iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045877

UUCD1 version

UUC-HoS-00813

Ensembl Protein ID

ENSP00000366271.3

UniProt Accession

Q8NHM5; A8MRS1; Q1RLM7; Q8NCI2; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75; KDM2B_HUMAN

Genbank Protein ID

CAD30700.1; BAB55112.1; BAB55301.1; BAC11159.1; BAG54483.1; AAH08735.2; AAI15380.1; CAB63721.2; BAA97672.1

Protein Name

Lysine-specific demethylase 2B; CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; Protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B

Genbank Nucleotide ID

AJ459424; AK027440; AK027692; AK074718; AK127328; AC048337; BC115379; AL133572; AB031230

Gene Name

KDM2B; CXXC2; FBL10; FBXL10; JHDM1B; PCCX2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000089094.17	ENST00000377069.8	ENSP00000366269.3
ENSG00000089094.17	ENST00000377071.8	ENSP00000366271.3
ENSG00000089094.17	ENST00000543025.5	ENSP00000438138.1
ENSG00000089094.17	ENST00000538046.6	ENSP00000474307.1
ENSG00000089094.17	ENST00000446152.6	ENSP00000398279.2
ENSG00000089094.17	ENST00000542030.5	ENSP00000444846.1
ENSG00000089094.17	ENST00000541318.1	ENSP00000443052.1
ENSG00000089094.17	ENST00000543852.5	ENSP00000440942.1
ENSG00000089094.17	ENST00000536437.5	ENSP00000445196.2
ENSG00000089094.17	ENST00000611216.4	ENSP00000480847.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	TRANSFAC	RepTar	miRNAMap
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/PHD	PHD	22825849

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	4.80e-05	25.1	1017	1105
E3 activity/RING/PHD	3.50e-14	54.4	660	725

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 56   rrtprqpprgpsaaakpkaglrseaaaapap.apaptptpeegpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwk 144
           r  pr   r p + + pk+         p p +p p   p    d g  + +  e+++ ++++l++++l+ + rvcr+w++ + +k+lw 
   Q: 1017 RSPPRVISRPPPSVSPPKCIQMERHVIRPPPiSPPPDSLP---LDDGAAHVMHREVWMAVFSYLSHQDLCVCMRVCRTWNRWCCDKRLWT 1103
           3346777788888888887555555555544133333444...36777888899**************************5555599998 PP
   S: 145  tv 146
           ++
   Q: 1104 RI 1105
           76 PP

E3 activity/RING/PHD

   S: 2    kvClvCgeggede.....k.....slveCekCrewfHpaClkls.....veeelpnsekwiCpkCrsk 54
           +vClvCge+g+++     +     +l+eC++C+e++Hp+Clk++     v++elpn+  w+CpkC+++
   Q: 660  AVCLVCGEAGKEDtveeeEgkfnlMLMECSICNEIIHPGCLKIKesegvVNDELPNC--WECPKCNHA 725
           79*********9977765156789*********************************..*******85 PP

Organism

Homo sapiens

Functional Description
(View)

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

Protein Sequence
(Fasta)

MAGPQMGGSA EDHPPRKRHA AEKQKKKTVI YTKCFEFESA TQRPIDRQRY DENEDLSDVE 60
EIVSVRGFSL EEKLRSQLYQ GDFVHAMEGK DFNYEYVQRE ALRVPLIFRE KDGLGIKMPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTGTCCAC ATCTTTGAGT GCCGGGAGTT TAAAAGTTAG GCAGTCCTTA TAGGTATGGA 60
AGCCGAGCTA ATTTCCTTCT GAGCCCCCCA AATGCCTCCT CCACATGGCG GGTCCGCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-1017--Isopeptide bond
KW-0433--Leucine-rich repeat
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0694--RNA-binding
KW-0699--rRNA-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR003347--JmjC_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF00646--F-box
PF16866--PHD_4
PF02008--zf-CXXC

SMART

SM00558--JmjC
SM00367--LRR_CC
SM00249--PHD

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0051864--F:histone demethylase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0019843--F:rRNA binding
GO:0008270--F:zinc ion binding
GO:0048596--P:embryonic camera-type eye morphogenesis
GO:0030900--P:forebrain development
GO:0021592--P:fourth ventricle development
GO:0030902--P:hindbrain development
GO:0035518--P:histone H2A monoubiquitination
GO:0021993--P:initiation of neural tube closure
GO:0021670--P:lateral ventricle development
GO:0030901--P:midbrain development
GO:0021555--P:midbrain-hindbrain boundary morphogenesis
GO:2000178--P:negative regulation of neural precursor cell proliferation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030307--P:positive regulation of cell growth
GO:1902459--P:positive regulation of stem cell population maintenance
GO:0007283--P:spermatogenesis
GO:0021678--P:third ventricle development
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:84678

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001358	Ailuropoda melanoleuca	96.01	0.00e+00	2271.00
IUUC-Apl-003787	Anas platyrhynchos	84.24	0.00e+00	1930.00
IUUC-Aca-004247	Anolis carolinensis	78.71	0.00e+00	1814.00
IUUC-Ame-011463	Astyanax mexicanus	75.00	5.00e-168	585.00
IUUC-Bta-013531	Bos taurus	96.22	0.00e+00	2307.00
IUUC-Cel-018303	Caenorhabditis elegans	44.55	4.00e-82	300.00
IUUC-Cja-018876	Callithrix jacchus	93.16	0.00e+00	2246.00
IUUC-Cfa-020857	Canis familiaris	96.61	0.00e+00	2312.00
IUUC-Cpo-021967	Cavia porcellus	92.75	0.00e+00	2111.00
IUUC-Csa-023210	Chlorocebus sabaeus	99.14	0.00e+00	2291.00
IUUC-Dre-028272	Danio rerio	64.33	0.00e+00	1523.00
IUUC-Dno-030034	Dasypus novemcinctus	94.45	0.00e+00	2221.00
IUUC-Dor-030736	Dipodomys ordii	85.87	0.00e+00	989.00
IUUC-Eca-034255	Equus caballus	97.19	0.00e+00	2229.00
IUUC-Eeu-035038	Erinaceus europaeus	97.36	0.00e+00	1182.00
IUUC-Fca-035786	Felis catus	96.17	0.00e+00	2276.00
IUUC-Fal-037589	Ficedula albicollis	83.85	0.00e+00	2039.00
IUUC-Gmo-038781	Gadus morhua	64.03	0.00e+00	686.00
IUUC-Gga-041103	Gallus gallus	86.58	0.00e+00	1144.00
IUUC-Gac-041304	Gasterosteus aculeatus	61.42	0.00e+00	1499.00
IUUC-Ggo-044522	Gorilla gorilla	99.80	0.00e+00	1765.00
IUUC-Itr-049003	Ictidomys tridecemlineatus	96.33	0.00e+00	1315.00
IUUC-Lch-049950	Latimeria chalumnae	76.65	0.00e+00	1868.00
IUUC-Loc-051972	Lepisosteus oculatus	72.07	0.00e+00	1097.00
IUUC-Laf-053623	Loxodonta africana	96.21	0.00e+00	2192.00
IUUC-Mcc-054943	Macaca mulatta	99.10	0.00e+00	2395.00
IUUC-Meu-056259	Macropus eugenii	86.32	0.00e+00	2083.00
IUUC-Mga-059671	Meleagris gallopavo	84.71	0.00e+00	1990.00
IUUC-Mmr-061003	Microcebus murinus	96.14	0.00e+00	2287.00
IUUC-Mmu-063584	Mus musculus	93.45	0.00e+00	2221.00
IUUC-Mpu-066056	Mustela putorius furo	96.46	0.00e+00	2276.00
IUUC-Mlu-067850	Myotis lucifugus	95.45	0.00e+00	2265.00
IUUC-Nle-069837	Nomascus leucogenys	96.46	0.00e+00	2074.00
IUUC-Opr-070943	Ochotona princeps	91.54	0.00e+00	2157.00
IUUC-Ont-071663	Oreochromis niloticus	65.31	0.00e+00	1585.00
IUUC-Oan-072934	Ornithorhynchus anatinus	75.47	0.00e+00	1251.00
IUUC-Ocu-074706	Oryctolagus cuniculus	96.23	0.00e+00	2304.00
IUUC-Ola-086543	Oryzias latipes	63.49	0.00e+00	1557.00
IUUC-Oga-088671	Otolemur garnettii	83.92	0.00e+00	1003.00
IUUC-Oar-089560	Ovis aries	91.35	0.00e+00	2204.00
IUUC-Ptr-090875	Pan troglodytes	99.85	0.00e+00	2444.00
IUUC-Pan-091788	Papio anubis	95.44	0.00e+00	2318.00
IUUC-Psi-093382	Pelodiscus sinensis	84.00	0.00e+00	2028.00
IUUC-Pma-094687	Petromyzon marinus	56.77	7.00e-92	332.00
IUUC-Pfo-096272	Poecilia formosa	63.34	0.00e+00	1508.00
IUUC-Pab-097907	Pongo abelii	94.99	0.00e+00	2247.00
IUUC-Pca-100628	Procavia capensis	85.86	0.00e+00	1866.00
IUUC-Pva-102956	Pteropus vampyrus	94.79	0.00e+00	1181.00
IUUC-Rno-105722	Rattus norvegicus	94.90	0.00e+00	1808.00
IUUC-Sha-106626	Sarcophilus harrisii	80.91	0.00e+00	1840.00
IUUC-Ssc-115918	Sus scrofa	95.06	0.00e+00	1751.00
IUUC-Tru-118638	Takifugu rubripes	69.42	0.00e+00	991.00
IUUC-Tbe-127654	Tupaia belangeri	79.60	0.00e+00	1674.00
IUUC-Ttr-128821	Tursiops truncatus	88.20	0.00e+00	2091.00
IUUC-Xtr-131823	Xenopus tropicalis	74.62	0.00e+00	1754.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence