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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063911
Ensembl Protein ID ENSMUSP00000025239.7
UniProt Accession O08539; Q62434; BIN1_MOUSE
Genbank Protein ID AAC53318.1; AAC52661.1
Protein Name Myc box-dependent-interacting protein 1; Amphiphysin II; Amphiphysin-like protein; Bridging integrator 1; SH3 domain-containing protein 9
Genbank Nucleotide ID U86405; U60884
Gene Name Bin1; Amphl; Sh3p9
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024381.15 ENSMUST00000091967.11 ENSMUSP00000089590.5
ENSMUSG00000024381.15 ENSMUST00000025239.7 ENSMUSP00000025239.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/SH3 SH3 17244534
Classification
Family E-value Score Start End
UBD/SH3 8.40e-26 90.8 516 588
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlvi...ekeeqdegWlkgvk........elegkrGlfPenFvekle 63
           +++kvq+++dy+a+++deL+lk+Gdvvlvi   ++eeqdegWl+gvk        ele++rG+fPenF+e+++
   Q: 516  FMFKVQAQHDYTATDTDELQLKAGDVVLVIpfqNPEEQDEGWLMGVKesdwnqhkELEKCRGVFPENFTERVQ 588
           799********************************************************************96 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Heterodimer with AMPH (By similarity). Interacts (via SH3 domain) with SYNJ1. Interacts (via SH3 domain) with DNM1. Interacts with CLTC. Interacts with AP2A2. Interacts with AP2B1. Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2. Binds SH3GLB1. Interacts with BIN2 (By similarity).
 Heterodimer with AMPH (By similarity). Interacts (via SH3 domain) with SYNJ1. Interacts (via SH3 domain) with DNM1. Interacts with CLTC. Interacts with AP2A2. Interacts with AP2B1. Interacts with MYC (via N-terminal transactivation domain); the interaction requires the integrity of the conserved MYC box regions 1 and 2. Binds SH3GLB1. Interacts with BIN2 (By similarity).
Protein Sequence
(Fasta)
MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR 60
LQKDLRTYLA SVKAMHEASK KLSECLQEVY EPEWPGRDEA NKIAENNDLL WMDYHQKLVD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063911|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATCCCCGCG TTGCTCACTC GCTCTCCCCG CGCACGCTCC GTCTCCGTCA GTCCCCTGAG 60
CTGTTCTAGT GCGCGGCGTG GAGCCAGGGC TCAGGCTGGT GGAGCGGCCG GGGCTGGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063911|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0254--Endocytosis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0043--Tumor suppressor
Interpro

IPR027267--AH/BAR-dom
IPR003005--Amphiphysin
IPR003023--Amphiphysin_2
IPR004148--BAR_dom
IPR001452--SH3_domain
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
PF14604--SH3_9
PRINTS

PR01251--AMPHIPHYSIN
PR01253--AMPHIPHYSIN2
PR00452--SH3DOMAIN
SMART

SM00721--BAR
SM00326--SH3
Gene Ontology

GO:0030424--C:axon
GO:0043194--C:axon initial segment
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0031674--C:I band
GO:0060987--C:lipid tube
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0033268--C:node of Ranvier
GO:0005635--C:nuclear envelope
GO:0005634--C:nucleus
GO:0030315--C:T-tubule
GO:0030018--C:Z disc
GO:0051015--F:actin filament binding
GO:0042802--F:identical protein binding
GO:0070063--F:RNA polymerase binding
GO:0048156--F:tau protein binding
GO:0006897--P:endocytosis
GO:0060988--P:lipid tube assembly
GO:0042692--P:muscle cell differentiation
GO:0051647--P:nucleus localization
GO:0006997--P:nucleus organization
GO:0043065--P:positive regulation of apoptotic process
GO:0048711--P:positive regulation of astrocyte differentiation
GO:0071156--P:regulation of cell cycle arrest
GO:0030100--P:regulation of endocytosis
GO:0045664--P:regulation of neuron differentiation
KEGG mmu:30948
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001292 Ailuropoda melanoleuca 85.89 3.00e-172 598.00
IUUC-Apl-003830 Anas platyrhynchos 75.25 0.00e+00 835.00
IUUC-Aca-005149 Anolis carolinensis 64.71 0.00e+00 684.00
IUUC-Ath-007087 Arabidopsis thaliana 44.44 1.20e+00 26.90
IUUC-Ame-011551 Astyanax mexicanus 49.09 2.00e-135 476.00
IUUC-Bta-013069 Bos taurus 93.33 0.00e+00 989.00
IUUC-Cja-019089 Callithrix jacchus 93.09 0.00e+00 1041.00
IUUC-Cfa-020825 Canis familiaris 79.06 4.00e-173 601.00
IUUC-Cpo-022197 Cavia porcellus 94.81 0.00e+00 995.00
IUUC-Csa-023301 Chlorocebus sabaeus 91.94 0.00e+00 1058.00
IUUC-Dre-028384 Danio rerio 67.93 3.00e-111 395.00
IUUC-Dno-029712 Dasypus novemcinctus 94.12 0.00e+00 806.00
IUUC-Dor-030441 Dipodomys ordii 82.35 0.00e+00 641.00
IUUC-Ete-032582 Echinops telfairi 71.75 0.00e+00 684.00
IUUC-Eca-034380 Equus caballus 93.12 0.00e+00 1001.00
IUUC-Eeu-035316 Erinaceus europaeus 89.12 1.00e-146 513.00
IUUC-Fca-036228 Felis catus 80.19 5.00e-167 581.00
IUUC-Fal-037539 Ficedula albicollis 74.56 0.00e+00 857.00
IUUC-Gmo-039190 Gadus morhua 67.13 2.00e-109 389.00
IUUC-Gga-041247 Gallus gallus 78.87 1.00e-143 502.00
IUUC-Gac-042188 Gasterosteus aculeatus 51.66 2.00e-156 545.00
IUUC-Ggo-044521 Gorilla gorilla 92.55 0.00e+00 1005.00
IUUC-Hsa-046050 Homo sapiens 94.27 0.00e+00 1066.00
IUUC-Itr-048478 Ictidomys tridecemlineatus 98.13 0.00e+00 722.00
IUUC-Lch-050550 Latimeria chalumnae 66.83 8.00e-128 451.00
IUUC-Mcc-055717 Macaca mulatta 89.21 0.00e+00 1001.00
IUUC-Meu-056110 Macropus eugenii 76.87 2.00e-116 412.00
IUUC-Mga-059369 Meleagris gallopavo 75.00 1.00e-157 550.00
IUUC-Mmr-061149 Microcebus murinus 92.93 0.00e+00 1037.00
IUUC-Mdo-062533 Monodelphis domestica 77.01 0.00e+00 792.00
IUUC-Mpu-066246 Mustela putorius furo 94.28 0.00e+00 1056.00
IUUC-Nle-069141 Nomascus leucogenys 87.39 0.00e+00 961.00
IUUC-Opr-070200 Ochotona princeps 75.42 0.00e+00 808.00
IUUC-Ont-071795 Oreochromis niloticus 69.34 1.00e-105 377.00
IUUC-Ocu-074817 Oryctolagus cuniculus 80.72 0.00e+00 807.00
IUUC-Obr-076905 Oryza brachyantha 31.46 3.70e-01 30.40
IUUC-Oin-079195 Oryza indica 45.16 2.50e-02 30.80
IUUC-Ola-087308 Oryzias latipes 46.46 1.00e-141 496.00
IUUC-Oga-088872 Otolemur garnettii 85.35 7.00e-161 560.00
IUUC-Ptr-091125 Pan troglodytes 92.80 0.00e+00 1033.00
IUUC-Pan-092349 Papio anubis 94.41 0.00e+00 1063.00
IUUC-Psi-093226 Pelodiscus sinensis 76.48 0.00e+00 816.00
IUUC-Pma-094139 Petromyzon marinus 50.75 4.00e-156 544.00
IUUC-Pfo-096470 Poecilia formosa 53.40 6.00e-112 398.00
IUUC-Pab-098085 Pongo abelii 81.62 0.00e+00 855.00
IUUC-Pop-098870 Populus trichocarpa 31.58 6.00e-05 40.40
IUUC-Pca-100306 Procavia capensis 86.61 2.00e-137 482.00
IUUC-Pva-103041 Pteropus vampyrus 83.84 0.00e+00 911.00
IUUC-Rno-105645 Rattus norvegicus 98.98 0.00e+00 1131.00
IUUC-Sar-113470 Sorex araneus 72.59 3.00e-113 402.00
IUUC-Tgu-117501 Taeniopygia guttata 79.17 5.00e-144 504.00
IUUC-Tru-118163 Takifugu rubripes 51.40 1.00e-147 516.00
IUUC-Tni-120465 Tetraodon nigroviridis 51.75 1.00e-142 499.00
IUUC-Tbe-127789 Tupaia belangeri 84.70 0.00e+00 643.00
IUUC-Ttr-129084 Tursiops truncatus 97.97 1.00e-172 599.00
IUUC-Xtr-132870 Xenopus tropicalis 60.34 4.00e-169 587.00
Created Date 25-Jun-2017

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