PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Ywhae Sqstm1 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k2 Sqstm1 19903815 innatedb exp Klf3 Sqstm1 23754749 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnfaip3 Sqstm1 25609235 innatedb exp G G G G G Sqstm1 Rpgrip1l 21565611 intact exp Sqstm1 Nlrp3 24374573 innatedb exp G G G Krt18 Sqstm1 24798445 intact exp GP G G G G G G G G G G G G G G G G G G G Ar Sqstm1 23637164 biogrid exp G G G G G G G G G G G G G G G G Uba52 Sqstm1 18083104 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim30a Sqstm1 18598672 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Nrif1 16252010 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fau Sqstm1 20206555 innatedb,biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Pgls 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Peli3 25483963 biogrid exp Klf2 Sqstm1 23754749 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Hsd3b7 16615898 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Atg16l1 22167182 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Gbp2 21757726 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G Nlrc4 Sqstm1 24374573 innatedb exp Krt8 Sqstm1 24798445 intact exp GP G G G G G G G G G G G G G G G G G G G G G Slc11a1 Sqstm1 20206555 biogrid exp G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Sqstm1 21715324 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sod1 Sqstm1 19765191,17296612 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf6 Sqstm1 19201866,14960283,17389358 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G Sqstm1 Map2k5 19903815,15102471 innatedb,mint,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapk3 Sqstm1 20154642 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Casp8 Sqstm1 21628531,21576355 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G Sesn2 Sqstm1 25040165 biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Cul3 22167182 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Keap1 24011591,20173742 innatedb,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Sqstm1 22167182,23637164,21715324 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Cyld 21878516,19201866,18174161,18382763 innatedb,biogrid exp, ortho Trim21 Sqstm1 19201866 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Htt Sqstm1 15379887,22396390 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Map1lc3b 18083104 innatedb exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ulk1 Sqstm1 17389358 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nbr1 Sqstm1 20616007,19250911 innatedb,biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapk1 Sqstm1 16517408,20154642 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk1 Sqstm1 18598672,21574998,17389358 innatedb,biogrid,dip exp, ortho Ripk1 Sqstm1 19850933 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G MCG19772, Protein Trim55 Sqstm1 24124537 biogrid exp, ortho Sqstm1 Map1lc3a 18524774,23637164,18083104,19765191 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Irf8 Sqstm1 19201866 innatedb exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Gria3 19004011 innatedb,biogrid exp, ortho P G G G G G G G G G G Sqstm1 Limd1 17092936 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gria2 Sqstm1 19004011 innatedb,biogrid exp, ortho G G G G G G G G G Sqstm1 Fhod3 21149568 intact exp, ortho G G G G G G G G G G G G G G G G Sqstm1 Optn 25026213 biogrid,intact exp, ortho Prkcd Sqstm1 19850933 biogrid exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gria1 Sqstm1 19004011 innatedb,biogrid exp, ortho G G G G G G G G Myd88 Sqstm1 20837465 innatedb exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntrk2 Sqstm1 21574998 biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Map3k3 Sqstm1 19903815 innatedb exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Bloc1s5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Trim50 ortho Rad23a Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r2 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Peo1 ortho Enpp1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G Sqstm1 Gtf3c1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Malt1 Sqstm1 ortho Sqstm1 Pphln1 ortho Dvl2 Sqstm1 ortho G G G G G G G G G G G G Ercc2 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tnk2 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Vim Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmd3 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kcna5 Sqstm1 ortho G G G G G G G G G G G G Sqstm1 Pan2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Osbpl6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Chmp2b ortho P Sqstm1 Mlh1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Ndufs2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Chek1 Sqstm1 ortho G G G G G G G G G G G G G G G Csnk2a1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctnnb1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Snx9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Kiaa0753 ortho Sqstm1 Smad3 ortho G G G G G G G G G G G G G G G Ikbkb Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nipsnap1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Tgfbr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Atg4b ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tuba1a Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Cdc45 ortho G G G G G G G G G G G Sqstm1 Ajuba ortho G G G G G G G G G G G G G G G G G Irak1 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smurf2 Sqstm1 ortho Sqstm1 Tollip ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Egln3 ortho G G G G G G G G G G G G G G G G G Sqstm1 Rad54l2 ortho G G G G G G G G G G G G G G Sqstm1 Cul2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Ptpn13 ortho GP G G G G G G G G G G G G G G G G G G G G G Sqstm1 Atg7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Smad1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3ca Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Toe1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Ncor1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Park2 ortho G G G G Ercc3 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Csnk1a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Sav1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sesn1 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mbp Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G Epas1 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G Sqstm1 Smurf1 ortho Ttn Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G Stat5a Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G Ina Sqstm1 ortho P G G G G G G G G G Sqstm1 Ptprj ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Ywhaz Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Gsk3b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Tmem17 ortho Protein Crnn Sqstm1 ortho Arhgef28 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G Pick1 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Reln Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl1 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hspa4 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Stxbp1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Tgm2 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Rptor ortho P Pml Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G Sqstm1 Pycard ortho GP G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Dcp2 ortho Sqstm1 Asph ortho GP G G G G G G G G G Mapk14 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Psmd10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Cep78 ortho Sqstm1 Hacd3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dip2b Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Camk2g ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Rragb ortho P Sqstm1 Abhd10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Csnk1e ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Camk2b Sqstm1 ortho GP G G G G G G G G G G G G G G G Sqstm1 Mlst8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Isg15 ortho P Llgl2 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Tardbp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cntrl Sqstm1 ortho G G G G G G Smad4 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hnrnpa2b1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cftr Sqstm1 ortho G G G G G G G G Sqstm1 Sass6 ortho G G G G G G G G G G G G G Lck Sqstm1 ortho G G G G G G G G G G G G G G Sqstm1 Plec ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Snca Sqstm1 ortho P G G G G G G G G G G G G G G G G Sqstm1 Krt73 ortho P Sqstm1 Xpo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gabrr1 Sqstm1 ortho G Sqstm1 Pck1 ortho GP G G G G G G G G G G G G G G G Gabrr2 Sqstm1 ortho G Sqstm1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fas Sqstm1 ortho G G G G G G G G G G G G G G G G G Sqstm1 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Gabarapl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gbas Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Ntrk3 ortho G G G G G G G G G Sqstm1 Sars2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Trp53inp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ctnnd1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23b Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Pars2 ortho G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Eppk1 ortho G G G G G G G G G G G G G G G G Cav1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Psmd12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tp53 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Cul1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Bnip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ikbkg Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Plec1 protein, Protein Parp10 ortho P Sqstm1 Tbk1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Zfand5 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Edem1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G Rps27a Sqstm1 ortho P Kcnab2 Sqstm1 ortho P G G G G G G G G G G G Sqstm1 Rpl37 ortho P Sqstm1 Slx4 ortho Sqstm1 Cep135 ortho P Irs1 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Yme1l1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Nsun4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Nfe2l2 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Aim2 ortho G G Cdk1 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G Smad2 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Acvr1 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Snw1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G Sqstm1 Epdr1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Bmpr1b Sqstm1 ortho G G G Sqstm1 Casp9 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Bcl2 Sqstm1 ortho G G G G G G G G G G G G G G G Hspa8 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Ulk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Dazap2 ortho Camk2a Sqstm1 ortho G G G G Fkbp4 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Camk2d ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Ndufa5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pik3r1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Med4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Ngfr ortho G G G G G G G G G Sqstm1 Synpo2 ortho GP G G G G G G G G G Sqstm1 Llgl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Bag3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Trim63 Sqstm1 ortho Sqstm1 Spred2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Glg1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Krt4 Sqstm1 ortho P G G G G Sqstm1 Tmx1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Csnk2a2 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hif1a Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Micu1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Traf4 Sqstm1 ortho G G G G G G G G G G G G G G G G G G Sqstm1 Tmem160 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tkt Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psmc2 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Nkd2 ortho G G Hspb1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Agap1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Pde4a Sqstm1 ortho GP G G G G G G G G G G G G G AL022818 Sqstm1 ortho P Crhbp Sqstm1 ortho Sqstm1 Cul7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Chaf1a ortho Sqstm1 Grb14 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Akt1s1 ortho P Sqstm1 Hadhb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Nkd1 ortho G G G G G G Sqstm1 Flnb ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dnai2 Sqstm1 ortho Psmd4 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mark2 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Atxn3 ortho P Sqstm1 Rps6kb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mapt Sqstm1 ortho P G G G G G G G G G G G G G G G Sqstm1 Sh3kbp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Rragc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Anxa1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Sdha ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Gem (Nuclear organelle) associated protein 4, Protein Gemin4 ortho P Gamma-aminobutyric acid (GABA) receptor, rho 3, MCG129069, Protein Gabrr3 Sqstm1 ortho Bid Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Gabarap ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dvl3 Sqstm1 ortho Meis2 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G Sqstm1 Pawr ortho GP G G G G G G G G G G G G G G G G G G G G G Fkbp14 Sqstm1 ortho Gabarapl2 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Emilin3 Sqstm1 ortho G G Ercc5 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Stk3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Insr Sqstm1 ortho P G G Sqstm1 Wash1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Npm1 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gpc4 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cd44 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Nr2f2 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Kif5b Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Stk4 ortho P G G G G G G G Eef1d Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Cox11 ortho Rara Sqstm1 ortho G G Sqstm1 Slc40a1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkci Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Mtor ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Trim13 ortho G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Dnai1 ortho Sqstm1 Hadha ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Mrps9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Tmlhe ortho GP G G G G G G G G G G G G G Sqstm1 Tnfrsf10b ortho G Sqstm1 Cdk9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Tradd Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Sh3glb1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Nod2 ortho Kcnab1 Sqstm1 ortho GP G G G G G G G G G G G G G Sqstm1 Txnl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdc37 Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Sccpdh ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Wdfy3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Hdac6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Prkcz Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G Tnfrsf1a Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Axin2 Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Micu2 ortho P Protein Bptf Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Myc Sqstm1 ortho G G G G G G G G G G G G G G G G G G G G G Clpb Sqstm1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Sqstm1 Mrpl38 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q64337 P08228 affinity chromatography technology 19765191 physical association X 2 Q64337 P08228 imaging technique 19765191 colocalization X 2 Q64337 P08228 affinity chromatography technology 19765191 physical association X 2 Q64337 Q91VR7 affinity chromatography technology 19765191 physical association X 2 Q64337 Q91VR7 affinity chromatography technology 18083104 physical association X 2 Q64337 Q91VR7 affinity chromatography technology 18083104 physical association X 2 Q64337 Q91VR7 affinity chromatography technology 18083104 physical association X 2 Q64337 Q91VR7 pull down 18083104 direct interaction X 2 Q64337 P08228 affinity chromatography technology 17296612 physical association X 2 Q64337 P08228 affinity chromatography technology 17296612 physical association X 2 Q64337 Q3UFB7 affinity chromatography technology 21574998 physical association X 2 Q64337 affinity chromatography technology 21574998 physical association X 2 Q64337 P35545 affinity chromatography technology 20206555 physical association X 2 Q64337 affinity chromatography technology 15379887 physical association X 2 Q64337 Q91VR7 pull down 18524774 direct interaction X 2 Q64337 Q91VR7 x-ray crystallography 18524774 association X 2 Q64337 Q91VR7 pull down 18524774 direct interaction X 2 Q64337 affinity chromatography technology 19004011 physical association X 2 Q64337 Q9Z2X8 affinity chromatography technology 20173742 physical association X 2 Q64337 Q9Z2X8 pull down 20173742 direct interaction X 2 Q64337 Q9Z2X8 affinity chromatography technology 20173742 physical association X 2 Q64337 Q9Z2X8 x-ray crystallography 20173742 association X 2 Q64337 Q9Z2X8 imaging technique 20173742 colocalization X 2 Q64337 Q9Z2X8 pull down 20173742 direct interaction X 2 Q64337 P63085 affinity chromatography technology 16517408 physical association X 2 Q64337 P63085 pull down 16517408 direct interaction X 2 Q64337 affinity chromatography technology 17389358 physical association X 2 Q64337 affinity chromatography technology 17389358 physical association X 2 Q64337 P70196 affinity chromatography technology 17389358 physical association X 2 Q64337 Q3UFB7 affinity chromatography technology 17389358 physical association X 2 Q64337 Q91VR7 affinity chromatography technology 23637164 physical association X 2 Q64337 affinity chromatography technology 24124537 physical association X 2 Q64337 Q8IYU2 affinity chromatography technology 24614889 physical association X 2 Q64337 P25686-2 affinity chromatography technology 22396390 physical association X 2 Q64337 affinity chromatography technology 22396390 physical association X 2 Q64337 P58043 affinity chromatography technology 25040165 physical association X 2 Q64337 Q60843 affinity chromatography technology 23754749 physical association X 2 Q64337 affinity chromatography technology 25180522 physical association X 2 Q64337 affinity chromatography technology 25180522 physical association X 2 Q64337 affinity chromatography technology 25180522 physical association X 2 Q64337 Q3UFB7 affinity chromatography technology 18598672 physical association X 2 Q64337 Q3UFB7 affinity chromatography technology 18598672 physical association X 2 Q64337 P15533 affinity chromatography technology 18598672 physical association X 2 Q64337 P15533 pull down 18598672 direct interaction X 2 Q64337 affinity chromatography technology 18382763 physical association X 2 Q64337 affinity chromatography technology 18174161 physical association X 2 Q64337 Q60855 affinity chromatography technology 19850933 physical association X 2 Q64337 P28867 affinity chromatography technology 19850933 physical association X 2 Q64337 affinity chromatography technology 21878516 physical association X 2 Q64337 affinity chromatography technology 15761153 physical association X 2 Q64337 D3DPA4 affinity chromatography technology 15761153 physical association X 2 Q64337 affinity chromatography technology 15761153 physical association X 2 Q64337 P0CG48 affinity chromatography technology 22167182 physical association X 2 Q64337 Q9JLV5 affinity chromatography technology 22167182 physical association X 2 Q64337 Q9JLV5 affinity chromatography technology 22167182 physical association X 2 Q64337 Q8C0J2-4 affinity chromatography technology 22167182 physical association X 2 Q64337 Q64337 x-ray crystallography 21715324 association X 2 Q64337 Q64337 pull down 21715324 direct interaction X 2 Q64337 P0CG49 pull down 21715324 direct interaction X 2 Q64337 P0CG49 affinity chromatography technology 21715324 physical association X 2 Q64337 P41251 imaging technique 20206555 colocalization X 2 Q64337 P0CG50 affinity chromatography technology 20206555 physical association X 2 Q64337 P0CG50 imaging technique 15379887 colocalization X 2 Q64337 Q9Z0E6 imaging technique 21757726 colocalization X 2 Q64337 Q7TNB5 affinity chromatography technology 19004011 physical association X 2 Q64337 P23819 affinity chromatography technology 19004011 physical association X 2 Q64337 Q63844 affinity chromatography technology 20154642 physical association X 2 Q64337 P19091 affinity chromatography technology 23637164 physical association X 2 Q64337 P19091 affinity chromatography technology 23637164 physical association X 2 Q64337 P0CG50 affinity chromatography technology 23637164 physical association X 2 Q64337 A0A024R1V3 affinity chromatography technology 24879152 physical association X 2 Q64337 Q8K3K8 pull down 25026213 direct interaction X 2 Q64337 Q60980 affinity chromatography technology 23754749 physical association X 2 Q64337 enzymatic study 25260751 direct interaction X 2 Q64337 Q9H492 affinity chromatography technology 21628531 physical association X 2 Q64337 O89110 affinity chromatography technology 21628531 physical association X 2 Q64337 O89110 imaging technique 21576355 colocalization X 2 Q64337 O89110 affinity chromatography technology 21576355 physical association X 2 Q64337 pull down 20616007 direct interaction X 2 Q64337 Q923B3 affinity chromatography technology 16252010 physical association X 2 Q64337 Q15796-2 affinity chromatography technology 15761153 physical association X 2 Q64337 A0A024R274 affinity chromatography technology 15761153 physical association X 2 Q64337 O00238 affinity chromatography technology 15761153 physical association X 2 Q64337 anti bait coimmunoprecipitation 17092936 association C 4 Q64337 anti bait coimmunoprecipitation 14960283 association C 3 Q64337 Q3UFB7 anti bait coimmunoprecipitation 17389358 physical association X 2 Q64337 anti bait coimmunoprecipitation 17389358 - C 6 Q64337 cosedimentation 16615898 colocalization C 1216 Q64337 anti bait coimmunoprecipitation 25026213 association C 3 Q64337 anti tag coimmunoprecipitation 20173742 physical association C 3 Q64337 anti bait coimmunoprecipitation 20154642 association C 3 Q64337 electron microscopy 18083104 colocalization C 3 Q64337 Q658J6 fluorescence microscopy 18083104 colocalization X 2 Q64337 P62984 fluorescence microscopy 18083104 colocalization X 2 Q64337 Q658J6 fluorescence microscopy 18083104 colocalization X 2 Q64337 Q658J6 pull down 18083104 direct interaction X 2 Q64337 P62984 electron microscopy 18083104 colocalization X 2 Q64337 Q658J6 anti tag coimmunoprecipitation 18083104 physical association X 2 Q64337 Q658J6 anti tag coimmunoprecipitation 19250911 physical association X 2 Q64337 P60520 anti tag coimmunoprecipitation 19250911 physical association X 2 Q64337 Q9Z2X8 pull down 20173742 direct interaction X 2 Q64337 Q9Z2X8 pull down 20173742 direct interaction X 2 Q64337 Q9Z2X8 anti tag coimmunoprecipitation 20173742 physical association X 2 Q64337 Q9Z2X8 x-ray crystallography 20173742 direct interaction X 2 Q64337 Q9Z2X8 isothermal titration calorimetry 20173742 direct interaction X 2 Q64337 A0A024R7C0 anti tag coimmunoprecipitation 20173742 physical association X 2 Q64337 Q76LL6 confocal microscopy 21149568 colocalization X 2 Q64337 P11679 confocal microscopy 24798445 colocalization X 2 Q64337 P05784 confocal microscopy 24798445 colocalization X 2 Q64337 P05784 proximity ligation assay 24798445 physical association X 2 Q64337 P11679 proximity ligation assay 24798445 physical association X 2 Q64337 anti tag coimmunoprecipitation 20173742 physical association C 3 Q64337 anti bait coimmunoprecipitation 25040165 association C 3 Q64337 Q9WVS7 two hybrid 15102471 physical association X 2 Q64337 Q9WVS7 two hybrid 15102471 physical association X 2 Q64337 Q9WVS7 two hybrid 15102471 physical association X 2 Q64337 A1L329 confocal microscopy 19250911 colocalization X 2 Q64337 A1L329 confocal microscopy 19250911 colocalization X 2 Q64337 Q676U5 fluorescence microscopy 23392225 colocalization X 2 Q64337 P58004 anti tag coimmunoprecipitation 25040165 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Sqstm1 Atg16l1 MI:0004(affinity chromatography technology) 22167182 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_320621 bait prey Sqstm1 Map1lc3a MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18083104,18524774,19765191,23637164 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_321864|BIOGRID_321611|BIOGRID_321866|BIOGRID_321865|BIOGRID_329753|BIOGRID_321617|BIOGRID_321616|BIOGRID_321615|BIOGRID_321600 bait|prey|prey|prey|bait|prey|bait|prey|bait prey|bait|bait|bait|prey|bait|prey|bait|prey Sqstm1 Map2k5 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15102471 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_163191|UniProt_163190|UniProt_163149 prey|prey|prey bait|bait|bait Htt Sqstm1 MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation) 15379887,16615898,22396390 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(biogrid)|(biogrid)|(intact) UniProt_167131|BIOGRID_321822|BIOGRID_333070|UniProt_167130 neutral component|bait|bait|neutral component neutral component|prey|prey|neutral component Sqstm1 Cul3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation) 16615898,22167182 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(intact) BIOGRID_320619|BIOGRID_320620|UniProt_167134 prey|bait|neutral component bait|prey|neutral component Slc11a1 Sqstm1 MI:0428(imaging technique) 20206555 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (biogrid) BIOGRID_321767 prey bait Sqstm1 Trim55 MI:0004(affinity chromatography technology) 24124537 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_331675 bait prey Sod1 Sqstm1 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation) 16615898,17296612,19765191 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(intact) UniProt_167131|UniProt_167130|UniProt_167134|UniProt_167135|UniProt_167126|BIOGRID_321599|BIOGRID_321722|BIOGRID_321723|BIOGRID_321598|BIOGRID_321597|UniProt_167127 neutral component|neutral component|neutral component|neutral component|neutral component|bait|bait|prey|prey|prey|neutral component neutral component|neutral component|neutral component|neutral component|neutral component|prey|prey|bait|bait|bait|neutral component Gria1 Sqstm1 MI:0004(affinity chromatography technology) 19004011 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322360 bait prey Ulk1 Sqstm1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17389358 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_328512|BIOGRID_328511 prey|bait bait|prey Ubc Sqstm1 MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0004(affinity chromatography technology) 15379887,20206555,23637164 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid) BIOGRID_329755|BIOGRID_321770|BIOGRID_321829 prey|prey|prey bait|bait|bait Gria2 Sqstm1 MI:0004(affinity chromatography technology) 19004011 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322361 bait prey Nbr1 Sqstm1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 19250911,20616007 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_168867|UniProt_168866|BIOGRID_319828 neutral component|neutral component|bait neutral component|neutral component|prey Mapk1 Sqstm1 MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down) 16517408,16615898,20154642 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(biogrid)|(intact)|(intact)|MI:0471(mint)|(intact) UniProt_167130|BIOGRID_325014|BIOGRID_325013|UniProt_167134|UniProt_167135|MINT_76307|UniProt_171346 neutral component|prey|bait|neutral component|neutral component|prey|prey neutral component|bait|prey|neutral component|neutral component|bait|bait Ntrk2 Sqstm1 MI:0004(affinity chromatography technology) 21574998 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321755 bait prey Fau Sqstm1 MI:0428(imaging technique) 20206555 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_321769 prey bait Mapk3 Sqstm1 MI:0027(cosedimentation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0096(pull down) 16615898,20154642 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|MI:0471(mint)|(intact) UniProt_167130|BIOGRID_326059|MINT_76307|UniProt_171346 neutral component|prey|prey|prey neutral component|bait|bait|bait Ntrk1 Sqstm1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17389358,18598672,21574998 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_312273|BIOGRID_312272|BIOGRID_328515|BIOGRID_321754 prey|bait|bait|bait bait|prey|prey|prey Ubb Sqstm1 MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 21715324 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_321589|BIOGRID_321588 prey|prey bait|bait Ubb Sqstm1 MI:0027(cosedimentation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16615898,18083104 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_167131|UniProt_168236|UniProt_168232|UniProt_168233|UniProt_92930|UniProt_167134|UniProt_167135|UniProt_167126 neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component|neutral component Sqstm1 Fhod3 MI:0424(protein kinase assay) 21149568 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization) (intact) UniProt_172394 neutral component neutral component Ripk1 Sqstm1 MI:0004(affinity chromatography technology) 19850933 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315169 prey bait Casp8 Sqstm1 MI:0004(affinity chromatography technology)|MI:0428(imaging technique)|MI:0428(imaging technique) 21576355,21628531 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_319572|BIOGRID_319646|BIOGRID_319647 bait|bait|bait prey|prey|prey Ar Sqstm1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23637164 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_329754|BIOGRID_329752 bait|prey prey|bait Traf6 Sqstm1 MI:0004(affinity chromatography technology) 17389358 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_328513 prey bait Sqstm1 Nrif1 MI:0004(affinity chromatography technology) 16252010 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_319838 prey bait Prkcd Sqstm1 MI:0004(affinity chromatography technology) 19850933 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_315170 prey bait Sqstm1 Keap1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20173742 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid) UniProt_170918|UniProt_105766|UniProt_170922|UniProt_170919|UniProt_170921|UniProt_170920|BIOGRID_323184|BIOGRID_323185|BIOGRID_323182|UniProt_170923|BIOGRID_323186|BIOGRID_323190|BIOGRID_323187 prey|prey|neutral component|bait|bait|prey|bait|bait|prey|neutral component|prey|prey|prey bait|bait|neutral component|prey|prey|bait|prey|prey|bait|neutral component|bait|bait|bait Sqstm1 Gria3 MI:0004(affinity chromatography technology) 19004011 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_322362 prey bait Trim30a Sqstm1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18598672 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_312275|BIOGRID_312274 bait|prey prey|bait Sqstm1 Cyld MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18174161,18382763,21878516 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_312297|BIOGRID_316143|BIOGRID_312340 prey|bait|prey bait|prey|bait Sqstm1 Gbp2 MI:0027(cosedimentation)|MI:0428(imaging technique) 16615898,21757726 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization) (intact)|(biogrid) UniProt_167130|BIOGRID_321840 neutral component|prey neutral component|bait

PPI - HINT Gene A Gene B PMID Method Quality UBC SQSTM1 18083104,21715324,18083104,21715324 0040,0114,0416,0096 LC YWHAE SQSTM1 16615898 0027 LC UBA52 SQSTM1 18083104,18083104 0040,0416 LC MAP3K2 SQSTM1 19903815 0107 LC MAP3K3 SQSTM1 19903815,19903815,19903815 0007,0096,0107 LC SQSTM1 SQSTM1 21715324,PDB_3B0F,21715324 0114,0114,0096 LC SQSTM1 MAP1LC3A 18524774,18524774 0096,0114 LC SQSTM1 PGLS 16615898 0027 LC SQSTM1 HSD3B7 16615898 0027 LC SQSTM1 MAP2K5 19903815,19903815,15102471 0096,0107,0018 LC SQSTM1 KEAP1 20173742,20173742,20173742,20173742,24011591,20173742,20173742 0004,0007,0428,0114,0114,0065,0096 LC TRIM55 SQSTM1 24124537 0004 LC ULK1 SQSTM1 17389358,17389358 0007,0004 LC CASP8 SQSTM1 21576355,21628531,21576355 0428,0004,0004 LC KRT18 SQSTM1 24798445,24798445 0813,0663 LC SOD1 SQSTM1 19765191,17296612,19765191 0004,0004,0428 LC UBB SQSTM1 21715324,21715324 0004,0096 LC UBC SQSTM1 23637164,15379887,22167182,21715324,20206555,21715324 0004,0428,0004,0114,0004,0096 LC KRT8 SQSTM1 24798445,24798445 0813,0663 LC NTRK2 SQSTM1 21574998 0004 LC TRIM30A SQSTM1 18598672,18598672 0096,0004 LC AR SQSTM1 23637164 0004 LC MYD88 SQSTM1 20837465 0007 LC GJA1 SQSTM1 25605500 0004 LC IRF8 SQSTM1 19201866 0007 LC GRIA1 SQSTM1 19004011 0004 LC GRIA2 SQSTM1 19004011 0004 LC PRKCD SQSTM1 19850933 0004 LC FAU SQSTM1 20206555,20206555 0004,0007 LC SLC11A1 SQSTM1 20206555 0428 LC HTT SQSTM1 22396390,15379887 0004,0004 LC SESN2 SQSTM1 25040165,25040165 0006,0004 LC MAPK1 SQSTM1 20154642,16517408,16517408 0006,0004,0096 LC TRAF6 SQSTM1 17389358,19201866,17389358 0007,0007,0004 LC NBR1 SQSTM1 19250911,20616007 0663,0096 LC NTRK1 SQSTM1 17389358,21574998,17389358,17389358,18598672 0007,0004,0006,0004,0004 LC KLF2 SQSTM1 23754749 0004 LC RIPK1 SQSTM1 19850933 0004 LC KLF3 SQSTM1 23754749 0004 LC MAP3K3 SQSTM1 19903815,19903815,19903815 0007,0096,0107 LC TRIM21 SQSTM1 19201866 0007 LC MAPK3 SQSTM1 20154642,20154642 0006,0004 LC SQSTM1 SQSTM1 21715324,21715324 0114,0096 LC SQSTM1 FHOD3 21149568 0663 LC SQSTM1 CYLD 21878516,19201866,18174161,18174161,18382763,18382763 0004,0007,0004,0007,0004,0007 LC SQSTM1 PELI3 25483963 0004 LC SQSTM1 ATG16L1 22167182 0004 LC SQSTM1 RPGRIP1L 21565611 0007 HT SQSTM1 OPTN 25026213,25026213 0096,0006 LC SQSTM1 RAB38 26885862 0676 LC SQSTM1 MAP1LC3A 23637164,18524774,18083104,18524774,18083104,19765191 0004,0096,0004,0114,0096,0004 LC SQSTM1 NRIF1 16252010 0004 LC SQSTM1 MAP1LC3B 18083104 0007 LC SQSTM1 CUL3 22167182 0004 LC SQSTM1 LIMD1 17092936 0004 LC SQSTM1 MAP2K5 19903815,19903815 0096,0107 LC SQSTM1 GBP2 21757726 0428 LC SQSTM1 GRIA3 19004011,19004011 0007,0004 LC SQSTM1 KEAP1 20173742,20173742,20173742,20173742,20173742,20173742 0004,0007,0428,0114,0065,0096 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q64337 Q53QD7 SQSTM1 DNAJB2 {ECO:0000312|HGNC:HGNC:5228} 0.21 Q64337 P58004 SQSTM1 SESN2 0.21 25040165 Q64337 P23242 SQSTM1 GJA1 0.21 25605500 Q64337 Q60843 SQSTM1 KLF2 0.21 23754749 Q64337 Q60980 SQSTM1 KLF3 0.21 23754749 Q64337 P23818 SQSTM1 GRIA1 0.21 19004011 Q64337 P23819 SQSTM1 GRIA2 0.21 19004011 Q8CG73 Q64337 RPGRIP1L SQSTM1 0.126 21565611 Q64337 P62259 SQSTM1 YWHAE 0.081 16615898 Q64337 Q04771 SQSTM1 ACVR1 0.126 15761153 Q9H492 Q64337 MAP1LC3A SQSTM1 0.21 21628531 Q8IYU2 Q64337 HACE1 SQSTM1 0.21 24614889 Q9HCE7 Q64337 SMURF1 SQSTM1 0.126 15761153 Q9JLV5 Q64337 CUL3 SQSTM1 0.376 22167182 Q8QZZ8 Q64337 RAB38 SQSTM1 0.126 26885862 Q9GZQ8 Q64337 MAP1LC3B SQSTM1 0.636 18083104,19250911 Q64337 P25686 SQSTM1 DNAJB2 0.21 22396390 Q64337 O70405 SQSTM1 ULK1 0.376 17389358 Q9Z0E6 Q64337 GBP2 SQSTM1 0.126 21757726 Q9Z2W9 Q64337 GRIA3 SQSTM1 0.21 19004011 Q64337 P11679 SQSTM1 KRT8 0.309 24798445 Q64337 P70196 SQSTM1 TRAF6 0.21 17389358 Q64337 P60520 SQSTM1 GABARAPL2 0.126 19250911 Q64337 P28867 SQSTM1 PRKCD 0.21 19850933 Q64337 P41251 SQSTM1 SLC11A1 0.126 20206555 Q64337 P35545 SQSTM1 FAU 0.21 20206555 Q676U5 Q64337 ATG16L1 SQSTM1 0.126 23392225 Q64337 P97432 SQSTM1 NBR1 0.416 19250911,20616007 Q64337 Q13501 SQSTM1 SQSTM1 0.21 20173742 Q64337 Q64337 SQSTM1 SQSTM1 0.332 21715324 Q64337 Q3UFB7 SQSTM1 NTRK1 0.61 18598672,17389358,21574998 Q64337 Q60855 SQSTM1 RIPK1 0.21 19850933 Q8BXR6 Q64337 PELI3 SQSTM1 0.376 25483963 Q76LL6 Q64337 FHOD3 SQSTM1 0.126 21149568 Q80TQ2 Q64337 CYLD SQSTM1 0.507 18174161,18382763,21878516 Q9WVS7 Q64337 MAP2K5 SQSTM1 0.183 15102471 Q8C0J2 Q64337 ATG16L1 SQSTM1 0.21 22167182 Q64337 P0CG50 SQSTM1 UBC 0.702 23637164,22167182,21715324 Q8K3K8 Q64337 OPTN SQSTM1 0.454 25026213 Q64337 P08228 SQSTM1 SOD1 0.659 19765191,17296612 Q64337 P05784 SQSTM1 KRT18 0.309 24798445 Q64337 Q63844 SQSTM1 MAPK3 0.376 20154642 Q64337 P62991 SQSTM1 UBA52 0.236 18083104 Q64337 P58043 SQSTM1 SESN2 0.376 25040165 Q64337 O89110 SQSTM1 CASP8 0.454 21628531,21576355 Q9Z2X8 Q64337 KEAP1 SQSTM1 0.932 20173742 Q91VR7 Q64337 MAP1LC3A SQSTM1 0.911 18083104,23637164,19765191,18524774 Q923B3 Q64337 NRIF1 SQSTM1 0.21 16252010 Q9CQ60 Q64337 PGLS SQSTM1 0.081 16615898 Q9EQC1 Q64337 HSD3B7 SQSTM1 0.081 16615898 Q9QXD8 Q64337 LIMD1 SQSTM1 0.21 17092936 Q64337 P84022 SQSTM1 SMAD3 0.126 15761153 Q64337 Q14145 SQSTM1 KEAP1 0.376 20173742 Q64337 Q13485 SQSTM1 SMAD4 0.126 15761153 Q64337 Q14596 SQSTM1 NBR1 0.21 24879152 Q64337 P19091 SQSTM1 AR 0.376 23637164 Q64337 Q14790 SQSTM1 CASP8 0.309 25450619 Q64337 P63085 SQSTM1 MAPK1 0.569 20154642,16517408 Q64337 Q15796 SQSTM1 SMAD2 0.126 15761153 Q64337 O00238 SQSTM1 BMPR1B 0.126 15761153 Q64337 P15209 SQSTM1 NTRK2 0.21 21574998 Q64337 P15533 SQSTM1 TRIM30A 0.454 18598672