PTM - CPLM Gene Name UniProt ID Type Position Code Usp5; Isot P56399 Acetylation 353 K Usp5; Isot P56399 Acetylation 357 K Usp5; Isot P56399 Acetylation 575 K Usp5; Isot P56399 Acetylation 743 K Usp5; Isot P56399 Acetylation 418 K Usp5; Isot P56399 Ubiquitination 318 K Usp5; Isot P56399 Ubiquitination 353 K Usp5; Isot P56399 Ubiquitination 357 K Usp5; Isot P56399 Ubiquitination 360 K Usp5; Isot P56399 Ubiquitination 379 K Usp5; Isot P56399 Ubiquitination 391 K Usp5; Isot P56399 Ubiquitination 406 K Usp5; Isot P56399 Ubiquitination 418 K Usp5; Isot P56399 Ubiquitination 423 K Usp5; Isot P56399 Ubiquitination 468 K Usp5; Isot P56399 Ubiquitination 476 K Usp5; Isot P56399 Ubiquitination 574 K Usp5; Isot P56399 Ubiquitination 575 K Usp5; Isot P56399 Ubiquitination 585 K Usp5; Isot P56399 Ubiquitination 586 K Usp5; Isot P56399 Ubiquitination 743 K Usp5; Isot P56399 Ubiquitination 793 K Usp5; Isot P56399 Ubiquitination 836 K Usp5; Isot P56399 Ubiquitination 499 K Usp5; Isot P56399 Ubiquitination 558 K

PTM - dbPAF Gene Name UniProt ID Position Type Species Usp5; Isot P56399 159 S Mus musculus(Mouse) Usp5; Isot P56399 161 S Mus musculus(Mouse) Usp5; Isot P56399 223 Y Mus musculus(Mouse) Usp5; Isot P56399 252 T Mus musculus(Mouse) Usp5; Isot P56399 292 T Mus musculus(Mouse) Usp5; Isot P56399 294 T Mus musculus(Mouse) Usp5; Isot P56399 453 S Mus musculus(Mouse) Usp5; Isot P56399 590 S Mus musculus(Mouse) Usp5; Isot P56399 623 T Mus musculus(Mouse) Usp5; Isot P56399 679 Y Mus musculus(Mouse) Usp5; Isot P56399 751 S Mus musculus(Mouse) Usp5; Isot P56399 775 S Mus musculus(Mouse) Usp5; Isot P56399 779 S Mus musculus(Mouse) Usp5; Isot P56399 783 S Mus musculus(Mouse) Usp5; Isot P56399 785 S Mus musculus(Mouse) Usp5; Isot P56399 787 S Mus musculus(Mouse) Usp5; Isot P56399 813 S Mus musculus(Mouse)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P56399 K163-ac Acetylation SADsAsRkQEVQAWD P56399 K360-ac Acetylation kYVDkLEkIFQNAPT P56399 S159-p Phosphorylation EALLSADsAsRkQEV P56399 S161-p Phosphorylation LLSADsAsRkQEVQA P56399 T252-p Phosphorylation AVKLGTItPDGADVY P56399 T623-p Phosphorylation DIAPPLVtPDEPKGS P56399 Y679-p Phosphorylation ACRkAVYyTGNSGAE P56399 S751-p Phosphorylation ALRATNNsLERAVDW P56399 S775-p Phosphorylation AEAAMDIsEGRsAAE P56399 S779-p Phosphorylation MDIsEGRsAAEsIsE P56399 S783-p Phosphorylation EGRsAAEsIsESVPV P56399 S785-p Phosphorylation RsAAEsIsESVPVGP P56399 S813-p Phosphorylation FISHMGTsTMCGHYV P56399 K20-ub Ubiquitination LPTIRVPkAGDRVHK P56399 K163-ub Ubiquitination SADsAsRkQEVQAWD P56399 K184-ub Ubiquitination SKHAFNLkQLDNPAR P56399 K291-ub Ubiquitination LKMQKTDkTMTELEI P56399 K318-ub Ubiquitination QESGVPLkPLFGPGY P56399 K353-ub Ubiquitination SIPDFQRkYVDkLEk P56399 K357-ub Ubiquitination FQRkYVDkLEkIFQN P56399 K360-ub Ubiquitination kYVDkLEkIFQNAPT P56399 K379-ub Ubiquitination DFSTQVAkLGHGLLS P56399 K391-ub Ubiquitination LLSGEYSkPALESGD P56399 K406-ub Ubiquitination GEQVPEQkEVQDGIA P56399 K418-ub Ubiquitination GIAPRMFkALIGkGH P56399 K423-ub Ubiquitination MFkALIGkGHPEFST P56399 K468-ub Ubiquitination FRFLVEEkIKCLATE P56399 K476-ub Ubiquitination IKCLATEkVKYTQRV P56399 K499-ub Ubiquitination PMDAALNkEELLEYE P56399 K553-ub Ubiquitination WSTALQAkSVAVkTT P56399 K558-ub Ubiquitination QAkSVAVkTTRFASF P56399 K574-ub Ubiquitination DYLVIQIkkFTFGLD P56399 K575-ub Ubiquitination YLVIQIkkFTFGLDW P56399 K585-ub Ubiquitination FGLDWVPkkLDVSIE P56399 K586-ub Ubiquitination GLDWVPkkLDVSIEM P56399 K675-ub Ubiquitination FPMDACRkAVYyTGN P56399 K743-ub Ubiquitination FSRDQALkALRATNN P56399 K793-ub Ubiquitination ESVPVGPkVRDGPGK P56399 K836-ub Ubiquitination WVIYNDQkVCASEkP P56399 K842-ub Ubiquitination QkVCASEkPPKDLGY

PTM - dbPTM UniProt ID Position Code Type Resources References P56399 623 T Phosphorylation Swiss-Prot 1010711 15345747 P56399 623 T Phosphorylation PhosphoELM.10011 15345747 P56399 767 D Caspase Phosphositeplus.1010730 19759058 P56399 751 S Phosphorylation Phosphositeplus.1010730 19737024;20415495 P56399 775 S Phosphorylation Phosphositeplus.1010730 20415495 P56399 779 S Phosphorylation Phosphositeplus.1010730 20415495;21183079 P56399 783 S Phosphorylation Phosphositeplus.1010730 21183079 P56399 785 S Phosphorylation Phosphositeplus.1010730 21183079 P56399 623 T Phosphorylation Phosphositeplus.1010730 15345747;18056256;19737024;20415495;21183079;21659604 P56399 219 C S-nitrosylation dbSNO 1.0 21278135 P56399 783 S Phosphorylation SysPTM 1.1 18846507 P56399 623 T Phosphorylation SysPTM 1.1 18056256

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P56399 623 T 15345747 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P56399 623 Phosphothreonine 15345747;21183079 P56399 779 Phosphoserine 21183079 P56399 783 Phosphoserine 21183079

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type Usp5 IPI00113214 S 751 LRATNNpSLERAVD phosphorylation Usp5 IPI00113214 S 775 EAAMDIpSEGRSAA phosphorylation Usp5 IPI00113214 S 779 DISEGRpSAAESIS phosphorylation Usp5 IPI00113214 S 783 GRSAAEpSISESVP phosphorylation Usp5 IPI00113214 S 785 SAAESIpSESVPVG phosphorylation Usp5 IPI00113214 T 623 IAPPLVpTPDEPKG phosphorylation

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID Usp5 Mus musculus (Mouse) 813; 353; 423; 476; 720; 574; 575; 468; 585; 586; 379; 391; 318; 357; 360; 406; 418; 770; 558; 499; 20; 163; 291; 184 "813,VIYNDQKVCASEK; 353,IPDFQRKYVDKLE; 423,FKALIGKGHPEFS; 476,KCLATEKVKYTQR; 720,SRDQALKALRATN; 574,YLVIQIKKFTFGL; 575,LVIQIKKFTFGLD; 468,RFLVEEKIKCLAT; 585,GLDWVPKKLDVSI; 586,LDWVPKKLDVSIE; 379,FSTQVAKLGHGLL; 391,LSGEYSKPALESG; 318,ESGVPLKPLFGPG; 357,QRKYVDKLEKIFQ; 360,YVDKLEKIFQNAP; 406,EQVPEQKEVQDGI; 418,IAPRMFKALIGKG; 770,SVPVGPKVRDGPG; 558,AKSVAVKTTRFAS; 499,MDAALNKEELLEY; 20,PTIRVPKAGDRVH; 163,ADSASRKQEVQAW; 291,KMQKTDKTMTELE; 184,KHAFNLKQLDNPA" 813:22790023; 353:22790023; 423:22790023; 476:22790023; 720:22790023; 574:22790023; 575:22790023; 468:22790023; 585:22790023; 586:22790023; 379:22790023; 391:22790023; 318:22790023; 357:22790023; 360:22790023; 406:22790023; 418:22790023; 770:22790023; 558:22790023; 499:22790023; 20:22790023; 163:22790023; 291:22790023; 184:22790023