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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-045911
Ensembl Protein ID ENSP00000250495.5
UniProt Accession Q15843; Q3SXN8; Q6LES6; NEDD8_HUMAN
Genbank Protein ID BAA04889.1; CAG28590.1; AAI04201.1; AAI04202.1; AAI04665.1
Protein Name NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; Ubiquitin-like protein Nedd8
Genbank Nucleotide ID D23662; CR407662; BC104200; BC104201; BC104664
Gene Name NEDD8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000129559.12 ENST00000250495.9 ENSP00000250495.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbCircNetmicroRNATRANSFAC
TargetScanRepTarmiRNAMapmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPHOSIDABioGRIDmUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
ULD/UBL/NEDD8 NEDD8 9353319
Classification
Family E-value Score Start End
ULD/UBL/NEDD8 7.00e-44 149.6 1 76
ULD/UDP/UBQ/UBQ_PIM 4.20e-22 79.5 1 71
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   ULD/UBL/NEDD8
   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           mlikvktLtgkeiei+ie++d++erikerveekeGiPP+qqrliy+Gkq++d+ktaady++ +gsvLhLvLaLrGG
   Q: 1    MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGG 76
           89*************************************************************************9 PP
   

   ULD/UDP/UBQ/UBQ_PIM
   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvv 71
           m ++vktl+gke+e+++++ d+ve+ Ke+++++ g+pp+qq+LIy+Gk+++D++t  +++i  gsv+hlv+
   Q: 1    MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVL 71
           789******************************************************************97 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
 Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
Protein Sequence
(Fasta)
MLIKVKTLTG KEIEIDIEPT DKVERIKERV EEKEGIPPQQ QRLIYSGKQM NDEKTAADYK 60
ILGGSVLHLV LALRGGGGLR Q 81
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045911|ULD,NEDD8;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGAACCGAAA CGCGGGAGCA ACCCTGAGCC TTTCCGGAAC CCAGTGGGGG GGGGGGGGGG 60
GGTGGAGCCA GACAGTGACC CGGAAGTAGA AGTGGCCCTT GCAGGCAAGA GTGCTGGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045911|ULD,NEDD8;ULD,UBQ_PIM|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
Pfam

PF00240--ubiquitin
PRINTS

PR00348--UBIQUITIN
SMART

SM00213--UBQ
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0031625--F:ubiquitin protein ligase binding
GO:0009653--P:anatomical structure morphogenesis
GO:0006464--P:cellular protein modification process
GO:0016579--P:protein deubiquitination
GO:0008104--P:protein localization
GO:0045116--P:protein neddylation
GO:0006508--P:proteolysis
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0014070--P:response to organic cyclic compound
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:4738
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001930 Ailuropoda melanoleuca 98.33 6.00e-21 91.70
IUUC-Atr-003172 Amborella trichopoda 83.33 7.00e-33 131.00
IUUC-Ago-008002 Ashbya gossypii 64.47 7.00e-24 101.00
IUUC-Acl-008037 Aspergillus clavatus 78.95 9.00e-30 120.00
IUUC-Afu-008979 Aspergillus fumigatus 73.68 5.00e-28 115.00
IUUC-Ani-009466 Aspergillus nidulans 75.31 1.00e-29 120.00
IUUC-Ang-009839 Aspergillus niger 77.63 2.00e-29 119.00
IUUC-Ame-011045 Astyanax mexicanus 97.44 4.00e-30 122.00
IUUC-Bgr-011975 Blumeria graminis 72.37 1.00e-26 110.00
IUUC-Bta-013565 Bos taurus 95.31 3.00e-22 96.30
IUUC-Bci-013689 Botrytis cinerea 71.05 3.00e-19 86.30
IUUC-Cel-018445 Caenorhabditis elegans 88.16 1.00e-24 103.00
IUUC-Cja-019714 Callithrix jacchus 100.00 5.00e-24 102.00
IUUC-Cfa-020576 Canis familiaris 98.33 6.00e-21 91.70
IUUC-Cpo-022447 Cavia porcellus 93.85 3.00e-22 96.30
IUUC-Csa-023443 Chlorocebus sabaeus 93.83 4.00e-39 152.00
IUUC-Cho-024788 Choloepus hoffmanni 97.50 2.00e-31 126.00
IUUC-Cin-025290 Ciona intestinalis 90.79 6.00e-27 111.00
IUUC-Cgl-026712 Colletotrichum gloeosporioides 72.37 2.00e-26 109.00
IUUC-Cme-027142 Cyanidioschyzon merolae 75.00 6.00e-24 102.00
IUUC-Dre-028273 Danio rerio 95.00 7.00e-30 121.00
IUUC-Dor-030213 Dipodomys ordii 96.30 1.00e-30 124.00
IUUC-Dse-031407 Dothistroma septosporum 77.63 6.00e-29 118.00
IUUC-Dme-031610 Drosophila melanogaster 89.87 6.00e-37 144.00
IUUC-Ete-032442 Echinops telfairi 100.00 2.00e-31 126.00
IUUC-Eca-033619 Equus caballus 100.00 5.00e-24 102.00
IUUC-Eeu-035250 Erinaceus europaeus 100.00 5.00e-24 102.00
IUUC-Fca-036565 Felis catus 96.72 3.00e-21 92.40
IUUC-Fal-036836 Ficedula albicollis 90.91 2.00e-21 93.60
IUUC-Fox-037878 Fusarium oxysporum 73.68 3.00e-27 112.00
IUUC-Fso-038359 Fusarium solani 72.15 2.00e-27 113.00
IUUC-Gmo-038699 Gadus morhua 98.46 3.00e-23 99.40
IUUC-Ggr-039872 Gaeumannomyces graminis 75.00 9.00e-28 114.00
IUUC-Gga-041132 Gallus gallus 98.63 4.00e-28 116.00
IUUC-Gac-042098 Gasterosteus aculeatus 93.83 1.00e-29 120.00
IUUC-Ggo-044777 Gorilla gorilla 100.00 8.00e-21 91.30
IUUC-Hvu-047076 Hordeum vulgare 84.00 2.00e-22 96.70
IUUC-Itr-048900 Ictidomys tridecemlineatus 97.53 5.00e-32 128.00
IUUC-Lch-050564 Latimeria chalumnae 98.68 9.00e-30 120.00
IUUC-Lma-053069 Leptosphaeria maculans 78.95 2.00e-29 119.00
IUUC-Laf-053906 Loxodonta africana 93.83 9.00e-31 124.00
IUUC-Mcc-054619 Macaca mulatta 85.25 9.00e-24 101.00
IUUC-Meu-056784 Macropus eugenii 98.46 3.00e-23 99.40
IUUC-Mor-057128 Magnaporthe oryzae 77.63 1.00e-28 117.00
IUUC-Mpo-057329 Magnaporthe poae 76.32 3.00e-28 115.00
IUUC-Mla-058992 Melampsora laricipopulina 73.68 1.00e-20 90.50
IUUC-Mvi-060369 Microbotryum violaceum 69.74 2.00e-26 109.00
IUUC-Mdo-062773 Monodelphis domestica 95.08 2.00e-20 89.70
IUUC-Mmu-063552 Mus musculus 100.00 2.00e-24 103.00
IUUC-Mpu-065984 Mustela putorius furo 96.10 1.00e-29 120.00
IUUC-Nfi-068282 Neosartorya fischeri 73.68 5.00e-28 115.00
IUUC-Ncr-068922 Neurospora crassa 75.00 7.00e-28 114.00
IUUC-Ocu-074716 Oryctolagus cuniculus 100.00 5.00e-24 102.00
IUUC-Opu-083943 Oryza punctata 61.33 1.00e-21 94.40
IUUC-Olu-087844 Ostreococcus lucimarinus 88.00 1.00e-23 100.00
IUUC-Oar-089805 Ovis aries 96.72 4.00e-21 92.00
IUUC-Pan-092763 Papio anubis 100.00 5.00e-24 102.00
IUUC-Pno-095039 Phaeosphaeria nodorum 80.26 3.00e-30 122.00
IUUC-Pfo-096478 Poecilia formosa 98.68 5.00e-30 121.00
IUUC-Pab-098633 Pongo abelii 98.46 4.00e-23 99.00
IUUC-Pca-100180 Procavia capensis 100.00 5.00e-24 102.00
IUUC-Pva-102640 Pteropus vampyrus 100.00 5.00e-24 102.00
IUUC-Pgr-103621 Puccinia graminis 71.05 1.00e-26 110.00
IUUC-Pte-104313 Pyrenophora teres 78.95 7.00e-30 121.00
IUUC-Pyt-104549 Pyrenophora triticirepentis 77.63 3.00e-29 119.00
IUUC-Rno-105633 Rattus norvegicus 100.00 2.00e-24 103.00
IUUC-Sce-106190 Saccharomyces cerevisiae 58.44 3.00e-21 92.80
IUUC-Sha-107504 Sarcophilus harrisii 88.75 5.00e-28 115.00
IUUC-Sja-107751 Schizosaccharomyces japonicus 80.52 1.00e-31 127.00
IUUC-Spo-108180 Schizosaccharomyces pombe 81.58 3.00e-31 126.00
IUUC-Smo-108916 Selaginella moellendorffii 70.65 1.00e-22 98.20
IUUC-Sar-113327 Sorex araneus 100.00 5.00e-24 102.00
IUUC-Sre-114970 Sporisorium reilianum 82.89 8.00e-32 127.00
IUUC-Ssc-115698 Sus scrofa 93.75 2.00e-21 93.20
IUUC-Tru-118771 Takifugu rubripes 95.00 3.00e-30 122.00
IUUC-Tsy-118907 Tarsius syrichta 100.00 5.00e-24 102.00
IUUC-Tni-120655 Tetraodon nigroviridis 98.68 9.00e-30 120.00
IUUC-Tre-122155 Trichoderma reesei 73.68 4.00e-27 112.00
IUUC-Tvi-122440 Trichoderma virens 73.68 2.00e-27 113.00
IUUC-Tme-126933 Tuber melanosporum 76.32 7.00e-29 118.00
IUUC-Ttr-128587 Tursiops truncatus 92.75 3.00e-22 95.90
IUUC-Uma-129335 Ustilago maydis 82.89 1.00e-31 127.00
IUUC-Vda-129767 Verticillium dahliae 68.35 2.00e-26 109.00
IUUC-Vpa-130121 Vicugna pacos 96.92 9.00e-23 97.80
IUUC-Xtr-132345 Xenopus tropicalis 98.68 1.00e-29 120.00
IUUC-Xma-134074 Xiphophorus maculatus 97.18 1.00e-26 110.00
IUUC-Yli-134497 Yarrowia lipolytica 63.64 1.00e-24 104.00
Created Date 25-Jun-2017

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