEEGL Q06587 S139-p Phosphorylation HNQQALsssIEEGLR Q06587 S140-p Phosphorylation NQQALsssIEEGLRM Q06587 S187-p Phosphorylation EGDGEDVssDsAPDS Q06587 S188-p Phosphorylation GDGEDVssDsAPDSA Q06587 S190-p Phosphorylation GEDVssDsAPDSAPG Q06587 S211-p Phosphorylation RGGGAGGsSVGtGGG Q06587 T215-p Phosphorylation AGGsSVGtGGGGtGG Q06587 T220-p Phosphorylation VGtGGGGtGGVGGGA Q06587 S229-p Phosphorylation GVGGGAGsEDsGDRG Q06587 S232-p Phosphorylation GGAGsEDsGDRGGtL Q06587 T238-p Phosphorylation DsGDRGGtLGGGTLG Q06587 S248-p Phosphorylation GGTLGPPsPPGAPsP Q06587 S254-p Phosphorylation PsPPGAPsPPEPGGE Q06587 T402-p Phosphorylation LELCYAPtkDPK___ Q06587 K12-ub Ubiquitination ANAQNAskTWELSLy Q06587 K62-ub Ubiquitination LKNTMTTkECLHRFC Q06587 K275-ub Ubiquitination PHPLLVEkGEYCQTR Q06587 K285-ub Ubiquitination YCQTRYVkTTGNATV Q06587 K297-ub Ubiquitination ATVDHLSkYLALRIA Q06587 K403-ub Ubiquitination ELCYAPtkDPK____

PTM - dbPTM UniProt ID Position Code Type Resources References Q06587 38 S Phosphorylation Swiss-Prot 1010711 18220336;18669648;19690332 Q06587 187 S Phosphorylation Swiss-Prot 1010711 18669648 Q06587 188 S Phosphorylation Swiss-Prot 1010711 18669648 Q06587 190 S Phosphorylation Swiss-Prot 1010711 18669648 Q06587 220 T Phosphorylation Swiss-Prot 1010711 19690332 Q06587 38 S Phosphorylation PhosphoELM.10011 18669648;18220336 Q06587 187 S Phosphorylation PhosphoELM.10011 18669648 Q06587 188 S Phosphorylation PhosphoELM.10011 18669648 Q06587 190 S Phosphorylation PhosphoELM.10011 18669648 Q06587 12 K Ubiquitylation Phosphositeplus.1010730 21890473 Q06587 275 K Ubiquitylation Phosphositeplus.1010730 21890473 Q06587 297 K Ubiquitylation Phosphositeplus.1010730 21890473 Q06587 140 S Phosphorylation Phosphositeplus.1010730 20068231 Q06587 187 S Phosphorylation Phosphositeplus.1010730 18669648;19276368 Q06587 188 S Phosphorylation Phosphositeplus.1010730 18669648;19276368 Q06587 190 S Phosphorylation Phosphositeplus.1010730 18669648;19276368 Q06587 211 S Phosphorylation Phosphositeplus.1010730 19690332 Q06587 248 S Phosphorylation Phosphositeplus.1010730 20068231 Q06587 254 S Phosphorylation Phosphositeplus.1010730 20068231 Q06587 38 S Phosphorylation Phosphositeplus.1010730 18220336;18669648;19276368;19690332 Q06587 215 T Phosphorylation Phosphositeplus.1010730 19690332 Q06587 220 T Phosphorylation Phosphositeplus.1010730 19690332 Q06587 38 S Phosphorylation HPRD 9.0 18669648 Q06587 140 S Phosphorylation HPRD 9.0 18452278,20068231 Q06587 163 S Phosphorylation HPRD 9.0 17081983 Q06587 187 S Phosphorylation HPRD 9.0 17081983,18669648 Q06587 188 S Phosphorylation HPRD 9.0 17081983,18669648 Q06587 190 S Phosphorylation HPRD 9.0 17081983,18669648 Q06587 194 S Phosphorylation HPRD 9.0 17081983 Q06587 229 S Phosphorylation HPRD 9.0 18452278,20068231 Q06587 248 S Phosphorylation HPRD 9.0 20068231 Q06587 254 S Phosphorylation HPRD 9.0 20068231 Q06587 166 T Phosphorylation HPRD 9.0 17081983 Q06587 220 T Phosphorylation HPRD 9.0 18452278 Q06587 238 T Phosphorylation HPRD 9.0 20068231 Q06587 398 C S-nitrosylation dbSNO 1.0 19483679 Q06587 38 S Phosphorylation SysPTM 1.1 18669648 Q06587 163 S Phosphorylation SysPTM 1.1 17081983 Q06587 187 S Phosphorylation SysPTM 1.1 18669648;17081983 Q06587 188 S Phosphorylation SysPTM 1.1 18669648;17081983 Q06587 190 S Phosphorylation SysPTM 1.1 18669648;17081983 Q06587 194 S Phosphorylation SysPTM 1.1 17081983 Q06587 166 T Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References RING1 140 S Phosphorylation 18452278,20068231 RING1 163 S Phosphorylation 17081983 RING1 166 T Phosphorylation 17081983 RING1 187 S Phosphorylation 17081983,18669648 RING1 188 S Phosphorylation 17081983,18669648 RING1 190 S Phosphorylation 17081983,18669648 RING1 194 S Phosphorylation 17081983 RING1 220 T Phosphorylation 18452278 RING1 229 S Phosphorylation 18452278,20068231 RING1 238 T Phosphorylation 20068231 RING1 248 S Phosphorylation 20068231 RING1 254 S Phosphorylation 20068231 RING1 38 S Phosphorylation 18669648

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q06587 187 S 18669648 HTP Phosphorylation Q06587 190 S 18669648 HTP Phosphorylation Q06587 38 S 18669648 HTP Phosphorylation Q06587 38 S 18220336 HTP Phosphorylation Q06587 188 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q06587 24 Phosphothreonine 24275569 Q06587 38 Phosphoserine 18220336;18669648;23186163;24275569 Q06587 140 Phosphoserine 20068231;23186163 Q06587 187 Phosphoserine 18669648;24275569 Q06587 190 Phosphoserine 18669648 Q06587 215 Phosphothreonine 24275569 Q06587 220 Phosphothreonine 19690332;24275569 Q06587 229 Phosphoserine 23186163;24275569 Q06587 232 Phosphoserine 24275569 Q06587 248 Phosphoserine 20068231 Q06587 254 Phosphoserine 20068231

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type RING1 IPI00455876 S 111 QQALSSpSIEEGLR phosphorylation RING1 IPI00455876 S 219 GTLGPPpSPPGAPS phosphorylation RING1 IPI00455876 S 225 SPPGAPpSPPEPGG phosphorylation RING1 IPI00455876 T 209 SGDRGGpTLGGGTL phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID RING1 Homo sapiens (Human) 275; 297; 12 "275,HPLLVEKGEYCQT; 297,TVDHLSKYLALRI; 12,NAQNASKTWELSL" 275:21890473; 297:21890473; 12:21890473 RING1 Homo sapiens (Human) 255; 277; 12 "255,HPLLVEKGEYCQT; 277,TVDHLSKYLALRI; 12,NAQNASKTWELSL" 255:21890473; 277:21890473; 12:21890473 RING1 Homo sapiens (Human) 275; 297; 12 "275,HPLLVEKGEYCQT; 297,TVDHLSKYLALRI; 12,NAQNASKTWELSL" 275:21890473; 297:21890473; 12:21890473 RING1 Homo sapiens (Human) 246; 268 "246,HPLLVEKGEYCQT; 268,TVDHLSKYLALRI" 246:21890473; 268:21890473 RING1 Homo sapiens (Human) 275; 297; 12 "275,HPLLVEKGEYCQT; 297,TVDHLSKYLALRI; 12,NAQNASKTWELSL" 275:21890473; 297:21890473; 12:21890473