PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Bin1 Sh3gl3 12456676 biogrid,i2d exp G G G G G G G G G G G Bin1 Wasl 25262827 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Ywhab 16635246 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Cacnb1 23917616 intact exp G G G G G G G G Bin1 Ywhae 16615898 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Atp6v1a 22707207 intact exp GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ryr1 Bin1 23917616 intact exp G G G G G G G G G G G G G Bin1 Dnm3 23640057 intact exp P G G G G G G G G G G G G G G Bin1 Sh3gl2 12456676 biogrid,i2d exp, ortho GP G G G G G G G G G G G G G G G G G G G Bin1 Mtm1 23917616 biogrid,intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Dnm1 23640057 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G Bin1 Dnm2 23640057 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Mapt 23399914 intact exp, ortho P G G G G G G G G G G G G G G G Bin1 Sh3glb1 12456676 biogrid,i2d exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Xrcc4 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin2 Bin1 ortho Bin1 Zbtb3 ortho G Bin1 Slc2a4 ortho G G G G G G G G G G G G G G G G G G G G Bin1 Appl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Ap2a2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Xrcc6 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Pkm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Ipo8 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Cltc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Elavl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Itga6 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Cacna1c ortho G G G G G G G G G G G G Bin1 Vps18 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Rin3 ortho Bin1 Amph ortho P G G G G G G G G G G Bin1 Abl1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Serine hydroxymethyltransferase ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Mbnl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Snx4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Rap1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Lrp1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Pld1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Pld2 ortho G G G G G G G G G G G G G G G G G G G G G G G Bin1 Myzap ortho GP G G G G G G G G G G G G G G G G G Bin1 Grb2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Syk ortho GP G G G G G G G G G G G G G G G G Bin1 Ap2a1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Bin1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Pik3ca ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dlgap4 Bin1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Sos1 ortho P G G G G G G G G G Bin1 Dguok ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Itga3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Tp73 ortho G Bin1 Atm ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Asap2 ortho P Bin1 Snapin ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Itga1 ortho P Bin1 Fabp4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Fhl2 ortho P G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Ptk2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Nf1 ortho GP G G G G G G G G G G G G G G G G G G G G Bin1 Sipa1 ortho G G G G G G G G G G G G G G G G G G G G Bin1 App ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Prkcg ortho G G G G Bin1 Reps2 ortho P Bin1 Syn1 ortho P G G G G G G G G G G Bin1 Hyou1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Necap2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Tnk2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Mov10 ortho G G G G G G G G G G G G G G G G G G G Bin1 Sos2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Synj2 ortho GP G G G G G G G G G G G G G G G G G Bin1 Atxn2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Snx17 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Myc ortho G G G G G G G G G G G G G G G G G G G G G Bin1 Clta ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Ubc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Map4k3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Rfx3 ortho Bin1 Rbm12 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Xrcc5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Clip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Rin2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Klf8 ortho Bin1 Fes ortho G G G G G G G G G G Bin1 Synj1 ortho P Bin1 Necap1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Nufip1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 L1cam ortho G G G G G G G G G G G G G G G G G G G G G G G G G G Bin1 Fbp1 ortho GP G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O08539 - 12456676 - X 2 O08539 Q62420 - 12456676 - X 2 Q62421 O08539 - 12456676 - X 2 O08539 cosedimentation 16615898 colocalization C 1216 O08539 cosedimentation through density gradient 16635246 colocalization C 608 O08539 Q8R3Z5 confocal microscopy 23917616 colocalization X 2 Q9Z2C5 O08539 confocal microscopy 23917616 colocalization X 2 Q9Z2C5 O08539 anti bait coimmunoprecipitation 23917616 physical association X 2 Q9Z2C5 O08539 anti bait coimmunoprecipitation 23917616 physical association X 2 O08539 O95219 fluorescence microscopy 12668730 colocalization X 2 O08539 O95219 anti tag coimmunoprecipitation 12668730 physical association X 2 E9PZQ0 O08539 confocal microscopy 23917616 colocalization X 2 P10637 O08539 anti bait coimmunoprecipitation 23399914 physical association X 2 P10637 O08539 anti bait coimmunoprecipitation 23399914 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Bin1 Mapt MI:0096(pull down)|MI:0096(pull down)|MI:0029(cosedimentation through density gradient)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 16615898,16635246,23399914 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact) UniProt_174612|UniProt_174611|UniProt_166352|UniProt_167130|UniProt_167115|UniProt_167116|UniProt_167114 bait|prey|neutral component|neutral component|neutral component|neutral component|neutral component prey|bait|neutral component|neutral component|neutral component|neutral component|neutral component Bin1 Mtm1 MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation)|MI:0007(anti tag coimmunoprecipitation) 23917616 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (intact)|(intact)|(intact) UniProt_177385|UniProt_177387|UniProt_177386 prey|neutral component|bait bait|neutral component|prey

PPI - HINT Gene A Gene B PMID Method Quality BIN1 IDO1 15711557 0255 LC BIN1 YWHAE 16615898 0027 LC BIN1 SH3GL2 12456676,12456676,12456676 0004,0096,0047 LC BIN1 SH3GL3 12456676,12456676,12456676 0004,0096,0047 LC BIN1 YWHAB 16635246 0029 LC RYR1 BIN1 23917616 0663 LC BIN1 MAPT 23399914 0006 LC BIN1 DNM1 23640057 0006 LC BIN1 DNM2 23640057 0006 LC BIN1 ATP6V1A 22707207 0006 LC BIN1 E2F1 25257171 0004 LC BIN1 SH3GL2 12456676,12456676,12456676 0004,0096,0047 LC BIN1 SH3GL3 12456676,12456676,12456676 0004,0096,0047 LC BIN1 DNM3 23640057 0006 LC BIN1 CACNB1 23917616 0663 LC BIN1 WASL 25262827 0004 LC BIN1 SH3GLB1 12456676 0096 LC BIN1 MTM1 23917616,23917616,23917616 0006,0004,0663 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62158 O08539 CALM3 BIN1 0.126 16512683 P62259 O08539 YWHAE BIN1 0.081 16615898 Q9JK48 O08539 SH3GLB1 BIN1 0.309 12456676 Q62420 O08539 SH3GL2 BIN1 0.309 12456676 Q62421 O08539 SH3GL3 BIN1 0.309 12456676 Q8BZ98 O08539 DNM3 BIN1 0.21 23640057 Q91YD9 O08539 WASL BIN1 0.376 25262827 Q9CQV8 O08539 YWHAB BIN1 0.081 16635246 P39053 O08539 DNM1 BIN1 0.21 23640057 P39054 O08539 DNM2 BIN1 0.21 23640057 O08539 E9PZQ0 BIN1 RYR1 0.126 23917616 P50516 O08539 ATP6V1A BIN1 0.126 22707207 Q07889 O08539 SOS1 BIN1 0.309 9182529 O95219 O08539 SNX4 BIN1 0.309 12668730 P10637 O08539 MAPT BIN1 0.21 23399914 Q61501 O08539 E2F1 BIN1 0.21 25257171 Q8R3Z5 O08539 CACNB1 BIN1 0.126 23917616 Q9Z2C5 O08539 MTM1 BIN1 0.454 23917616