PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Usp5 Isg15 14673145 biogrid exp P Usp5 Eed 24457600 innatedb,biogrid exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ywhae 16615898 intact exp, ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Gnb2l1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Adam19 Usp5 ortho G G G G G G G G G G G G G G G G G G G G G G G Usp5 Tial1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ubp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Cnot7 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Stk33 ortho Usp5 Rps6ka5 ortho Usp5 Znf593 ortho P Usp5 Taldo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Kdm5c Usp5 ortho P G G G G G G G G Usp5 Rad18 ortho G G G G G G G Usp5 Rhoc ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Cct6a ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Msn Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pgk1 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Dazap2 ortho Usp5 Ino80 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Rps27a ortho P Usp5 Prkab1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Tktl2 ortho Usp5 Bcap31 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Atp6v1a Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Akr1b8 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Urm1 ortho G G G G G G G G G G G G G G G G G G G G G Usp5 Trim26 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Rap1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Oxsr1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Hint1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Tenm2 ortho P G G G G G G Usp5 Tada3 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Pja1 Usp5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ntrk1 ortho Ubr1 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Traf6 ortho G G G G G G G G G G G G G G G G G G G G Usp5 Thtpa ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G App Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Trim63 ortho Pdia3 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Set ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Triml1 ortho P Usp5 Mre11a ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Eef1d ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Vcp ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Prdx1 Usp5 ortho P Usp5 Arhgdia ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ube2h ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Mlh1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Pgd ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mcm5 Usp5 ortho P G G G G G G G G G G G G G G Usp5 Smo ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G Calr Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G P4hb Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Cdk5 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mdh2 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Herc4 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Isyna1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Rnf11 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Cdc34 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Stub1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Trnt1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Sec24c, SEC24 related gene family, member C (S. cerevisiae), isoform CRA_a Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23a Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Hsd17b10 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ubc Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Tmod3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ipo9 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Twf1 ortho P Gnpda1 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Trim54 ortho G G G G G G G Adssl1 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G Sod2 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ddhd2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Postmeiotic segregation increased 1 (S. cerevisiae), Protein Pms1 ortho P Usp5 Timm10 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Sirt7 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Rps3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Fkbp14 ortho Usp5 Uba1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Lcp1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Calu Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Glo1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Tmem239 ortho Wars Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Anxa11 ortho P Usp5 Uba5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Uchl3 ortho P Usp5 Usp28 ortho Ncam1 Usp5 ortho G G G G G G G G G G G G G G G G G Usp5 Ube2s ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Psme1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dld Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Sumo3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Rffl ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Rad23b Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Pbk ortho G G G G G G G G G G G G G G G G G G G G Usp5 Xiap ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Protein Agl Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Txndc17 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Psmd1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Med13 ortho P Usp5 Mcts1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Psma3 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ubtd2 ortho Usp5 Ist1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Nt5c2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Exoc2 ortho P Anxa6 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccng1 Usp5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ythdf2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ntan1 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Ythdf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fkbp2 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Cnn3 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MCG19772, Protein Trim55 Usp5 ortho Usp5 Zfp91 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Rap1gds1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Hgs ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Stip1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Mov10 Usp5 ortho G G G G G G G G G G G G G G G G G G G G Usp5 Acaa2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Clns1a ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Nxf1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Fructose-bisphosphate aldolase Usp5 ortho P G Pcna Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ntn1 Usp5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Dvl2 ortho G G G G G G G G G G G G Usp5 Txnl1 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Dmd Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Rad54l ortho G G G G G G G G G G Usp5 Cdk2 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G Txn Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Atp5b ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Ccnd2 Usp5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Trim39 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Cep19 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Gdi1 Usp5 ortho GP G G G G G G G G G G G G G G G G G G G G G G G G G G G G G Usp5 Usp13 ortho G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P56399 Q921E6 affinity chromatography technology 24457600 physical association X 2 P56399 Q64339 pull down 14673145 direct interaction X 2 P56399 cosedimentation 16615898 colocalization C 1216 P56399 P0CG48 pull down 11689694 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Usp5 Isg15 MI:0096(pull down)|MI:0027(cosedimentation)|MI:0027(cosedimentation)|MI:0027(cosedimentation) 14673145,16615898 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association)|MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact)|(intact) BIOGRID_323115|UniProt_167130|UniProt_167118|UniProt_167134 prey|neutral component|neutral component|neutral component bait|neutral component|neutral component|neutral component Usp5 Eed MI:0004(affinity chromatography technology) 24457600 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0915(physical association) (biogrid) BIOGRID_332676 prey bait

PPI - HINT Gene A Gene B PMID Method Quality USP5 YWHAE 16615898 0027 LC USP5 ISG15 14673145 0096 LC USP5 EED 24457600 0004 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62259 P56399 YWHAE USP5 0.081 16615898 Q64339 P56399 ISG15 USP5 0.309 14673145 Q921E6 P56399 EED USP5 0.126 24457600 P56399 P48039 USP5 MTNR1A 0.126 26514267 P56399 P0CG48 USP5 UBC 0.21 11689694