PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Lck Hcls1 10713104,7628441 mint,intact exp G G G G G G G G Fyn Hcls1 10713104 intact exp G G G G G G G G Hcls1 Nfe2 20211142 biogrid exp G G G G Hcls1 Ywhae 16615898 intact exp P G G G G G G G G Lyn Hcls1 10713104,10428862 i2d,mint,intact exp, ortho P Hax1 Hcls1 i2d exp, ortho G G G G G G G G Hcls1 Hs1bp3 10590261 biogrid,i2d,mint,intact exp, ortho P G G G G G Hcls1 Acta1 ortho P G G G G G G G G Hcls1 Grap ortho Ikbkg Hcls1 ortho P G G G G G G G G Hcls1 Blzf1 ortho G G G G G G G G Hcls1 Actr3 ortho P G G G G G G G G Syk Hcls1 ortho P G G G G G G G G Hcls1 Sh2d4a ortho P Hcls1 Lztr1 ortho G G G G G G G G Hcls1 Actr2 ortho P G G G G G G G G Hcls1 Map4k1 ortho P G G G G G Hcls1 Wipf1 ortho G G G G G G G G Hcls1 Trim29 ortho P G G G G Hcls1 Ptk2b ortho P G G G G G G G G Cftr Hcls1 ortho G G G Hcls1 Qki ortho P G G G G G G G G Hcls1 Casp3 ortho P G G G G G G G G Csk Hcls1 ortho P G G G G G G G G Hcls1 Igf1r ortho P G G G G G G G G Cd79a Hcls1 ortho G G G G G G G Hcls1 Was ortho G G G G G G G MCG10049, Protein Zbtb25 Hcls1 ortho G G G G G G Hcls1 Ssbp3 ortho G G G G G G G G Hcls1 Csnk2a1 ortho P G G G G G G G G Fgr Hcls1 ortho G G G G G G G Hcls1 Grb2 ortho P G G G G G G G G Hcls1 Terf1 ortho G G G G G G G G Hcls1 Notch1 ortho G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P49710 two hybrid 20211142 direct interaction X 2 P49710 Q3TC93 unspecified method 10590261 direct interaction X 2 P49710 Q3TC93 affinity chromatography technology 10590261 physical association X 2 P49710 cosedimentation 16615898 colocalization C 1216 P39688 P49710 anti bait coimmunoprecipitation 10713104 physical association X 2 P49710 Q3TC93 anti bait coimmunoprecipitation 10590261 physical association X 2 P49710 Q3TC93 filter binding 10590261 physical association X 2 P49710 P06240 anti bait coimmunoprecipitation 10713104 physical association X 2 P49710 P06240 filter binding 7628441 physical association X 2 P49710 P06240 filter binding 7628441 physical association X 2 P49710 P06240 filter binding 7628441 direct interaction X 2 P49710 P06240 filter binding 7628441 direct interaction X 2 P49710 P06240 anti bait coimmunoprecipitation 7628441 physical association X 2 P25911 P49710 experimental interaction detection 10428862 phosphorylation reaction X 2 P25911 P49710 anti bait coimmunoprecipitation 10713104 physical association X 2 P25911 P49710 pull down 10713104 direct interaction X 2 P25911 P49710 two hybrid 10713104 physical association X 2 P25911 P49710 anti bait coimmunoprecipitation 10713104 physical association X 2 P25911 P49710 anti bait coimmunoprecipitation 10713104 physical association X 2 P25911 P49710 anti bait coimmunoprecipitation 10713104 physical association X 2 P25911 P49710 anti bait coimmunoprecipitation 10713104 physical association X 2 P25911 P49710 imaging technique 10713104 colocalization X 2 P25911 P49710 anti bait coimmunoprecipitation 10713104 physical association X 2 P25911 P49710 two hybrid 10713104 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Lyn Hcls1 MI:0027(cosedimentation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 10428862,10713104,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0217(phosphorylation reaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0217(phosphorylation reaction) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0471(mint) UniProt_167133|UniProt_160792|UniProt_160793|UniProt_160794|UniProt_160789|UniProt_160788|UniProt_160787|UniProt_160796|UniProt_161685|UniProt_160786|UniProt_160795|UniProt_160785|MINT_59913 neutral component|bait|bait|bait|prey|bait|bait|neutral component|unspecified role|prey|bait|bait|unspecified role neutral component|prey|prey|prey|bait|prey|prey|neutral component|unspecified role|bait|prey|prey|unspecified role Hcls1 Hs1bp3 MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0686(unspecified method)|MI:0686(unspecified method)|MI:0049(filter binding)|MI:0049(filter binding) 10590261,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0403(colocalization)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(intact)|(intact)|(intact)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0471(mint) UniProt_167130|UniProt_167133|UniProt_161091|UniProt_161092|BIOGRID_325358|BIOGRID_325357|MINT_65730|MINT_65731 neutral component|neutral component|prey|prey|prey|bait|prey|prey neutral component|neutral component|bait|bait|bait|prey|bait|bait Fyn Hcls1 MI:0018(two hybrid) 10713104 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (intact) UniProt_160791 bait prey Hcls1 Nfe2 MI:0018(two hybrid) 20211142 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_313140 bait prey Lck Hcls1 MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation)|MI:0018(two hybrid) 10713104,7628441 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(intact)|(intact)|MI:0471(mint)|(intact)|(intact)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact) MINT_74123|UniProt_177632|UniProt_177633|MINT_73948|UniProt_177630|UniProt_177629|UniProt_177631|MINT_74119|MINT_73674|MINT_73943|UniProt_160790 prey|prey|prey|prey|bait|prey|prey|prey|prey|bait|bait bait|bait|bait|bait|prey|bait|bait|bait|bait|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality LCK HCLS1 7628441,7628441 0006,0049 LC LYN HCLS1 10713104,10428862,10713104,10713104,10713104 0096,0045,0018,0428,0006 LC HCLS1 YWHAE 16615898 0027 LC HCLS1 NFE2 20211142 0018 HT HCLS1 HS1BP3 10590261,10590261,10590261 0049,0006,0004 LC LCK HCLS1 7628441,7628441,10713104 0006,0049,0006 LC LYN HCLS1 10713104,10713104,10713104,10713104 0096,0018,0428,0006 LC FYN HCLS1 10713104 0006 LC HCLS1 HS1BP3 10590261,10590261,10590261 0049,0006,0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62259 P49710 YWHAE HCLS1 0.081 16615898 P49710 P25911 HCLS1 LYN 0.826 10428862,10713104 P49710 P06240 HCLS1 LCK 0.814 7628441,10713104 P49710 P39688 HCLS1 FYN 0.21 10713104 Q07279 P49710 NFE2 HCLS1 0.183 20211142 Q3TC93 P49710 HS1BP3 HCLS1 0.659 10590261