iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	24523286

Organism

Homo sapiens

Functional Description
(View)

May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis (PubMed:20719964).

Protein Sequence
(Fasta)

MEQEPQNGEP AEIKIIREAY KKAFLFVNKG LNTDELGQKE EAKNYYKQGI GHLLRGISIS 60
SKESEHTGPG WESARQMQQK MKETLQNVRT RLEILEKGLA TSLQNDLQEV PKLYPEFPPK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCAGTACCA GCCCCCACCT TCCGTCTGTG CATGTTTTCT TCAGTCCTGG AAGGAAATCA 60
TAAGTGATTT GCCCCAAAAG GATTGCTGTT GAGTGAGTAA AGAGATAAAC TTTATTATCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0890--Hereditary spastic paraplegia
KW-1017--Isopeptide bond
KW-0523--Neurodegeneration
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR007330--MIT
IPR009686--Senescence/spartin

Pfam

PF06911--Senescence

SMART

SM00745--MIT

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0030496--C:midbody
GO:0005741--C:mitochondrial outer membrane
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0031625--F:ubiquitin protein ligase binding
GO:0009838--P:abscission
GO:0060612--P:adipose tissue development
GO:0051301--P:cell division
GO:0034389--P:lipid particle organization
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0048698--P:negative regulation of collateral sprouting in absence of injury
GO:0050905--P:neuromuscular process
GO:0051881--P:regulation of mitochondrial membrane potential

KEGG

hsa:23111

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000945	Aegilops tauschii	30.92	5.00e-08	50.80
IUUC-Aml-001571	Ailuropoda melanoleuca	90.76	0.00e+00	1169.00
IUUC-Atr-002839	Amborella trichopoda	25.73	1.00e-05	44.70
IUUC-Apl-003342	Anas platyrhynchos	64.26	0.00e+00	770.00
IUUC-Aca-004468	Anolis carolinensis	61.77	0.00e+00	708.00
IUUC-Aly-005982	Arabidopsis lyrata	27.57	1.00e-11	64.70
IUUC-Ath-006815	Arabidopsis thaliana	27.03	6.00e-12	65.50
IUUC-Acl-008081	Aspergillus clavatus	26.52	6.00e-03	35.80
IUUC-Afl-008421	Aspergillus flavus	24.53	1.00e-05	44.70
IUUC-Afu-008811	Aspergillus fumigatus	24.24	1.00e-03	37.70
IUUC-Ani-009356	Aspergillus nidulans	22.61	9.00e-07	48.50
IUUC-Ang-009547	Aspergillus niger	22.92	1.30e-02	34.70
IUUC-Aor-010117	Aspergillus oryzae	24.53	1.00e-05	44.70
IUUC-Ate-010328	Aspergillus terreus	25.27	2.00e-06	47.80
IUUC-Ame-011529	Astyanax mexicanus	52.59	0.00e+00	637.00
IUUC-Bgr-012228	Blumeria graminis	23.56	3.00e-10	60.10
IUUC-Bta-013103	Bos taurus	88.02	0.00e+00	1105.00
IUUC-Bci-013688	Botrytis cinerea	28.03	1.00e-05	45.10
IUUC-Bdi-014064	Brachypodium distachyon	29.47	1.00e-09	57.40
IUUC-Bol-016309	Brassica oleracea	26.74	7.00e-12	65.10
IUUC-Bra-017489	Brassica rapa	26.74	5.00e-09	55.80
IUUC-Cel-018285	Caenorhabditis elegans	23.24	1.00e-16	81.30
IUUC-Cja-019466	Callithrix jacchus	96.96	0.00e+00	1156.00
IUUC-Cfa-020238	Canis familiaris	89.91	0.00e+00	1201.00
IUUC-Cpo-021344	Cavia porcellus	85.91	0.00e+00	1075.00
IUUC-Csa-024111	Chlorocebus sabaeus	99.08	0.00e+00	1286.00
IUUC-Cho-024779	Choloepus hoffmanni	76.79	0.00e+00	983.00
IUUC-Cin-025499	Ciona intestinalis	47.83	4.00e-19	86.70
IUUC-Csv-026280	Ciona savignyi	38.69	2.00e-23	102.00
IUUC-Cgl-026688	Colletotrichum gloeosporioides	21.52	4.00e-08	52.80
IUUC-Cne-026893	Cryptococcus neoformans	28.57	9.00e-04	38.90
IUUC-Dre-027489	Danio rerio	54.38	0.00e+00	651.00
IUUC-Dno-029328	Dasypus novemcinctus	89.40	0.00e+00	1165.00
IUUC-Dor-030753	Dipodomys ordii	79.89	0.00e+00	823.00
IUUC-Dse-031221	Dothistroma septosporum	24.48	6.00e-10	58.90
IUUC-Dme-031968	Drosophila melanogaster	32.70	2.00e-30	127.00
IUUC-Ete-032874	Echinops telfairi	61.61	2.00e-91	329.00
IUUC-Eca-033971	Equus caballus	88.80	0.00e+00	1159.00
IUUC-Eeu-035263	Erinaceus europaeus	89.54	0.00e+00	1021.00
IUUC-Fca-036286	Felis catus	91.05	0.00e+00	701.00
IUUC-Fal-037321	Ficedula albicollis	61.85	0.00e+00	662.00
IUUC-Fox-037921	Fusarium oxysporum	23.70	6.00e-05	42.40
IUUC-Fso-038444	Fusarium solani	21.93	7.00e-07	48.90
IUUC-Gmo-039462	Gadus morhua	51.07	8.00e-128	451.00
IUUC-Ggr-039967	Gaeumannomyces graminis	26.56	1.00e-05	44.70
IUUC-Gga-041260	Gallus gallus	59.56	0.00e+00	689.00
IUUC-Gac-041547	Gasterosteus aculeatus	50.75	0.00e+00	639.00
IUUC-Gma-042931	Glycine max	28.90	2.00e-08	53.90
IUUC-Ggo-045407	Gorilla gorilla	99.23	0.00e+00	1237.00
IUUC-Hvu-047233	Hordeum vulgare	29.32	1.00e-08	53.50
IUUC-Itr-048591	Ictidomys tridecemlineatus	89.42	0.00e+00	1136.00
IUUC-Lch-050176	Latimeria chalumnae	56.13	0.00e+00	698.00
IUUC-Lpe-050882	Leersia perrieri	28.42	2.00e-09	57.40
IUUC-Loc-052571	Lepisosteus oculatus	54.15	2.00e-179	622.00
IUUC-Lma-053077	Leptosphaeria maculans	30.43	2.00e-04	38.50
IUUC-Laf-053740	Loxodonta africana	85.49	0.00e+00	1080.00
IUUC-Mcc-055063	Macaca mulatta	98.62	0.00e+00	1283.00
IUUC-Meu-056127	Macropus eugenii	59.79	0.00e+00	762.00
IUUC-Mor-057259	Magnaporthe oryzae	27.08	1.00e-09	58.20
IUUC-Mpo-057625	Magnaporthe poae	28.12	9.00e-11	62.00
IUUC-Mtr-058491	Medicago truncatula	28.09	7.00e-11	62.00
IUUC-Mla-058900	Melampsora laricipopulina	23.94	8.00e-09	55.50
IUUC-Mga-059734	Meleagris gallopavo	63.41	0.00e+00	774.00
IUUC-Mvi-060325	Microbotryum violaceum	21.81	7.00e-03	35.40
IUUC-Mmr-061457	Microcebus murinus	93.63	0.00e+00	1206.00
IUUC-Mdo-062577	Monodelphis domestica	65.03	0.00e+00	719.00
IUUC-Mmu-063257	Mus musculus	84.72	0.00e+00	1063.00
IUUC-Mac-064898	Musa acuminata	25.79	2.00e-07	50.80
IUUC-Mpu-065678	Mustela putorius furo	89.97	0.00e+00	1134.00
IUUC-Mlu-067614	Myotis lucifugus	84.62	0.00e+00	1015.00
IUUC-Nfi-068348	Neosartorya fischeri	24.24	3.00e-03	36.60
IUUC-Ncr-068664	Neurospora crassa	26.04	9.00e-10	58.50
IUUC-Nle-069575	Nomascus leucogenys	99.54	0.00e+00	1241.00
IUUC-Opr-070834	Ochotona princeps	91.50	1.00e-81	296.00
IUUC-Ont-072621	Oreochromis niloticus	54.91	0.00e+00	654.00
IUUC-Oan-073131	Ornithorhynchus anatinus	65.58	0.00e+00	731.00
IUUC-Ocu-074756	Oryctolagus cuniculus	90.44	0.00e+00	1186.00
IUUC-Oba-075775	Oryza barthii	24.61	2.00e-09	57.80
IUUC-Obr-076409	Oryza brachyantha	27.89	2.00e-09	57.40
IUUC-Ogl-077634	Oryza glaberrima	27.89	4.00e-09	55.80
IUUC-Ogu-078693	Oryza glumaepatula	27.89	1.00e-08	55.10
IUUC-Oin-080082	Oryza indica	27.89	5.00e-09	55.80
IUUC-Olo-080279	Oryza longistaminata	24.48	3.00e-09	56.20
IUUC-Ome-081481	Oryza meridionalis	27.89	5.00e-09	55.80
IUUC-Oni-083049	Oryza nivara	27.89	6.00e-09	55.50
IUUC-Opu-084128	Oryza punctata	27.89	3.00e-09	57.40
IUUC-Oru-084416	Oryza rufipogon	27.89	5.00e-09	55.80
IUUC-Osa-086030	Oryza sativa	27.89	5.00e-09	55.80
IUUC-Ola-087108	Oryzias latipes	53.52	0.00e+00	656.00
IUUC-Oga-088151	Otolemur garnettii	92.25	0.00e+00	1148.00
IUUC-Oar-090075	Ovis aries	87.74	0.00e+00	1135.00
IUUC-Ptr-091392	Pan troglodytes	99.70	0.00e+00	1267.00
IUUC-Pan-092608	Papio anubis	98.93	0.00e+00	1285.00
IUUC-Psi-093926	Pelodiscus sinensis	61.28	0.00e+00	751.00
IUUC-Pma-094547	Petromyzon marinus	38.20	1.00e-62	233.00
IUUC-Pno-094899	Phaeosphaeria nodorum	24.39	1.00e-07	51.20
IUUC-Ppa-095830	Physcomitrella patens	26.60	7.00e-10	58.50
IUUC-Pfo-097424	Poecilia formosa	52.47	2.00e-175	608.00
IUUC-Pab-098036	Pongo abelii	99.39	0.00e+00	1243.00
IUUC-Pop-099177	Populus trichocarpa	25.91	1.00e-06	48.10
IUUC-Pca-101087	Procavia capensis	72.78	0.00e+00	668.00
IUUC-Ppe-101563	Prunus persica	23.97	3.00e-04	40.00
IUUC-Pva-102133	Pteropus vampyrus	89.40	0.00e+00	1145.00
IUUC-Pgr-103281	Puccinia graminis	30.95	9.00e-04	38.50
IUUC-Ptt-103905	Puccinia triticina	25.00	1.00e-11	65.10
IUUC-Pte-104229	Pyrenophora teres	23.41	3.00e-08	53.50
IUUC-Pyt-104557	Pyrenophora triticirepentis	23.90	3.00e-09	57.00
IUUC-Rno-105284	Rattus norvegicus	84.17	0.00e+00	1089.00
IUUC-Sha-106644	Sarcophilus harrisii	63.42	0.00e+00	772.00
IUUC-Ssl-108616	Sclerotinia sclerotiorum	26.87	3.00e-04	40.00
IUUC-Smo-109029	Selaginella moellendorffii	22.80	3.00e-10	59.70
IUUC-Sit-110774	Setaria italica	25.00	4.00e-12	66.20
IUUC-Sly-111084	Solanum lycopersicum	25.71	5.00e-08	52.40
IUUC-Stu-112484	Solanum tuberosum	26.32	5.00e-09	55.80
IUUC-Sar-113552	Sorex araneus	79.91	0.00e+00	993.00
IUUC-Sbi-114127	Sorghum bicolor	28.65	1.00e-08	54.70
IUUC-Ssc-116159	Sus scrofa	90.00	0.00e+00	1078.00
IUUC-Tgu-117516	Taeniopygia guttata	63.35	0.00e+00	789.00
IUUC-Tru-118377	Takifugu rubripes	53.23	9.00e-179	620.00
IUUC-Tsy-119529	Tarsius syrichta	84.04	0.00e+00	1032.00
IUUC-Tni-120666	Tetraodon nigroviridis	50.62	2.00e-165	575.00
IUUC-Tca-121317	Theobroma cacao	28.16	1.00e-11	64.70
IUUC-Tre-121928	Trichoderma reesei	22.46	3.00e-05	43.90
IUUC-Tvi-122390	Trichoderma virens	21.93	2.00e-06	47.00
IUUC-Tae-122800	Triticum aestivum	30.57	2.00e-10	60.10
IUUC-Tur-126670	Triticum urartu	37.21	2.50e-01	28.90
IUUC-Tme-127076	Tuber melanosporum	22.99	2.00e-07	50.80
IUUC-Tbe-127776	Tupaia belangeri	84.69	0.00e+00	1103.00
IUUC-Ttr-128669	Tursiops truncatus	89.30	0.00e+00	1127.00
IUUC-Vda-129839	Verticillium dahliae	26.21	2.00e-12	67.40
IUUC-Vpa-130069	Vicugna pacos	88.86	2.00e-164	573.00
IUUC-Xtr-132948	Xenopus tropicalis	57.40	0.00e+00	672.00
IUUC-Xma-133239	Xiphophorus maculatus	52.08	6.00e-179	620.00
IUUC-Zma-134720	Zea mays	28.22	1.00e-08	54.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence