iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000034771.15	ENSMUST00000135211.7	ENSMUSP00000117453.1
ENSMUSG00000034771.15	ENSMUST00000146916.7	ENSMUSP00000121173.1
ENSMUSG00000034771.15	ENSMUST00000143285.7	ENSMUSP00000122074.1
ENSMUSG00000034771.15	ENSMUST00000146358.7	ENSMUSP00000121125.1
ENSMUSG00000034771.15	ENSMUST00000124854.7	ENSMUSP00000118334.1
ENSMUSG00000034771.15	ENSMUST00000131411.1	ENSMUSP00000114400.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.30e-23	80.6	611	649

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd..tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++ sd  t+l++G+ D+t+++WDlr+g++l+
   Q: 611  GHTDGASCIDISDygTRLWTGGLDNTVRCWDLREGRQLQ 649
           8**********6668*********************998 PP

Organism

Mus musculus

Functional Description
(View)

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

Protein Sequence
(Fasta)

MYPQGRHPTP LQSGQPFKFS VLEICDRIKE EFQFLQAQYH SLKLECEKLA SEKTEMQRHY 60
VMAAPHQCPQ GGTSYPHWPR LSPLQYYEMS YGLNIEMHKQ AEIVKRLSAI CAQMVPFLTQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGAGGGGCT GGGGGCGTGG TCATGGGTGA CTTCTGCCTA GAATCCCTCG GTGAAGGGCT 60
GGGGGTGTGG TCAGAGGTAG AGCTGCTGCC TAGAATCTCC CAGTGAAGGT CTGGGGGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005615--C:extracellular space
GO:0005925--C:focal adhesion
GO:0016604--C:nuclear body
GO:0005634--C:nucleus
GO:0003714--F:transcription corepressor activity
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
GO:0016055--P:Wnt signaling pathway

KEGG

mmu:21886

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002339	Ailuropoda melanoleuca	90.06	0.00e+00	926.00
IUUC-Bta-013343	Bos taurus	86.44	0.00e+00	1087.00
IUUC-Cja-018857	Callithrix jacchus	86.85	0.00e+00	1036.00
IUUC-Cfa-021227	Canis familiaris	86.43	0.00e+00	1069.00
IUUC-Cpo-021907	Cavia porcellus	87.22	0.00e+00	913.00
IUUC-Csa-023394	Chlorocebus sabaeus	77.68	0.00e+00	1050.00
IUUC-Dno-029791	Dasypus novemcinctus	88.60	0.00e+00	922.00
IUUC-Ete-032720	Echinops telfairi	72.21	0.00e+00	890.00
IUUC-Eca-033329	Equus caballus	86.69	0.00e+00	1110.00
IUUC-Fca-036428	Felis catus	89.33	0.00e+00	907.00
IUUC-Fal-037319	Ficedula albicollis	83.72	0.00e+00	719.00
IUUC-Ggo-045645	Gorilla gorilla	82.08	0.00e+00	845.00
IUUC-Hsa-046801	Homo sapiens	87.92	0.00e+00	1168.00
IUUC-Itr-048745	Ictidomys tridecemlineatus	90.77	0.00e+00	939.00
IUUC-Laf-053750	Loxodonta africana	86.88	0.00e+00	1167.00
IUUC-Mcc-055481	Macaca mulatta	88.31	0.00e+00	1174.00
IUUC-Mmr-061248	Microcebus murinus	87.66	0.00e+00	1191.00
IUUC-Mlu-068206	Myotis lucifugus	77.28	0.00e+00	1048.00
IUUC-Oga-089089	Otolemur garnettii	82.86	0.00e+00	1170.00
IUUC-Oar-089937	Ovis aries	81.04	0.00e+00	1049.00
IUUC-Ptr-090844	Pan troglodytes	82.21	0.00e+00	1023.00
IUUC-Pan-091708	Papio anubis	88.31	0.00e+00	1174.00
IUUC-Psi-094070	Pelodiscus sinensis	64.01	0.00e+00	865.00
IUUC-Pca-100236	Procavia capensis	84.82	0.00e+00	1156.00
IUUC-Rno-105639	Rattus norvegicus	88.27	0.00e+00	1137.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence