iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000065717.14	ENST00000262953.10	ENSP00000262953.5
ENSG00000065717.14	ENST00000591529.5	ENSP00000468279.1
ENSG00000065717.14	ENST00000586422.5	ENSP00000465519.1
ENSG00000065717.14	ENST00000443826.7	ENSP00000392427.2
ENSG00000065717.14	ENST00000590536.5	ENSP00000466542.1
ENSG00000065717.14	ENST00000589364.5	ENSP00000465292.1
ENSG00000065717.14	ENST00000591457.5	ENSP00000467337.1
ENSG00000065717.14	ENST00000587137.5	ENSP00000467358.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17041588; 17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.60e-23	81.1	587	625

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd..tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++ sd  t+l++G+ D+t+++WDlr+g++l+
   Q: 587  GHTDGASCIDISDygTRLWTGGLDNTVRCWDLREGRQLQ 625
           8**********6668*********************998 PP

Organism

Homo sapiens

Functional Description
(View)

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Protein Sequence
(Fasta)

MYPQGRHPTP LQSGQPFKFS ILEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY 60
VMYYEMSYGL NIEMHKQAEI VKRLSGICAQ IIPFLTQEHQ QQVLQAVERA KQVTVGELNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAATTGTA CTGAGAATTA GAACTTCTGC AAGGGCTCAA GAGTGTCAGC TAGTAATAAT 60
AATAATAACA ATAGTAAGTA TTACTGATAT TGATGTTGCT GGCAGCAGAA GGATGCCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005615--C:extracellular space
GO:0005925--C:focal adhesion
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0003714--F:transcription corepressor activity
GO:0009887--P:animal organ morphogenesis
GO:1904837--P:beta-catenin-TCF complex assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0007165--P:signal transduction
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:7089

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002339	Ailuropoda melanoleuca	94.92	0.00e+00	963.00
IUUC-Aca-004777	Anolis carolinensis	74.91	0.00e+00	804.00
IUUC-Bta-013343	Bos taurus	95.73	0.00e+00	1168.00
IUUC-Cja-018857	Callithrix jacchus	94.35	0.00e+00	1113.00
IUUC-Cfa-021227	Canis familiaris	95.64	0.00e+00	1152.00
IUUC-Cpo-021907	Cavia porcellus	90.77	0.00e+00	949.00
IUUC-Csa-023394	Chlorocebus sabaeus	87.33	0.00e+00	1131.00
IUUC-Dno-029791	Dasypus novemcinctus	93.47	0.00e+00	976.00
IUUC-Ete-032720	Echinops telfairi	80.22	0.00e+00	963.00
IUUC-Eca-033329	Equus caballus	96.16	0.00e+00	1188.00
IUUC-Fca-036428	Felis catus	94.21	0.00e+00	948.00
IUUC-Fal-037319	Ficedula albicollis	86.25	0.00e+00	736.00
IUUC-Itr-048745	Ictidomys tridecemlineatus	89.11	0.00e+00	1196.00
IUUC-Laf-053750	Loxodonta africana	92.33	0.00e+00	1203.00
IUUC-Mcc-055481	Macaca mulatta	99.06	0.00e+00	1261.00
IUUC-Mmr-061248	Microcebus murinus	96.64	0.00e+00	1278.00
IUUC-Mdo-061812	Monodelphis domestica	73.50	0.00e+00	858.00
IUUC-Mmu-064041	Mus musculus	87.78	0.00e+00	1157.00
IUUC-Mlu-068206	Myotis lucifugus	84.86	0.00e+00	1119.00
IUUC-Opr-070260	Ochotona princeps	85.69	0.00e+00	867.00
IUUC-Oga-089089	Otolemur garnettii	93.48	0.00e+00	1255.00
IUUC-Oar-089937	Ovis aries	88.44	0.00e+00	1110.00
IUUC-Ptr-090844	Pan troglodytes	93.41	0.00e+00	1125.00
IUUC-Pan-091708	Papio anubis	98.92	0.00e+00	1261.00
IUUC-Psi-094070	Pelodiscus sinensis	67.80	0.00e+00	888.00
IUUC-Pca-100236	Procavia capensis	92.73	0.00e+00	1238.00
IUUC-Pva-102187	Pteropus vampyrus	91.40	0.00e+00	706.00
IUUC-Rno-105639	Rattus norvegicus	84.85	0.00e+00	1083.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence