PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus Rag1 Ywhae 16615898 intact exp G G G Rag1 Sf3a2 19324890 biogrid exp G G G Rag1 Rag1 21149691,14671314 biogrid,dip exp G G G Rag1 Gmeb1 19324890 biogrid exp G G Rag1 Rag2 21149691,22157821 i2d,intact,dip exp, ortho Rag1 Kpna2 19324890 biogrid exp, ortho G G G Rag1 Kpna1 ortho G G G Hsp90ab1 Rag1 ortho G G G Rag1 Hmgb2 ortho G G G Rag1 Cacybp ortho G G G Rag1 Hist1h3b, Hist1h3c, Hist1h3d, Hist1h3e, Hist1h3f, Hist2h3b, Hist2h3c1, Hist2h3c2 ortho G App Rag1 ortho G G G Rag1 Ppp5c ortho G G G Rag1 Hist2h2ac ortho Nudc Rag1 ortho G G G Rag1 Sugt1 ortho G G G Myc Rag1 ortho G G G Rag1 Nck1 ortho G G G Rag1 Cul4a ortho G G G Rag1 Runx1 ortho G G G Rag1 Plcg1 ortho Rag1 Ddb1 ortho G G G Rag1 Ube2d2 ortho G G G Rag1 Fkbp5 ortho G G G Rag1 Vprbp ortho G G G Rag1 Hist1h4a, Hist1h4b, Hist1h4c, Hist1h4d, Hist1h4f, Hist1h4h, Hist1h4i, Hist1h4j, Hist1h4k, Hist1h4m, Hist2h4a, Hist4h4 ortho G G Rag1 Hspa8 ortho G G G Hsp90aa1 Rag1 ortho G G G Rag1 Ube2h ortho G G G Rag1 Crk ortho G G G Rag1 Nudcd3 ortho G G G Rag1 Mdc1 ortho

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9JL60 P15919 two hybrid 19324890 direct interaction X 2 A0A087WW00 P15919 pull down 14671314 direct interaction X 2 P15919 P62837 pull down 14671314 direct interaction X 2 P15919 O00762 pull down 14671314 direct interaction X 2 P15919 P52293 two hybrid 19324890 direct interaction X 2 P15919 two hybrid 19324890 direct interaction X 2 A0A024R1Z1 P15919 pull down 14671314 direct interaction X 2 P0CG48 P15919 affinity chromatography technology 14671314 physical association X 2 P0CG48 P15919 enzymatic study 14671314 direct interaction X 2 P15919 pull down 14671314 direct interaction X 2 P15919 A0A024R2K3 pull down 14671314 direct interaction X 2 P15919 P15919 enzymatic study 14671314 direct interaction X 2 P15919 anti bait coimmunoprecipitation 9094713 association C 5 P21784 P15919 anti bait coimmunoprecipitation 9094713 association X 2 P15919 P15919 cross-linking study 21149691 direct interaction Y 1 P15919 P15919 molecular sieving 19396172 direct interaction Y 1 P15919 P15919 x-ray crystallography 19396172 direct interaction Y 1 P15919 P15919 light scattering 19396172 direct interaction Y 1 P21784 P15919 molecular sieving 21149691 direct interaction X 2 P21784 P15919 cross-linking study 21149691 direct interaction X 2 P21784 P15919 pull down 19396172 direct interaction X 2 P15919 pull down 22157821 physical association C 3 P15919 pull down 22157821 association C 3 P15919 pull down 22157821 association C 6 P15919 pull down 22157821 association C 3 P21784 P15919 coimmunoprecipitation - - X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B Rag1 Kpna2 MI:0018(two hybrid) 19324890 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_327668 bait prey Rag1 Rag2 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0067(light scattering)|MI:0096(pull down)|MI:0096(pull down) 19396172,22157821 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0914(association)|MI:0914(association) (intact)|(intact)|(intact)|(intact)|(intact)|(intact)|MI:0465(dip)|(intact)|(intact) UniProt_121841|UniProt_175306|UniProt_121842|UniProt_175307|UniProt_175309|UniProt_121844|DIP_773|UniProt_121843|UniProt_175308 unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|unspecified role|-|unspecified role|unspecified role unspecified role|unspecified role|unspecified role|unspecified role|neutral component|neutral component|-|unspecified role|unspecified role Rag1 Gmeb1 MI:0018(two hybrid) 19324890 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_327670 bait prey Rag1 Sf3a2 MI:0018(two hybrid) 19324890 taxid:10090(Mus musculus) taxid:10090(Mus musculus) MI:0407(direct interaction) (biogrid) BIOGRID_327669 bait prey

PPI - HINT Gene A Gene B PMID Method Quality RAG1 RAG1 19396172,19396172,14671314,19396172,21149691,25707801 0071,0114,0415,0067,0030,0114 LC RAG1 RAG2 21149691,25707801,21149691,9036966;11417858 0071,0114,0030,0019 LC RAG1 KPNA2 19324890 0018 LC RAG1 YWHAE 16615898 0027 LC RAG1 SF3A2 19324890 0018 LC RAG1 GMEB1 19324890 0018 LC REL RAG1 15845455 0007 LC RAG1 RAG2 22157821,9094713,19396172 0096,0006,0096 LC RAG1 NFKB1 15845455 0007 LC RAG1 RELA 15845455 0007 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P52293 P15919 KPNA2 RAG1 0.309 19324890 P51965 P15919 UBE2E1 RAG1 0.309 14671314 P51668 P15919 UBE2D1 RAG1 0.309 14671314 P49427 P15919 CDC34 RAG1 0.309 14671314 P15919 O00762 RAG1 UBE2C 0.309 14671314 Q9JL60 P15919 GMEB1 RAG1 0.309 19324890 P62837 P15919 UBE2D2 RAG1 0.309 14671314 P62256 P15919 UBE2H RAG1 0.309 14671314 P62259 P15919 YWHAE RAG1 0.081 16615898 P15919 P0CG48 RAG1 UBC 0.454 14671314 Q9Y4B6 P15919 VPRBP RAG1 0.376 22157821 P21784 P15919 RAG2 RAG1 0.569 22157821,19396172 P15919 P15919 RAG1 RAG1 0.801 19396172,14671314 Q13619 P15919 CUL4A RAG1 0.21 22157821 P52294 P15919 KPNA1 RAG1 0.21 22157821