PTM - dbPAF Gene Name UniProt ID Position Type Species Btk; Bpk P35991 115 S Mus musculus(Mouse) Btk; Bpk P35991 174 S Mus musculus(Mouse) Btk; Bpk P35991 179 S Mus musculus(Mouse) Btk; Bpk P35991 180 S Mus musculus(Mouse) Btk; Bpk P35991 191 T Mus musculus(Mouse) Btk; Bpk P35991 21 S Mus musculus(Mouse) Btk; Bpk P35991 223 Y Mus musculus(Mouse) Btk; Bpk P35991 225 Y Mus musculus(Mouse) Btk; Bpk P35991 315 Y Mus musculus(Mouse) Btk; Bpk P35991 334 Y Mus musculus(Mouse) Btk; Bpk P35991 344 Y Mus musculus(Mouse) Btk; Bpk P35991 345 Y Mus musculus(Mouse) Btk; Bpk P35991 361 Y Mus musculus(Mouse) Btk; Bpk P35991 375 Y Mus musculus(Mouse) Btk; Bpk P35991 40 Y Mus musculus(Mouse) Btk; Bpk P35991 425 Y Mus musculus(Mouse) Btk; Bpk P35991 436 S Mus musculus(Mouse) Btk; Bpk P35991 461 Y Mus musculus(Mouse) Btk; Bpk P35991 543 S Mus musculus(Mouse) Btk; Bpk P35991 545 Y Mus musculus(Mouse) Btk; Bpk P35991 551 Y Mus musculus(Mouse) Btk; Bpk P35991 553 S Mus musculus(Mouse) Btk; Bpk P35991 617 Y Mus musculus(Mouse) Btk; Bpk P35991 623 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P35991 S21-p Phosphorylation SQQKKKTsPLNFKKR P35991 Y40-p Phosphorylation TVHKLSYyEYDFERG P35991 S115-p Phosphorylation EGPLYVFsPTEELRK P35991 Y134-p Phosphorylation QLKNVIRyNSDLVQK P35991 S174-p Phosphorylation ILENRNGsLKPGssH P35991 S179-p Phosphorylation NGsLKPGssHRKTKK P35991 S180-p Phosphorylation GsLKPGssHRKTKKP P35991 T191-p Phosphorylation TKKPLPPtPEEDQIL P35991 T207-p Phosphorylation KPLPPEPtAAPISTt P35991 T214-p Phosphorylation tAAPISTtELKKVVA P35991 Y223-p Phosphorylation LKKVVALyDyMPMNA P35991 Y225-p Phosphorylation KVVALyDyMPMNAND P35991 Y334-p Phosphorylation PQGVIRHyVVCSTPQ P35991 Y344-p Phosphorylation CSTPQSQyyLAEKHL P35991 Y345-p Phosphorylation STPQSQyyLAEKHLF P35991 Y361-p Phosphorylation TIPELINyHQHNSAG P35991 Y375-p Phosphorylation GLISRLKyPVSKQNK P35991 Y425-p Phosphorylation YGKWRGQyDVAIKMI P35991 S436-p Phosphorylation IKMIREGsMSEDEFI P35991 Y461-p Phosphorylation HEKLVQLyGVCTKQR P35991 S543-p Phosphorylation KVSDFGLsRYVLDDE P35991 Y551-p Phosphorylation RYVLDDEyTsSVGSK P35991 S553-p Phosphorylation VLDDEyTsSVGSKFP P35991 Y617-p Phosphorylation IAQGLRLyRPHLAsE P35991 S623-p Phosphorylation LyRPHLAsERVYTIM

PTM - dbPTM UniProt ID Position Code Type Resources References P35991 40 Y Phosphorylation Swiss-Prot 1010711 17947660 P35991 223 Y Phosphorylation Swiss-Prot 1010711 8630736 P35991 344 Y Phosphorylation Swiss-Prot 1010711 17947660 P35991 551 Y Phosphorylation Swiss-Prot 1010711 8629002;17947660 P35991 115 S Phosphorylation Phosphositeplus.1010730 16644721 P35991 180 S Phosphorylation Phosphositeplus.1010730 11598012 P35991 21 S Phosphorylation Phosphositeplus.1010730 16644721 P35991 543 S Phosphorylation Phosphositeplus.1010730 20415495 P35991 623 S Phosphorylation Phosphositeplus.1010730 15375214 P35991 223 Y Phosphorylation Phosphositeplus.1010730 11598012;12023340;9012831;9391111 P35991 344 Y Phosphorylation Phosphositeplus.1010730 17947660 P35991 375 Y Phosphorylation Phosphositeplus.1010730 16291652 P35991 40 Y Phosphorylation Phosphositeplus.1010730 17947660 P35991 551 Y Phosphorylation Phosphositeplus.1010730 11598012;12023340;16291652;17947660;19854140;20670933;7565679;9012831;9391111 P35991 617 Y Phosphorylation Phosphositeplus.1010730 15375214 P35991 315 Y Phosphorylation SysPTM 1.1 15879432 P35991 545 Y Phosphorylation SysPTM 1.1 15879432

PTM - UniProt UniProt ID Position Type PMIDs P35991 40 Phosphotyrosine 17947660 P35991 223 Phosphotyrosine; by autocatalysis 8630736 P35991 344 Phosphotyrosine 17947660 P35991 551 Phosphotyrosine; by LYN and SYK 17947660;8629002